| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hung-Li Wang, Yi-Chuan Cheng, Tu-Hsueh Yeh, Han-Fang Liu, Yi-Hsin Weng, Rou-Shayn Chen, Yi-Chun Chen, Juu-Chin Lu, Tsong-Long Hwang, Kuo-Chen Wei, Yu-Chuan Liu, Yu-Ting Wang, Chia-Chen Hsu, Tai-Ju Chiu, Ching-Chi Chi. HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease. Biochemical pharmacology. 2023-03-31. PMID:37001680. |
conditioned medium (cm) of fmlf-treated microglia cells, which contains neurotoxic il-1β, il-6 and tnf-α, caused apoptotic death of differentiated sh-sy5y dopaminergic neurons by inducing mitochondrial oxidative stress and activating pro-apoptotic signaling. |
2023-03-31 |
2023-08-14 |
mouse |
| Nazende Zeren, Zobia Afzal, Sara Morgan, Gregory Marshall, Maithrayee Uppiliappan, James Merritt, Salvatore J Conigli. The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982211. |
interestingly, treatment of a murine microglia cell line with glioma conditioned media resulted in a strong induction of ccr1 gene and protein expression. |
2023-03-29 |
2023-08-14 |
Not clear |
| Nazende Zeren, Zobia Afzal, Sara Morgan, Gregory Marshall, Maithrayee Uppiliappan, James Merritt, Salvatore J Conigli. The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma Invasion. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982211. |
in addition, glioma conditioned media treatment of microglia resulted in a rapid upregulation of gene expression of several ccr1 ligands including ccl3, ccl5, ccl6 and ccl9. |
2023-03-29 |
2023-08-14 |
Not clear |
| Rebecca K Holloway, Liang Zhang, Irene Molina-Gonzalez, Kathy Ton, James A R Nicoll, James P Boardman, Yan Liang, Anna Williams, Veronique E Miro. Localized microglia dysregulation impairs central nervous system myelination in development. Acta neuropathologica communications. vol 11. issue 1. 2023-03-23. PMID:36949514. |
we functionally link these findings by showing that conditioned media from interferon-stimulated microglia is sufficient to dysregulate myelin process formation by oligodendrocytes in culture. |
2023-03-23 |
2023-08-14 |
human |
| Xuhui Ge, Zheng Zhou, Siting Yang, Wu Ye, Zhuanghui Wang, Jiaxing Wang, Chenyu Xiao, Min Cui, Jiawen Zhou, Yufeng Zhu, Rixiao Wang, Yu Gao, Haofan Wang, Pengyu Tang, Xuhui Zhou, Ce Wang, Weihua Ca. Exosomal USP13 derived from microvascular endothelial cells regulates immune microenvironment and improves functional recovery after spinal cord injury by stabilizing IκBα. Cell & bioscience. vol 13. issue 1. 2023-03-14. PMID:36915206. |
lipopolysaccharide (lps) was used to pretreat bv2 microglia and raw264.7 macrophages followed by administration of conditioned medium from microvascular endothelial cell line bend.3 cells (ecm). |
2023-03-14 |
2023-08-14 |
Not clear |
| Yijie Yang, Ning Wang, Li Xu, Yixin Liu, Lulu Huang, Mengyang Gu, Yue Wu, Wenyi Guo, Hao Su. Aryl hydrocarbon receptor dependent anti-inflammation and neuroprotective effects of tryptophan metabolites on retinal ischemia/reperfusion injury. Cell death & disease. vol 14. issue 2. 2023-02-08. PMID:36754954. |
we further revealed that ite could inhibit inflammation in bv2 microglia and alleviate the neurotoxicity of microglial conditioned medium to rgcs under ir. |
2023-02-08 |
2023-08-14 |
Not clear |
| Hong-Yang Sun, Jin Wu, Rui Wang, Shun Zhang, Hao Xu, Еlena Kaznacheyeva, Xiao-Jun Lu, Hai-Gang Ren, Guang-Hui Wan. Pazopanib alleviates neuroinflammation and protects dopaminergic neurons in LPS-stimulated mouse model by inhibiting MEK4-JNK-AP-1 pathway. Acta pharmacologica Sinica. 2022-12-19. PMID:36536076. |
the conditioned medium from lps-treated microglia caused mouse da neuronal mes23.5 cell damage, which was greatly attenuated by pretreatment of the microglia with pazopanib. |
2022-12-19 |
2023-08-14 |
mouse |
| Jueun Lee, Jin A Shin, Eun-Mi Lee, Miso Nam, Eun-Mi Par. Noggin-mediated effects on metabolite profiles of microglia and oligodendrocytes after ischemic insult. Journal of pharmaceutical and biomedical analysis. vol 224. 2022-12-18. PMID:36529041. |
we previously reported that an antagonist of the bone morphogenetic protein, noggin, enhanced myelination in the ischemic brain during the chronic phase, and conditioned media (cm) from activated bv2 microglia treated with noggin after ischemia/reperfusion (i/r) increased the expression of myelin basic protein (mbp) in oligodendrocytes (mo3.13). |
2022-12-18 |
2023-08-14 |
Not clear |
| Prashant Koshal, Ilenia Matera, Vittorio Abruzzese, Angela Ostuni, Faustino Bisacci. The Crosstalk between HepG2 and HMC-III Cells: In Vitro Modulation of Gene Expression with Conditioned Media. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430920. |
real-time pcr and western blot analysis were used to characterize the effects on gene and protein expression of human hepatoblastoma (hepg2) and human microglia (hmc-iii) cells after exchanging part of their conditioned medium. |
2022-11-26 |
2023-08-14 |
human |
| Prashant Koshal, Ilenia Matera, Vittorio Abruzzese, Angela Ostuni, Faustino Bisacci. The Crosstalk between HepG2 and HMC-III Cells: In Vitro Modulation of Gene Expression with Conditioned Media. International journal of molecular sciences. vol 23. issue 22. 2022-11-26. PMID:36430920. |
in contrast, hepg2 but not hmc-iii cells seem to trigger autophagic processes following treatment with conditioned medium of microglia, thus suggesting a cell-specific adaptive response. |
2022-11-26 |
2023-08-14 |
human |
| Qiburi Qiburi, Tsogzolmaa Ganbold, Aoqier Aoqier, Dezhi Yang, Zhiyu Su, Mingming Bao, Meng He, Saren Gaowa, Temuqile Temuqile, Huricha Baigud. Analysis and identification of key anti-inflammatory molecules in Eerdun Wurile and exploration of their mechanism of action in microglia. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 1211. 2022-10-02. PMID:36183605. |
moreover, the conditioned culture media obtained from f4-6 treated microglia significantly enhanced proliferation of n2a cells, and promoted neurite outgrowth possibly through upregulation of nefh and dlg4. |
2022-10-02 |
2023-08-14 |
Not clear |
| Ling-Yu Yang, Yong-Ren Chen, Jing-Er Lee, Kuo-Wei Chen, Hui-Tzung Luh, Yi-Tzu Chen, Kuo-Chuan Wang, Sung-Tsang Hsie. Dental Pulp Stem Cell-Derived Conditioned Medium Alleviates Subarachnoid Hemorrhage-Induced Microcirculation Impairment by Promoting M2 Microglia Polarization and Reducing Astrocyte Swelling. Translational stroke research. 2022-10-01. PMID:36181630. |
dental pulp stem cell-derived conditioned medium alleviates subarachnoid hemorrhage-induced microcirculation impairment by promoting m2 microglia polarization and reducing astrocyte swelling. |
2022-10-01 |
2023-08-14 |
rat |
| Sumonto Mitra, Ruchi Gera, Julia Sundheimer, Marine Lemee, Lars U Wahlberg, Bengt Linderoth, Maria Eriksdotter, Homira Behbahan. Microglia Impairs Proliferation and Induces Senescence In-Vitro in NGF Releasing Cells Used in Encapsulated Cell Biodelivery for Alzheimer's Disease Therapy. International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012296. |
further, we exposed the hmngf secreting human arpe-19 cell line (ngc0211) to microglia (hmc3) conditioned medium (mcm; untreated or treated with il-1β/ifnγ/aβ |
2022-08-26 |
2023-08-14 |
human |
| Matheus B Victor, Noelle Leary, Xochitl Luna, Hiruy S Meharena, Aine Ni Scannail, P Lorenzo Bozzelli, George Samaan, Mitchell H Murdock, Djuna von Maydell, Audrey H Effenberger, Oyku Cerit, Hsin-Lan Wen, Liwang Liu, Gwyneth Welch, Maeve Bonner, Li-Huei Tsa. Lipid accumulation induced by APOE4 impairs microglial surveillance of neuronal-network activity. Cell stem cell. vol 29. issue 8. 2022-08-05. PMID:35931030. |
by examining the transcriptional signatures of apoe3 versus apoe4 microglia in response to neuronal conditioned media, we established that neuronal cues differentially induce a lipogenic program in apoe4 microglia that exacerbates pro-inflammatory signals. |
2022-08-05 |
2023-08-14 |
Not clear |
| Yapeng Lu, Panpan Chang, Wangwang Ding, Jiangpei Bian, Dan Wang, Xueting Wang, Qianqian Luo, Xiaomei Wu, Li Zh. Pharmacological inhibition of mitochondrial division attenuates simulated high-altitude exposure-induced cerebral edema in mice: Involvement of inhibition of the NF-κB signaling pathway in glial cells. European journal of pharmacology. 2022-07-06. PMID:35793726. |
when astrocytes were treated with the conditioned medium of microglia exposed to hypoxia (h-mcm), the protein levels of p-drp1, p-p65, and aqp4 as well as the mrna levels of il-6, tnf-α, and il-1β in astrocytes were increased. |
2022-07-06 |
2023-08-14 |
mouse |
| Prachya Kongtawelert, Chayanut Kaewmool, Thanyaluck Phitak, Mattabhorn Phimphilai, Peraphan Pothacharoen, Thuzar Hla Shw. Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances through modulating p38 and JNK signaling pathways. Scientific reports. vol 12. issue 1. 2022-07-05. PMID:35788665. |
next, conditioned medium (cm) collected from high glucose-activated bv2 cell culture was used to show aggravated neurotoxicity in differentiated pc12 cells, indicating that high glucose-activated microglia could induce neurotoxicity. |
2022-07-05 |
2023-08-14 |
Not clear |
| Rachel E James Bates, Eleanor Browne, Renee Schalks, Heather Jacobs, Li Tan, Puja Parekh, Roberta Magliozzi, Massimiliano Calabrese, Nicholas D Mazarakis, Richard Reynold. Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration. Brain : a journal of neurology. 2022-07-01. PMID:35776111. |
conditioned medium from ltα treated microglia was able to induce a reactive phenotype in astrocytes. |
2022-07-01 |
2023-08-14 |
rat |
| Sara Merlo, Grazia Ilaria Caruso, Laura Bonfili, Simona Federica Spampinato, Giuseppe Costantino, Anna Maria Eleuteri, Maria Angela Sortin. Microglial polarization differentially affects neuronal vulnerability to the β-amyloid protein: modulation by melatonin. Biochemical pharmacology. 2022-06-24. PMID:35750198. |
differentiated neuronal-like sh-sy5y cells were exposed to aβ42 (200 nm for 24 h) in basal medium or in the presence of conditioned medium (cm) collected from microglia exposed for different times to aβ42 alone or in combination with melco or melpost. |
2022-06-24 |
2023-08-14 |
human |
| Yuka Okusha, Benjamin J Lang, Ayesha Murshid, Thiago J Borges, Kristina M Holton, Joanne Clark-Matott, Sachin Doshi, Tsuneya Ikezu, Stuart K Calderwoo. Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell stress & chaperones. 2022-06-10. PMID:35689138. |
additionally, the toxicity of conditioned media obtained from microglia treated with faβ was attenuated by addition of ehsp90α. |
2022-06-10 |
2023-08-14 |
Not clear |
| Yuka Okusha, Benjamin J Lang, Ayesha Murshid, Thiago J Borges, Kristina M Holton, Joanne Clark-Matott, Sachin Doshi, Tsuneya Ikezu, Stuart K Calderwoo. Extracellular Hsp90α stimulates a unique innate gene profile in microglial cells with simultaneous activation of Nrf2 and protection from oxidative stress. Cell stress & chaperones. 2022-06-10. PMID:35689138. |
using a co-culture system of microglia and hippocampal neuronal cell line ht22 cells separated by a chamber insert, the neurotoxicity of medium conditioned by microglia treated with faβ was reduced when ehsp90α was also added. |
2022-06-10 |
2023-08-14 |
Not clear |