| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R S Kiser, D C Germa. Opiate effects on aversive midbrain stimulation in rats. Neuroscience letters. vol 10. issue 1-2. 2009-12-15. PMID:19605280. |
morphine blocked decremental bar pressing of rats to escape electrical stimulation of aversive midbrain sites. |
2009-12-15 |
2023-08-12 |
rat |
| K S Gomes, R L Nunes-De-Souz. Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19625008. |
it has been emphasized that the dorsal portion of the midbrain periaqueductal gray (dpag) plays a role on this enhanced aversion phenomenon in maze-experienced rodents. |
2009-11-17 |
2023-08-12 |
mouse |
| Dean Mobbs, Jennifer L Marchant, Demis Hassabis, Ben Seymour, Geoffrey Tan, Marcus Gray, Predrag Petrovic, Raymond J Dolan, Christopher D Frit. From threat to fear: the neural organization of defensive fear systems in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 29. issue 39. 2009-10-13. PMID:19793982. |
conversely, active avoidance during circa-strike threat increased activity in mid-dorsal acc and midbrain areas. |
2009-10-13 |
2023-08-12 |
human |
| Alexies Dagnino-Subiabre, Pablo Muñoz-Llancao, Gonzalo Terreros, Ursula Wyneken, Gabriela Díaz-Véliz, Benjamin Porter, Michael P Kilgard, Marco Atzori, Francisco Aboiti. Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: effects on auditory conditioning. Behavioural brain research. vol 203. issue 1. 2009-08-31. PMID:19397934. |
chronic stress induces dendritic atrophy in the inferior colliculus (ic, auditory mesencephalon) and impairs auditory avoidance conditioning. |
2009-08-31 |
2023-08-12 |
rat |
| Gregory J Quirk, Francisco Sotres-Bayo. Signaling aversive events in the midbrain: worse than expected. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285461. |
signaling aversive events in the midbrain: worse than expected. |
2009-04-01 |
2023-08-12 |
Not clear |
| Gregory J Quirk, Francisco Sotres-Bayo. Signaling aversive events in the midbrain: worse than expected. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285461. |
in this issue of neuron, jhou and colleagues identify a region in the midbrain tegmentum that signals aversive events and inhibits midbrain dopamine neurons. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
the rostromedial tegmental nucleus (rmtg), a gabaergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
we show that neurons in the recently identified gabaergic rostromedial tegmental nucleus (rmtg), which receive a major lhb input, project heavily to midbrain dopamine neurons, and show phasic activations and/or fos induction after aversive stimuli (footshocks, shock-predictive cues, food deprivation, or reward omission) and inhibitions after rewards or reward-predictive stimuli. |
2009-04-01 |
2023-08-12 |
Not clear |
| Thomas C Jhou, Howard L Fields, Mark G Baxter, Clifford B Saper, Peter C Hollan. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285474. |
these findings suggest that aversive inputs from widespread brain regions and stimulus modalities converge onto the rmtg, which opposes reward and motor-activating functions of midbrain dopamine neurons. |
2009-04-01 |
2023-08-12 |
Not clear |
| Frederico G Graeff, Cristina M Del-Be. Neurobiology of panic disorder: from animal models to brain neuroimaging. Neuroscience and biobehavioral reviews. vol 32. issue 7. 2009-02-19. PMID:18573531. |
evidence from animal models of anxiety has led to the hypothesis that serotonin enhances inhibitory avoidance (related to anxiety) in the forebrain, but inhibits one-way escape (panic) in the midbrain periaqueductal gray (pag). |
2009-02-19 |
2023-08-12 |
rat |
| F A Moreira, D C Aguiar, A C Campos, S F Lisboa, A L Terzian, L B Resstel, F S Guimarãe. Antiaversive effects of cannabinoids: is the periaqueductal gray involved? Neural plasticity. vol 2009. 2009-02-10. PMID:19096514. |
cannabinoid type 1 (cb1) receptors are widely distributed in the central nervous system and are present in the periaqueductal gray (pag), a midbrain structure closely involved in responses related to aversive states. |
2009-02-10 |
2023-08-12 |
rat |
| Mati Joshua, Avital Adler, Rea Mitelman, Eilon Vaadia, Hagai Bergma. Midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 45. 2008-12-31. PMID:18987203. |
midbrain dopaminergic neurons and striatal cholinergic interneurons encode the difference between reward and aversive events at different epochs of probabilistic classical conditioning trials. |
2008-12-31 |
2023-08-12 |
monkey |
| Adriano E Reimer, Amanda R Oliveira, Marcus L Brandã. Selective involvement of GABAergic mechanisms of the dorsal periaqueductal gray and inferior colliculus on the memory of the contextual fear as assessed by the fear potentiated startle test. Brain research bulletin. vol 76. issue 5. 2008-09-04. PMID:18534264. |
it is certain that gaba has a regulatory role on the aversive states generated and elaborated in these midbrain structures. |
2008-09-04 |
2023-08-12 |
rat |
| Lucinéia Dos Santos, Telma G C S de Andrade, Hélio Zangrossi Junio. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 18. issue 4. 2008-04-23. PMID:17728111. |
intra-mrn injection of way-100635, which has a disinhibitory effect on the activity of 5-ht neurons in this midbrain area, only facilitated inhibitory avoidance. |
2008-04-23 |
2023-08-12 |
rat |
| Dan J Stei. Panic disorder: the psychobiology of external treat and introceptive distress. CNS spectrums. vol 13. issue 1. 2008-04-14. PMID:18204411. |
distant threats activate prefrontal cortex (involved in complex planning of avoidance strategies), while immediate threats activate midbrain structures (involved in fast reflexive behaviors). |
2008-04-14 |
2023-08-12 |
Not clear |
| Michael Numa. Hypothalamic neural circuits regulating maternal responsiveness toward infants. Behavioral and cognitive neuroscience reviews. vol 5. issue 4. 2007-01-23. PMID:17099111. |
it is proposed that efferents from a hormone-primed mpoa (a) depress a central aversion system (composed of neural circuits between the amygdala, medial hypothalamus, and midbrain) so that novel infant stimuli do not activate defensive or avoidance behavior and (b) excite the mesolimbic dopamine system so that active, voluntary maternal responses are promoted. |
2007-01-23 |
2023-08-12 |
Not clear |
| Leandro José Bertoglio, Hélio Zangross. Involvement of dorsolateral periaqueductal gray N-methyl-D-aspartic acid glutamate receptors in the regulation of risk assessment and inhibitory avoidance behaviors in the rat elevated T-maze. Behavioural pharmacology. vol 17. issue 7. 2006-12-06. PMID:17021391. |
it is still a matter of investigation, however, whether this midbrain area may have a relevant role in the modulation of more subtle defensive responses associated with anxiety such as risk assessment and inhibitory avoidance. |
2006-12-06 |
2023-08-12 |
rat |
| G F Molodtsov. Metabolism and receptor binding of serotonin in brain structures during performance of a conditioned passive avoidance response. Neuroscience and behavioral physiology. vol 35. issue 7. 2006-03-02. PMID:16433063. |
the levels of serotonin and its metabolite 5-hydroxyindoleacetic acid, monoamine oxidase activity, and the specific binding of the radioligand [3h]serotonin were measured in the prefrontal cortex, striatum, amygdaloid complex, hippocampus, and periacqueductal gray matter of the midbrain in rats at different time points after training to a conditioned passive avoidance reaction. |
2006-03-02 |
2023-08-12 |
rat |
| D P Finn, M D Jhaveri, S R G Beckett, C H Roe, D A Kendall, C A Marsden, V Chapma. Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology. vol 45. issue 5. 2003-12-19. PMID:12941373. |
we investigated the hypothesis that the midbrain periaqueductal grey (pag) is a common substrate mediating the anti-nociceptive and potential aversive effects of cannabinoids. |
2003-12-19 |
2023-08-12 |
rat |
| René Missli. The defense system of fear: behavior and neurocircuitry. Neurophysiologie clinique = Clinical neurophysiology. vol 33. issue 2. 2003-10-06. PMID:12837573. |
the central nucleus of the amygdala projects to the midbrain periaqueductal gray (pag), the hypothalamus and the brainstem which coordinate various defensive responses such as flight, defensive fight, freezing, avoidance reactions, submissive postures, tonic immobilization, hypoalgesia and autonomic arousal. |
2003-10-06 |
2023-08-12 |
Not clear |