All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
Darakhshan Jabeen Haleem, Tabinda Salman, Shazia Nawaz, Huma Ikra. Co-treatment with low doses of buspirone prevents rewarding effects of methylphenidate and upregulates expression of 5-HT1A receptor mRNA in the nucleus accumbens. Behavioural brain research. vol 418. 2021-12-11. PMID:34752844. animals treated with mpd exhibit a downregulation of 5-ht1a receptor mrna in the nucleus accumbens which is also prevented in rats co-treated with 0.1 and 0.3 mg/kg but not 1.0 and 2.0 mg/kg buspirone. 2021-12-11 2023-08-13 rat
Darakhshan Jabeen Haleem, Tabinda Salman, Shazia Nawaz, Huma Ikra. Co-treatment with low doses of buspirone prevents rewarding effects of methylphenidate and upregulates expression of 5-HT1A receptor mRNA in the nucleus accumbens. Behavioural brain research. vol 418. 2021-12-11. PMID:34752844. administration of buspirone in these doses is not rewarding in cpp test and upregulates 5-ht1a receptor mrna in the nucleus accumbens. 2021-12-11 2023-08-13 rat
Jillian H Broadbear, Ronan Y Depoortere, Kristina Vacy, David Ralph, Brendan J Tunstall, Adrian Newman-Tancred. Discriminative stimulus properties of the 5-HT1A receptor biased agonists NLX-101 and F13714, in rats trained to discriminate 8-OH-DPAT from saline. Behavioural pharmacology. vol 32. issue 8. 2021-11-17. PMID:34751175. the 5-ht1a receptor partial agonist, buspirone, partially substituted (~80%) at 1 and 2 mg/kg i.p., doses which also decreased response rates. 2021-11-17 2023-08-13 rat
Jillian H Broadbear, Ronan Y Depoortere, Kristina Vacy, David Ralph, Brendan J Tunstall, Adrian Newman-Tancred. Discriminative stimulus properties of the 5-HT1A receptor biased agonists NLX-101 and F13714, in rats trained to discriminate 8-OH-DPAT from saline. Behavioural pharmacology. vol 32. issue 8. 2021-11-17. PMID:34751175. the selective 5-ht1a receptor antagonist way-100 635 (1 mg/kg s.c., 40 min pretreatment) elicited almost no responding on the 8-oh-dpat-associated lever by itself, but blocked the discriminative stimulus effects produced by administration (20 min pretreatment) of 8-oh-dpat (0.1 mg/kg), f13714 (0.025 mg/kg), nlx-101 (0.5 mg/kg) or buspirone (1 mg/kg). 2021-11-17 2023-08-13 rat
Sarah Thomas Broome, Teagan Fisher, Alen Faiz, Kevin A Keay, Giuseppe Musumeci, Ghaith Al-Badri, Alessandro Castorin. Assessing the Anti-Inflammatory Activity of the Anxiolytic Drug Buspirone Using CRISPR-Cas9 Gene Editing in LPS-Stimulated BV-2 Microglial Cells. Cells. vol 10. issue 6. 2021-11-01. PMID:34070429. buspirone is an anxiolytic drug with robust serotonin receptor 1a (htr1a) agonist activities. 2021-11-01 2023-08-13 Not clear
Jeon-Kyung Kim, Sang-Kap Han, Min-Kyung Joo, Dong-Hyun Ki. Buspirone alleviates anxiety, depression, and colitis; and modulates gut microbiota in mice. Scientific reports. vol 11. issue 1. 2021-10-13. PMID:33731795. buspirone, an agonist for serotonin 5-ht1a receptors, is used for the treatment of anxiety/depression. 2021-10-13 2023-08-13 mouse
Jeffrey T Dunn, Jessica Mroczek, Harsh R Patel, Michael E Ragozzin. Tandospirone, a Partial 5-HT1A Receptor Agonist, Administered Systemically or Into Anterior Cingulate Attenuates Repetitive Behaviors in Shank3B Mice. The international journal of neuropsychopharmacology. vol 23. issue 8. 2021-09-21. PMID:32619232. tandospirone, a partial 5-ht1a receptor agonist, administered systemically or into anterior cingulate attenuates repetitive behaviors in shank3b mice. 2021-09-21 2023-08-13 mouse
Anes Ju, Beatriz Fernandez-Arroyo, Yifan Wu, Débora Jacky, Anna Beyele. Expression of serotonin 1A and 2A receptors in molecular- and projection-defined neurons of the mouse insular cortex. Molecular brain. vol 13. issue 1. 2021-07-08. PMID:32594910. the serotonin (5-ht) system is the target of multiple anxiolytics, including buspirone, which is a partial agonist of the serotonin 1a receptor (5-ht1a). 2021-07-08 2023-08-13 mouse
Shawn Zheng Kai Tan, Yasin Temel, Ariel Yovela Chan, Andrea Tsz Ching Mok, Jose Angelo Udal Perucho, Arjan Blokland, Luca Aquili, Wei Ling Lim, Lee Wei Li. Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation. Brain structure & function. vol 225. issue 7. 2021-07-06. PMID:32594260. in this study, we further analysed our previous data on the effects of escitalopram (a selective serotonin reuptake inhibitor, ssri) and buspirone (a 5-ht1a receptor partial agonist) on dlpag-induced anticipatory fear behaviour in a rat model using freezing as a measure. 2021-07-06 2023-08-13 rat
Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinin. Neonatal pain modulates in adolescent rats the antinociceptive effects of fluoxetine and buspirone administrated to their depressive dams during gestation. Canadian journal of physiology and pharmacology. vol 99. issue 6. 2021-06-22. PMID:33186073. previously, we have shown that the administration of a selective serotonin reuptake inhibitor fluoxetine or a 5-ht1a receptor agonist buspirone to stressed rats during gestation causes in the offspring alleviation of formalin-induced pain, strengthened by prenatal stress. 2021-06-22 2023-08-13 rat
Xuefei Huang, Yaqi Kang, Xinrui Jiang, Jing Yang, An-Guo Wu, Chuanqing Zhang, Dalian Qin, Shousong Cao, Qibin Mei, Yun Ye, Jianming W. Tandospirone enhances the anti-myocardial fibrosis effect of valsartan in spontaneously hypertensive rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 126. 2021-01-26. PMID:32179201. tandospirone, a partial agonist of the 5-ht1a receptor, has been commonly used to relieve psychiatric symptoms. 2021-01-26 2023-08-13 rat
Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Gordon A Bar. Differences Between the Prenatal Effects of Fluoxetine or Buspirone Alone or in Combination on Pain and Affective Behaviors in Prenatally Stressed Male and Female Rats. Frontiers in behavioral neuroscience. vol 13. 2020-10-01. PMID:31244623. the selective serotonin reuptake inhibitor fluoxetine and the 5-ht1a receptor agonist buspirone are used to treat depression and anxiety. 2020-10-01 2023-08-13 rat
Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Anna M Aloisi, Gordon A Bar. Long-Term Effects of Chronic Buspirone during Adolescence Reduce the Adverse Influences of Neonatal Inflammatory Pain and Stress on Adaptive Behavior in Adult Male Rats. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28184190. we tested whether these alterations have long-lasting effects and if those effects can be improved by the 5-hydroxytryptamine 1a (5-ht1a) receptor agonist buspirone injected chronically during the adolescent period. 2020-09-30 2023-08-13 rat
Irina P Butkevich, Viktor A Mikhailenko, Elena A Vershinina, Anna M Aloisi, Gordon A Bar. Long-Term Effects of Chronic Buspirone during Adolescence Reduce the Adverse Influences of Neonatal Inflammatory Pain and Stress on Adaptive Behavior in Adult Male Rats. Frontiers in behavioral neuroscience. vol 11. 2020-09-30. PMID:28184190. these data highlight the role of 5-ht1a receptors in long-term effects of neonatal inflammatory pain and stress of short mi on adaptive behavior and possibility of correction of the pain and psychoemotional behavior that were altered by adverse pain/stress intervention using buspirone during critical adolescent period. 2020-09-30 2023-08-13 rat
Takehiro Tamura, Hiroki Shiwaku, Daisuke Jitoku, Akeo Kurumaj. Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness. The primary care companion for CNS disorders. vol 21. issue 5. 2020-04-23. PMID:31509356. effect of tandospirone, a partial agonist of the 5-ht1a receptor, in a patient with chronic poststroke emotional incontinence with anxiousness. 2020-04-23 2023-08-13 Not clear
Joanna Sniecikowska, Adrian Newman-Tancredi, Marcin Kolaczkowsk. From Receptor Selectivity to Functional Selectivity: The Rise of Biased Agonism in 5-HT1A Receptor Drug Discovery. Current topics in medicinal chemistry. vol 19. issue 26. 2019-12-31. PMID:31544717. commonly used drugs targeting 5-ht1a receptors, such as buspirone or other azapirone compounds, possess only limited selectivity over cross-reacting sites, act as partial agonists for 5-ht1a receptor activation, and are metabolically labile, generating active metabolites. 2019-12-31 2023-08-13 Not clear
Xuefei Huang, Jing Yang, Sijin Yang, Shousong Cao, Dalian Qin, Ya Zhou, Xiaoli Li, Yun Ye, Jianming W. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254282. role of tandospirone, a 5-ht1a receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. 2019-11-20 2023-08-13 Not clear
Xuefei Huang, Jing Yang, Sijin Yang, Shousong Cao, Dalian Qin, Ya Zhou, Xiaoli Li, Yun Ye, Jianming W. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. vol 8. issue 60. 2019-11-20. PMID:29254282. tandospirone, an azapirone derivative with strong and selective agonist effect on 5-ht1a receptor, has been used for the treatment of anxiety disorders especially generalized anxiety disorder for decades. 2019-11-20 2023-08-13 Not clear
A Kaur Gill, Y Bansal, R Bhandari, S Kaur, J Kaur, R Singh, A Kuhad, A Kuha. Gepirone hydrochloride: a novel antidepressant with 5-HT1A agonistic properties. Drugs of today (Barcelona, Spain : 1998). vol 55. issue 7. 2019-07-31. PMID:31347611. gepirone hydrochloride: a novel antidepressant with 5-ht1a agonistic properties. 2019-07-31 2023-08-13 Not clear
A Kaur Gill, Y Bansal, R Bhandari, S Kaur, J Kaur, R Singh, A Kuhad, A Kuha. Gepirone hydrochloride: a novel antidepressant with 5-HT1A agonistic properties. Drugs of today (Barcelona, Spain : 1998). vol 55. issue 7. 2019-07-31. PMID:31347611. gepirone is a drug of the azapirone group which is a 5-ht1a receptor agonist belonging to the buspirone family. 2019-07-31 2023-08-13 Not clear