All Relations between aversion and mesencephalon

Publication Sentence Publish Date Extraction Date Species
Sebastian Hormigo, Ji Zhou, Dorian Chabbert, Bharanidharan Shanmugasundaram, Manuel A Castro-Alamanco. Basal Ganglia Output Has a Permissive Non-Driving Role in a Signaled Locomotor Action Mediated by the Midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 7. 2021-04-29. PMID:33328292. using mice of either sex, we found that the main basal ganglia gabaergic output in the midbrain, the substantia nigra pars reticulata (snr), shows movement-related neural activity during the expression of a negatively reinforced signaled locomotor action known as signaled active avoidance; this action involves mice moving away during a warning signal to avoid a threat. 2021-04-29 2023-08-13 mouse
Sebastian Hormigo, Ji Zhou, Dorian Chabbert, Bharanidharan Shanmugasundaram, Manuel A Castro-Alamanco. Basal Ganglia Output Has a Permissive Non-Driving Role in a Signaled Locomotor Action Mediated by the Midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 7. 2021-04-29. PMID:33328292. we found that optogenetic excitation of snr or striatal gabaergic fibers that project to an area in the pedunculopontine tegmentum (ppt) within the midbrain locomotor region abolishes signaled active avoidance responses, while optogenetic inhibition of snr cells (mimicking the snr deactivation observed during an active avoidance behavior) serves as an effective conditioned stimulus signal to drive avoidance responses by disinhibiting ppt neurons. 2021-04-29 2023-08-13 mouse
Sebastian Hormigo, Ji Zhou, Dorian Chabbert, Bharanidharan Shanmugasundaram, Manuel A Castro-Alamanco. Basal Ganglia Output Has a Permissive Non-Driving Role in a Signaled Locomotor Action Mediated by the Midbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 7. 2021-04-29. PMID:33328292. however, preclusion of snr deactivation, or direct inhibition of snr fibers in the ppt, does not impair the expression of signaled active avoidance, indicating that snr output does not drive the expression of a signaled locomotor action mediated by the midbrain. 2021-04-29 2023-08-13 mouse
Quentin Montardy, Zheng Zhou, Xuemei Liu, Zhuogui Lei, Pengyu Zeng, Chen Chen, Yuanming Liu, Kang Huang, Mengxia Wei, Liping Wan. Glutamatergic and gabaergic neuronal populations in the dorsal Periacqueductual Gray have different functional roles in aversive conditioning. Neuroscience letters. vol 732. 2021-04-27. PMID:32454151. the dorsal periacqueductal gray (dpag) is a midbrain structure having an essential role in coordinating defensive behaviors in response to aversive stimulation. 2021-04-27 2023-08-13 Not clear
Adrien T Stanley, Pellegrino Lippiello, David Sulzer, Maria Concetta Miniac. Roles for the Dorsal Striatum in Aversive Behavior. Frontiers in cellular neuroscience. vol 15. 2021-03-08. PMID:33664651. our understanding of how the brain encodes aversive behaviors has been primarily focused on roles for the amygdala, hippocampus (hipp), prefrontal cortex, ventral midbrain, and ventral striatum. 2021-03-08 2023-08-13 Not clear
Dan Qiao, Aixia Zhang, Ning Sun, Chunxia Yang, Jianying Li, Ting Zhao, Yuchen Wang, Yifan Xu, Yujiao Wen, Kerang Zhang, Zhifen Li. Altered Static and Dynamic Functional Connectivity of Habenula Associated With Suicidal Ideation in First-Episode, Drug-Naïve Patients With Major Depressive Disorder. Frontiers in psychiatry. vol 11. 2021-01-05. PMID:33391057. the habenula is a key brain region that links the forebrain to midbrain, crucial for the processing of reward and aversion. 2021-01-05 2023-08-13 human
Stephen D Smith, Tiffany A Kolesar, Jennifer Kornelse. Lateralized Brainstem and Cervical Spinal Cord Responses to Aversive Sounds: A Spinal fMRI Study. Brain sciences. vol 8. issue 9. 2020-09-30. PMID:30200289. aversive sounds elicited greater activity than neutral sounds in the right midbrain and brainstem, and in right dorsal and ventral regions of the cervical spinal cord. 2020-09-30 2023-08-13 human
Stephen D Smith, Tiffany A Kolesar, Jennifer Kornelse. Lateralized Brainstem and Cervical Spinal Cord Responses to Aversive Sounds: A Spinal fMRI Study. Brain sciences. vol 8. issue 9. 2020-09-30. PMID:30200289. neutral stimuli, on the other hand, elicited less neural activity than aversive sounds overall; these responses were left lateralized and were found in the medial midbrain and the dorsal sensory regions of the cervical spinal cord. 2020-09-30 2023-08-13 human
John D Boughter, Lianyi Lu, Louis N Saites, Kenichi Tokit. Sweet and bitter taste stimuli activate VTA projection neurons in the parabrachial nucleus. Brain research. vol 1714. 2020-09-17. PMID:30807736. these results indicate that information about both appetitive and aversive tastes is delivered to a key midbrain reward interface via direct projections from the pbn. 2020-09-17 2023-08-13 mouse
Hao Li, Dominika Pullmann, Jennifer Y Cho, Maya Eid, Thomas C Jho. Generality and opponency of rostromedial tegmental (RMTg) roles in valence processing. eLife. vol 8. 2020-04-20. PMID:30667358. the rostromedial tegmental nucleus (rmtg), a gabaergic afferent to midbrain dopamine (da) neurons, has been hypothesized to be broadly activated by aversive stimuli. 2020-04-20 2023-08-13 Not clear
Rao Fu, Wanhong Zuo, Nimisha Shiwalkar, Qinghua Mei, Qing Fan, Xuejun Chen, Jing Li, Alex Bekker, Jiang-Hong Y. Alcohol withdrawal drives depressive behaviors by activating neurons in the rostromedial tegmental nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 44. issue 8. 2020-03-31. PMID:30928995. rostromedial tegmental nucleus (rmtg) gaba neurons exert a primary inhibitory drive onto midbrain dopamine neurons and are excited by a variety of aversive stimuli. 2020-03-31 2023-08-13 rat
Leandra R Mangieri, Zhiying Jiang, Yungang Lu, Yuanzhong Xu, Ryan M Cassidy, Nicholas Justice, Yong Xu, Benjamin R Arenkiel, Qingchun Ton. Defensive Behaviors Driven by a Hypothalamic-Ventral Midbrain Circuit. eNeuro. vol 6. issue 4. 2020-03-06. PMID:31331938. we mapped pvh outputs that densely terminate in the ventral midbrain (vmb) area, and found that activation of the pvh→vmb circuit produced profound defensive behavioral changes, including escape jumping, hiding, hyperlocomotion, and learned aversion. 2020-03-06 2023-08-13 mouse
Jennifer M Wenzel, Erik B Oleson, Willard N Gove, Anthony B Cole, Utsav Gyawali, Hannah M Dantrassy, Rebecca J Bluett, Dilyan I Dryanovski, Garret D Stuber, Karl Deisseroth, Brian N Mathur, Sachin Patel, Carl R Lupica, Joseph F Chee. Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain. Current biology : CB. vol 28. issue 9. 2019-11-25. PMID:29681476. phasic dopamine signals in the nucleus accumbens that cause active avoidance require endocannabinoid mobilization in the midbrain. 2019-11-25 2023-08-13 Not clear
Jennifer M Wenzel, Erik B Oleson, Willard N Gove, Anthony B Cole, Utsav Gyawali, Hannah M Dantrassy, Rebecca J Bluett, Dilyan I Dryanovski, Garret D Stuber, Karl Deisseroth, Brian N Mathur, Sachin Patel, Carl R Lupica, Joseph F Chee. Phasic Dopamine Signals in the Nucleus Accumbens that Cause Active Avoidance Require Endocannabinoid Mobilization in the Midbrain. Current biology : CB. vol 28. issue 9. 2019-11-25. PMID:29681476. dopaminergic control of avoidance requires endocannabinoids (ecbs), as perturbing ecb signaling in the midbrain disrupts avoidance, which is rescued by optical stimulation of da neurons. 2019-11-25 2023-08-13 Not clear
Yo Otsu, Salvatore Lecca, Katarzyna Pietrajtis, Charly Vincent Rousseau, Païkan Marcaggi, Guillaume Pierre Dugué, Caroline Mailhes-Hamon, Manuel Mameli, Marco Alberto Dian. Functional Principles of Posterior Septal Inputs to the Medial Habenula. Cell reports. vol 22. issue 3. 2019-07-09. PMID:29346767. the medial habenula (mhb) is an epithalamic hub contributing to expression and extinction of aversive states by bridging forebrain areas and midbrain monoaminergic centers. 2019-07-09 2023-08-13 Not clear
Marc Fakhour. The tail of the ventral tegmental area in behavioral processes and in the effect of psychostimulants and drugs of abuse. Progress in neuro-psychopharmacology & biological psychiatry. vol 84. issue Pt A. 2019-02-14. PMID:29421265. as an important inhibitory afferent to midbrain da neurons, the tvta is also implicated in drug abuse and in the complex interplay between reward and aversion processes. 2019-02-14 2023-08-13 mouse
Ray Luo, Akira Uematsu, Adam Weitemier, Luca Aquili, Jenny Koivumaa, Thomas J McHugh, Joshua P Johanse. A dopaminergic switch for fear to safety transitions. Nature communications. vol 9. issue 1. 2019-01-11. PMID:29950562. we report that when an expected aversive outcome does not occur, activity in midbrain dopamine neurons is necessary to extinguish behavioral fear responses and engage molecular signaling events in extinction learning circuits. 2019-01-11 2023-08-13 Not clear
Avi Shah, Wanhong Zuo, Seungwoo Kang, Jing Li, Rao Fu, Haifeng Zhang, Alex Bekker, Jiang-Hong Y. The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. Pharmacology, biochemistry, and behavior. vol 162. 2018-06-18. PMID:28624587. this review will center on the effects of alcohol in the lateral habenula (lhb), an epithalamic structure that connects the forebrain with the midbrain and encodes aversive signaling. 2018-06-18 2023-08-13 Not clear
Peter Koppensteiner, Riccardo Melani, Ipe Nina. A Cooperative Mechanism Involving Ca Cell reports. vol 20. issue 5. 2018-04-17. PMID:28768196. a cooperative mechanism involving ca the medial habenula-interpeduncular nucleus (mhb-ipn) pathway, which connects the limbic forebrain to the midbrain, has recently been implicated in aversive behaviors. 2018-04-17 2023-08-13 Not clear
Peter J Vento, Nathan W Burnham, Courtney S Rowley, Thomas C Jho. Learning From One's Mistakes: A Dual Role for the Rostromedial Tegmental Nucleus in the Encoding and Expression of Punished Reward Seeking. Biological psychiatry. vol 81. issue 12. 2018-03-02. PMID:27931744. the recently identified rostromedial tegmental nucleus (rmtg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections to midbrain dopamine neurons, leading to the hypothesis that the rmtg provides a brake to reward signaling in response to aversive costs. 2018-03-02 2023-08-13 Not clear