| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuang Wu, Linlang Li, Long-Tai Zheng, Zhihong Xu, Lin Guo, Xuechu Zhe. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation. Journal of neurochemistry. vol 134. issue 5. 2015-11-03. PMID:26031312. |
furthermore, in a microglia-conditioned media system, skf83959 inhibited the cytotoxicity of conditioned medium generated by lps-activated microglia toward ht-22 neuroblastoma cells. |
2015-11-03 |
2023-08-13 |
Not clear |
| Tatsuhide Tanaka, Koichi Murakami, Yoshio Bando, Shigetaka Yoshid. Interferon regulatory factor 7 participates in the M1-like microglial polarization switch. Glia. vol 63. issue 4. 2015-10-29. PMID:25422089. |
the addition of m2-like microglial conditioned medium (cm) to primary neurons resulted in an increase in neurite length when compared with neurons treated with m1-like microglial cm, possibly because of the enhanced secretion of neurotrophic factors by m2-like microglia. |
2015-10-29 |
2023-08-13 |
Not clear |
| Dasa Cizkova, Stéphanie Devaux, Françoise Le Marrec-Croq, Julien Franck, Lucia Slovinska, Juraj Blasko, Jan Rosocha, Timea Spakova, Christophe Lefebvre, Isabelle Fournier, Michel Salze. Modulation properties of factors released by bone marrow stromal cells on activated microglia: an in vitro study. Scientific reports. vol 4. 2015-10-02. PMID:25524416. |
in the present paper we develop a new non-cell based (cell-free) therapeutic approach applied to bv2 microglial cells and spinal cord derived primary microglia (pm) using conditioned media from rat bone marrow stromal cells (bmscs-cm). |
2015-10-02 |
2023-08-13 |
rat |
| Moonhee Lee, Edith McGeer, Patrick L McGee. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25169677. |
to test the viability of this hypothesis, we exposed differentiated sh-sy5y and n-tera2/d1 (n-tera2) cells to conditioned medium (cm) from lps/ifnγ-stimulated human microglia. |
2015-09-21 |
2023-08-13 |
human |
| Chien-Cheng Chen, Tai-Ho Hung, Chao Yu Lee, Liang-Fei Wang, Chun-Hu Wu, Chia-Hua Ke, Szu-Fu Che. Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injury. PloS one. vol 9. issue 12. 2015-09-04. PMID:25546475. |
the protective effect of berberine was also investigated in cultured neurons either subjected to stretch injury or exposed to conditioned media with activated microglia. |
2015-09-04 |
2023-08-13 |
mouse |
| Zhongwang Yu, Dingya Sun, Jifeng Feng, Weixing Tan, Xue Fang, Ming Zhao, Xiaolin Zhao, Yingyan Pu, Aijun Huang, Zhenghua Xiang, Li Cao, Cheng H. MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 16. 2015-07-16. PMID:25904788. |
the conditioned medium from msx3-transduced microglia promoted oligodendrocyte progenitor survival, differentiation, and neurite outgrowth. |
2015-07-16 |
2023-08-13 |
Not clear |
| Veronika E Neubrand, Marta Pedreño, Marta Caro, Irene Forte-Lago, Mario Delgado, Elena Gonzalez-Re. Mesenchymal stem cells induce the ramification of microglia via the small RhoGTPases Cdc42 and Rac1. Glia. vol 62. issue 12. 2015-06-19. PMID:24995657. |
microglia exposed to ascs or their secreted factors (conditioned medium) underwent a cell shape change into a ramifying morphology in basal and inflammatory conditions, similar to that observed in microglia found in healthy brain. |
2015-06-19 |
2023-08-13 |
Not clear |
| Linn Malmsten, Swetha Vijayaraghavan, Outi Hovatta, Amelia Marutle, Taher Darreh-Shor. Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation. Journal of cellular and molecular medicine. vol 18. issue 9. 2015-04-13. PMID:25109373. |
the hes were cultured as neurospheres and exposed to fibrillar and oligomeric aβ(1-42) (aβf, aβo) or to conditioned medium from human primary microglia activated with either aβ(1-42) or lipopolysaccharide. |
2015-04-13 |
2023-08-13 |
human |
| Masatoshi Ohnishi, Ayaka Monda, Ryoko Takemoto, Yukina Fujimoto, Mitsumasa Sugitani, Takahiro Iwamura, Takashi Hiroyasu, Atsuko Inou. High-mobility group box 1 up-regulates aquaporin 4 expression via microglia-astrocyte interaction. Neurochemistry international. vol 75. 2015-03-30. PMID:24893328. |
the exposure of microglia to conditioned medium with hmgb1 and 3mm adenosine 5'-triphosphate for 6h significantly increased aqp4 mrna in astrocytes after 6h. |
2015-03-30 |
2023-08-13 |
rat |
| Ana J Chucair-Elliott, Christopher Conrady, Min Zheng, Chandra M Kroll, Thomas E Lane, Daniel J J Car. Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells. Glia. vol 62. issue 9. 2015-03-13. PMID:24807365. |
the neuronal loss was prevented by the addition of microglia or conditioned media from npc/microglia co-cultures. |
2015-03-13 |
2023-08-13 |
human |
| Xiu-Yun Song, Jin-Feng Hu, Ming-Na Sun, Zhi-Peng Li, Zhi-Xiang Zhu, Lian-Kun Song, Yu-He Yuan, Gang Liu, Nai-Hong Che. IMM-H004, a novel coumarin derivative compound, attenuates the production of inflammatory mediatory mediators in lipopolysaccharide-activated BV2 microglia. Brain research bulletin. vol 106. 2015-03-12. PMID:24878446. |
our observations indicated that treatment with imm-h004 significantly inhibited bv2 microglia activation, protected pc12 cells and primary neurons against indirect toxicity mediated by exposure to conditioned medium (cm) from lps-treated bv2 cells. |
2015-03-12 |
2023-08-13 |
Not clear |
| Robert Nunan, Harri Sivasathiaseelan, Damla Khan, Malik Zaben, William Gra. Microglial VPAC1R mediates a novel mechanism of neuroimmune-modulation of hippocampal precursor cells via IL-4 release. Glia. vol 62. issue 8. 2015-02-04. PMID:24801739. |
furthermore, addition of purified hippocampal microglia, or their conditioned media, is trophic and proliferative to nspcs. |
2015-02-04 |
2023-08-13 |
Not clear |
| Qun Zhang, Lin Yuan, Dexiang Liu, Jianmei Wang, Shuanglian Wang, Qingrui Zhang, Yanfen Gong, Hongda Liu, Aijun Hao, Zhen Wan. Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. Pharmacological research. vol 84. 2015-01-05. PMID:24788079. |
in addition, treating murine primary cortical neurons with conditioned medium (cm) from hypoxia-stimulated microglia induced neuronal apoptosis, an effect that was reversed by cm treated with nahs. |
2015-01-05 |
2023-08-13 |
mouse |
| Mareike Caesar, Sandra Felk, Susanne Zach, Gunnar Brønstad, Jan O Aasly, Thomas Gasser, Frank Gillardo. Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2. Glia. vol 62. issue 7. 2015-01-02. PMID:24652679. |
here we show that pgrn levels are significantly reduced in conditioned medium of lrrk2(r1441g) mutant mouse fibroblasts, leukocytes, and microglia, whereas levels of proinflammatory factors, like interleukin-1β and keratinocyte-derived chemokine, were significantly increased. |
2015-01-02 |
2023-08-12 |
mouse |
| Kae M Pusic, Aya D Pusic, Jordan Kemme, Richard P Krai. Spreading depression requires microglia and is decreased by their M2a polarization from environmental enrichment. Glia. vol 62. issue 7. 2015-01-02. PMID:24723305. |
similarly, application of conditioned medium from m2a polarized primary microglia to slice cultures also increased sd threshold. |
2015-01-02 |
2023-08-13 |
rat |
| Wei Wei, Yu-He Yuan, Yan-Na Gao, Wen-Fen Yan, Chuang-Jun Li, Dong-Ming Zhang, Nai-Hong Che. Polygalasaponin F inhibits secretion of inflammatory cytokines via NF-κB pathway regulation. Journal of Asian natural products research. vol 16. issue 8. 2014-10-31. PMID:25082394. |
in addition, ps-f could significantly inhibit the cytotoxicity of conditioned medium prepared by lps-stimulated bv-2 microglia (lps conditioned media) to neuronal pc12 cells and improve cell viability. |
2014-10-31 |
2023-08-13 |
Not clear |
| Aditya Sunkaria, Deep Raj Sharma, Willayat Yousuf Wani, Kiran Dip Gil. Attenuation of dichlorvos-induced microglial activation and neuronal apoptosis by 4-hydroxy TEMPO. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23884618. |
microglia were treated with dichlorvos for 24 h and supernatant was collected (dichlorvos-induced conditioned medium, dcm). |
2014-10-27 |
2023-08-12 |
rat |
| Shing-Chuan Shen, Ming-Shun Wu, Hui-Yi Lin, Liang-Yo Yang, Yi-Hsuan Chen, Yen-Chou Che. Reactive oxygen species-dependent nitric oxide production in reciprocal interactions of glioma and microglial cells. Journal of cellular physiology. vol 229. issue 12. 2014-10-20. PMID:24777714. |
conditioned mediums (cms) from glioma cells u87, gbm-8401, and c6 significantly induced inos protein and no production by microglial cells bv-2 but without altering the cell viability or cell-cycle progression of bv2 microglia. |
2014-10-20 |
2023-08-13 |
Not clear |
| Yicong Liu, Zhou Wu, Xinwen Zhang, Junjun Ni, Weixian Yu, Yanmin Zhou, Hiroshi Nakanish. Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS. Mediators of inflammation. vol 2013. 2014-10-14. PMID:24363500. |
furthermore, the mean mrna levels of tnf-α and il-1β in microglia after treatment with the conditioned medium from p.g. |
2014-10-14 |
2023-08-12 |
mouse |
| Charanjit Kaur, Viswanathan Sivakumar, Zhirong Zou, Eng-Ang Lin. Microglia-derived proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta induce Purkinje neuronal apoptosis via their receptors in hypoxic neonatal rat brain. Brain structure & function. vol 219. issue 1. 2014-09-19. PMID:23262920. |
moreover, cultured purkinje neurons treated with conditioned medium derived from hypoxic microglia underwent apoptosis but the incidence was significantly reduced when the cells were treated with the same medium that was neutralized with tnf-α/il-1β antibody. |
2014-09-19 |
2023-08-12 |
rat |