| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Taida Huang, Xiaonan Guo, Xiaomin Huang, Chenju Yi, Yihui Cui, Yiyan Don. Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics. Journal of Zhejiang University. Science. B. 2024-04-14. PMID:38616136. |
lhb subregions also separately assign aversive valence via dissociable projections to the downstream targets in the midbrain which provides feedback loops. |
2024-04-14 |
2024-04-17 |
Not clear |
| Yixin Fu, Wenfu Li, Yunlin Mai, Junhao Guan, Ruxuan Ding, Jiawei Hou, Bingqing Chen, Guoxin Cao, Shizhu Sun, Ying Tang, Rao F. Association between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice. International journal of molecular sciences. vol 25. issue 5. 2024-03-13. PMID:38474180. |
the rostromedial tegmental nucleus (rmtg), which inhibits midbrain dopamine neurons and signals aversion, has been shown to increase ethanol consumption and negative emotional states during abstinence. |
2024-03-13 |
2024-03-15 |
mouse |
| Gabriela Izowit, Magdalena Walczak, Gniewosz Drwięga, Wojciech Solecki, Tomasz Błasia. Brain state-dependent responses of midbrain dopaminergic neurons to footshock under urethane anaesthesia. The European journal of neuroscience. 2024-01-18. PMID:38233998. |
adding to the knowledge of aversion signalling by midbrain da neurons, we report that significant proportion of vta&snc da neurons can change their responses to an aversive stimulus in a brain state-dependent manner. |
2024-01-18 |
2024-01-20 |
rat |
| Véronique Coizet, Racha Al Tannir, Arnaud Pautrat, Paul G Overto. Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures. Current neuropharmacology. 2023-08-18. PMID:37594168. |
in this review, we describe how brainstem structures also project to the main input structures of the basal ganglia, namely the striatum, the subthalamic nucleus and midbrain dopaminergic neurons, in the context of approach and avoidance (including escape from threat), two fundamental, mutually exclusive behavioral choices in an animal's repertoire in which the brainstem is strongly involved. |
2023-08-18 |
2023-09-07 |
Not clear |
| Shaohua Ma, Hao Zhong, Xuemei Liu, Liping Wan. Spatial Distribution of Neurons Expressing Single, Double, and Triple Molecular Characteristics of Glutamatergic, Dopaminergic, or GABAergic Neurons in the Mouse Ventral Tegmental Area. Journal of molecular neuroscience : MN. 2023-05-27. PMID:37243808. |
the ventral tegmental area (vta) is a heterogeneous midbrain area that plays a significant role in diverse neural processes such as reward, aversion, and motivation. |
2023-05-27 |
2023-08-14 |
mouse |
| Ying S Chao, Jeffrey Parrilla-Carrero, Maya Eid, Oliver P Culver, Tyler B Jackson, Rachel Lipat, Makoto Taniguchi, Thomas C Jho. Innate cocaine-seeking vulnerability arising from loss of serotonin-mediated aversive effects of cocaine in rats. Cell reports. vol 42. issue 5. 2023-04-21. PMID:37083325. |
however, cocaine also blocks serotonin uptake, which we show drives, in rats, individually variable aversive effects that depend on serotonin 2c receptors (5-ht2crs) in the rostromedial tegmental nucleus (rmtg), a major gabaergic afferent to midbrain dopamine neurons. |
2023-04-21 |
2023-08-14 |
rat |
| Meng-Nan Liu, Xiao-Yu Tian, Ting Fang, Ning Wu, Hong Li, Jin L. Insights into the Involvement and Therapeutic Target Potential of the Dopamine System in the Posttraumatic Stress Disorder. Molecular neurobiology. 2023-03-18. PMID:36933147. |
while the midbrain dopamine system can affect physiological processes such as aversive fear memory learning, consolidation, persistence, and extinction, by altering the functions of the dopaminergic neurons, our viewpoint is that the dopamine system plays a considerable role in the ptsd occurrence and acts as a potential therapeutic target of the disorder. |
2023-03-18 |
2023-08-14 |
Not clear |
| Quentin Montardy, Zheng Zhou, Zhuogui Lei, Xuemei Liu, Pengyu Zeng, Chen Chen, Yuanming Liu, Paula Sanz-Leon, Kang Huang, Liping Wan. Characterization of glutamatergic VTA neural population responses to aversive and rewarding conditioning in freely-moving mice. Science bulletin. vol 64. issue 16. 2023-01-20. PMID:36659688. |
the ventral tegmental area (vta) is a midbrain structure known to integrate aversive and rewarding stimuli, but little is known about the role of vta glutamatergic (vglut2) neurons in these functions. |
2023-01-20 |
2023-08-14 |
mouse |
| Susanna Molas, Rubing Zhao-Shea, Timothy G Freels, Andrew R Tappe. Viral tracing confirms paranigral ventral tegmental area dopaminergic inputs to the interpeduncular nucleus where dopamine release encodes motivated exploration. eNeuro. 2023-01-04. PMID:36599671. |
previous work identifying a mesointerpeduncular circuit consisting of vta daergic neurons projecting to the interpeduncular nucleus (ipn), a midbrain area implicated in aversion, anxiety-like behavior, and familiarity, has recently come into question. |
2023-01-04 |
2023-08-14 |
mouse |
| Ying Duan, Pei-Jung Tsai, Betty Jo Salmeron, Yuzheng Hu, Hong Gu, Hanbing Lu, Jean Lud Cadet, Elliot A Stein, Yihong Yan. Compulsive drug-taking is associated with habenula-frontal cortex connectivity. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 50. 2022-12-05. PMID:36469769. |
as a critical node connecting the forebrain with the midbrain, the lateral habenula (lhb) processes negative feedback in response to aversive events and plays an essential role in value-based decision-making. |
2022-12-05 |
2023-08-14 |
rat |
| Alice Servonnet, Saleem M Nicol. Dips in dopamine say "no" to nicotine. Neuron. vol 110. issue 18. 2022-09-22. PMID:36137519. |
show that nicotine aversion depends on both desensitization of high-affinity nicotinic acetylcholine receptors (nachrs) that activate midbrain dopamine neurons and activation of low-affinity nachrs that inhibit dopamine neurons via the laterodorsal tegmental nucleus (ldt). |
2022-09-22 |
2023-08-14 |
Not clear |
| Sukjae J Kang, Shijia Liu, Mao Ye, Dong-Il Kim, Gerald M Pao, Bryan A Copits, Benjamin Z Roberts, Kuo-Fen Lee, Michael R Bruchas, Sung Ha. A central alarm system that gates multi-sensory innate threat cues to the amygdala. Cell reports. vol 40. issue 7. 2022-08-17. PMID:35977501. |
previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. |
2022-08-17 |
2023-08-14 |
Not clear |
| Mario Bogdanov, Sophia LoParco, A Ross Otto, Madeleine Shar. Dopaminergic medication increases motivation to exert cognitive control by reducing subjective effort costs in Parkinson's patients. Neurobiology of learning and memory. 2022-06-20. PMID:35724812. |
to address this question, we assessed cognitive effort avoidance in patients (n = 38) with parkinson's disease, a condition characterized by loss of midbrain dopaminergic neurons, both on and off dopaminergic medication and compared them to healthy controls (n = 24). |
2022-06-20 |
2023-08-14 |
human |
| Todd B Nentwig, Dylan T Vaughan, Kevin M Braunscheidel, Brittney D Browning, John J Woodward, L Judson Chandle. The lateral habenula is not required for ethanol dependence-induced escalation of drinking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-06-18. PMID:35717465. |
the lhb controls activity of the rostromedial tegmental nucleus (rmtg), a midbrain nucleus activated by aversive experiences including ethanol withdrawal. |
2022-06-18 |
2023-08-14 |
rat |
| Xue Liu, Hongren Huang, Yulin Zhang, Liping Wang, Feng Wan. Sexual Dimorphism of Inputs to the Lateral Habenula in Mice. Neuroscience bulletin. 2022-06-01. PMID:35644002. |
the lateral habenula (lhb), which is a critical neuroanatomical hub and a regulator of midbrain monoaminergic centers, is activated by events resulting in negative valence and contributes to the expression of both appetitive and aversive behaviors. |
2022-06-01 |
2023-08-13 |
mouse |
| Theodoros Tsetsenis, Julia K Badyna, Julianne A Wilson, Xiaowen Zhang, Elizabeth N Krizman, Manivannan Subramaniyan, Kechun Yang, Steven A Thomas, John A Dan. Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 40. 2021-12-06. PMID:34580198. |
midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. |
2021-12-06 |
2023-08-13 |
mouse |
| Feng He, Pei Zhang, Qian Zhang, Guangjian Qi, Hongwei Cai, Tongxia Li, Ming Li, Jiazhen Lu, Jiaen Lin, Jie Ming, Bo Tia. Dopaminergic Projection from Ventral Tegmental Area to Substantia Nigra Pars Reticulata Mediates Chronic Social Defeat Stress-Induced Hypolocomotion. Molecular neurobiology. vol 58. issue 11. 2021-11-18. PMID:34382160. |
in mdd, the midbrain ventral tegmental area (vta) dopamine (da) neurons are closely related to regulate the information processing of reward, motivation, cognition, and aversion. |
2021-11-18 |
2023-08-13 |
mouse |
| Laura A Bradfield, Mihaela D Iordanov. Threat perception: Fear and the retrorubal field. Current biology : CB. vol 31. issue 10. 2021-11-11. PMID:34033766. |
a new study has found that neurons within a structure of the rat midbrain known as the retrorubral field show diverse responses to stimuli that signal different levels of threat, as well as a separate pattern of diverse responses to differentially predicted aversive outcomes. |
2021-11-11 |
2023-08-13 |
rat |
| Margherita Zaupa, Seyedeh Maryam Alavi Naini, Maroun Abi Younes, Erika Bullier, Erik R Duboué, Hervé Le Corronc, Hédi Soula, Sebastien Wolf, Raphaël Candelier, Pascal Legendre, Marnie E Halpern, Jean-Marie Mangin, Elim Hon. Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway. Current biology : CB. vol 31. issue 21. 2021-11-11. PMID:34529937. |
the evolutionarily conserved forebrain to midbrain habenulo-interpeduncular nucleus (hb-ipn) pathway consists of cholinergic and non-cholinergic neurons, which mediate different aversive behaviors. |
2021-11-11 |
2023-08-13 |
Not clear |
| Sebastian Hormigo, Ji Zhou, Manuel A Castro-Alamanco. Zona Incerta GABAergic Output Controls a Signaled Locomotor Action in the Midbrain Tegmentum. eNeuro. vol 7. issue 1. 2021-06-18. PMID:32041743. |
inhibition of zona incerta gabaergic cells drives active avoidance responses, while excitation of these cells blocks signaled active avoidance mainly by inhibiting cells in the midbrain pedunculopontine tegmental nucleus (ppt). |
2021-06-18 |
2023-08-13 |
mouse |