| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Kleven, E P Prinssen, W Koe. Role of 5-HT1A receptors in the ability of mixed 5-HT1A receptor agonist/dopamine D2 receptor antagonists to inhibit methylphenidate-induced behaviors in rats. European journal of pharmacology. vol 313. issue 1-2. 1997-02-27. PMID:8905325. |
were examined in rats after administration of the 5-ht1a receptor agonists (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and flesinoxan, the mixed 5-ht1a receptor agonist/dopamine d2 receptor antagonists buspirone and 1-[-4-fluorobenzoylamino)ethyl]-ethyl]-4-(7-methoxynaphthyl) piperazine (s 14506), the neuroleptics haloperidol and clozapine, and the sigma receptor ligand/partial 5-ht1a receptor agonist alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine-butanol (bmy 14802). |
1997-02-27 |
2023-08-12 |
rat |
| Z Chilmonczyk, H Ksycińska, J Cybulski, A Woźniakowska-Szelejewsk. Buspirone analogues as ligands of the 5-HT1A receptor. II: Capacity factors as chromatographic parameter of lipophilicity evaluation in a series of 5-HT1A and 5-HT2A receptor ligands. Die Pharmazie. vol 51. issue 12. 1997-02-26. PMID:8985981. |
buspirone analogues as ligands of the 5-ht1a receptor. |
1997-02-26 |
2023-08-12 |
Not clear |
| K Wedzony, M Maćkowiak, K Fijał, K Gołembiowsk. Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex. European journal of pharmacology. vol 305. issue 1-3. 1997-02-20. PMID:8813534. |
the above effects of ipsapirone were mimicked by buspirone (2.5 and 5 mg/kg), another 5-ht1a receptor agonist, but not 1-pp (1-pyrimidinylpiperazine, 5 mg/kg)-a centrally active metabolite of ipsapirone. |
1997-02-20 |
2023-08-12 |
rat |
| F F Matos, C Urban, F D Yocc. Serotonin (5-HT) release in the dorsal raphé and ventral hippocampus: raphé control of somatodendritic and terminal 5-HT release. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 1-2. 1997-02-18. PMID:9026372. |
systemic injections with 5-ht1a agonist, buspirone (1.0-5.0 mg/kg, i.p.) |
1997-02-18 |
2023-08-12 |
rat |
| H Y Meltzer, M Mae. Effect of pindolol on hormone secretion and body temperature: partial agonist effects. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 1-2. 1997-02-18. PMID:9026379. |
it has also been reported to inhibit the effects of other 5-ht1a partial agonists such as ipsapirone and buspirone on hormone secretion and body temperature in man, indicating its antagonist action at 5-ht1a receptors in man. |
1997-02-18 |
2023-08-12 |
human |
| B Wilken, P Lalley, A M Bischoff, H J Christen, J Behnke, F Hanefeld, D W Richte. Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist. The Journal of pediatrics. vol 130. issue 1. 1997-02-14. PMID:9003856. |
this observation encouraged a treatment of severe apneusis with buspirone, an agonist for 5-ht1a receptors, in a child after neurosurgery for an astrocytoma in the pons and medulla oblongata. |
1997-02-14 |
2023-08-12 |
rat |
| S B Kasture, S N Mandhane, C T Chopd. Baclofen-induced catatonia: modification by serotonergic agents. Neuropharmacology. vol 35. issue 5. 1997-02-13. PMID:8887967. |
the 5-ht releaser fenfluramine (10 mg/kg) and the uptake inhibitor fluoxetine (10 mg/kg) reversed, whereas the 5-ht1a agonist buspirone (3 mg/kg) potentiated baclofen-induced catatonia. |
1997-02-13 |
2023-08-12 |
rat |
| T J Zethof, J A Van der Heyden, J T Tolboom, B Olivie. Stress-induced hyperthermia as a putative anxiety model. European journal of pharmacology. vol 294. issue 1. 1997-02-12. PMID:8788424. |
using this protocol, various drugs, belonging to different pharmacological classes, were tested in order to investigate their putative anxiolytic effect, measured as a decrease in delta t. benzodiazepines (diazepam, alprazolam), alcohol, and some (flesinoxan, buspirone), but not all (ipsapirone) 5-ht1a receptor agonists had anxiolytic properties with this protocol. |
1997-02-12 |
2023-08-12 |
mouse |
| F Ferriere, N A Khan, D Troutaud, P Deschau. Serotonin modulation of lymphocyte proliferation via 5-HT1A receptors in rainbow trout (Oncorhynchus mykiss). Developmental and comparative immunology. vol 20. issue 4. 1997-02-06. PMID:8915629. |
interestingly, the agonists (8-oh-dpat and buspirone) and antagonist (nan-190) of the 5-ht1a receptor subtype failed to displace 3h-5ht binding to receptor sites in resting cells, whereas these agents inhibited 3h-5ht binding in lps- and pha-stimulated lymphocytes significantly, suggesting that after mitogenic stimulation, 5-ht1a receptors are expressed on lymphocytes. |
1997-02-06 |
2023-08-12 |
Not clear |
| G C Rigdon, M H Norman, B R Cooper, J L Howard, V M Boncek, W L Faison, K P Nanry, G T Pollar. 1192U90 in animal tests that predict antipsychotic efficacy, anxiolysis, and extrapyramidal side effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 15. issue 3. 1997-01-15. PMID:8873106. |
1192u90 was also submitted to three tests that predict anxiolysis: it produced only a small increase in punished lever pressing for food in rat (geller-seifter conflict test), which is specific for rapid-onset efficacy, but produced large increases in punished key pecking for food in pigeon and cork gnawing in rat, which identify the delayed onset 5-ht1a agonists such as buspirone. |
1997-01-15 |
2023-08-12 |
mouse |
| G K Matheson, B U Raess, G Tunniclif. Effects of repeated doses of azapirones on rat brain 5-HT1A receptors and plasma corticosterone levels. General pharmacology. vol 27. issue 2. 1997-01-10. PMID:8919656. |
effects of repeated doses of azapirones on rat brain 5-ht1a receptors and plasma corticosterone levels. |
1997-01-10 |
2023-08-12 |
rat |
| C López-Rubalcav. Pre- or postsynaptic activity of 5-HT1A compounds in mice depends on the anxiety paradigm. Pharmacology, biochemistry, and behavior. vol 54. issue 4. 1997-01-06. PMID:8853189. |
to this aim, the 5-ht1a ligands buspirone, ipsapirone, indorenate, and 8-oh-dpat were tested in the burying behavior test and the avoidance exploratory behavior paradigm in control, pcpa-treated, and 5,7-dht-lesioned mice, p-cpa and 5,7-dht treatments did not modify the burying behavior per se, while 5-ht1a agonists produced a significant reduction in this behavior in both p-cpa- and 5,7,-dht-lesioned animals. |
1997-01-06 |
2023-08-12 |
mouse |
| L D Van de Ka. Forebrain pathways mediating stress-induced renin secretion. Clinical and experimental pharmacology & physiology. vol 23. issue 2. 1996-12-10. PMID:8819647. |
activation of serotonin1a (5ht1a) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. |
1996-12-10 |
2023-08-12 |
rat |
| S Belcheva, V D Petkov, E Konstantinova, V V Petkov, E Boyanov. Effects on nociception of the Ca2+ and 5-HT antagonist dotarizine and other 5-HT receptor agonists and antagonists. Acta physiologica et pharmacologica Bulgarica. vol 21. issue 4. 1996-12-06. PMID:8830881. |
the 5-ht1a and 5-ht1b/1c receptor agonists buspirone and m-cpp decreased the pain threshold. |
1996-12-06 |
2023-08-12 |
Not clear |
| C Routledg. Development of 5-HT1A receptor antagonists. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788494. |
the discovery that non-benzodiazepine anxiolytic agents such as buspirone bind with high affinity to the 5-ht1a receptor has stimulated the development of selective 5-ht1a receptor ligands as potential drug candidates. |
1996-12-04 |
2023-08-12 |
Not clear |
| C Routledg. Development of 5-HT1A receptor antagonists. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788494. |
however, the lack of selective 5-ht1a receptor antagonists has hampered the elucidation of the mechanism of action of these agents, indeed, it is still unclear whether buspirone exerts its anxiolytic effects via an agonist action at presynaptic (somatodendritic) or an antagonist action at postsynaptic 5-ht1a receptors. |
1996-12-04 |
2023-08-12 |
Not clear |
| E A Johnson, J L Fox, A J Azzar. The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788529. |
the anxiolytic serotonin 5-ht1a receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. |
1996-12-04 |
2023-08-12 |
rat |
| E A Johnson, J L Fox, A J Azzar. The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research. vol 73. issue 1-2. 1996-12-04. PMID:8788529. |
the anxiolytics buspirone (bus), ipsapirone (ipsap) and gepirone (gep) were investigated as 5-ht1a receptor-mediated inhibitors of tyrosine hydroxylation (th) in a synaptosome-rich preparation of rat striatum. |
1996-12-04 |
2023-08-12 |
rat |
| I Korzeniewska, A Płaźni. Influence of serotonergic drugs on restraint stress induced analgesia. Polish journal of pharmacology. vol 47. issue 5. 1996-11-27. PMID:8868128. |
ritanserin, a 5-ht2a/2c receptor antagonist, ondansetron, a 5-ht3 receptor antagonist and citalopram, a selective serotonin re-uptake blocker increased the baseline pain threshold, whereas 8-oh-dpat, a full 5-ht1a receptor agonist and buspirone, a partial 5-ht1a receptor agonist expressing also high affinity towards dopaminergic d2 receptors, were without effect on pain perception and stress induced analgesia. |
1996-11-27 |
2023-08-12 |
rat |
| Y Takada, T Urano, J Malyszko, A Takad. Changes in serotonergic measures in whole blood and various brain regions of rats administered with the 5-HT1A agonist tandospirone and/or exposed to electric foot-shock. Brain research bulletin. vol 40. issue 1. 1996-11-18. PMID:8722753. |
changes in serotonergic measures in whole blood and various brain regions of rats administered with the 5-ht1a agonist tandospirone and/or exposed to electric foot-shock. |
1996-11-18 |
2023-08-12 |
rat |