| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Zhang, N Surguladze, B Slagle-Webb, A Cozzi, J R Conno. Cellular iron status influences the functional relationship between microglia and oligodendrocytes. Glia. vol 54. issue 8. 2007-01-05. PMID:16958088. |
we found that conditioned media from iron-loaded microglia increases the survival of oligodendrocytes; but conditioned media from iron loaded activated microglia is toxic to oligodendrocytes. |
2007-01-05 |
2023-08-12 |
Not clear |
| Yun-Jung Kim, So-Young Hwang, Eok-Soo Oh, Seikwan Oh, Inn-Oc Ha. IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways. Journal of neuroscience research. vol 84. issue 5. 2006-11-28. PMID:16881054. |
we observed consistently that conditioned medium (cm) from activated microglia resulted in the induction of inos in c6 cells, and il-1beta was shown to be a key regulator of inos induction. |
2006-11-28 |
2023-08-12 |
Not clear |
| Kazuyuki Nakajima, Manuel B Graeber, Maya Sonoda, Yoko Tohyama, Shinichi Kohsaka, Tadashi Kurihar. In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion. Journal of neuroscience research. vol 84. issue 2. 2006-09-19. PMID:16673407. |
to examine the mechanism underlying this proliferation, the expression of the mitogens and specific receptors of the microglia were analyzed in conditioned medium (cm) and cells. |
2006-09-19 |
2023-08-12 |
rat |
| Hannah M Gibbons, Mike Draguno. Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16564033. |
to investigate the microglial-neuronal interactions, we used the murine bv-2 microglial cell line and the human neuronal-like sk-n-sh neuroblastoma cell line in a co-culture system that enabled proximity-dependent interaction and communication, a trans-well system that allowed proximity-independent communication through diffusible molecules only, and a conditioned media system through which no proximity-dependent interactions or cell-to-cell communication is possible. |
2006-08-10 |
2023-08-12 |
human |
| Hannah M Gibbons, Mike Draguno. Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain research. vol 1084. issue 1. 2006-08-10. PMID:16564033. |
in contrast, activation of bv-2 cells in the trans-well and conditioned media system did not have any effect on the viability of sk-n-sh cells, suggesting that microglia must be in close proximity to the neural cells to elicit cytotoxicity. |
2006-08-10 |
2023-08-12 |
human |
| b' Radmila Filipovi\\xc4\\x87, Nada Zecevi\\xc4\\x8. Interaction between microglia and oligodendrocyte cell progenitors involves Golli proteins. Annals of the New York Academy of Sciences. vol 1048. 2006-07-19. PMID:16154930.' |
furthermore, golli proteins were demonstrated only in the conditioned medium from lps-treated microglial cell cultures (lps-mcm), and were absent in either conditioned medium from lps-treated astrocytes or control media. |
2006-07-19 |
2023-08-12 |
mouse |
| Henry H Majed, Siddharthan Chandran, Simone P Niclou, Richard S Nicholas, Alastair Wilkins, Mark G Wing, Kate E Rhodes, Maria Grazia Spillantini, Alastair Compsto. A novel role for Sema3A in neuroprotection from injury mediated by activated microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 6. 2006-04-26. PMID:16467521. |
in this study, microglia derived from newborn rat cortices were cultured and activated by interferon-gamma (ifngamma) treatment, then exposed to recombinant sema3a or conditioned medium derived from stressed embryonic cortical neurons. |
2006-04-26 |
2023-08-12 |
rat |
| William Même, Charles-Félix Calvo, Nicolas Froger, Pascal Ezan, Edwige Amigou, Annette Koulakoff, Christian Giaum. Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 3. 2006-04-21. PMID:16423877. |
this inhibition is mimicked by treating astrocyte cultures with conditioned medium harvested from activated microglia. |
2006-04-21 |
2023-08-12 |
Not clear |
| Si Qin, Catherine Colin, Ina Hinners, Annie Gervais, Cyril Cheret, Michel Malla. System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 12. 2006-04-14. PMID:16554485. |
immunodepletion of apoe or targeted inactivation of the apoe gene in microglia abrogated neuroprotection by microglial conditioned medium, whereas supplementation by human apoe isoforms restored protection, which was potentiated by the presence of microglia-derived cofactors. |
2006-04-14 |
2023-08-12 |
mouse |
| Deanna L Taylor, Fleur Jones, Eva S F Chen Seho Kubota, Jennifer M Pococ. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha-induced neurotoxicity in concert with microglial-derived Fas ligand. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 11. 2006-03-13. PMID:15772355. |
the toxicity of tnfalpha could be prevented by coexposure of neurons to conditioned medium from microglia stimulated by the specific group iii agonist l-2-amino-4-phosphono-butyric acid. |
2006-03-13 |
2023-08-12 |
rat |
| Angela M Floden, Shanshan Li, Colin K Comb. Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 10. 2006-03-02. PMID:15758166. |
we used abeta-stimulated conditioned media from primary mouse microglia to identify more stable neurotoxic secretions. |
2006-03-02 |
2023-08-12 |
mouse |
| Yong Zhou, Yan Wang, Monika Kovacs, Jinghua Jin, Jing Zhan. Microglial activation induced by neurodegeneration: a proteomic analysis. Molecular & cellular proteomics : MCP. vol 4. issue 10. 2006-02-21. PMID:15975914. |
detailed scrutiny of neuron-microglia interactions identified a fraction of the conditioned media derived from a daergic cell line treated with mn-ebdc or mpp+ that potently activated microglia. |
2006-02-21 |
2023-08-12 |
rat |
| Xijin Wang, Shengdi Chen, Guozhao Ma, Min Ye, Guoqiang L. Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration. Mechanisms of ageing and development. vol 126. issue 12. 2006-01-26. PMID:16112714. |
using lipopolysaccharide (lps) (1-100 ng/ml) as a tool, we observed that microglia activation-mediated a selective dopaminergic neurodegeneration in vm neuron-glia cultures, which was supported by the further study showing that conditioned medium (cm) from microglia-enriched cultures treated with lps (10-100 ng/ml) decreased pc12 cell viability. |
2006-01-26 |
2023-08-12 |
rat |
| Nazira El-Hage, Guanghan Wu, Juan Wang, Jayakrishna Ambati, Pamela E Knapp, Janelle L Reed, Annadora J Bruce-Keller, Kurt F Hause. HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Glia. vol 53. issue 2. 2006-01-20. PMID:16206161. |
using a chemotaxis assay, n9 microglial cell migration was found to be significantly greater in conditioned medium from mouse striatal astrocytes exposed to morphine and/or tat(1-72) than in vehicle-, mu-opioid receptor (mor) antagonist-, or inactive, mutant tat(delta31-61)-treated controls. |
2006-01-20 |
2023-08-12 |
mouse |
| Zhou Wu, Jian Zhang, Hiroshi Nakanish. Leptomeningeal cells activate microglia and astrocytes to induce IL-10 production by releasing pro-inflammatory cytokines during systemic inflammation. Journal of neuroimmunology. vol 167. issue 1-2. 2005-11-21. PMID:16095726. |
when primary cultured rat astrocytes and microglia were treated with the conditioned medium of lps-activated cultured leptomeningeal cells, the immunoreactivity of il-10 was markedly increased. |
2005-11-21 |
2023-08-12 |
rat |
| Jose L M Madrigal, Douglas L Feinstein, Cinzia Dello Russ. Norepinephrine protects cortical neurons against microglial-induced cell death. Journal of neuroscience research. vol 81. issue 3. 2005-11-07. PMID:15948176. |
incubation of cortical neurons with conditioned media (cm) obtained from lipopolysaccharide (lps)-treated microglia induced neuronal nos2 expression and increased neuronal cell death, and these responses were reduced if the neurons were coincubated with interleukin-1 receptor antagonist. |
2005-11-07 |
2023-08-12 |
Not clear |
| Xuan Liu, Xiao-Lan Fan, Yan Zhao, Guang-Rui Luo, Xu-Ping Li, Rui Li, Wei-Dong L. Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia. Journal of neuroscience research. vol 81. issue 5. 2005-11-01. PMID:16013043. |
we demonstrate here in primary cultures of rat mesencephalic neurons that estrogen protects them from injury induced by conditioned medium obtained from lipopolysaccharide (lps)-activated microglia. |
2005-11-01 |
2023-08-12 |
rat |
| Daisuke Tsuji, Aya Kuroki, Yasuhiro Ishibashi, Tomohiro Itakura, Kohji Ito. Metabolic correction in microglia derived from Sandhoff disease model mice. Journal of neurochemistry. vol 94. issue 6. 2005-10-27. PMID:16092933. |
recomibinant hexa isozyme isolated from the conditioned medium of a chinese hamster ovary (cho) cell line simultaneously expressing the human hexa (alpha-subunit) and hexb genes was also found to be incorporated into the sd microglia via cell surface cation-independent mannose 6-phosphate receptor and mannose receptor to degrade the intracellularly accumulated gm2 and glcnac-oligosaccharides. |
2005-10-27 |
2023-08-12 |
mouse |
| Da Yong Lee, Young J Oh, Byung Kwan Ji. Thrombin-activated microglia contribute to death of dopaminergic neurons in rat mesencephalic cultures: dual roles of mitogen-activated protein kinase signaling pathways. Glia. vol 51. issue 2. 2005-08-25. PMID:15789435. |
in mesencephalic neurons treated with conditioned media (cm) taken from thrombin-activated microglia, the number of dopaminergic neurons was significantly attenuated. |
2005-08-25 |
2023-08-12 |
rat |
| Naoko Takayama, Hiroshi Ued. Morphine-induced chemotaxis and brain-derived neurotrophic factor expression in microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 2. 2005-08-17. PMID:15647486. |
the addition of conditioned medium derived from the culture of morphine-treated microglia also increased the phosphorylation of erk1/2. |
2005-08-17 |
2023-08-12 |
Not clear |