| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Takada, T Urano, J Malyszko, A Takad. Changes in serotonergic measures in whole blood and various brain regions of rats administered with the 5-HT1A agonist tandospirone and/or exposed to electric foot-shock. Brain research bulletin. vol 40. issue 1. 1996-11-18. PMID:8722753. |
we studied the effects of foot-shock on tryptophan, serotonin [5-hydroxytryptamine (5-ht)], and its metabolite, 5-hydroxyindole acetic acid (5-hiaa) in whole blood and various brain regions of rats pretreated with tandospirone, a novel 5-ht1a receptor agonist. |
1996-11-18 |
2023-08-12 |
rat |
| J A Kim, M J Drus. Protective effects of maternal buspirone treatment on serotonin reuptake sites in ethanol-exposed offspring. Brain research. Developmental brain research. vol 92. issue 2. 1996-11-08. PMID:8738126. |
in addition, we attempted to overcome the potential negative impact of the ethanol-associated deficit of fetal 5-ht, by administering a 5-ht1a agonist, buspirone, to pregnant rats. |
1996-11-08 |
2023-08-12 |
rat |
| P Chiodera, R Volpi, L Capretti, G Caffarri, M G Magotti, V Coir. Different effects of the serotonergic agonists buspirone and sumatriptan on the posterior pituitary hormonal responses to hypoglycemia in humans. Neuropeptides. vol 30. issue 2. 1996-11-01. PMID:8771561. |
on the other hand, the pretreatment with the 5ht1a agonist buspirone significantly enhanced the ot response during hypoglycemia, without modifying the avp rise. |
1996-11-01 |
2023-08-12 |
Not clear |
| J Strosznajder, M Chalimoniuk, M Samochock. Activation of serotonergic 5-HT1A receptor reduces Ca(2+)- and glutamatergic receptor-evoked arachidonic acid and No/cGMP release in adult hippocampus. Neurochemistry international. vol 28. issue 4. 1996-10-29. PMID:8740452. |
the agonist of 5-ht1a receptor, buspirone, in a way similar to serotonin itself, counteracts the ca(2+)- and also nmda receptor-evoked aa release and cgmp accumulation. |
1996-10-29 |
2023-08-12 |
rat |
| J Strosznajder, M Chalimoniuk, M Samochock. Activation of serotonergic 5-HT1A receptor reduces Ca(2+)- and glutamatergic receptor-evoked arachidonic acid and No/cGMP release in adult hippocampus. Neurochemistry international. vol 28. issue 4. 1996-10-29. PMID:8740452. |
an antagonist of 5-ht1a receptor, nan-190, eliminates the effect of serotonin and buspirone on aa and no/cgmp liberation. |
1996-10-29 |
2023-08-12 |
rat |
| N McNaughton, K S Panickar, B Loga. The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide. Pharmacology, biochemistry, and behavior. vol 54. issue 1. 1996-10-23. PMID:8728538. |
it is interesting, therefore, that buspirone and other 5-ht1a agonists release stress hormones at moderate doses. |
1996-10-23 |
2023-08-12 |
rat |
| D Charrier, M H Thiébo. Effects of psychotropic drugs on rat responding in an operant paradigm involving choice between delayed reinforcers. Pharmacology, biochemistry, and behavior. vol 54. issue 1. 1996-10-23. PMID:8728552. |
whatever the experimental parameters and stage of the learning, an acute administration of drugs able to reduce 5-ht neuronal activity (benzodiazepines; 5-ht1a receptor partial agonists: buspirone and mdl 73005ef) or enhance 5-ht transmission (5-ht reuptake inhibitors: indalpine and zimelidine; 5-ht1a receptor full agonist: 8-oh-dpat) failed significantly to alter choice strategy (decreased or increased preference for the large but delayed reward, respectively), as they did in other situations such as a t-maze procedure. |
1996-10-23 |
2023-08-12 |
rat |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
tandospirone inhibited forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes by activation of 5-ht1a receptors and had high efficacy comparable to 5-ht1a receptor agonists such as 5-ht and 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
1996-10-23 |
2023-08-12 |
rat |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
tandospirone suppressed carbachol-stimulated phosphatidyl-inositol metabolism (pi response), which was shown to be a 5-ht1a receptor-mediated event. |
1996-10-23 |
2023-08-12 |
rat |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
these findings suggested that tandospirone shows high agonistic efficacy on the postsynaptic 5-ht1a receptors but does not affect the presynaptic autoreceptors located on nerve endings. |
1996-10-23 |
2023-08-12 |
rat |
| H Tanaka, T Tatsuno, H Shimizu, A Hirose, Y Kumasaka, M Nakamur. Effects of tandospirone on second messenger systems and neurotransmitter release in the rat brain. General pharmacology. vol 26. issue 8. 1996-10-23. PMID:8745167. |
the modulation of the second messenger system via postsynaptic 5-ht1a receptors might be involved in the anxiolytic efficacy of tandospirone. |
1996-10-23 |
2023-08-12 |
rat |
| D Manahan-Vaughan, R Anwyl, M J Rowa. The azapirone metabolite 1-(2-pyrimidinyl)piperazine depresses excitatory synaptic transmission in the hippocampus of the alert rat via 5-HT1A receptors. European journal of pharmacology. vol 294. issue 2-3. 1996-10-23. PMID:8750726. |
the effects of acute and repeated treatment with 1-(2-pyrimidinyl)piperazine (1-pp), a metabolite of the 5-ht1a receptor ligand azapirones, were investigated on hippocampal excitatory synaptic transmission. |
1996-10-23 |
2023-08-12 |
rat |
| Y Sugimoto, J Yamada, I Kimura, K Horisak. The effects of the serotonin1A receptor agonist buspirone on tolbutamide-induced hypoglycemia in rats. Biological & pharmaceutical bulletin. vol 18. issue 9. 1996-10-23. PMID:8845828. |
the effects of the serotonin1a(5-ht1a) receptor agonist buspirone on hypoglycemia elicited by tolbutamide were investigated in rats. |
1996-10-23 |
2023-08-12 |
rat |
| Y Sugimoto, J Yamada, I Kimura, K Horisak. The effects of the serotonin1A receptor agonist buspirone on tolbutamide-induced hypoglycemia in rats. Biological & pharmaceutical bulletin. vol 18. issue 9. 1996-10-23. PMID:8845828. |
the inhibitory effects of buspirone on tolbutamide-induced hypoglycemia were antagonized by the 5-ht1a receptor antagonist pindolol. |
1996-10-23 |
2023-08-12 |
rat |
| Y Sugimoto, J Yamada, I Kimura, K Horisak. The effects of the serotonin1A receptor agonist buspirone on tolbutamide-induced hypoglycemia in rats. Biological & pharmaceutical bulletin. vol 18. issue 9. 1996-10-23. PMID:8845828. |
these results suggest that buspirone inhibits tolbutamide-induced hypoglycemia mediated by the 5-ht1a receptor, and adrenaline release may be involved in the effects of buspirone. |
1996-10-23 |
2023-08-12 |
rat |
| U Fre. Cerebral metabolic effects of serotonin drugs and neurotoxins. Life sciences. vol 59. issue 11. 1996-10-21. PMID:8795699. |
sequential measurements of regional cerebral blood flow (rcbf) were obtained during combined pharmacological challange with the 5-ht1a agonist buspirone and cognitive activation. |
1996-10-21 |
2023-08-12 |
human |
| P Blier, R Bergero. Sequential administration of augmentation strategies in treatment-resistant obsessive-compulsive disorder: preliminary findings. International clinical psychopharmacology. vol 11. issue 1. 1996-10-10. PMID:8732312. |
the 5-ht1a agonist buspirone as well as 5-hydroxytryptophan, the immediate precursor of 5-ht, added to the sri-pindolol regimen, were not effective in attenuating the intensity of ocd. |
1996-10-10 |
2023-08-12 |
Not clear |
| L I Robles, M Barrios, E Del Pozo, A Dordal, J M Baeyen. Effects of K+ channel blockers and openers on antinociception induced by agonists of 5-HT1A receptors. European journal of pharmacology. vol 295. issue 2-3. 1996-09-26. PMID:8720582. |
all the 5-ht1a receptor agonists tested induced dose-dependent antinociception, the order of potency being (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin (8-oh-dpat) > buspirone > or = lesopitron > or = tandospirone. |
1996-09-26 |
2023-08-12 |
mouse |
| L I Robles, M Barrios, E Del Pozo, A Dordal, J M Baeyen. Effects of K+ channel blockers and openers on antinociception induced by agonists of 5-HT1A receptors. European journal of pharmacology. vol 295. issue 2-3. 1996-09-26. PMID:8720582. |
the same results were found with other agonists of 5-ht1a receptors (lesopitron, buspirone and tandospirone): gliquidone inhibited whereas cromakalim increased their antinociceptive effects. |
1996-09-26 |
2023-08-12 |
mouse |
| P Trouillas, J Xie, J C Getenet, P Adeleine, N Nighoghossian, J Honnorat, G Riche, L Dere. [Effect of buspirone, a serotonergic 5-HT-1A agonist in cerebellar ataxia: a pilot study. Preliminary communication]. Revue neurologique. vol 151. issue 12. 1996-09-26. PMID:8787101. |
buspirone, a 5-ht1a agonist usable in human medicine, has been studied in a group of 14 patients with cerebellar cortical atrophy. |
1996-09-26 |
2023-08-12 |
human |