| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J L Griffiths, T A Lovic. Co-localization of 5-HT 2A -receptor- and GABA-immunoreactivity in neurones in the periaqueductal grey matter of the rat. Neuroscience letters. vol 326. issue 3. 2003-06-05. PMID:12095644. |
the dorsal half of the midbrain periaqueductal grey matter (dpag) functions as a midbrain aversive system. |
2003-06-05 |
2023-08-12 |
rat |
| G C D Eichenberger, S J Ribeiro, M Y Osaki, R Y Maruoka, G C C Resende, L Castellan-Baldan, S A L Corrêa, L A Da Silva, N C Coimbr. Neuroanatomical and psychopharmacological evidence for interaction between opioid and GABAergic neural pathways in the modulation of fear and defense elicited by electrical and chemical stimulation of the deep layers of the superior colliculus and dorsal periaqueductal gray matter. Neuropharmacology. vol 42. issue 1. 2002-02-20. PMID:11750915. |
these findings, in addition to the psychopharmacological evidence for the interaction between opioid and gabaergic mechanisms, offer a neuroanatomical basis of a possible presynaptic opioid inhibition of gabaergic nigro-tectal neurons modulating the fear in aversive structures of the cranial mesencephalon, in a short link, and maybe through a major neural circuit, also in gaba-containing perikarya of nigro-tectal neurons. |
2002-02-20 |
2023-08-12 |
Not clear |
| I Liberzon, S F Taylor, L M Fig, L R Decker, R A Koeppe, S Minoshim. Limbic activation and psychophysiologic responses to aversive visual stimuli. Interaction with cognitive task. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 23. issue 5. 2000-11-21. PMID:11027916. |
aversive pictures, relative to neutral pictures, increased cerebral activity in bilateral amygdala, thalamic/hypothalamic area, midbrain, and left lateral prefrontal cortex, along with greater skin conductance responses (scr). |
2000-11-21 |
2023-08-12 |
human |
| W A Carlezon, C N Haile, R Coppersmith, Y Hayashi, R Malinow, R L Neve, E J Nestle. Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 5. 2000-06-02. PMID:10684909. |
distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing glur1. |
2000-06-02 |
2023-08-12 |
rat |
| M L Brandão, V Z Anseloni, J E Pandóssio, J E De Araújo, V M Castilh. Neurochemical mechanisms of the defensive behavior in the dorsal midbrain. Neuroscience and biobehavioral reviews. vol 23. issue 6. 1999-12-13. PMID:10541061. |
some regions in the mesencephalon, such as dorsal periaqueductal gray, inferior colliculus and deep layers of superior colliculus have been grouped together as a continuous strip of midbrain structures involved in the integration of the different components of aversive states in the brain. |
1999-12-13 |
2023-08-12 |
Not clear |
| M L Brandão, V Z Anseloni, J E Pandóssio, J E De Araújo, V M Castilh. Neurochemical mechanisms of the defensive behavior in the dorsal midbrain. Neuroscience and biobehavioral reviews. vol 23. issue 6. 1999-12-13. PMID:10541061. |
now, efforts have been made to characterize the mode of action of these neurotransmitters on their multiple receptors and how they interact with each other to produce or regulate the neural substrates of aversion in the midbrain. |
1999-12-13 |
2023-08-12 |
Not clear |
| T A Lovick, V V Stezhk. Neurones in the dorsolateral periaqueductal grey matter in coronal slices of rat midbrain: electrophysiological and morphological characteristics. Experimental brain research. vol 124. issue 1. 1999-03-29. PMID:9928789. |
intracellular recordings using the whole-cell patch-clamp configuration were made from 87 neurones in the dorsolateral "aversive" region of the periaqueductal grey matter (pag) in coronal slices of rat midbrain. |
1999-03-29 |
2023-08-12 |
rat |
| M M Hämäläinen, T A Lovic. Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat. Neuroscience. vol 80. issue 3. 1997-10-27. PMID:9276497. |
nitric oxide may act in association with 5-hydroxytryptamine to control the excitability of the aversive system in the midbrain. |
1997-10-27 |
2023-08-12 |
rat |
| T A Lovic. Role of nitric oxide in medullary raphe-evoked inhibition of neuronal activity in the periaqueductal gray matter. Neuroscience. vol 75. issue 4. 1997-03-26. PMID:8938753. |
the results suggest that nitric oxide plays a role in the regulation of the excitability of neurons in the midbrain aversive system by the medullary raphe. |
1997-03-26 |
2023-08-12 |
rat |
| O V Galkina, E K Podgornay. Regional brain patterns of dopamine, metabolites and D2 receptors in memory. Pharmacology, biochemistry, and behavior. vol 54. issue 2. 1997-02-12. PMID:8743608. |
patterns of dopamine (da), 3,4-dihydroxyphenyl acetic (dopac), and homovanillic (hva) acids, para-tyramine (p-ta), and d2 receptors for eleven structures of forebrain and midbrain were examined at 1 and 6 days after one trial passive avoidance training of rats, at 1 day after "psychogenic" amnesia production, immediately following training, and at the last day after foot shock of rats with previous "psychogenic" amnesia administration. |
1997-02-12 |
2023-08-12 |
rat |
| G M Gerke. Central tinnitus and lateral inhibition: an auditory brainstem model. Hearing research. vol 97. issue 1-2. 1996-12-26. PMID:8844188. |
one non-auditory function, the initiation of aversive behavioral responses, may be demonstrated with electrical or chemical stimulation of auditory nuclei in the vicinity of the midbrain. |
1996-12-26 |
2023-08-12 |
Not clear |
| M Fendt, M Koch, H U Schnitzle. Lesions of the central gray block conditioned fear as measured with the potentiated startle paradigm. Behavioural brain research. vol 74. issue 1-2. 1996-12-05. PMID:8851921. |
based on our previous finding that the midbrain central gray (cg) is involved in the mediation of the facilitatory effects on the asr of unconditioned aversive events, the present study tested the hypothesis that the cg is important for the potentiation of the asr by conditioned fear. |
1996-12-05 |
2023-08-12 |
rat |
| M LYO. THE ROLE OF CENTRAL MIDBRAIN STRUCTURES IN CONDITIONED RESPONDING TO AVERSIVE NOISE IN THE RAT. The Journal of comparative neurology. vol 122. 1996-12-01. PMID:14184863. |
the role of central midbrain structures in conditioned responding to aversive noise in the rat. |
1996-12-01 |
2023-08-12 |
rat |
| J Mirenowicz, W Schult. Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli. Nature. vol 379. issue 6564. 1996-02-27. PMID:8559249. |
preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli. |
1996-02-27 |
2023-08-12 |
monkey |
| T A Lovic. Influence of the dorsal and median raphe nuclei on neurons in the periaqueductal gray matter: role of 5-hydroxytryptamine. Neuroscience. vol 59. issue 4. 1994-09-12. PMID:8058131. |
this projection may be involved in modulating the level of excitability of neurons in the midbrain aversive system which integrate defence behaviour. |
1994-09-12 |
2023-08-12 |
rat |
| N C Coimbra, M L Brandã. GABAergic nigro-collicular pathways modulate the defensive behaviour elicited by midbrain tectum stimulation. Behavioural brain research. vol 59. issue 1-2. 1994-05-19. PMID:8155280. |
these results suggest an inhibitory control of gabaergic fibers from the substantia nigra, pars reticulata, on aversive behaviour induced by midbrain stimulation. |
1994-05-19 |
2023-08-12 |
rat |
| T A Lovic. The periaqueductal gray-rostral medulla connection in the defence reaction: efferent pathways and descending control mechanisms. Behavioural brain research. vol 58. issue 1-2. 1994-04-25. PMID:8136045. |
neurones in the rvlm act as relays in the descending efferent pathway to the sympathetic outflows from the dorsal periaqueductal gray matter (dpag) which integrates the characteristic "defensive" pattern of cardiovascular response that accompanies activation of the midbrain aversive system. |
1994-04-25 |
2023-08-12 |
Not clear |
| A Depaulis, K A Keay, R Bandle. Longitudinal neuronal organization of defensive reactions in the midbrain periaqueductal gray region of the rat. Experimental brain research. vol 90. issue 2. 1992-11-23. PMID:1397145. |
kainic acid injections into the area lateral to the midbrain aqueduct in the caudal third of the pag evoked: (i) forward avoidance behavior, characterized by forward locomotion and occasional hop/jumps; (ii) reactive immobility ("freezing"), in which the rat remained immobile, but reacted with forward avoidance behavior to investigative, non-aggressive contact initiated by the partner; and (iii) 22-28 khz ultrasonic vocalizations. |
1992-11-23 |
2023-08-11 |
rat |
| A Herz, T S Shippenberg, R Bals-Kubik, R Spanage. [Opiate addiction. Pharmacologic and biochemical aspects]. Arzneimittel-Forschung. vol 42. issue 2A. 1992-06-16. PMID:1586396. |
opposite effects on da are observed in response to microinjections of selective antagonists for these receptor types, suggesting the existence of tonically active endogenous opioid systems which maintain da release in the mesolimbic system: a continuous "reward" tone, probably mediated by beta-endorphin in the ventral tegmentum of the midbrain and an "aversive" tone, mediated by dynorphin in the nucleus accumbens. |
1992-06-16 |
2023-08-11 |
Not clear |
| S F Ivanova, J Bure. Acquisition of conditioned taste aversion in rats is prevented by tetrodotoxin blockade of a small midbrain region centered around the parabrachial nuclei. Physiology & behavior. vol 48. issue 4. 1991-04-16. PMID:1963689. |
acquisition of conditioned taste aversion in rats is prevented by tetrodotoxin blockade of a small midbrain region centered around the parabrachial nuclei. |
1991-04-16 |
2023-08-11 |
rat |