| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Bohmaker, F Bordi, E Melle. The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. Neuropharmacology. vol 31. issue 5. 1992-10-20. PMID:1356248. |
completely analogous effects were found at the somatodendritic 5-ht1a autoreceptor in the raphe nuclei, mediating inhibition of the synthesis of serotonin (5-ht); the full agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) and the partial agonist, buspirone were utilized to inhibit the synthesis of 5-ht, as measured by changes in levels of l-5-hydroxytryptophan (5-htp). |
1992-10-20 |
2023-08-11 |
Not clear |
| P M Grasby, K J Friston, C Bench, P J Cowen, C D Frith, P F Liddle, R S Frackowiak, R J Dola. Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man. Psychopharmacology. vol 108. issue 3. 1992-10-15. PMID:1523287. |
effect of the 5-ht1a partial agonist buspirone on regional cerebral blood flow in man. |
1992-10-15 |
2023-08-11 |
human |
| P M Grasby, K J Friston, C Bench, P J Cowen, C D Frith, P F Liddle, R S Frackowiak, R J Dola. Effect of the 5-HT1A partial agonist buspirone on regional cerebral blood flow in man. Psychopharmacology. vol 108. issue 3. 1992-10-15. PMID:1523287. |
repeated measurements of regional cerebral blood flow (rcbf) were made in normal volunteers before, and after, the administration of the 5-ht1a partial agonist, buspirone, or placebo. |
1992-10-15 |
2023-08-11 |
human |
| H Shimizu, Y Kumasaka, H Tanaka, A Hirose, M Nakamur. Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats. Japanese journal of pharmacology. vol 58. issue 3. 1992-09-30. PMID:1355147. |
tandospirone is a novel non-benzodiazepine compound possessing potent anxiolytic properties in a water lick conflict paradigm in rats and a high affinity for central 5-ht1a receptors. |
1992-09-30 |
2023-08-11 |
rat |
| H Shimizu, Y Kumasaka, H Tanaka, A Hirose, M Nakamur. Anticonflict action of tandospirone in a modified Geller-Seifter conflict test in rats. Japanese journal of pharmacology. vol 58. issue 3. 1992-09-30. PMID:1355147. |
therefore, the possibility exists that the anticonflict action of tandospirone is related to its agonist action on 5-ht1a receptors, not on benzodiazepine receptors. |
1992-09-30 |
2023-08-11 |
rat |
| B Olivier, J Mo. Rodent models of aggressive behavior and serotonergic drugs. Progress in neuro-psychopharmacology & biological psychiatry. vol 16. issue 6. 1992-09-30. PMID:1513929. |
the 5-ht1a agonists buspirone, ipsapirone and 8-oh-dpat decreased aggression in ri and ma, but simultaneously led to a marked decrease in social interest and activity, indicative of a non-specific anti-aggressive profile. |
1992-09-30 |
2023-08-11 |
rat |
| H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology. vol 59. issue 1. 1992-09-22. PMID:1354771. |
to clarify which 5-ht1a receptors, autoreceptors located in the raphe nuclei or post-synaptic receptors in the forebrain areas receiving a 5-ht input, mediate the anticonflict action of tandospirone (a 5-ht1a receptor-related anxiolytics), the behavioral effects of tandospirone were studied in 5,7-dihydroxytryptamine (5,7-dht) treated rats. |
1992-09-22 |
2023-08-11 |
rat |
| H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology. vol 59. issue 1. 1992-09-22. PMID:1354771. |
these results suggested that the anticonflict action of tandospirone may be produced, at least in part, by binding to postsynaptic 5-ht1a receptors and activating them as agonists, and not to 5-ht1a autoreceptors located on the cell bodies of 5-ht neurons. |
1992-09-22 |
2023-08-11 |
rat |
| K J Friston, P M Grasby, C J Bench, C D Frith, P J Cowen, P F Liddle, R S Frackowiak, R Dola. Measuring the neuromodulatory effects of drugs in man with positron emission tomography. Neuroscience letters. vol 141. issue 1. 1992-09-22. PMID:1354845. |
using positron emission tomography (pet), measurements of regional cerebral blood flow were made during the performance of memory tasks, before and after the administration of apomorphine (dopamine agonist), buspirone (5-ht1a partial agonist) or placebo. |
1992-09-22 |
2023-08-11 |
Not clear |
| J N Murthy, M R Pranzatell. Brainstem 5-hydroxytrytamine1A binding sites are not down-regulated by agonists which induce tolerance in the rat: myoclonus and other serotonergic behaviors. Journal of receptor research. vol 12. issue 3. 1992-09-22. PMID:1387164. |
there was no cross tolerance to 8-oh-dpat in rats chronically injected with ipsapirone or buspirone (presynaptic 5-ht1a agonists). |
1992-09-22 |
2023-08-11 |
human |
| H Yoshimura, K Watanab. [Comparison of the effects of benzodiazepine and non-benzodiazepine anxiolytics on agonistic behavior in male mice]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 99. issue 3. 1992-09-21. PMID:1354630. |
these evidence indicate that tandospirone, a 5-ht1a receptor agonist, has different pharmacological properties from diazepam. |
1992-09-21 |
2023-08-11 |
mouse |
| M J Millan, J M Rivet, H Canton, F Lejeune, K Bervoets, M Brocco, A Gobert, B Lefebvre de Ladonchamps, S Le Marouille-Girardon, L Verriel. S 14671: a naphtylpiperazine 5-hydroxytryptamine1A agonist of exceptional potency and high efficacy possessing antagonist activity at 5-hydroxytryptamine1C/2 receptors. The Journal of pharmacology and experimental therapeutics. vol 262. issue 2. 1992-09-11. PMID:1323650. |
the interaction at 5-hydroxytryptamine (5-ht) receptors of the novel naphtylpiperazine, s 14671 (1-[2-(2-thenoylamino)ethyl]-4[1-(7- methoxynaphtyl)]piperazine), was compared to that of the 5-ht1a ligands, 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-oh-dpat), wy 50,324 [n-(29(4-(2-pyrimidinyl)-1-piperazinyl)ethyl)tricyclo(3.3.1.1(3,7) )- decane-1-carboxamide], (+)-flesinoxan, buspirone and bmy 7378 [(8-[2-[4-(2-methoxyphenyl)- 1-piperazinyl]ethyl]-8-azaspirol[-4-]-decane-7,9-dione 2hcl]. |
1992-09-11 |
2023-08-11 |
rat |
| B Söderpalm, J A Enge. Serotonergic involvement in conflict behaviour. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 1. issue 1. 1992-08-25. PMID:2136217. |
the putative 5-ht1a receptor agonists buspirone, gepirone, ipsapirone and 8-oh-dpat all produced anxiolytic-like effects in narrow low dose-ranges, while in higher doses the behavior returned towards that seen in controls and, after the highest doses of buspirone and gepirone, was suppressed below that of controls. |
1992-08-25 |
2023-08-11 |
Not clear |
| S J Peroutka, A J Sleight, B G McCarthy, P A Pierce, A W Schmidt, C R Hekmatpana. The clinical utility of pharmacological agents that act at serotonin receptors. The Journal of neuropsychiatry and clinical neurosciences. vol 1. issue 3. 1992-08-18. PMID:2562495. |
the putative novel anxiolytic effects of 5-ht1a partial agonists such as buspirone, the antidepressant effects of selective serotonin (5-ht) uptake blockers such as fluoxetine, and the unique and potent antiemetic effects of 5-ht3 antagonists in cancer chemotherapy are excellent examples of the clinical relevance of selective 5-ht receptor agents. |
1992-08-18 |
2023-08-11 |
human |
| J V Lucey, G Butcher, A W Clare, T G Dina. Buspirone induced prolactin responses in obsessive-compulsive disorder (OCD): is OCD a 5-HT2 receptor disorder? International clinical psychopharmacology. vol 7. issue 1. 1992-08-07. PMID:1624756. |
buspirone (busp) is a serotonergic (5-ht) agonist with activity at the 5-ht1a receptor. |
1992-08-07 |
2023-08-11 |
Not clear |
| K C Corley, V B Singh, T H Phan, M C Boadle-Bibe. Effect of gepirone on increases in tryptophan hydroxylase in response to sound stress. European journal of pharmacology. vol 213. issue 3. 1992-08-06. PMID:1377631. |
gepirone may block the sound stress-induced biochemical increases by its inhibition of serotonergic neuronal firing in the dorsal raphe nucleus that is mediated by its agonist action at the somatodendritic (5-ht1a) autoreceptors. |
1992-08-06 |
2023-08-11 |
rat |
| F D Yocca, L Iben, E Melle. Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes. Molecular pharmacology. vol 41. issue 6. 1992-07-28. PMID:1352034. |
5-ht1a agonists with anxiolytic properties (e.g., buspirone, gepirone, and ipsapirone) display full intrinsic activity at these receptors but are partial agonists at postsynaptic 5-ht1a receptors, which suggests that the latter sites may be devoid of a receptor reserve. |
1992-07-28 |
2023-08-11 |
rat |
| K J Friston, P M Grasby, C D Frith, C J Bench, R J Dolan, P J Cowen, P F Liddle, R S Frackowia. The neurotransmitter basis of cognition: psychopharmacological activation studies using positron emission tomography. Ciba Foundation symposium. vol 163. 1992-07-02. PMID:1687731. |
the effects of buspirone (a 5-ht1a receptor partial agonist) on changes in regional cerebral blood flow (rcbf) associated with free word recall were examined. |
1992-07-02 |
2023-08-11 |
Not clear |
| V Motta, S Maisonnette, S Morato, P Castrechini, M L Brandã. Effects of blockade of 5-HT2 receptors and activation of 5-HT1A receptors on the exploratory activity of rats in the elevated plus-maze. Psychopharmacology. vol 107. issue 1. 1992-06-24. PMID:1350349. |
acute administration of gepirone, a 5-ht1a agonist, caused a dose dependent (1-10 mg/kg, ip) reduction in the locomotor activity (open and closed arms) of rats tested in the elevated plus-maze. |
1992-06-24 |
2023-08-11 |
rat |
| J D Amsterda. Gepirone, a selective serotonin (5HT1A) partial agonist in the treatment of major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 16. issue 3. 1992-06-24. PMID:1350353. |
gepirone, a selective serotonin (5ht1a) partial agonist in the treatment of major depression. |
1992-06-24 |
2023-08-11 |
human |