| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K R Bonson, R G Johnson, D Fiorella, R A Rabin, J C Winte. Serotonergic control of androgen-induced dominance. Pharmacology, biochemistry, and behavior. vol 49. issue 2. 1995-02-15. PMID:7529925. |
when rats that had become dominant following administration of testosterone propionate received serotonergic agonists with selectivity for the 5-ht1a receptor (8-oh-dpat, buspirone, gepirone), the 5-h1b receptor (eltoprazine, tfmpp), or the 5-ht2a/2c receptor (dom), a dose-dependent decrease in dominance was demonstrated. |
1995-02-15 |
2023-08-12 |
rat |
| N N Bogdanov, M B Bogdano. The role of 5-HT1A serotonin and D2 dopamine receptors in buspirone effects on cortical electrical activity in rats. Neuroscience letters. vol 177. issue 1-2. 1995-02-10. PMID:7824156. |
the role of 5-ht1a serotonin and d2 dopamine receptors in buspirone effects on cortical electrical activity in rats. |
1995-02-10 |
2023-08-12 |
rat |
| P J McGrath, J W Stewart, F M Quitkin, S Wager, S W Jenkins, D G Archibald, J C Stringfellow, D S Robinso. Gepirone treatment of atypical depression: preliminary evidence of serotonergic involvement. Journal of clinical psychopharmacology. vol 14. issue 5. 1995-02-01. PMID:7806692. |
this is a report of a controlled trial of gepirone, a 5-hydroxytryptamine (5-ht1a) partial agonist azapirone related to buspirone, in the treatment of atypical depression. |
1995-02-01 |
2023-08-12 |
Not clear |
| A Moulignie. [Central serotonin receptors. Principal fundamental and functional aspects. Therapeutic applications]. Revue neurologique. vol 150. issue 1. 1995-01-26. PMID:7801037. |
better knowledge of 5-ht receptors has already led to the development of new drugs, such as buspirone, a 5-ht1a partial agonist devoid of benzodiazepine-like properties for the treatment of generalized anxiety. |
1995-01-26 |
2023-08-12 |
Not clear |
| J Strosznajder, M Samochocki, M Dura. Serotonin, a potent modulator of arachidonic acid turnover, interaction with glutamatergic receptor in brain cortex. Neurochemistry international. vol 25. issue 2. 1995-01-19. PMID:7994200. |
buspirone, an agonist of 5-ht1a receptor, has a similar effect on aa incorporation into membrane lipids as serotonin itself. |
1995-01-19 |
2023-08-12 |
Not clear |
| D Manahan-Vaughan, R Anwyl, M J Rowa. 5-HT1A receptor-mediated inhibition in the hippocampus of the alert rat--effects of repeated gepirone treatment. European journal of pharmacology. vol 260. issue 2-3. 1995-01-09. PMID:7988638. |
5-ht1a receptor-mediated inhibition in the hippocampus of the alert rat--effects of repeated gepirone treatment. |
1995-01-09 |
2023-08-12 |
rat |
| D Manahan-Vaughan, R Anwyl, M J Rowa. 5-HT1A receptor-mediated inhibition in the hippocampus of the alert rat--effects of repeated gepirone treatment. European journal of pharmacology. vol 260. issue 2-3. 1995-01-09. PMID:7988638. |
the effects of acute and repeated treatment with the 5-ht1a receptor ligand gepirone on hippocampal excitatory synaptic transmission were investigated. |
1995-01-09 |
2023-08-12 |
rat |
| D Manahan-Vaughan, R Anwyl, M J Rowa. 5-HT1A receptor-mediated inhibition in the hippocampus of the alert rat--effects of repeated gepirone treatment. European journal of pharmacology. vol 260. issue 2-3. 1995-01-09. PMID:7988638. |
the chronic baseline reduction was transiently reversed by the 5-ht1a receptor antagonist spiroxatrine and complete recovery to pretreatment levels was observed 48 h after the last gepirone dose. |
1995-01-09 |
2023-08-12 |
rat |
| C J Done, T Shar. Biochemical evidence for the regulation of central noradrenergic activity by 5-HT1A and 5-HT2 receptors: microdialysis studies in the awake and anaesthetized rat. Neuropharmacology. vol 33. issue 3-4. 1994-12-30. PMID:7984279. |
in the anaesthetized rat, administration of the 5-ht1a agonists buspirone, gepirone and ipsapirone increased noradrenaline levels in the microdialysates. |
1994-12-30 |
2023-08-12 |
rat |
| R B McCall, N A Escandon, L T Harris, M E Clemen. Tolerance development to the vagal-mediated bradycardia produced by 5-HT1A receptor agonists. The Journal of pharmacology and experimental therapeutics. vol 271. issue 2. 1994-12-29. PMID:7965796. |
5-ht1a receptor agonists studied included 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), buspirone, gepirone, flesinoxan and u-93385e (cis-(3ar)-(-)-2,3,3a,4,5,9b-hexahydro-3-propyl-1h-benz[e]indole-9 - carboxamide). |
1994-12-29 |
2023-08-12 |
cat |
| K Kasamo, K Tada, N Ueda, T Kojima, M Kogure, K Ishikaw. Effects of several 5-HT1A agonists on hippocampal rhythmical slow activity in unanesthetized rats. Neuropharmacology. vol 33. issue 7. 1994-12-28. PMID:7969811. |
selective 5-ht1a agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), flesinoxan, buspirone and ipsapirone significantly decreased the power value of 7-9 hz band activity and the median frequency of wr-rsa. |
1994-12-28 |
2023-08-12 |
rat |
| E Di Pasquale, R Monteau, G Hilair. Endogenous serotonin modulates the fetal respiratory rhythm: an in vitro study in the rat. Brain research. Developmental brain research. vol 80. issue 1-2. 1994-12-20. PMID:7955347. |
both 5-ht1 (8-oh-dpat, buspirone) and 5-ht2 agonists (doi, alpha-methyl-5-ht) increased the rf but only the 5-ht1a agonist 8-oh-dpat was efficient at submicromolar concentrations. |
1994-12-20 |
2023-08-12 |
rat |
| Mark J Milla. Serotonin and pain: evidence that activation of 5-HT1A receptors does not elicit antinociception against noxious thermal, mechanical and chemical stimuli in mice. Pain. vol 58. issue 1. 1994-12-19. PMID:7970839. |
in the hot-plate test, only certain agonists (e.g., 8-oh-dpat) and partial agonists (e.g., gepirone) elicited antinociception and their actions were not attenuated by 5-ht1a antagonists which, themselves, were inactive in this paradigm. |
1994-12-19 |
2023-08-12 |
mouse |
| L Lima, P Matus, M Urbin. Serotonin inhibits outgrowth of goldfish retina and impairs the trophic effect of taurine. Journal of neuroscience research. vol 38. issue 4. 1994-11-23. PMID:7523693. |
serotonin, its precursor, 5-hydroxytryptophan, and the 5ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone, inhibited the outgrowth. |
1994-11-23 |
2023-08-12 |
Not clear |
| J L Evende. The effect of 5-HT1A receptor agonists on locomotor activity in the guinea-pig. British journal of pharmacology. vol 112. issue 3. 1994-11-09. PMID:7921613. |
the present study examined the effects of 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), flesinoxan, ipsapirone and buspirone, all agonists at the 5-ht1a receptor, on the locomotor activity of guinea-pigs. |
1994-11-09 |
2023-08-12 |
mouse |
| C A Fornal, W J Litto, C W Metzler, F Marrosu, K Tada, B L Jacob. Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats. The Journal of pharmacology and experimental therapeutics. vol 270. issue 3. 1994-11-07. PMID:7932189. |
the 5-ht1a agonist drugs 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), ipsapirone, buspirone and 5-methoxy-n,n-dimethyltryptamine produced a rapid, dose-dependent inhibition of neuronal activity. |
1994-11-07 |
2023-08-12 |
Not clear |
| D Quartermain, J Clemente, A Sheme. The 5-HT1A agonist tandospirone disrupts retention but not acquisition of active avoidance learning. Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938139. |
the 5-ht1a agonist tandospirone disrupts retention but not acquisition of active avoidance learning. |
1994-11-04 |
2023-08-12 |
mouse |
| D Quartermain, J Clemente, A Sheme. The 5-HT1A agonist tandospirone disrupts retention but not acquisition of active avoidance learning. Pharmacology, biochemistry, and behavior. vol 48. issue 3. 1994-11-04. PMID:7938139. |
to determine the effects of the 5-ht1a partial agonist tandospirone on acquisition and retention, mice were trained on a one-way active avoidance task and tested for retention 24 h later. |
1994-11-04 |
2023-08-12 |
mouse |
| N R Cutler, J M Hesselink, J J Srame. A phase II multicenter dose-finding, efficacy and safety trial of ipsapirone in outpatients with generalized anxiety disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 18. issue 3. 1994-10-06. PMID:7915845. |
ipsapirone is a novel anxiolytic azapirone which has high specificity for the 5-ht1a receptor and which has the potential for offering certain advantages over buspirone. |
1994-10-06 |
2023-08-12 |
Not clear |
| L O Wilkinson, D N Middlemiss, P H Hutso. 5-HT1A receptor activation increases hippocampal acetylcholine efflux and motor activity in the guinea pig: agonist efficacy influences functional activity in vivo. The Journal of pharmacology and experimental therapeutics. vol 270. issue 2. 1994-09-28. PMID:8071858. |
systemic administration of the 5-ht1a receptor partial agonists buspirone and ipsapirone produced marked increases in ach efflux with less pronounced motor effects, whereas 8-[2-(2,3-dihydro-1,4-benzodioxin-2-yl- methylamino)ethyl]-8-azaspiro[4,5]-decane-7,9-dione methyl sulphonate (mdl 73005) modestly increased ach efflux with no effect on motor activity. |
1994-09-28 |
2023-08-12 |
Not clear |