| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana L Cardoso, Joana R Guedes, Luís Pereira de Almeida, Maria C Pedroso de Lim. miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology. vol 135. issue 1. 2012-02-06. PMID:22043967. |
finally, treatment of neuronal primary cultures with conditioned medium obtained from microglia cells, in which mir-155 was inhibited before cell activation, decreased inflammatory-mediated neuronal cell death. |
2012-02-06 |
2023-08-12 |
Not clear |
| Gurugirijha Rathnasamy, Eng-Ang Ling, Charanjit Kau. Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159112. |
primary oligodendrocytes treated with conditioned medium from hypoxic microglia exhibited reduced glutathione levels, increased lipid peroxidation, upregulated caspase-3 expression, and reduced proliferation. |
2012-02-02 |
2023-08-12 |
rat |
| Gurugirijha Rathnasamy, Eng-Ang Ling, Charanjit Kau. Iron and iron regulatory proteins in amoeboid microglial cells are linked to oligodendrocyte death in hypoxic neonatal rat periventricular white matter through production of proinflammatory cytokines and reactive oxygen/nitrogen species. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 49. 2012-02-02. PMID:22159112. |
this was reversed to control levels on treatment with conditioned medium from deferoxamine treated hypoxic microglia; also, there was reduction in apoptosis of oligodendrocytes. |
2012-02-02 |
2023-08-12 |
rat |
| L A Pasquini, V Millet, H C Hoyos, J P Giannoni, D O Croci, M Marder, F T Liu, G A Rabinovich, J M Pasquin. Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function. Cell death and differentiation. vol 18. issue 11. 2012-02-01. PMID:21566659. |
accordingly, conditioned media from galectin-3-expressing, but not galectin-3-deficient (lgals3(-/-)) microglia, successfully promoted olg differentiation. |
2012-02-01 |
2023-08-12 |
mouse |
| Rommy von Bernhardi, Juan Tichauer, Laura Eugenín-von Bernhard. Proliferating culture of aged microglia for the study of neurodegenerative diseases. Journal of neuroscience methods. vol 202. issue 1. 2012-01-23. PMID:21889955. |
here, we present a conditioned media-dependent culture system that promotes proliferation of adult microglia. |
2012-01-23 |
2023-08-12 |
Not clear |
| Raffaela Cipriani, Pia Villa, Giuseppina Chece, Clotilde Lauro, Alessandra Paladini, Edoardo Micotti, Carlo Perego, Maria-Grazia De Simoni, Bertil B Fredholm, Fabrizio Eusebi, Cristina Limatol. CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 45. 2012-01-04. PMID:22072684. |
we also report that cx3cl1 induced a different phagocytic activity in wild type and cx3cl1⁻/⁻ microglia in vitro during cotreatment with the medium conditioned by neurons damaged by oxygen-glucose deprivation. |
2012-01-04 |
2023-08-12 |
mouse |
| Clara Quintas, Sónia Fraga, Jorge Gonçalves, Glória Queiro. P2Y receptors on astrocytes and microglia mediate opposite effects in astroglial proliferation. Purinergic signalling. vol 7. issue 2. 2011-11-10. PMID:21559785. |
however, conditioned medium from microglia cultures or co-cultures treated with adpβs, when tested in highly enriched astroglial cultures, also prevented adpβs proliferative effect. |
2011-11-10 |
2023-08-12 |
Not clear |
| Juan A Orellana, Nicolas Froger, Pascal Ezan, Jean X Jiang, Michael V L Bennett, Christian C Naus, Christian Giaume, Juan C Sáe. ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. Journal of neurochemistry. vol 118. issue 5. 2011-10-14. PMID:21294731. |
both responses were greater and longer lasting in astrocytes previously exposed for 24 h to conditioned medium from aβ-treated microglia (cm-aβ). |
2011-10-14 |
2023-08-12 |
human |
| D S Markovic, K Vinnakota, N van Rooijen, J Kiwit, M Synowitz, R Glass, H Kettenman. Minocycline reduces glioma expansion and invasion by attenuating microglial MT1-MMP expression. Brain, behavior, and immunity. vol 25. issue 4. 2011-08-29. PMID:21324352. |
here, we show that minocycline blocked the increase in mt1-mmp expression and activity in cultivated microglia stimulated with glioma conditioned medium. |
2011-08-29 |
2023-08-12 |
mouse |
| Guang Yang, Ya Meng, Wenxia Li, Yue Yong, Zhiqin Fan, Hanqing Ding, Youzhen Wei, Jia Luo, Zun-Ji K. Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism. Brain pathology (Zurich, Switzerland). vol 21. issue 3. 2011-08-18. PMID:21029241. |
the conditioned medium collected from td-induced neurons caused microglia activation. |
2011-08-18 |
2023-08-12 |
mouse |
| Viswanathan Sivakumar, Wallace S Foulds, Chi D Luu, Eng-Ang Ling, Charanjit Kau. Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. The Journal of pathology. vol 224. issue 2. 2011-07-25. PMID:21404274. |
primary cultured retinal ganglion cells (rgcs) treated with conditioned medium derived from hypoxic microglia showed enhanced apoptosis, which was significantly reduced when the cells were treated with microglia conditioned medium neutralized with tnf-α/il-1β antibody. |
2011-07-25 |
2023-08-12 |
rat |
| Sangseop Kim, Jiyeon Ock, Ae Kyung Kim, Ho Won Lee, Je-Yoel Cho, Deok Ryong Kim, Jae-Yong Park, Kyoungho Su. Neurotoxicity of microglial cathepsin D revealed by secretome analysis. Journal of neurochemistry. vol 103. issue 6. 2011-07-19. PMID:17953665. |
to characterize secreted proteins of activated microglia, conditioned media obtained from bv-2 mouse microglia cells were analyzed by two-dimensional gel electrophoresis or liquid chromatography coupled with tandem mass spectrometry. |
2011-07-19 |
2023-08-12 |
mouse |
| Sangseop Kim, Jiyeon Ock, Ae Kyung Kim, Ho Won Lee, Je-Yoel Cho, Deok Ryong Kim, Jae-Yong Park, Kyoungho Su. Neurotoxicity of microglial cathepsin D revealed by secretome analysis. Journal of neurochemistry. vol 103. issue 6. 2011-07-19. PMID:17953665. |
among many proteins identified in the secretome of activated microglia, an aspartic endoprotease cathepsin d has been found to mediate microglial neurotoxicity based on the following results: (i) the expression of cathepsin d protein was markedly increased in lipopolysaccharide/interferon-γ-stimulated microglia compared with resting microglia as determined by western blot analysis of conditioned media; (ii) knockdown of cathepsin d expression in microglia using short hairpin rna diminished the neurotoxicity in the coculture of microglia and neuroblastoma cells and (iii) recombinant procathepsin d protein exerted cytotoxic effects toward cultured neurons. |
2011-07-19 |
2023-08-12 |
mouse |
| Sandra L Silva, Catarina Osório, Ana R Vaz, Andreia Barateiro, Ana S Falcão, Rui F M Silva, Dora Brite. Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin. Journal of neurochemistry. vol 117. issue 3. 2011-06-10. PMID:21275990. |
conditioned medium from ucb-challenged neurons, although down-regulating tumor necrosis factor-α and interleukin-1β promoted the release of interleukin-6 and nitric oxide, the activation of matrix metalloproteinase-9, and cell death, as compared with ucb-direct effects on microglia. |
2011-06-10 |
2023-08-12 |
Not clear |
| Anja Henn, Susanne Kirner, Marcel Leis. TLR2 hypersensitivity of astrocytes as functional consequence of previous inflammatory episodes. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 5. 2011-05-16. PMID:21282508. |
cells prestimulated with il-1β, with a tlr3 ligand, with a complete cytokine mix consisting of tnf-α, il-1β, and ifn-γ, or with media conditioned by activated microglia responded strongly to fsl1 or p3c stimulation, whereas the sensitivity of the nf-κb response to other pattern recognition receptors was unchanged. |
2011-05-16 |
2023-08-12 |
Not clear |
| A D Dic. Influence of microglia on retinal progenitor cell turnover and cell replacement. Eye (London, England). vol 23. issue 10. 2011-03-25. PMID:19098699. |
myeloid cell response differs depending on insult: it is evident that during inflammation microglia and the infiltrating myeloid cell function are conditioned by the cytokine environment. |
2011-03-25 |
2023-08-12 |
human |
| Olaf Hoffmann, Olga Rung, Ae-Rie Im, Dorette Freyer, Juan Zhang, Josephin Held, Werner Stenzel, Christof Dam. Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Infection and immunity. vol 79. issue 2. 2011-03-15. PMID:21149592. |
in murine primary microglia and raw264.7 macrophages, upregulation of tpo mrna was induced by d39-conditioned medium but not by bacterial lipopeptide or by medium conditioned by pneumococcal mutants defective in hydrogen peroxide formation (Δspxb) or pneumolysin (Δpln). |
2011-03-15 |
2023-08-12 |
mouse |
| Sushil Sharma, Bing Yang, Roger Strong, XiaoPei Xi, Miranda Brenneman, James C Grotta, Jaroslaw Aronowski, Sean I Savit. Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke. Journal of neuroscience research. vol 88. issue 13. 2010-12-06. PMID:20629187. |
neuronal cultures were then exposed to conditioned media derived from activated macrophages or microglia. |
2010-12-06 |
2023-08-12 |
Not clear |
| Saebyeol Jang, Ryan N Dilger, Rodney W Johnso. Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. The Journal of nutrition. vol 140. issue 10. 2010-10-19. PMID:20685893. |
however, treating microglia with luteolin prior to lps reduced neuronal cell death caused by conditioned supernatants, indicating luteolin was neuroprotective. |
2010-10-19 |
2023-08-12 |
mouse |
| Wei Zhu, Honghua Zheng, Xinli Shao, Wei Wang, Qing Yao, Zhengli L. Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo. Journal of neurochemistry. vol 114. issue 2. 2010-08-23. PMID:20438614. |
ka activated microglia conditioned media ((ka-mcm) significantly enhanced the amplitude of the population spike at rat's hippocampal ca3 region. |
2010-08-23 |
2023-08-12 |
rat |