All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
K Tominaga, S Shibata, S Ueki, S Watanab. Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters. European journal of pharmacology. vol 214. issue 1. 1992-06-16. PMID:1316283. the effects of 5-ht1a receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), buspirone and ipsapirone on wheel-running activity in hamsters were investigated in comparison with those of gabaa receptor agonist muscimol and benzodiazepine triazolam. 1992-06-16 2023-08-11 Not clear
I M Anderson, P J Cowe. Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology. vol 106. issue 3. 1992-05-22. PMID:1570392. ten healthy subjects received buspirone (30 mg orally) with and without pre-treatment with the 5-ht1a receptor antagonist, pindolol (80 mg over 3 days). 1992-05-22 2023-08-11 human
I M Anderson, P J Cowe. Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology. vol 106. issue 3. 1992-05-22. PMID:1570392. the data suggest that the growth hormone and hypothermic responses to buspirone in humans are mediated by 5-ht1a receptors, but an explanation founded on pharmacokinetic factors cannot presently be excluded. 1992-05-22 2023-08-11 human
I M Anderson, P J Cowe. Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology. vol 106. issue 3. 1992-05-22. PMID:1570392. both this latter possibility and the lack of selectivity of pindolol for 5-ht receptors indicate the need for the further neuroendocrine studies of the mode of action of buspirone, preferably with more selective 5-ht1a receptor antagonists. 1992-05-22 2023-08-11 human
P Broqua, V Baudrie, M T Bluet-Pajot, F Chaoulof. Buspirone, ipsapirone and 1-(2-pyrimidinyl)-piperazine decrease cold-induced thyrotropin secretion in rats. European journal of pharmacology. vol 204. issue 2. 1992-05-14. PMID:1687218. the aim of this study was to analyse the effects of the 5-ht1a receptor-related antidepressants/anxiolytics, buspirone and ipsapirone (1-10 mg/kg i.v. 1992-05-14 2023-08-11 rat
P Broqua, V Baudrie, M T Bluet-Pajot, F Chaoulof. Buspirone, ipsapirone and 1-(2-pyrimidinyl)-piperazine decrease cold-induced thyrotropin secretion in rats. European journal of pharmacology. vol 204. issue 2. 1992-05-14. PMID:1687218. these data suggest that both central 5-ht1a receptors and alpha 2-adrenoceptors mediate the effects of azapirones on cold-induced tsh secretion. 1992-05-14 2023-08-11 rat
M J Millan, H Canton, J M Rivet, F Lejeune, M Laubie, G Laviell. S 14671: a novel naphthylpiperazine 5-HT1A agonist of high efficacy and exceptional in vivo potency. European journal of pharmacology. vol 203. issue 2. 1992-04-21. PMID:1839284. the novel, naphthylpiperazine 5-ht1a agonist, s 14671 (4-[(thenoyl-2)aminoethyl]-1-(7-methoxynaphtylpiperazine], displayed very high affinity for 5-ht1a binding sites (pki = 9.3) as compared to the serotonin (5-ht)1a agonists, 8-oh-dpat (9.2) and (+)-flesinoxan (8.7) and the 5-ht1a partial agonists, buspirone (7.9) and bmy 7378 (8.8). 1992-04-21 2023-08-11 Not clear
C E Ybema, J L Slangen, B Olivier, J Mo. Discriminative stimulus properties of the serotonergic compound eltoprazine. The Journal of pharmacology and experimental therapeutics. vol 260. issue 3. 1992-04-13. PMID:1532031. the eltoprazine cue partially generalized to the cues of the 5-ht1a agonists flesinoxan and buspirone, (m-cpp), the 5-ht1b/1c agonist 1,3-chlorophenyl-piperazine dihydrochloride and the 5-ht1c/2 antagonist mesulergine, and did not generalize to the 5-ht2/1c agonist doi. 1992-04-13 2023-08-11 rat
C Small, C M Brown, W S Redfern, M Speddin. The guinea-pig ileum preparation as a model for 5-HT1A receptors: anomalous effects with RS-30199-193. British journal of pharmacology. vol 104. issue 2. 1992-04-13. PMID:1839137. the hybrid compound of rs-30199-193 with buspirone, rs-64459-193 (5-chloro-2-[4-(8-azaspiro[4,5]decane-7,9-dione)-but-1-yl]- 1,2,3,4,8,9,10,10a-octahydronaphth[1,8-cd]-3-azepine hydrochloride) maintained high affinity for the 5-ht1a binding site in rat brain and both inhibited the response to field stimulation and antagonized the responses to 8-oh-dpat and dp5ct. 1992-04-13 2023-08-11 rat
R Tsuji, Y Ohno, A Hirose, H Shimizu, H Tanaka, M Nakamur. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on the pressor response elicited by stimulation of the posterior hypothalamus in cats. Archives internationales de pharmacodynamie et de therapie. vol 311. 1992-03-26. PMID:1686389. effects of tandospirone, a 5-ht1a receptor-related anxiolytic, on the pressor response elicited by stimulation of the posterior hypothalamus in cats. 1992-03-26 2023-08-11 Not clear
R Tsuji, Y Ohno, A Hirose, H Shimizu, H Tanaka, M Nakamur. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on the pressor response elicited by stimulation of the posterior hypothalamus in cats. Archives internationales de pharmacodynamie et de therapie. vol 311. 1992-03-26. PMID:1686389. the effects of tandospirone, a novel 5-ht1a receptor-related anxiolytic, on pressor responses elicited by activation of the posterior hypothalamus were examined in alpha-chloralose-anesthetized cats and compared with those of diazepam and tofisopam. 1992-03-26 2023-08-11 Not clear
R Tsuji, Y Ohno, A Hirose, H Shimizu, H Tanaka, M Nakamur. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on the pressor response elicited by stimulation of the posterior hypothalamus in cats. Archives internationales de pharmacodynamie et de therapie. vol 311. 1992-03-26. PMID:1686389. the inhibition of the posterior hypothalamus-induced pressor response by tandospirone was significantly antagonized by pindolol (a 5-ht1a receptor antagonist) but not by cgs-8216 (a benzodiazepine receptor antagonist), while the latter reduced the inhibitory effects of diazepam. 1992-03-26 2023-08-11 Not clear
R Tsuji, Y Ohno, A Hirose, H Shimizu, H Tanaka, M Nakamur. Effects of tandospirone, a 5-HT1A receptor-related anxiolytic, on the pressor response elicited by stimulation of the posterior hypothalamus in cats. Archives internationales de pharmacodynamie et de therapie. vol 311. 1992-03-26. PMID:1686389. in addition, tandospirone and diazepam exert this effect through different mechanisms, the former probably through 5-ht1a receptors and the latter through benzodiazepine receptors. 1992-03-26 2023-08-11 Not clear
S M White, R F Kucharik, J A Moye. Effects of serotonergic agents on isolation-induced aggression. Pharmacology, biochemistry, and behavior. vol 39. issue 3. 1992-03-19. PMID:1686105. all compounds with 5-ht1a activity [buspirone, gepirone, ipsapirone, tandospirone (sm-3997), 8-oh-dpat, wy-48,723, bmy-7378, wy-47,846] reduced aggression at doses below those which produced debilitation in the rotorod motor coordination test. 1992-03-19 2023-08-11 Not clear
P M Grasby, T Sharp, T Allen, P A Kelly, D G Grahame-Smit. Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat. Psychopharmacology. vol 106. issue 1. 1992-03-18. PMID:1346724. effects of the 5-ht1a partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat. 1992-03-18 2023-08-11 rat
P M Grasby, T Sharp, T Allen, P A Kelly, D G Grahame-Smit. Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat. Psychopharmacology. vol 106. issue 1. 1992-03-18. PMID:1346724. the findings emphasize the potential importance of the hippocampus as a site of action for 5-ht1a receptor active drugs in vivo and also suggest that functional activity in the striatal/limbic-habenular-raphe pathway may be influenced by gepirone, ipsapirone and buspirone. 1992-03-18 2023-08-11 rat
H Lal, P L Prather, S M Rezazade. Anxiogenic behavior in rats during acute and protracted ethanol withdrawal: reversal by buspirone. Alcohol (Fayetteville, N.Y.). vol 8. issue 6. 1992-03-18. PMID:1781924. the anxiolytic-like activity of buspirone observed during ethanol withdrawal may be due to a reduction in serotonergic neurotransmission through activation of presynaptic 5-ht1a autoreceptors. 1992-03-18 2023-08-11 rat
T Matsuda, Y Nakano, T Kanda, H Iwata, A Bab. Gonadectomy changes the pituitary-adrenocortical response in mice to 5-HT1A receptor agonists. European journal of pharmacology. vol 200. issue 2-3. 1992-03-13. PMID:1838334. the effects of 5-ht1a receptor agonists such as 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), bp-554 and buspirone on the serum corticosterone level were significantly more pronounced in female than in male mice. 1992-03-13 2023-08-11 mouse
A E Walsh, C J Ware, P J Cowe. Lithium and 5-HT1A receptor sensitivity: a neuroendocrine study in healthy volunteers. Psychopharmacology. vol 105. issue 4. 1992-02-27. PMID:1663254. the effect of lithium administration (800 mg daily for 7 days) on the neuroendocrine and temperature responses to the 5-ht1a receptor agonist, gepirone, was studied in eight healthy male volunteers. 1992-02-27 2023-08-11 human
J T Winslow, T R Inse. Serotonergic modulation of the rat pup ultrasonic isolation call: studies with 5HT1 and 5HT2 subtype-selective agonists and antagonists. Psychopharmacology. vol 105. issue 4. 1992-02-27. PMID:1771219. consistent with previous reports, acute administration of 5ht1a agonists buspirone and 8-oh-dpat [+/-)-8-hydroxy-2-(di-n-propylamino)tetralin) reduced the rate of calling at doses which did not affect motor activity or core body temperature. 1992-02-27 2023-08-11 rat