| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana Boriero, Alessandra Carcereri de Prati, Lorenzo Antonini, Rino Ragno, Kazuo Sohji, Sofia Mariotto, Elena Butturin. The anti-STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death. The FEBS journal. vol 288. issue 7. 2021-07-20. PMID:32981207. |
herein, we investigated the anti-inflammatory effect of myr and its ability to protect neurons from death in an in vitro model of neurotoxicity using the neuroblast-like sh-sy5y cells that were exposed to conditioned media from hypoxia-activated microglia bv2 cells. |
2021-07-20 |
2023-08-13 |
Not clear |
| Diana Boriero, Alessandra Carcereri de Prati, Lorenzo Antonini, Rino Ragno, Kazuo Sohji, Sofia Mariotto, Elena Butturin. The anti-STAT1 polyphenol myricetin inhibits M1 microglia activation and counteracts neuronal death. The FEBS journal. vol 288. issue 7. 2021-07-20. PMID:32981207. |
moreover, treatment of sh-sy5y cells with conditioned medium from hypoxia-activated microglia pretreated with myr produced a significant reduction in neuronal viability. |
2021-07-20 |
2023-08-13 |
Not clear |
| Jiao Tang, Rui Chen, Lingling Wang, Lu Yu, Dandan Zuo, Guiyun Cui, Xiaoqian Gon. Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis. Inflammation. vol 43. issue 5. 2021-07-15. PMID:32705396. |
in further experiments investigating the protection conferred by melatonin, incubating ht22 cells with conditioned medium (cm) from thrombin-stimulated microglia induced ht22 cell apoptosis, and this effect was reversed after treating cm with either melatonin or n-acetyl-l-cysteine (nac). |
2021-07-15 |
2023-08-13 |
Not clear |
| Chao Gu, Fen Wang, Yu-Ting Zhang, Shi-Zhuang Wei, Jun-Yi Liu, Hong-Yang Sun, Guang-Hui Wang, Chun-Feng Li. Microglial MT1 activation inhibits LPS-induced neuroinflammation via regulation of metabolic reprogramming. Aging cell. vol 20. issue 6. 2021-06-26. PMID:33964119. |
furthermore, in lps-treated microglia, mt1 activation decreased the toxicity of conditioned media to the dopaminergic (da) cell line mes23.5. |
2021-06-26 |
2023-08-13 |
mouse |
| Issan Zhang, Paula Lépine, Chanshuai Han, María Lacalle-Aurioles, Carol X-Q Chen, Rainer Haag, Thomas M Durcan, Dusica Maysinge. Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures. Cells. vol 9. issue 11. 2021-06-16. PMID:33171886. |
glioblastoma tumoroids of astrocytic origin respond to activated microglia with enhanced invasiveness, whereas conditioned media from dpgs-treated microglia reduce tumoroid invasiveness. |
2021-06-16 |
2023-08-13 |
human |
| Eriko Kuroda, Kaneyasu Nishimura, Shohei Kawanishi, Mari Sueyoshi, Fumitaka Ueno, Yumiko Toji, Naoko Abo, Toko Konishi, Koki Harada, Shiho Satake, Chiaki Shima, Yuki Toda, Yoshihisa Kitamura, Shun Shimohama, Eishi Ashihara, Kazuyuki Takat. Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ. Neuroscience. vol 438. 2021-05-14. PMID:32522344. |
high levels of transforming growth factor-β1 (tgf-β1) were present in the conditioned medium, and bmdml cells and microglia expressed tgf-β1 mrna and tgf-β receptor type 1 (tgf-βr1) protein, respectively. |
2021-05-14 |
2023-08-13 |
mouse |
| Alessandra Bispo da Silva, Paulo Lucas Cerqueira Coelho, Mona das Neves Oliveira, Joana Luz Oliveira, Jéssika Alves Oliveira Amparo, Karina Costa da Silva, Janaina Ribeiro Pereira Soares, Bruno Penas Seara Pitanga, Cleide Dos Santos Souza, Giselle Pinto de Faria Lopes, Victor Diogenes Amaral da Silva, Maria de Fátima Dias Costa, Marie Pierre Junier, Hervé Chneiweiss, Vivaldo Moura-Neto, Silvia Lima Cost. The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity. Brain, behavior, and immunity. vol 85. 2021-04-27. PMID:31059805. |
treatment of microglia and c6 cells either in co-cultures or during indirect interaction, via conditioned media from glioma cells treated with flavonoids or via conditioned media from microglia treated with flavonoids reduced proliferation and migration of glioma cells. |
2021-04-27 |
2023-08-13 |
human |
| Yue Han, Jiutai Wang, Qiuying Zhao, Xiaofang Xie, Rui Song, Ying Xiao, Xixi Kang, Lijuan Zhang, Yue Zhang, Cheng Peng, Zili Yo. Pioglitazone alleviates maternal sleep deprivation-induced cognitive deficits in male rat offspring by enhancing microglia-mediated neurogenesis. Brain, behavior, and immunity. vol 87. 2021-04-27. PMID:32032783. |
conditioned medium from pioglitazone-treated microglia promoted proliferation and differentiation of neural progenitor cells. |
2021-04-27 |
2023-08-13 |
rat |
| Yi Li, Ning Chen, Chao Wu, Yongquan Lu, Ge Gao, Chunli Duan, Hui Yang, Lingling L. Galectin-1 attenuates neurodegeneration in Parkinson's disease model by modulating microglial MAPK/IκB/NFκB axis through its carbohydrate-recognition domain. Brain, behavior, and immunity. vol 83. 2021-03-08. PMID:31669519. |
it was found that galectin-1 attenuated the inflammatory insult and the apoptosis of sk-n-sh human neuroblastoma cells from conditioned medium of activated microglia induced by lipopolysaccharides (lps). |
2021-03-08 |
2023-08-13 |
mouse |
| Li-Shang Liao, Ming-Wei Zhang, Ying-Jiang Gu, Xiao-Chuan Su. Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice. Aging. vol 12. issue 14. 2021-03-04. PMID:32575072. |
conditioned medium from oxyhb-treated microglia induced neuronal apoptosis, while the percentage of apoptotic neurons in the conditioned medium from microglia transfected with ccl20 sirna or ccr6 sirna was decreased. |
2021-03-04 |
2023-08-13 |
mouse |
| Li-Shang Liao, Ming-Wei Zhang, Ying-Jiang Gu, Xiao-Chuan Su. Targeting CCL20 inhibits subarachnoid hemorrhage-related neuroinflammation in mice. Aging. vol 12. issue 14. 2021-03-04. PMID:32575072. |
conditioned medium from oxyhb-treated neurons led to microglial activation and induced ccr6, il-1β and tnf-α expression, while ccl20 knockdown in neurons or ccr6 knockdown in microglia reversed those effects. |
2021-03-04 |
2023-08-13 |
mouse |
| Xiali Zhong, Jingwei Wu, Weijian Ke, Yuejin Yu, Di Ji, Jianmeng Kang, Jiahuang Qiu, Can Wang, Panpan Yu, Yanhong We. Neonatal exposure to organophosphorus flame retardant TDCPP elicits neurotoxicity in mouse hippocampus via microglia-mediated inflammation in vivo and in vitro. Archives of toxicology. vol 94. issue 2. 2021-02-23. PMID:31894355. |
neurite outgrowth of primary mouse hippocampal neurons was inhibited by treatment with the conditioned medium harvested from microglia exposed to tdcpp. |
2021-02-23 |
2023-08-13 |
mouse |
| Luisa Dietrich, Ralph Lucius, Johann Roider, Alexa Klettne. Interaction of inflammatorily activated retinal pigment epithelium with retinal microglia and neuronal cells. Experimental eye research. vol 199. 2021-01-28. PMID:32735798. |
the treatment of the shsy-5y with supernatant of microglia previously treated with rpe conditioned medium significantly decreased shsy-5y viability with and without pro-inflammatory treatment. |
2021-01-28 |
2023-08-13 |
human |
| Yinyin Zhang, Wenya Shao, Jingwen Wu, Shouxiong Huang, Hongyu Yang, Zhousong Luo, Fuli Zheng, Yuan-Liang Wang, Ping Cai, Zhenkun Guo, Siying Wu, Huangyuan L. Inflammatory lncRNA AK039862 regulates paraquat-inhibited proliferation and migration of microglial and neuronal cells through the Pafah1b1/Foxa1 pathway in co-culture environments. Ecotoxicology and environmental safety. vol 208. 2021-01-07. PMID:33120262. |
to simulate the coexisting dopaminergic cells and microglia cells in vitro, we applied several non-contact co-culture models, including conditioned medium and transwell co-culture systems. |
2021-01-07 |
2023-08-13 |
mouse |
| Dongfang Dai, Jia Yuan, Yan Wang, Jing Xu, Chaoming Mao, Yichuan Xia. Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Scientific reports. vol 9. issue 1. 2020-10-20. PMID:31142803. |
accordingly, peli1 deficiency markedly inhibited neuron death induced by the conditioned medium from lps-stimulated microglia. |
2020-10-20 |
2023-08-13 |
mouse |
| Yiheng Liu, Yuan Fu, Yunxia Zhang, Fangfang Liu, Gregory M Rose, Xiaowen He, Xinan Yi, Rui Ren, Yiying Li, Yusheng Zhang, Hui Wu, Chuanzhu Lv, Haiying Zhan. Butein attenuates the cytotoxic effects of LPS-stimulated microglia on the SH-SY5Y neuronal cell line. European journal of pharmacology. vol 868. 2020-10-14. PMID:31837307. |
here, we examined the effect of butein on sh-sy5y neuroblastoma cells grown with conditioned medium from bv2 microglia cells that had been activated by lipopolysaccharide (lps) as a neuroinflammation model. |
2020-10-14 |
2023-08-13 |
Not clear |
| Cayla M Duffy, Jacob Swanson, William Northrop, Joshua P Nixon, Tammy A Butteric. Microglial Immune Response to Low Concentrations of Combustion-Generated Nanoparticles: An In Vitro Model of Brain Health. Nanomaterials (Basel, Switzerland). vol 8. issue 3. 2020-10-01. PMID:29522448. |
finally, we show conditioned media from cgnp-stimulated microglia significantly reduced hypothalamic neuronal survival in vitro. |
2020-10-01 |
2023-08-13 |
Not clear |
| Lu Liu, Dandan An, Junying Xu, Bin Shao, Xing Li, Jing Sh. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29662435. |
here, we investigated the mechanism by which the anxa1 peptide ac2-26 decreases high tnf-α production and ikkβ activity, which was caused by oxygen glucose deprivation/reperfusion (ogd/r)-induced neuronal conditioned medium (ncm) in microglia. |
2020-10-01 |
2023-08-13 |
Not clear |
| Chao Gu, Qingsong Hu, Jiayuan Wu, Chenchen Mu, Haigang Ren, Chun-Feng Liu, Guanghui Wan. P7C3 Inhibits LPS-Induced Microglial Activation to Protect Dopaminergic Neurons Against Inflammatory Factor-Induced Cell Death Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30455635. |
furthermore, in lps-treated microglia, p7c3-pretreatment decreased the toxicity of conditioned media to mes23.5 cells (a dopaminergic (da) cell line). |
2020-09-30 |
2023-08-13 |
mouse |
| Meng-Meng Jin, Fen Wang, Di Qi, Wen-Wen Liu, Chao Gu, Cheng-Jie Mao, Ya-Ping Yang, Zhong Zhao, Li-Fang Hu, Chun-Feng Li. A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30515090. |
more important, tnf-α stimulated microglia conditioned medium caused neurotoxicity when added to neuronal cells. |
2020-09-30 |
2023-08-13 |
Not clear |