| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alyssa M West, Katherine M Holleran, Sara R Jone. Kappa Opioid Receptors Reduce Serotonin Uptake and Escitalopram Efficacy in the Mouse Substantia Nigra Pars Reticulata. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768403. |
the serotonin and kappa opioid receptor (kor) systems are strongly implicated in disorders of negative affect, such as anxiety and depression. |
2023-02-11 |
2023-08-14 |
mouse |
| Alyssa M West, Katherine M Holleran, Sara R Jone. Kappa Opioid Receptors Reduce Serotonin Uptake and Escitalopram Efficacy in the Mouse Substantia Nigra Pars Reticulata. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36768403. |
these interactions between kors and serotonin may contribute to the complexity in the responses to treatments for disorders of negative affect. |
2023-02-11 |
2023-08-14 |
mouse |
| Zoltan Rihmer, Péter Döme, Cornelius Katon. Serotonin and depression - a riposte to Moncrieff et al. (2022). Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 24. issue 3. 2022-11-10. PMID:36356194. |
the decreased activity of serotonin, which undoubtedly plays an essential role in the pathogenesis of depression, is characteristic of only a subgroup of depressed subjects whose clinical picture is mostly dominated by intensified negative emotions, agitation, anxiety, insomnia, decreased appetite, self-blame and suicidality and these individuals are primarily responsive to ssris. |
2022-11-10 |
2023-08-14 |
human |
| Marta Kędziora, Serena Boccella, Ida Marabese, Jakub Mlost, Rosmara Infantino, Sabatino Maione, Katarzyna Starowic. Inhibition of anandamide breakdown reduces pain and restores LTP and monoamine levels in the rat hippocampus via the CB Neuropharmacology. vol 222. 2022-11-07. PMID:36341807. |
a substantial body of evidence demonstrate that hippocampal neural circuits, especially monoamine dopamine and serotonin levels, contributes to negative affect and avoidance motivation experienced during pain. |
2022-11-07 |
2023-08-14 |
rat |
| Kanza M Khan, Gabrielle Bierlein-De La Rosa, Natalie Biggerstaff, Govindhasamy Pushpavathi Selvakumar, Ruixiang Wang, Suzanne Mason, Michael E Dailey, Catherine A Marcinkiewc. Adolescent ethanol drinking promotes hyperalgesia, neuroinflammation and serotonergic deficits in mice that persist into adulthood. Brain, behavior, and immunity. 2022-07-30. PMID:35907582. |
taken together, these results indicate that microglial activation in the drn may be a primary driver of pain, negative affect, and 5-ht depletion after aie. |
2022-07-30 |
2023-08-14 |
mouse |
| Ying Xu, Li Xu, Yu Zhen. Application of Chaihu-Guizhi-Longgu-Muli decoction combined with Liuwei Dihuang Pills in the treatment of menopausal insomnia and its effect on sleep quality. Pakistan journal of pharmaceutical sciences. vol 34. issue 5(Special). 2021-12-06. PMID:34862869. |
the pittsburgh sleep quality index (psqi), estrogen level, negative emotion score, quality of life score, serum β-endorphin (β-ep) level, serotonin level (5-ht) and treatment effective rate were compared between the two groups of patients. |
2021-12-06 |
2023-08-13 |
Not clear |
| Tomoko Soga, Shingo Nakajima, Ishwar S Parha. Expression of Repressor Element 1 Silencing Transcription Factor (REST) in Serotonin Neurons in the Adult Male Nile Tilapia ( Frontiers in neuroanatomy. vol 14. 2021-03-30. PMID:33776659. |
we hypothesized that rest is co-expressed in 5-ht neurons, which, if demonstrated, would be useful to understand the mechanism of 5-ht dysfunction-related disorders such as negative emotions and depression. |
2021-03-30 |
2023-08-13 |
Not clear |
| Lola Welsch, Julie Bailly, Emmanuel Darcq, Brigitte Lina Kieffe. The Negative Affect of Protracted Opioid Abstinence: Progress and Perspectives From Rodent Models. Biological psychiatry. vol 87. issue 1. 2021-01-06. PMID:31521334. |
behavioral rodent models have successfully recapitulated behavioral signs of the oud-related negative affect, and several neurotransmitter systems were identified (i.e., serotonin, dynorphin, corticotropin-releasing factor, oxytocin). |
2021-01-06 |
2023-08-13 |
human |
| Christine Muench, Audrey Luo, Katrin Charlet, Jisoo Lee, Daniel B Rosoff, Hui Sun, Samantha J Fede, Jeesun Jung, Reza Momenan, Falk W Lohof. Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence. Alcohol and alcoholism (Oxford, Oxfordshire). vol 54. issue 3. 2019-11-25. PMID:31008507. |
lack of association between serotonin transporter gene (slc6a4) promoter methylation and amygdala response during negative emotion processing in individuals with alcohol dependence. |
2019-11-25 |
2023-08-13 |
Not clear |
| Robbie Schepers, C Rob Marku. Gene by cognition interaction on stress-induced attention bias for food: Effects of 5-HTTLPR and ruminative thinking. Biological psychology. vol 128. 2018-04-09. PMID:28712729. |
an s-allele of the 5-httlpr gene has been linked to decreased (brain) serotonin efficiency, leading to decreased stress resilience and increased risks for negative affect and eating related disturbances. |
2018-04-09 |
2023-08-13 |
Not clear |
| Alini Daniéli Viana Sabino, Marcos Hortes N Chagas, Flávia L Osóri. Effects of psychotropic drugs used in the treatment of anxiety disorders on the recognition of facial expressions of emotion: Critical analysis of literature. Neuroscience and biobehavioral reviews. vol 71. 2017-10-17. PMID:27810346. |
increased and decreased recognition of negative emotions were associated with the use of selective serotonin and/or norepinephrine reuptake inhibitors, respectively. |
2017-10-17 |
2023-08-13 |
human |
| Tim Outhred, Pritha Das, Carol Dobson-Stone, Kim L Felmingham, Richard A Bryant, Pradeep J Nathan, Gin S Malhi, Andrew H Kem. Impact of 5-HTTLPR on SSRI serotonin transporter blockade during emotion regulation: A preliminary fMRI study. Journal of affective disorders. vol 196. 2016-12-13. PMID:26896742. |
the short ('s') allele of the serotonin transporter (5-htt)-linked polymorphic region (5-httlpr) is associated with increased negative emotion processing bias, and this polymorphism moderates acute effects of selective serotonin reuptake inhibitor (ssri) treatment. |
2016-12-13 |
2023-08-13 |
Not clear |
| Andreas Frick, Fredrik Åhs, Jonas Engman, My Jonasson, Iman Alaie, Johannes Björkstrand, Örjan Frans, Vanda Faria, Clas Linnman, Lieuwe Appel, Kurt Wahlstedt, Mark Lubberink, Mats Fredrikson, Tomas Furmar. Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study. JAMA psychiatry. vol 72. issue 8. 2015-10-30. PMID:26083190. |
serotonin is involved in negative affect, but whether anxiety syndromes, such as social anxiety disorder (sad), are characterized by an overactive or underactive serotonin system has not been established. |
2015-10-30 |
2023-08-13 |
Not clear |
| Tim Outhred, Pritha Das, Carol Dobson-Stone, Kim L Felmingham, Richard A Bryant, Pradeep J Nathan, Gin S Malhi, Andrew H Kem. The impact of 5-HTTLPR on acute serotonin transporter blockade by escitalopram on emotion processing: preliminary findings from a randomised, crossover fMRI study. The Australian and New Zealand journal of psychiatry. vol 48. issue 12. 2015-07-22. PMID:24810870. |
the short ('s') allele of the serotonin transporter (5-htt)-linked polymorphic region (5-httlpr) is associated with both negative emotion processing biases and poorer treatment outcomes. |
2015-07-22 |
2023-08-13 |
Not clear |
| Seiko Yasuda, Mitsuhiro Yoshida, Hirotaka Yamagata, Yasutake Iwanaga, Hiromi Suenaga, Kozo Ishikawa, Masako Nakano, Satoshi Okuyama, Yoshiko Furukawa, Shoei Furukawa, Toshizo Ishikaw. Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor. Cellular and molecular neurobiology. vol 34. issue 8. 2015-06-10. PMID:25156823. |
these results show that imi reduces pain-related negative emotion without influencing pain and that this effect is diminished by denervation of 5-ht neurons and by anti-bdnf treatment. |
2015-06-10 |
2023-08-13 |
rat |
| Mei-See Man, Yevheniia Mikheenko, Katrin Braesicke, Gemma Cockcroft, Angela C Robert. Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates. The international journal of neuropsychopharmacology. vol 15. issue 1. 2015-01-22. PMID:21726490. |
impaired top-down regulation of the amygdala, and its modulation by serotonin (5-ht), is strongly implicated in the dysregulation of negative emotion that characterizes a number of affective disorders. |
2015-01-22 |
2023-08-12 |
marmoset |
| Huirong Guo, Yuming Ren, Ning Zhao, Yali Wang, Shuying Li, He Cui, Sijia Zhang, Jianhua Zhan. Synergistic effect of 5-HT2A receptor gene and MAOA gene on the negative emotion of patients with depression. Clinical physiology and functional imaging. vol 34. issue 4. 2015-01-14. PMID:24314147. |
to analyse the synergistic effect of polymorphism of the tandem repeat sequence u-vntr of 5-hydroxytryptamine 2a (5-ht2a) receptor gene and monoamine oxidase a (maoa) gene on the negative emotion in frontal lobe of patients with depression through functional magnetic resonance imaging (fmri) technique. |
2015-01-14 |
2023-08-12 |
Not clear |
| Christine Firk, Nicolette Siep, C Rob Marku. Serotonin transporter genotype modulates cognitive reappraisal of negative emotions: a functional magnetic resonance imaging study. Social cognitive and affective neuroscience. vol 8. issue 3. 2013-09-10. PMID:22345383. |
serotonin transporter genotype modulates cognitive reappraisal of negative emotions: a functional magnetic resonance imaging study. |
2013-09-10 |
2023-08-12 |
human |
| A Kobiella, M Reimold, D E Ulshöfer, V N Ikonomidou, C Vollmert, S Vollstädt-Klein, M Rietschel, G Reischl, A Heinz, M N Smolk. How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure. Translational psychiatry. vol 1. 2013-04-04. PMID:22832611. |
the serotonin transporter-linked promoter region (5-httlpr) polymorphism of the serotonin transporter gene is associated with amygdala response during negative emotion. |
2013-04-04 |
2023-08-12 |
human |
| Kim Hinkelmann, Laura Dragoi, Julia Gompf, Christoph Muhtz, Cüneyt Demiralay, Alexander Yassouridis, Klaus Wiedemann, Michael Kellne. Decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype. Psychiatry research. vol 177. issue 3. 2010-07-01. PMID:20381161. |
decreased recognition of negative affect after selective serotonin reuptake inhibition is dependent on genotype. |
2010-07-01 |
2023-08-12 |
Not clear |