| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Herdman, P J Cowen, G M Campling, R A Hockney, D Laver, A L Sharple. Effect of lofepramine on 5-HT function and sleep. Journal of affective disorders. vol 29. issue 1. 1994-01-13. PMID:8254146. |
we studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1a (5-ht1a) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). |
1994-01-13 |
2023-08-12 |
human |
| S Maisonnette, S Morato, M L Brandã. Role of resocialization and of 5-HT1A receptor activation on the anxiogenic effects induced by isolation in the elevated plus-maze test. Physiology & behavior. vol 54. issue 4. 1994-01-03. PMID:7902588. |
chronic treatment, but not acute treatment, with gepirone, a 5-ht1a agonist, inhibited the anxiogenic effects caused by a 2-week period of isolation. |
1994-01-03 |
2023-08-12 |
rat |
| H Mizoguchi, T Suzuki, M Misaw. Effects of serotonergic anxiolytics on physical dependence on diazepam in mice. Neuroscience letters. vol 160. issue 1. 1993-12-23. PMID:7902543. |
co-administration of buspirone (5-ht1a agonist) or ondansetron (5-ht3 antagonist), but not mianserin (5-ht1c antagonist) or ketanserin (5-ht2 antagonist) with diazepam potentiated the hypersensitivity to fg 7142 following chronic treatment with diazepam. |
1993-12-23 |
2023-08-12 |
mouse |
| H Mizoguchi, T Suzuki, M Misaw. Effects of serotonergic anxiolytics on physical dependence on diazepam in mice. Neuroscience letters. vol 160. issue 1. 1993-12-23. PMID:7902543. |
these results suggest that co-administration of buspirone or ondansetron with diazepam may potentiate the development of physical dependence on diazepam; 5-ht1a and 5-ht3 receptors may be partially involved in the development of physical dependence on diazepam. |
1993-12-23 |
2023-08-12 |
mouse |
| B Söderpalm, B Lundin, S Hjort. Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7901030. |
sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-ht1a receptor agonist, buspirone, after prolonged chronic administration. |
1993-12-01 |
2023-08-12 |
rat |
| B Söderpalm, B Lundin, S Hjort. Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:7901030. |
the results indicate that the functional capacity of 5-ht release-controlling 5-ht1a autoreceptors is retained upon chronic administration of buspirone, and that this effect may well be associated with the anxiolytic-like action of the compound. |
1993-12-01 |
2023-08-12 |
rat |
| C Routledge, J Gurling, I K Wright, C T Douris. Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223894. |
in contrast, the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) (0.1 mg/kg s.c.) and the partial agonists bmy 7378 (1.0 mg/kg s.c.) and buspirone (5 mg/kg s.c.) significantly decreased hippocampal 5-ht. |
1993-12-01 |
2023-08-12 |
rat |
| M J Benvenga, J D Leande. Antidepressant-like effect of LY228729 as measured in the rodent forced swim paradigm. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223903. |
the tricyclic antidepressant, imipramine, as well as the 5-ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and gepirone, produced dose-related decreases in immobility in the forced swim test following subchronic treatment in rats. |
1993-12-01 |
2023-08-12 |
rat |
| M Suzuki, M Uchiumi, M Murasak. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on daytime sleepiness and psychomotor functions: a comparative double-blind study with diazepam. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 13. issue 4. 1993-11-26. PMID:7901952. |
effects of tandospirone, a 5-ht1a receptor-related anxiolytic, on daytime sleepiness and psychomotor functions: a comparative double-blind study with diazepam. |
1993-11-26 |
2023-08-12 |
human |
| M Suzuki, M Uchiumi, M Murasak. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on daytime sleepiness and psychomotor functions: a comparative double-blind study with diazepam. Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology. vol 13. issue 4. 1993-11-26. PMID:7901952. |
a double-blind cross-over placebo-controlled study was designed to compare the effects of a single oral dose of tandospirone (30 mg), a new 5-ht1a receptor-related anxiolytic, on daytime sleepiness, psychomotor function and short-term memory with those of diazepam (5 mg), a benzodiazepine, in 12 healthy japanese volunteers. |
1993-11-26 |
2023-08-12 |
human |
| R A Glennon, R Young, J L Herndo. Antagonism of a (+)N-allylnormetazocine stimulus by (-)PPAP and several structurally related analogs. Pharmacology, biochemistry, and behavior. vol 45. issue 4. 1993-10-26. PMID:8105490. |
the nonselective serotonergic agent 1-(3-trifluoromethyl)phenylpiperazine (tfmpp) produced partial generalization in (+)nanm-trained animals whereas buspirone, a 5-hydroxytryptamine1a (5-ht1a) agonist, attenuated (to 27% drug-appropriate responding) the (+)nanm stimulus. |
1993-10-26 |
2023-08-12 |
rat |
| R D Porsol. Serotonin: neurotransmitter "a la mode". Report on the Third International I.T.E.M.-LABO symposium on strategies in psychopharmacology: serotonin: animal models and clinical targets. Pharmacopsychiatry. vol 26. issue 1. 1993-10-21. PMID:8378408. |
available 5-ht1a agonists (buspirone, gepirone, ipsapirone) are somewhat disappointing as anxiolytics but more specific compounds (flesinoxan, s 20499, e 4424) are now in development. |
1993-10-21 |
2023-08-12 |
Not clear |
| S Ahlenius, V Hillegaart, P Salmi, A Wijkströ. Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. Pharmacology & toxicology. vol 72. issue 6. 1993-09-30. PMID:8361951. |
the effects of the 5-ht1a receptor agonists 8-oh-dpat (0.15-2.5 mumol kg-1 subcutaneously), flesinoxan (0.6-10.0 mumol kg-1 subcutaneously) and buspirone (1.9-30.0 mumol kg-1 subcutaneously) on spontaneous motor activity in male sprague-dawley rats was examined in a photocell-equipped open-field arena. |
1993-09-30 |
2023-08-12 |
rat |
| S Ahlenius, V Hillegaart, P Salmi, A Wijkströ. Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. Pharmacology & toxicology. vol 72. issue 6. 1993-09-30. PMID:8361951. |
this stimulation of locomotor activity in reserpine-treated rats is in all probability related to 5-ht1a receptor stimulation since concomitant da d2 receptor blockade, in the case of buspirone, did not markedly affect this behavioural response. |
1993-09-30 |
2023-08-12 |
rat |
| C A Sannerud, N A Ator, R R Griffith. Behavioral pharmacology of tandospirone in baboons: chronic administration and withdrawal, self-injection and drug discrimination. Drug and alcohol dependence. vol 32. issue 3. 1993-09-16. PMID:8102330. |
the behavioral pharmacology of tandospirone (sm 3997), a novel anxiolytic/antidepressant pyrimidinylpiperazine compound with selective pharmacological effects at the 5-ht1a binding site, was investigated in baboons. |
1993-09-16 |
2023-08-12 |
Not clear |
| G Bagdy, K T Kalogera. Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin release in the male rat. Brain research. vol 611. issue 2. 1993-08-26. PMID:8334526. |
plasma oxytocin responses to the 5-ht1a receptor agonists 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), buspirone and ipsapirone, and the 5-ht2/5-ht1c receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)2-aminopropane (doi) have been studied in conscious, freely moving male rats. |
1993-08-26 |
2023-08-12 |
rat |
| K Bohmaker, A S Eison, F D Yocca, E Melle. Comparative effects of chronic 8-OH-DPAT, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-HT1A autoreceptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8336817. |
comparative effects of chronic 8-oh-dpat, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-ht1a autoreceptors. |
1993-08-25 |
2023-08-12 |
rat |
| K Bohmaker, A S Eison, F D Yocca, E Melle. Comparative effects of chronic 8-OH-DPAT, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-HT1A autoreceptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8336817. |
the present results are consistent with the suggestion that the clinical anxiolytic effects of gepirone and ipsapirone, and not of 8-oh-dpat, may be related to their ability to desensitize somatodendritic 5-ht1a autoreceptors; other potential mechanisms are discussed. |
1993-08-25 |
2023-08-12 |
rat |
| S Wieland, C T Fischette, I Luck. Effect of chronic treatments with tandospirone and imipramine on serotonin-mediated behavioral responses and monoamine receptors. Neuropharmacology. vol 32. issue 6. 1993-08-25. PMID:8393153. |
the effects of acute and chronic treatment of rats with the tricyclic antidepressant imipramine, the 5-ht1a receptor partial agonist tandospirone, or its metabolite 1-pp were compared on behavioral responses produced by the activation of 5-ht receptors and on brain monoamine receptors. |
1993-08-25 |
2023-08-12 |
rat |
| S D Mendelson, D Quartermain, T Francisco, A Sheme. 5-HT1A receptor agonists induce anterograde amnesia in mice through a postsynaptic mechanism. European journal of pharmacology. vol 236. issue 2. 1993-08-05. PMID:8319749. |
the effect of the 5-ht1a receptor partial agonist tandospirone on memory was investigated in mice using a single trial, step-through passive avoidance task. |
1993-08-05 |
2023-08-12 |
mouse |