All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
Bernadette Astier, Laura Lambás Señas, Fabienne Soulière, Patricia Schmitt, Nadia Urbain, Nicolas Rentero, Lionel Bert, Luc Denoroy, Bernard Renaud, Monique Lesourd, Carmen Muñoz, Guy Chouve. In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity. European journal of pharmacology. vol 459. issue 1. 2003-04-30. PMID:12505530. in vivo comparison of two 5-ht1a receptors agonists alnespirone (s-20499) and buspirone on locus coeruleus neuronal activity. 2003-04-30 2023-08-12 rat
Eugene M Cassidy, Esther Tomkins, Neda Sharifi, Timothy Dinan, Orla Hardiman, Veronica O'Kean. Differing central amine receptor sensitivity in different migraine subtypes? A neuroendocrine study using buspirone. Pain. vol 101. issue 3. 2003-04-10. PMID:12583871. prolactin (prl) responses to the 5ht1a receptor agonist drug buspirone were compared in 30 female subjects with migraine (ten migraine with aura, ma; ten migraine without aura, mo and ten chronic/transformed migraine, cm), and ten healthy controls matched for age, gender and menstrual status. 2003-04-10 2023-08-12 human
Takashi Nakayama, Tetsuya Suhara, Yoshiro Okubo, Tetsuya Ichimiya, Fumihiko Yasuno, Jun Maeda, Akihiro Takano, Tomoyuki Saijo, Kazutoshi Suzuk. In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response. Psychopharmacology. vol 165. issue 1. 2003-03-20. PMID:12474116. in vivo drug action of tandospirone at 5-ht1a receptor examined using positron emission tomography and neuroendocrine response. 2003-03-20 2023-08-12 human
Rita M Condren, Timothy G Dinan, Jogin H Thakor. A preliminary study of buspirone stimulated prolactin release in generalised social phobia: evidence for enhanced serotonergic responsivity? European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 12. issue 4. 2002-11-15. PMID:12126875. buspirone, which is a partial agonist at 5ht1a receptors, increases prolactin release and may be used as a probe to examine serotonergic responses, dysfunction of which may be relevant to the pathophysiology of social phobia. 2002-11-15 2023-08-12 human
Yasuhiro Fujino, Masashi Nakajima, Yoshio Tsuboi, Yasuhiko Baba, Tatsuo Yamad. [Clinical effectiveness of tandospirone citrate (5-HT1A agonist) on patients with progressive supranuclear palsy]. Rinsho shinkeigaku = Clinical neurology. vol 42. issue 1. 2002-10-28. PMID:12355852. [clinical effectiveness of tandospirone citrate (5-ht1a agonist) on patients with progressive supranuclear palsy]. 2002-10-28 2023-08-12 Not clear
M Sasa, S Takeshita, T Amano, K Kuris. Primary neurotransmitters and regulatory substances onto vestibular nucleus neurons. Uchu Seibutsu Kagaku. vol 15. issue 4. 2002-09-27. PMID:12101361. as such, the 5-ht1a agonist, tandospirone, may be effective in preventing and/or treating motion sickness and/or space sickness. 2002-09-27 2023-08-12 Not clear
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. gepirone, a pyridinyl piperazine 5-ht1a receptor agonist, has been developed by fabre-kramer as an antidepressant. 2002-09-11 2023-08-12 Not clear
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. mechanism of action studies have demonstrated that gepirone, compared to buspirone, possesses a much greater selectivity for 5-ht1a receptors over dopamine d2 receptors. 2002-09-11 2023-08-12 Not clear
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. long-term studies have shown that gepirone has a differential action at presynaptic (agonist) and post-synaptic (partial agonist) 5-ht1a receptors. 2002-09-11 2023-08-12 Not clear
R A Lesli. Gepirone. Organon. Current opinion in investigational drugs (London, England : 2000). vol 2. issue 8. 2002-09-11. PMID:11892924. however, further studies are still required to determine the relative contribution of pre- and post-synaptic 5-ht1a receptors to the therapeutic action of gepirone and related compounds. 2002-09-11 2023-08-12 Not clear
Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. in order to address this issue in humans, 12 healthy volunteers underwent a dietary tryptophan depletion paradigm to decrease 5-ht availability, under double-blind conditions, during which body temperature was monitored following oral administration of the 5-ht1a agonist buspirone (30 mg). 2002-08-07 2023-08-12 human
Pierre Blier, Bernard Seletti, Francois Gilbert, Simon N Young, Chawki Benkelfa. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 27. issue 2. 2002-08-07. PMID:12093604. in conclusion, these results strongly suggest that the hypothermia and the increases in prolactin and growth hormone produced by buspirone are attributable to the enhanced activation of postsynaptic 5-ht1a receptors, and not to a decrease in 5-ht transmission resulting from the activation of the 5-ht1a cell body autoreceptors on 5-ht neurons. 2002-08-07 2023-08-12 human
Antoni Sastre-Coll, Susana Esteban, Jesús A García-Sevill. Supersensitivity of 5-HT1A autoreceptors and alpha2-adrenoceptors regulating monoamine synthesis in the brain of morphine-dependent rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 3. 2002-07-22. PMID:11882917. in morphine-dependent rats (tolerant and withdrawn states) the inhibitory effects of the 5-ht1a agonists 8-oh-dpat and buspirone (0.1 mg/kg, 1 h), and that of the alpha2-adrenoceptor agonist clonidine (0.1 mg/kg, 1 h), on the synthesis of 5-htp/5-ht were potentiated (25%-50%). 2002-07-22 2023-08-12 rat
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. molecular dynamics of 5-ht1a and 5-ht2a serotonin receptors with methylated buspirone analogues. 2002-06-10 2023-08-12 Not clear
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. in the present study experimentally determined ligand selectivity of three methylated buspirone analogues (denoted as mm2, mm5 and p55) towards 5-ht1a and 5-ht2a serotonin receptors was theoretically investigated on a molecular level. 2002-06-10 2023-08-12 Not clear
A Bronowska, Z Chilmonczyk, A Leś, O Edvardsen, R Ostensen, I Sylt. Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues. Journal of computer-aided molecular design. vol 15. issue 11. 2002-06-10. PMID:11989622. moreover, both location and topography of putative binding sites for buspirone analogues are different at 5-ht1a and 5-ht2a receptors. 2002-06-10 2023-08-12 Not clear
Vera Targino Moreira Lima, Danielle Silveira Macedo, Carlos Renato Alves Nogueira, Silvânia Maria Mendes Vasconcelos, Glauce Socorro de Barros Viana, Francisca Cléa Florenço de Sous. [Buspirone increases D2-like dopaminergic receptor density in rat corpus striatum]. Arquivos de neuro-psiquiatria. vol 60. issue 1. 2002-05-23. PMID:11965407. buspirone (busp) a piperazinyl derivative with anxiolytic properties is a partial agonist on 5-ht1a with affinity for d2-like dopaminergic receptors (rd2). 2002-05-23 2023-08-12 rat
David L Walker, Michael Davi. Light-enhanced startle: further pharmacological and behavioral characterization. Psychopharmacology. vol 159. issue 3. 2002-05-07. PMID:11862363. the phenomenon is disrupted by the 5ht1a partial agonist and the d2 receptor antagonist buspirone, a compound that also blocks the effect on startle of conditioned fear, and it was suggested that light-enhanced startle reflects an anxious state produced by bright light. 2002-05-07 2023-08-12 rat
Asako Takei, Sanae Honma, Atushi Kawashima, Ichiro Yabe, Toshiyuki Fukazawa, Keiko Hamada, Takeshi Hamada, Kunio Tashir. Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease. Psychiatry and clinical neurosciences. vol 56. issue 2. 2002-04-30. PMID:11952922. tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 a [5-ht1a]). 2002-04-30 2023-08-12 Not clear
Asako Takei, Sanae Honma, Atushi Kawashima, Ichiro Yabe, Toshiyuki Fukazawa, Keiko Hamada, Takeshi Hamada, Kunio Tashir. Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease. Psychiatry and clinical neurosciences. vol 56. issue 2. 2002-04-30. PMID:11952922. in addition, his leg pain, insomnia, anorexia, and depression, which are thought to be related to 5-ht1a receptors, were also remarkably alleviated by treatment with tandospirone. 2002-04-30 2023-08-12 Not clear