| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H C Dringenberg, R A Kornelsen, R Pacelli, K Petersen, C H Vanderwol. Effects of amygdaloid lesions, hippocampal lesions, and buspirone on black-white exploration and food carrying in rats. Behavioural brain research. vol 96. issue 1-2. 1999-02-05. PMID:9821552. |
treatment with the 5-ht1a receptor agonist buspirone (0.1 mg/kg, s.c.) increased the time that unlesioned rats spent in the uncovered compartment (103 s), an effect that was less pronounced in hippocampus-lesioned rats and completely abolished by amygdala lesions. |
1999-02-05 |
2023-08-12 |
rat |
| P J Winsauer, F H Rodriguez, A E Cha, J M Moerschbaeche. Full and partial 5-HT1A receptor agonists disrupt learning and performance in rats. The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862788. |
as a means of characterizing the role of 5-hydroxytryptamine (5-ht1a) receptors in learning, a full 5-ht1a receptor agonist, 8-hydroxy-dipropylaminotetralin (8-oh-dpat), was administered both alone and in combination with two partial agonists (buspirone and 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl] piperazine hydrobromide (nan-190)) and a 5-ht1a receptor antagonist (p-mppi) to rats responding under a multiple schedule of repeated acquisition and performance of response sequences. |
1999-02-05 |
2023-08-12 |
rat |
| G Biał. Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice. Polish journal of pharmacology. vol 50. issue 2. 1999-01-08. PMID:9798263. |
these results suggest that 5-ht1a agonists and dihydropyridine calcium channel blockers may have antidepressant efficacy in the forced swimming test, but the effects of buspirone and 8-oh-dpat may be mediated via different mechanisms. |
1999-01-08 |
2023-08-12 |
mouse |
| N Haddjeri, P Blier, C de Montign. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822768. |
however, after long-term treatment with the tricyclic antidepressant imipramine, the selective 5-ht reuptake inhibitor paroxetine, the reversible monoamine oxidase-a inhibitor befloxatone, the alpha2-adrenergic antagonist mirtazapine, or the 5-ht1a receptor agonist gepirone or multiple electroconvulsive shock (ecs) administration, way 100635 markedly increased (60-200%) the firing activity of ca3 pyramidal neurons. |
1998-12-18 |
2023-08-12 |
rat |
| M Spedding, A Newman-Tancredi, M J Millan, C Dacquet, A N Michel, E Jacoby, B Vickery, D Tallentir. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. vol 37. issue 6. 1998-11-12. PMID:9707291. |
rs-30199 and rs-64459, an analogue of buspirone with a buspirone side chain, were compared with the classic, partial agonist at 5-ht1a receptors, 8-hydroxy-2 (di-n-propylamino) tetralin (8-oh-dpat) and buspirone. |
1998-11-12 |
2023-08-12 |
human |
| M Spedding, A Newman-Tancredi, M J Millan, C Dacquet, A N Michel, E Jacoby, B Vickery, D Tallentir. Interaction of the anxiogenic agent, RS-30199, with 5-HT1A receptors: modulation of sexual activity in the male rat. Neuropharmacology. vol 37. issue 6. 1998-11-12. PMID:9707291. |
at human (h) 5-ht1a receptors in cho cells, rs-30199-193 (racemate) and its enantiomers (-197, -198) inhibited [3h]-8-oh-dpat binding (rs-30199-198, ki, 29.7 +/- 11.7 nm; rs-30199-197, ki, 74.1 +/- 11.7 nm) as did rs-64459 (ki, 24.9 +/- 6.0 nm), but rs-30199-197 and -198 were almost full agonists in a [35s]-gtpgammas binding assay, whereas rs-64459 was a partial agonist, resembling buspirone and 8-oh-dpat. |
1998-11-12 |
2023-08-12 |
human |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
the affinity of f 11440 for 5-ht1a binding sites (pki, 8.33) was higher than that of buspirone (pki, 7.50), and somewhat lower than that of flesinoxan (pki, 8.91). |
1998-11-05 |
2023-08-12 |
human |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in vivo, f 11440 was 4- to 20-fold more potent than flesinoxan, and 30- to 60-fold more potent than buspirone, in exerting 5-ht1a agonist activity at pre- and postsynaptic receptors in rats (measured by, for example, its ability to decrease hippocampal extracellular serotonin (5-ht) levels and to increase plasma corticosterone levels, respectively). |
1998-11-05 |
2023-08-12 |
human |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
f 11440 did not have detectable antidopaminergic activity (unlike buspirone, which inhibited all of the directly observable behavioral effects of methylphenidate in rats), showed no evidence of antihistaminergic activity (unlike flesinoxan, which protected against the effects of a histamine aerosol in guinea pigs), and had a 70-fold separation between its 5-ht1a agonist and alpha-1 adrenergic antagonist properties (measured as the ability to inhibit the methoxamineinduced increase in blood pressure in rats), unlike flesinoxan, which showed a <3-fold separation. |
1998-11-05 |
2023-08-12 |
human |
| W Koek, J F Patoiseau, M B Assié, C Cosi, M S Kleven, E Dupont-Passelaigue, E Carilla-Durand, C Palmier, J P Valentin, G John, P J Pauwels, J P Tarayre, F C Colpaer. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. The Journal of pharmacology and experimental therapeutics. vol 287. issue 1. 1998-11-05. PMID:9765347. |
in hela cells expressing human 5-ht1a receptors, f 11440 decreased the forskolin-induced increase in amp, and, based on its maximal effect, was found to have an intrinsic activity of 1.0 relative to that of 5-ht, which was significantly higher than that of buspirone (0.49), ipsapirone (0.46) and flesinoxan (0.93). |
1998-11-05 |
2023-08-12 |
human |
| J P Redrobe, M Bouri. Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test. Psychopharmacology. vol 138. issue 2. 1998-10-26. PMID:9718290. |
the results of the present study suggested that low dose buspirone enhanced the activity of subactive doses of ssris in the mouse forced swimming test, probably via an action at 5-ht1a receptors. |
1998-10-26 |
2023-08-12 |
mouse |
| G Griebel, G Perrault, D J Sange. Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone. Psychopharmacology. vol 138. issue 1. 1998-10-19. PMID:9694527. |
the present series of experiments compared the behavioral effects of the novel non-peptide crf antagonist cp-154,526 with those of diazepam and the 5-ht1a receptor partial agonist buspirone in classical animal models of anxiety including conflict tests (punished lever pressing and punished drinking tests in rats) and exploratory models (elevated plus-maze test in rats, light/dark choice and free-exploration tests in mice), and a recently developed mouse defense test battery (mdtb) which has been validated for the screening of anxiolytic drugs. |
1998-10-19 |
2023-08-12 |
mouse |
| P Fischer, J Tauscher, B Küfferle, S Kaspe. Weak antidepressant response after buspirone augmentation of serotonin reuptake inhibitors in refractory severe depression. International clinical psychopharmacology. vol 13. issue 2. 1998-10-01. PMID:9669189. |
buspirone acts as a partial serotonin agonist at the 5-ht1a receptor. |
1998-10-01 |
2023-08-12 |
Not clear |
| D J Bootle, J J Adcock, A G Ramag. The role of central 5-HT receptors in the bronchoconstriction evoked by inhaled capsaicin in anaesthetised guinea-pigs. Neuropharmacology. vol 37. issue 2. 1998-10-01. PMID:9680249. |
the effects of intracisternal (i.c) injections of the 5-ht1a receptor agonists, buspirone and 8-oh-dpat, and the antagonists way-100635; and (-)-pindolol, the 5-ht1b/1d receptor agonist sumatriptan and antagonist gr127935, the 5-ht2 receptor agonist doi and the antagonist cinanserin, the 5-ht3 receptor antagonist granisetron, the alpha-adrenoceptor agonist clonidine and the antagonist idazoxan, the d2 receptor antagonists (-)-sulpiride and the 5-ht uptake inhibitor fluoxetine on capsaicin-evoked increase in tracheal inflation pressure (bronchoconstriction) were investigated in alpha-chloralose anaesthetised, neuromuscularly blocked, artificially ventilated guinea-pigs. |
1998-10-01 |
2023-08-12 |
Not clear |
| L E Rueter, C de Montigny, P Blie. In vivo electrophysiological assessment of the agonistic properties of flibanserin at pre- and postsynaptic 5-HT1A receptors in the rat brain. Synapse (New York, N.Y.). vol 29. issue 4. 1998-09-24. PMID:9661257. |
indeed, using the forskolin-stimulated camp accumulation technique, flibanserin but not the 5-ht1a agonists buspirone and 8-oh-dpat had agonistic activity at postsynaptic 5-ht1a receptors in the cerebral cortex. |
1998-09-24 |
2023-08-12 |
rat |
| C P Mac Sweeney, M Lesourd, J M Gando. Antidepressant-like effects of alnespirone (S 20499) in the learned helplessness test in rats. European journal of pharmacology. vol 345. issue 2. 1998-07-27. PMID:9600628. |
it is concluded that alnespirone exerts antidepressant-like properties in the learned helplessness test in rats, in a manner similar to 8-oh-dpat (8-hydroxy-2-(di-n-propylamino)tetralin), buspirone and ipsapirone, other 5-ht1a receptor agonists. |
1998-07-27 |
2023-08-12 |
rat |
| N Sussma. Anxiolytic antidepressant augmentation. The Journal of clinical psychiatry. vol 59 Suppl 5. 1998-06-24. PMID:9635547. |
on the other hand, the anxiolytic agent buspirone does facilitate direct antidepressant response, largely through its ability to activate both presynaptic and postsynaptic 5-ht1a receptors and thus modulate serotonin release. |
1998-06-24 |
2023-08-12 |
Not clear |
| K M Garrett, I Niekrasz, D Haque, K M Parker, T W Seal. Genotypic differences between C57BL/6 and A inbred mice in anxiolytic and sedative actions of diazepam. Behavior genetics. vol 28. issue 2. 1998-06-23. PMID:9583238. |
in contrast, the two strains were equally responsive to the anxiolytic effects of the 5-ht1a receptor partial agonist, buspirone. |
1998-06-23 |
2023-08-12 |
mouse |
| A Canto-de-Souza, R L Nunes de Souza, I R Pelá, F G Graef. Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice. European journal of pharmacology. vol 345. issue 3. 1998-06-23. PMID:9592023. |
recent results from our laboratory have shown that 30-bites social conflict in mice produces a high-intensity, short-term analgesia which is attenuated by systemically injected 5-ht1a receptor agonists, such as bay r 1531 (6-methoxy-4-(di-n-propylamino)-1,3,4,5-tetrahydrobenz((c,d)indole hydrochloride) and gepirone. |
1998-06-23 |
2023-08-12 |
mouse |
| A Canto-de-Souza, R L Nunes de Souza, I R Pelá, F G Graef. Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice. European journal of pharmacology. vol 345. issue 3. 1998-06-23. PMID:9592023. |
the full 5-ht1a receptor agonist bay r 1531 blocked, whereas, way 100135 and gepirone intensified 30-bites analgesia. |
1998-06-23 |
2023-08-12 |
mouse |