| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kelly Hennigan, Kimberlee D'Ardenne, Samuel M McClur. Distinct midbrain and habenula pathways are involved in processing aversive events in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 1. 2015-03-20. PMID:25568114. |
robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (vta) and the other in the substantia nigra (sn). |
2015-03-20 |
2023-08-13 |
Not clear |
| S Muthuraju, M J Nobre, V M N Saito, M L Branda. Distinct effects of haloperidol in the mediation of conditioned fear in the mesolimbic system and processing of unconditioned aversive information in the inferior colliculus. Neuroscience. vol 261. 2014-09-19. PMID:24384225. |
thus, da appears to regulate unconditioned fear at the midbrain level, likely by reducing the sensory gating of aversive events and reducing conditioned fear by acting at more rostral levels of the brain. |
2014-09-19 |
2023-08-12 |
rat |
| M Camplesi, V C de Bortoli, V de Paula Soares, R L Nogueira, H Zangross. Dorsal periaqueductal gray stimulation facilitates anxiety-, but not panic-related, defensive responses in rats tested in the elevated T-maze. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 45. issue 11. 2014-08-29. PMID:22850873. |
in order to explore the validity of the dpag stimulation model for the study of panic disorder, we determined if the aversive consequences of the electrical or chemical stimulation of this midbrain area can be detected subsequently in the elevated t-maze. |
2014-08-29 |
2023-08-12 |
rat |
| Stephan Lammel, Byung Kook Lim, Robert C Malenk. Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23578393. |
reward and aversion in a heterogeneous midbrain dopamine system. |
2014-07-29 |
2023-08-12 |
Not clear |
| Stephan Lammel, Byung Kook Lim, Robert C Malenk. Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology. vol 76 Pt B. 2014-07-29. PMID:23578393. |
here we will focus on recent advances in understanding the neural circuits mediating reward and aversion in the vta and how stress as well as drugs of abuse, in particular cocaine, alter circuit function within a heterogeneous midbrain da system. |
2014-07-29 |
2023-08-12 |
Not clear |
| Kimberly A Young, Teresa R Franklin, David C S Roberts, Kanchana Jagannathan, Jesse J Suh, Reagan R Wetherill, Ze Wang, Kyle M Kampman, Charles P O'Brien, Anna Rose Childres. Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 14. 2014-05-22. PMID:24695721. |
we observed that baclofen-treated participants displayed significantly less activation in response to subliminal cocaine (vs neutral) cues, but not sexual or aversive (vs neutral) cues, than placebo-treated participants in a large interconnected bilateral cluster spanning the ventral striatum, ventral pallidum, amygdala, midbrain, and orbitofrontal cortex (voxel threshold p < 0.005; cluster corrected at p < 0.05). |
2014-05-22 |
2023-08-13 |
human |
| Daniel W Grupe, Desmond J Oathes, Jack B Nitschk. Dissecting the anticipation of aversion reveals dissociable neural networks. Cerebral cortex (New York, N.Y. : 1991). vol 23. issue 8. 2014-02-26. PMID:22763169. |
the amcc showed increased functional coupling with the midbrain during sustained anticipation of aversion, highlighting a circuit critical for the expression of preparatory fear responses. |
2014-02-26 |
2023-08-12 |
human |
| Simon Hon. Dopamine system: manager of neural pathways. Frontiers in human neuroscience. vol 7. 2013-12-24. PMID:24367324. |
there are a growing number of roles that midbrain dopamine (da) neurons assume, such as, reward, aversion, alerting and vigor. |
2013-12-24 |
2023-08-12 |
Not clear |
| Paul Leon Brown, Paul D Shepar. Lesions of the fasciculus retroflexus alter footshock-induced cFos expression in the mesopontine rostromedial tegmental area of rats. PloS one. vol 8. issue 4. 2013-10-22. PMID:23593280. |
the lateral habenula (lhb), an epithalamic structure that forms reciprocal connections with midbrain dopamine neurons, shows the opposite response being activated by reward omission or aversive stimuli and inhibited by reward-predicting cues. |
2013-10-22 |
2023-08-12 |
rat |
| Christopher D Fiorillo, Minryung R Song, Sora R Yu. Multiphasic temporal dynamics in responses of midbrain dopamine neurons to appetitive and aversive stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 11. 2013-05-06. PMID:23486944. |
multiphasic temporal dynamics in responses of midbrain dopamine neurons to appetitive and aversive stimuli. |
2013-05-06 |
2023-08-12 |
Not clear |
| A P Iacopucci, R O Mello, R Barbosa-Silva, L Melo-Thoma. L-NOARG-induced catalepsy can be influenced by glutamatergic neurotransmission mediated by NMDA receptors in the inferior colliculus. Behavioural brain research. vol 234. issue 2. 2013-01-21. PMID:22749845. |
the inferior colliculus (ic), a midbrain structure that processes acoustic information of aversive nature, is distinguished from other auditory nuclei in the brainstem by its connections with structures of the motor system. |
2013-01-21 |
2023-08-12 |
rat |
| Alice M Stamatakis, Garret D Stube. Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nature neuroscience. vol 15. issue 8. 2012-10-25. PMID:22729176. |
activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. |
2012-10-25 |
2023-08-12 |
mouse |
| Alice M Stamatakis, Garret D Stube. Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nature neuroscience. vol 15. issue 8. 2012-10-25. PMID:22729176. |
thus, activity of lhb efferents to the midbrain is aversive but can also serve to negatively reinforce behavioral responding. |
2012-10-25 |
2023-08-12 |
mouse |
| E A Audi, J C de Aguiar, F G Graef. Mediation by serotonin of the antiaversive effect of zimelidine and propranolol injected into the dorsal midbrain central grey. Journal of psychopharmacology (Oxford, England). vol 2. issue 1. 2012-10-02. PMID:22159666. |
previously reported results indicate that serotonin (5-ht) inhibits the neural sub strate of aversion in the dorsal midbrain central grey (dcg) of the rat. |
2012-10-02 |
2023-08-12 |
rat |
| Masayuki Matsumoto, Okihide Hikosak. Electrical stimulation of the primate lateral habenula suppresses saccadic eye movement through a learning mechanism. PloS one. vol 6. issue 10. 2012-02-28. PMID:22039537. |
neurons in the lhb are excited by unpleasant events such as reward omission and aversive stimuli, and transmit these signals to midbrain dopamine neurons which are involved in learning and motivation. |
2012-02-28 |
2023-08-12 |
monkey |
| Yong-Jun Liu, Qian Wang, Bing L. Neuronal responses to looming objects in the superior colliculus of the cat. Brain, behavior and evolution. vol 77. issue 3. 2011-10-03. PMID:21546772. |
the superior colliculus (sc) in the mammalian mesencephalon is involved in avoidance or escape behaviors, but little is known about the response properties of collicular neurons to an object approaching on a collision course towards the animal. |
2011-10-03 |
2023-08-12 |
cat |
| Larry S Zweifel, Jonathan P Fadok, Emmanuela Argilli, Michael G Garelick, Graham L Jones, Tavis M K Dickerson, James M Allen, Sheri J Y Mizumori, Antonello Bonci, Richard D Palmite. Activation of dopamine neurons is critical for aversive conditioning and prevention of generalized anxiety. Nature neuroscience. vol 14. issue 5. 2011-07-01. PMID:21499253. |
dopamine neurons of the ventral midbrain exhibit heterogeneous responses to aversive stimuli that are thought to provide a critical modulatory signal to facilitate orientation to environmental changes and assignment of motivational value to unexpected events. |
2011-07-01 |
2023-08-12 |
mouse |
| Salvatore Lecca, Miriam Melis, Antonio Luchicchi, Maria Grazia Ennas, Maria Paola Castelli, Anna Lisa Muntoni, Marco Pisti. Effects of drugs of abuse on putative rostromedial tegmental neurons, inhibitory afferents to midbrain dopamine cells. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 3. 2011-05-09. PMID:21048703. |
our results suggest that activity of rmtg neurons is profoundly influenced by drugs of abuse and, as important inhibitory afferents to midbrain da neurons, they might take place in the complex interplay between the neural circuits mediating aversion and reward. |
2011-05-09 |
2023-08-12 |
rat |
| Bo Li, Joaquin Piriz, Martine Mirrione, ChiHye Chung, Christophe D Proulx, Daniela Schulz, Fritz Henn, Roberto Malino. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. vol 470. issue 7335. 2011-03-11. PMID:21350486. |
recent studies in monkeys indicate that neurons in the lateral habenula (lhb), a nucleus that mediates communication between forebrain and midbrain structures, can increase their activity when an animal fails to receive an expected positive reward or receives a stimulus that predicts aversive conditions (that is, disappointment or anticipation of a negative outcome). |
2011-03-11 |
2023-08-12 |
rat |
| R S Kiser, D C Germa. Opiate effects on aversive midbrain stimulation in rats. Neuroscience letters. vol 10. issue 1-2. 2009-12-15. PMID:19605280. |
opiate effects on aversive midbrain stimulation in rats. |
2009-12-15 |
2023-08-12 |
rat |