| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Khazar Ahmadi, Joana B Pereira, Danielle van Westen, Ofer Pasternak, Fan Zhang, Markus Nilsson, Erik Stomrud, Nicola Spotorno, Oskar Hansso. Fixel-based analysis reveals tau-related white matter changes in early stages of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-04-02. PMID:38565289. |
despite the spatially extensive between-group differences in dti-metrics, the link between wm and tau aggregation was only revealed using fba metrics implying high sensitivity but low specificity of dti-based measures in identifying subtle tau-related wm degeneration. |
2024-04-02 |
2024-04-05 |
Not clear |
| Qing Wang, Suzanne E Schindler, Gengsheng Chen, Nicole S Mckay, Austin McCullough, Shaney Flores, Jingxia Liu, Zhexian Sun, Sicheng Wang, Wenshang Wang, Jason Hassenstab, Carlos Cruchaga, Richard J Perrin, Anne M Fagan, John C Morris, Yong Wang, Tammie L S Benzinge. Investigating White Matter Neuroinflammation in Alzheimer Disease Using Diffusion-Based Neuroinflammation Imaging. Neurology. vol 102. issue 4. 2024-02-05. PMID:38315956. |
alzheimer disease (ad) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it is now acknowledged that neuroinflammation, particularly in white matter (wm), significantly contributes to the development and progression of ad. |
2024-02-05 |
2024-02-09 |
Not clear |
| Chiara Prinzi, Anna Kostenko, Gioacchino de Leo, Rosario Gulino, Giampiero Leanza, Antonella Caccam. Selective Noradrenaline Depletion in the Neocortex and Hippocampus Induces Working Memory Deficits and Regional Occurrence of Pathological Proteins. Biology. vol 12. issue 9. 2023-09-28. PMID:37759663. |
at about 12 weeks post-lesion, dose-dependent working memory deficits were detected in these animals, associated with a marked increase in cortical and hippocampal levels of tdp-43 phosphorylated at ser 409/410 and tau phosphorylated at thr 217. |
2023-09-28 |
2023-10-07 |
rat |
| Wataru Uchida, Koji Kamagata, Christina Andica, Kaito Takabayashi, Yuya Saito, Mana Owaki, Shohei Fujita, Akifumi Hagiwara, Akihiko Wada, Toshiaki Akashi, Katsuhiro Sano, Masaaki Hori, Shigeki Aok. Fiber-specific micro- and macroscopic white matter alterations in progressive supranuclear palsy and corticobasal syndrome. NPJ Parkinson's disease. vol 9. issue 1. 2023-08-17. PMID:37591877. |
progressive supranuclear palsy (psp) and corticobasal syndrome (cbs) are characterized by progressive white matter (wm) alterations associated with the prion-like spreading of four-repeat tau, which has been pathologically confirmed. |
2023-08-17 |
2023-09-07 |
Not clear |
| Lucia Aa Giannini, Merel O Mol, Ana Rajicic, Renee van Buuren, Lana Sarkar, Sanaz Arezoumandan, Daniel T Ohm, David J Irwin, Annemieke Jm Rozemuller, John C van Swieten, Harro Seelaa. Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration. Acta neuropathologica communications. vol 11. issue 1. 2023-08-02. PMID:37533060. |
in a subset of regions (10 gm, 8 wm) used for clinicopathological staging, clinical severity correlated strongly with neuronal degeneration (rho = 0.72, p < 0.001), less strongly with gm tau burden (rho = 0.57, p = 0.006), and did not with wm tau burden (p = 0.9). |
2023-08-02 |
2023-08-14 |
Not clear |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
then, we evaluated the associations between these measurements and ndis in 29 candidate wm tracts using pearson correlation and multiple regression models results: based on 223 participants who were amyloid positive (mean age of 78 y/o and 57.0% male, 119 cognitively unimpaired, 56 mci, 48 dementia), the results showed that wm tracts ndi decreased with increasing regional braak tau suvrs. |
2023-04-17 |
2023-08-14 |
human |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
the increase in tau deposition measurable outside the medial temporal lobes in braak iii-vi was associated with a decrease in ndi in the middle and inferior temporal wm tracts. |
2023-04-17 |
2023-08-14 |
human |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
specifically, we focused on noddi's neurite density index (ndi), which aids in capturing axonal degeneration in wm and has greater specificity than single-shell diffusion mri methods method: we estimated regional flortaucipir pet suvrs from three regions corresponding to braak stage i, iii/iv, and v/vi to capture the spatial distribution pattern of the 3r/4r tau in ad. |
2023-04-17 |
2023-08-14 |
human |
| Jianqiao Tian, Sheela Kumari Raghavan Pillai, Robert I Reid, Scott A Przybelski, Timothy G Lesnick, Robel K Gebre, Jonathan Graff-Radford, Christopher G Schwarz, Val J Lowe, Kejal Kantarci, David S Knopman, Ronald C Petersen, Clifford R Jack, Prashanthi Vemur. White Matter Degeneration Pathways Associated With Tau Deposition in Alzheimer Disease. Neurology. 2023-04-17. PMID:37068958. |
of all the significant wm tracts, the uncinate fasciculus ([formula: see text]-0.274 for braak i, -0.311 for braak iii/iv, and -0.292 for braak v/vi, [formula: see text] 0.05) and cingulum adjoining hippocampus ([formula: see text] -0.274, -0.288, -0.233, [formula: see text] 0.05), both tracts anatomically connected to areas of early tau deposition, were consistently found to be within the top five distinguishing wm tracts associated with flortaucipir suvrs. |
2023-04-17 |
2023-08-14 |
human |
| Nira Cedres, Daniel Ferreira, Milan Nemy, Alejandra Machado, Joana B Pereira, Sara Shams, Lars-Olof Wahlund, Anna Zettergren, Olga Stepankova, Lenka Vyslouzilova, Maria Eriksdotter, Stefan Teipel, Michel J Grothe, Kaj Blennow, Henrik Zetterberg, Michael Schöll, Silke Kern, Ingmar Skoog, Eric Westma. Association of Cerebrovascular and Alzheimer Disease Biomarkers With Cholinergic White Matter Degeneration in Cognitively Unimpaired Individuals. Neurology. 2022-08-02. PMID:35918153. |
we aimed to determine the contribution of amyloid, tau, and cerebrovascular biomarkers towards the degeneration of cholinergic white matter (wm) projections in cognitively unimpaired individuals. |
2022-08-02 |
2023-08-14 |
Not clear |
| Jeremy F Strain, Nicolas Barthelemy, Kanta Horie, Brian A Gordon, Collin Kilgore, Andrew Aschenbrenner, Carlos Cruchaga, Chengjie Xiong, Nelly Joseph-Mathurin, Jason Hassenstab, Anne M Fagan, Yan Li, Celeste M Karch, Richard Perrin, Sarah B Berman, Jasmeer P Chhatwal, Neill R Graff-Radford, Hiroshi Mori, Johannes Levin, James M Noble, Ricardo Allegri, Peter R Schofield, Daniel S Marcus, David M Holtzman, John C Morris, Tammie L S Benzinger, Eric M McDade, Randall J Bateman, Beau M Ance. CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of disease. 2022-03-31. PMID:35358703. |
however, it remains unknown whether white matter (wm) decline due to ad is associated with specific tau phosphorylation site(s). |
2022-03-31 |
2023-08-13 |
Not clear |
| Daniel T Ohm, Katheryn A Q Cousins, Sharon X Xie, Claire Peterson, Corey T McMillan, Lauren Massimo, Katya Raskovsky, David A Wolk, Vivianna M Van Deerlin, Lauren Elman, Meredith Spindler, Andres Deik, John Q Trojanowski, Edward B Lee, Murray Grossman, David J Irwi. Signature laminar distributions of pathology in frontotemporal lobar degeneration. Acta neuropathologica. 2022-01-08. PMID:34997851. |
we digitally measured the percent area occupied by tau and tdp-43 pathology in upper layers (i-iii), lower layers (iv-vi), and juxtacortical white matter (wm) from isocortical regions in both hemispheres where available. |
2022-01-08 |
2023-08-13 |
Not clear |
| Daniel T Ohm, Katheryn A Q Cousins, Sharon X Xie, Claire Peterson, Corey T McMillan, Lauren Massimo, Katya Raskovsky, David A Wolk, Vivianna M Van Deerlin, Lauren Elman, Meredith Spindler, Andres Deik, John Q Trojanowski, Edward B Lee, Murray Grossman, David J Irwi. Signature laminar distributions of pathology in frontotemporal lobar degeneration. Acta neuropathologica. 2022-01-08. PMID:34997851. |
ftld-tau displayed lower ratios of layer pathology related to greater wm tau pathology (p = 0.002) and to earlier involved/severe pathology regions (p = 0.007). |
2022-01-08 |
2023-08-13 |
Not clear |
| Seraphina K Solders, Vitaly L Galinsky, Alexandra L Clark, Scott F Sorg, Alexandra J Weigand, Mark W Bondi, Lawrence R Fran. Diffusion MRI tractography of the locus coeruleus-transentorhinal cortex connections using GO-ESP. Magnetic resonance in medicine. 2021-12-11. PMID:34792198. |
tau pathology is hypothesized to propagate in a prion-like manner along the lc-transentorhinal cortex (tec) white matter (wm) pathway, leading to atrophy of the entorhinal cortex and adjacent cortical regions in a progressive and stereotypical manner. |
2021-12-11 |
2023-08-13 |
Not clear |
| Dibyadeep Datta, John F Enwright, Dominique Arion, Constantinos D Paspalas, Yury M Morozov, David A Lewis, Amy F T Arnste. Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits. Frontiers in neuroanatomy. vol 14. 2021-10-12. PMID:33328902. |
camp signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlpfc), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons. |
2021-10-12 |
2023-08-13 |
human |
| Miranda Robbins, Emma Clayton, Gabriele S Kaminski Schierl. Synaptic tau: A pathological or physiological phenomenon? Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34503576. |
whilst the clinical diagnosis of ad patients is a loss of working memory and long-term declarative memory, the histological diagnosis is the presence of neurofibrillary tangles of hyperphosphorylated tau and amyloid-beta plaques. |
2021-09-22 |
2023-08-13 |
Not clear |
| Brianne M Bettcher, Kaitlin E Olson, Nichole E Carlson, Brice V McConnell, Tim Boyd, Vanesa Adame, D Adriana Solano, Paige Anton, Neil Markham, Ashesh A Thaker, Alexandria M Jensen, Erika N Dallmann, Huntington Potter, Christina Coughla. Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease. Neurobiology of aging. vol 103. 2021-09-17. PMID:33845398. |
we examined the association between blood gfap, memory, and white matter (wm) integrity, accounting for blood markers of ad pathology (i.e., aβ42) and neurodegeneration (i.e., total tau; neurofilament light chain) in 114 older adults (asymptomatic, n = 69; mci/ad dementia, n = 45). |
2021-09-17 |
2023-08-13 |
Not clear |
| Alexis Moscoso, Michel J Grothe, Michael Schöl. Reduced [ European journal of nuclear medicine and molecular imaging. vol 48. issue 7. 2021-06-25. PMID:33475761. |
however, tau tracers display affinity for the β-sheet structure formed by myelin, and thus wm lesions might influence tracer retention. |
2021-06-25 |
2023-08-13 |
Not clear |
| Rafael Badenes, Ega Qeva, Giovanni Giordano, Nekane Romero-García, Federico Bilott. Intranasal Insulin Administration to Prevent Delayed Neurocognitive Recovery and Postoperative Neurocognitive Disorder: A Narrative Review. International journal of environmental research and public health. vol 18. issue 5. 2021-04-23. PMID:33799976. |
acute or chronic intranasal insulin administration, which has no influence on the blood glucose concentration, appears to improve working memory, verbal fluency, attention, recognition of objects, etc., in animal models, cognitively healthy humans, and memory-impaired patients by restoring the insulin receptor signaling pathway, attenuating anesthesia-induced tau protein hyperphosphorylation, etc. |
2021-04-23 |
2023-08-13 |
Not clear |
| b' Jian-Guo Li, Jin Chiu, Domenico Pratic\\xc3\\xb. Full recovery of the Alzheimer\'s disease phenotype by gain of function of vacuolar protein sorting 35. Molecular psychiatry. vol 25. issue 10. 2021-03-31. PMID:30733594.' |
compared with controls, animals overexpressing vps35 had an amelioration of spatial learning and working memory, which associated with a significant reduction in aβ levels and deposition and tau phosphorylation. |
2021-03-31 |
2023-08-13 |
mouse |