| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Kaneda, T Morimoto, A Fuji. Gynecomastia induced by treatment with tandospirone, a 5-HT1A agonist. Journal of psychiatry & neuroscience : JPN. vol 26. issue 2. 2001-07-12. PMID:11291533. |
gynecomastia induced by treatment with tandospirone, a 5-ht1a agonist. |
2001-07-12 |
2023-08-12 |
Not clear |
| A W Wilson, B Costall, J C Neil. Manipulation of operant responding for an ethanol-paired conditioned stimulus in the rat by pharmacological alteration of the serotonergic system. Journal of psychopharmacology (Oxford, England). vol 14. issue 4. 2001-05-31. PMID:11198050. |
results showed that the 5-ht releaser d-fenfluramine, the selective serotonin reuptake inhibitor fluoxetine, the 5-ht1a receptor agonist 8-hydroxy-2[di-n-propylamino]tetralin, the partial 5-ht1a receptor agonist buspirone, and the 5-ht1b/5-ht2c receptor agonist 1-(3-trifluoromethylphenyl)piperazine, but not the 5-ht2a/5-ht2c receptor agonist 1-(2,5-dimethoxy-4-iodophenylaminopropane)-2, selectively reduced responding on a lever leading to presentation of an ethanol paired conditioned stimulus. |
2001-05-31 |
2023-08-12 |
rat |
| A Bronowska, I Sylte, Ø Edvardsen, R Østensen, A Leś, Z Chilmonczy. Theoretical models of interactions between buspirone analogues and 5-HT1A and 5-HT2A serotonin receptor subtypes. Acta poloniae pharmaceutica. vol 57 Suppl. 2001-05-03. PMID:11293260. |
theoretical models of interactions between buspirone analogues and 5-ht1a and 5-ht2a serotonin receptor subtypes. |
2001-05-03 |
2023-08-12 |
human |
| A Bronowska, I Sylte, Ø Edvardsen, R Østensen, A Leś, Z Chilmonczy. Theoretical models of interactions between buspirone analogues and 5-HT1A and 5-HT2A serotonin receptor subtypes. Acta poloniae pharmaceutica. vol 57 Suppl. 2001-05-03. PMID:11293260. |
in present study the structure-selectivity relationship of buspirone and six of its analogues towards 5-ht1a and 5-ht2a serotonin receptors was investigated on molecular level. |
2001-05-03 |
2023-08-12 |
human |
| K Pruus, T Skrebuhhova-Malmros, R Rudissaar, V Matto, L Allikmet. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 51. issue 4 Pt 2. 2001-03-22. PMID:11220492. |
5-ht1a receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male wistar rats. |
2001-03-22 |
2023-08-12 |
rat |
| K Pruus, T Skrebuhhova-Malmros, R Rudissaar, V Matto, L Allikmet. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 51. issue 4 Pt 2. 2001-03-22. PMID:11220492. |
we have studied the effects of acute serotonin (5-ht) 5-ht1a receptor agonist buspirone (0.5, 1.0, 2.5 and 5.0 mg/kg, s.c.), gepirone (5.0 and 10 mg/kg, s.c.), and 8-oh-dpat (0.1, 0.25, and 0.5 mg/kg, i.p.) |
2001-03-22 |
2023-08-12 |
rat |
| K Pruus, T Skrebuhhova-Malmros, R Rudissaar, V Matto, L Allikmet. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 51. issue 4 Pt 2. 2001-03-22. PMID:11220492. |
the antiaggressive effect of buspirone (2.5 mg/kg) and gepirone (10 mg/kg) was not reversed by a 5-ht1a receptor antagonist way 100635 (0.3 mg/kg). |
2001-03-22 |
2023-08-12 |
rat |
| K Pruus, T Skrebuhhova-Malmros, R Rudissaar, V Matto, L Allikmet. 5-HT1A receptor agonists buspirone and gepirone attenuate apomorphine-induced aggressive behaviour in adult male Wistar rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 51. issue 4 Pt 2. 2001-03-22. PMID:11220492. |
all 5-ht1a receptor agonists tested dose-dependently decreased the exploratory behaviour of experimentally naive rats, while buspirone (2.5 mg/kg) and gepirone (10 mg/kg) had only a weak effect on the locomotor activity and stereotyped behaviour in the apomorphine-pre-sensitised rats. |
2001-03-22 |
2023-08-12 |
rat |
| M B Assié, W Koe. Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. European journal of pharmacology. vol 409. issue 2. 2001-02-15. PMID:11104831. |
taken together, the results are evidence that buspirone, s 14506 and 8-oh-dpat, administered in cumulative doses, decreased 5-ht release by activating similar 5-ht1a receptors, because a common apparent pa2 value was obtained for way 100635. |
2001-02-15 |
2023-08-12 |
rat |
| T Umez. Behavioral effects of plant-derived essential oils in the geller type conflict test in mice. Japanese journal of pharmacology. vol 83. issue 2. 2000-12-27. PMID:10928328. |
the benzodiazepine anxiolytic diazepam increased the response (lever pressing) rate during the alarm period (i.e., an anticonflict effect), but the 5-ht1a partial agonist buspirone did not. |
2000-12-27 |
2023-08-12 |
mouse |
| K Kishimoto, S Koyama, N Akaik. Presynaptic modulation of synaptic gamma-aminobutyric acid transmission by tandospirone in rat basolateral amygdala. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068021. |
the similar inhibition of miniature ipsc frequency was mimicked by a specific 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat, 1 microm), and the effects of tandospirone were prevented in the presence of a specific 5-ht1a receptor antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190, 1 microm). |
2000-12-27 |
2023-08-12 |
rat |
| K Kishimoto, S Koyama, N Akaik. Presynaptic modulation of synaptic gamma-aminobutyric acid transmission by tandospirone in rat basolateral amygdala. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068021. |
activation of 5-ht1a receptors by 8-oh-dpat (1 microm) evoked no direct postsynaptic effects in enzyme-treated isolated basolateral amygdala neurons, suggesting that tandospirone acts at presynaptic 5-ht1a receptors. |
2000-12-27 |
2023-08-12 |
rat |
| K Kishimoto, S Koyama, N Akaik. Presynaptic modulation of synaptic gamma-aminobutyric acid transmission by tandospirone in rat basolateral amygdala. European journal of pharmacology. vol 407. issue 3. 2000-12-27. PMID:11068021. |
in conclusion, in the basolateral amygdala nuclei, tandospirone activated presynaptic 5-ht1a receptors on the gabaergic nerve terminals projecting to ovoid-shaped neurons and inhibited synaptic gaba transmission via g-proteins. |
2000-12-27 |
2023-08-12 |
rat |
| O Stork, H Welzl, D Wolfer, T Schuster, N Mantei, S Stork, D Hoyer, H Lipp, K Obata, M Schachne. Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180. The European journal of neuroscience. vol 12. issue 9. 2000-11-07. PMID:10998113. |
it furthermore prevented a hypersensitivity of ncam-/- mice to the anxiolytic serotonin1a (5-ht1a) receptor agonist buspirone. |
2000-11-07 |
2023-08-12 |
mouse |
| H T Zhan. [Regulation of the central opioidergic nervous system on the emotional state of anxiety and its possible mechanisms]. Sheng li ke xue jin zhan [Progress in physiology]. vol 28. issue 1. 2000-08-09. PMID:10921076. |
the spontaneous withdrawal from morphine in morphine-dependent rats significantly decreased the duration of active interaction in social interaction test and the number of licks during the shock-punished period in vogel's conflict procedure, which were attenuated by buspirone, a 5-ht1a agonist, as well as para-chlorophenylalanine (pcpa), an inhibitor of tryptophan hydroxylase. |
2000-08-09 |
2023-08-12 |
rat |
| S D Gleason, J D Leande. Influence of light cycle on response to 5-HT1A ligands in punished responding in rats. Behavioural pharmacology. vol 10. issue 8. 2000-05-18. PMID:10780294. |
since the introduction of buspirone, the 5-ht1a receptor has been a focal point for serotonergic research into the treatment of anxiety. |
2000-05-18 |
2023-08-12 |
rat |
| O Van Reeth, E Olivares, Y Zhang, B Tripathi, F W Ture. Chronobiotic effects of gepirone, a potential antidepressant with 5HT1A receptor partial agonist properties. Behavioural pharmacology. vol 10. issue 2. 2000-05-18. PMID:10780825. |
chronobiotic effects of gepirone, a potential antidepressant with 5ht1a receptor partial agonist properties. |
2000-05-18 |
2023-08-12 |
Not clear |
| O Van Reeth, E Olivares, Y Zhang, B Tripathi, F W Ture. Chronobiotic effects of gepirone, a potential antidepressant with 5HT1A receptor partial agonist properties. Behavioural pharmacology. vol 10. issue 2. 2000-05-18. PMID:10780825. |
gepirone, a 5ht1a receptor partial agonist, has anxiolytic and antidepressant properties. |
2000-05-18 |
2023-08-12 |
Not clear |
| R C Silva, M L Brandã. Acute and chronic effects of gepirone and fluoxetine in rats tested in the elevated plus-maze: an ethological analysis. Pharmacology, biochemistry, and behavior. vol 65. issue 2. 2000-03-14. PMID:10672971. |
in the present study we provided an ethopharmacological analysis (in addition to conventional measures) of the behavior of rats in the elevated plus-maze with transparent walls after acute and chronic treatments with gepirone, an agonist of 5-ht1a receptors, and fluoxetine, a selective inhibitor of serotonin reuptake. |
2000-03-14 |
2023-08-12 |
human |
| M A Phillips, E Szabadi, C M Bradsha. The effects of the novel anxiolytic drug lesopitron, a full and selective 5-HT1A receptor agonist, on pupil diameter and oral temperature in man: comparison with buspirone. Journal of psychopharmacology (Oxford, England). vol 13. issue 4. 2000-02-18. PMID:10667616. |
the effects of the novel anxiolytic drug lesopitron, a full and selective 5-ht1a receptor agonist, on pupil diameter and oral temperature in man: comparison with buspirone. |
2000-02-18 |
2023-08-12 |
human |