All Relations between 5-ht receptor 1a and Azapirones

Publication Sentence Publish Date Extraction Date Species
G Curzo. Effects of tryptophan and of 5-hydroxytryptamine receptor subtype agonists on feeding. Advances in experimental medicine and biology. vol 294. 1992-02-25. PMID:1837683. thus, 5-ht1a agonists (8-oh-dpat, buspirone, gepirone etc.) 1992-02-25 2023-08-11 human
K P Lesc. 5-HT1A receptor responsivity in anxiety disorders and depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 6. 1992-02-13. PMID:1763190. azapirones, selective partial agonists at the 5-ht1a receptor subtype, induce hypothermia and corticotropin (acth)/cortisol release as specific functional correlates of central 5-ht1a receptor activation. 1992-02-13 2023-08-11 Not clear
K P Lesc. [Psychobiology of compulsive disease]. Fortschritte der Neurologie-Psychiatrie. vol 59. issue 10. 1992-02-07. PMID:1761269. in addition, growing evidence suggests that potent inhibitors of 5-ht reuptake and other 5-ht subsystem-selective agents, such as the azapirones with partial agonist properties at the 5-ht1a receptor, are effective in ocd not only has improved the therapeutic perspective but may also reveal clues to the aetiopathogenesis of ocd. 1992-02-07 2023-08-11 Not clear
L Zhang, J E Barret. Imipramine as a discriminative stimulus. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1762063. drug-appropriate responding occurred in pigeons trained at the lower dose of imipramine with the 5-ht1a compounds 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide and gepirone; partial substitution occurred in pigeons trained with the higher dose of imipramine. 1992-02-07 2023-08-11 Not clear
L Zhang, J E Barret. Imipramine as a discriminative stimulus. The Journal of pharmacology and experimental therapeutics. vol 259. issue 3. 1992-02-07. PMID:1762063. substitution for the imipramine stimulus by gepirone, an antidepressant with actions mediated by the 5-ht1a receptor, as well as with 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide, suggests that imipramine may have effects at this receptor site and confirms reports that compounds active at this receptor may have antidepressant activity. 1992-02-07 2023-08-11 Not clear
M Y Chou, Y Watanabe, T Shibuy. Neuropsychopharmacological studies of a Ca2+ channel blocker on the modulation of brain Ca2+ mobilization of spontaneously hypertensive rats under mild stress. Neuroscience research. vol 12. issue 2. 1992-02-06. PMID:1661879. such hyperactivity was significantly blocked after 10 days of repeated administration of diazepam (dzp), tandospirone (sm-3997; sm), a 5-ht1a anxiolytic, and nitrendipene (nit), a ca antagonist. 1992-02-06 2023-08-11 rat
P A Broderick, M F Pierce. 5-HT1A agonists uncouple noradrenergic somatodendritic impulse flow and terminal release. Brain research bulletin. vol 27. issue 5. 1992-02-06. PMID:1684526. we have used microelectrode recordings of nerve cell impulse frequencies and in vivo voltammetric recordings of monoamine release to evaluate effects of the arylpiperazine 5-ht1a anxiolytics, buspirone and ipsapirone. 1992-02-06 2023-08-11 Not clear
I Luck. Behavioral studies of serotonin receptor agonists as antidepressant drugs. The Journal of clinical psychiatry. vol 52 Suppl. 1992-01-30. PMID:1684363. in addition, the 5-ht1a receptor partial agonist buspirone and other similarly structured compounds termed azapirones are also candidates for antidepressant therapy. 1992-01-30 2023-08-11 Not clear
I Luck. Behavioral studies of serotonin receptor agonists as antidepressant drugs. The Journal of clinical psychiatry. vol 52 Suppl. 1992-01-30. PMID:1684363. evidence does not support the involvement of a common metabolite 1-pp in the antidepressant activity of 5-ht1a receptor-selective azapirones. 1992-01-30 2023-08-11 Not clear
H S Lee, H Y Meltze. Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man. Journal of neural transmission. General section. vol 86. issue 1. 1992-01-24. PMID:1751030. thus, buspirone may be a weaker agonist at those 5-ht1a receptors which mediate hypothermia compared to ipsapirone or gepirone, two other 5-ht1a partial agonists which have been reported to produce hypothermia by a 5-ht1a-mediated mechanism. 1992-01-24 2023-08-11 human
D P Sachs, S J Leischo. Pharmacologic approaches to smoking cessation. Clinics in chest medicine. vol 12. issue 4. 1992-01-23. PMID:1747993. other agents in various phases of preclinical and clinical evaluation include 5-ht1a partial agonists such as buspirone; alpha 2-noradrenergic agonists such as clonidine; tricyclics such as doxepin; serotonin re-uptake antagonists such as fluoxetine; acth; 5-ht2 antagonists such as ritanserin; central excitatory amino acid inhibitors such as kynurenate; and calcium channel blockers. 1992-01-23 2023-08-11 Not clear
J A Martinez, L Buén. Buspirone inhibits corticotropin-releasing factor and stress-induced cecal motor response in rats by acting through 5-HT1A receptors. European journal of pharmacology. vol 202. issue 3. 1992-01-23. PMID:1748159. buspirone inhibits corticotropin-releasing factor and stress-induced cecal motor response in rats by acting through 5-ht1a receptors. 1992-01-23 2023-08-11 rat
J A Martinez, L Buén. Buspirone inhibits corticotropin-releasing factor and stress-induced cecal motor response in rats by acting through 5-HT1A receptors. European journal of pharmacology. vol 202. issue 3. 1992-01-23. PMID:1748159. the effect of buspirone on corticotropin-releasing factor (crf) and stress-stimulated cecal motility and its antagonism by 5-ht1a (spiroxatrine) and sigma (bmy 14802) antagonists were evaluated by electromyography in rats equipped with chronically implanted electrodes on the cecum and a small catheter into the right lateral ventricle of the brain. 1992-01-23 2023-08-11 rat
J A Martinez, L Buén. Buspirone inhibits corticotropin-releasing factor and stress-induced cecal motor response in rats by acting through 5-HT1A receptors. European journal of pharmacology. vol 202. issue 3. 1992-01-23. PMID:1748159. it is concluded that s.c. administration of buspirone suppresses the stress-induced cecal motor response through 5-ht1a receptors, probably by inhibiting the central or peripheral pathways involved in crf mediation of these effects. 1992-01-23 2023-08-11 rat
F D Yocca, A S Eison, D K Hyslop, E Ryan, D P Taylor, G Gianutso. Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment. Life sciences. vol 49. issue 24. 1991-12-26. PMID:1682780. the effect of continuous treatment with the selective 5-ht1a agonist gepirone upon 5-ht2-mediated behavior and cortical 5-ht2 receptor binding sites was examined in naive rats or rats receiving noradrenergic (dsp4) or serotonergic (5,7-dht) lesions. 1991-12-26 2023-08-11 rat
F D Yocca, A S Eison, D K Hyslop, E Ryan, D P Taylor, G Gianutso. Unique modulation of central 5-HT2 receptor binding sites and 5-HT2 receptor-mediated behavior by continuous gepirone treatment. Life sciences. vol 49. issue 24. 1991-12-26. PMID:1682780. furthermore, the postsynaptic action of gepirone which reduces the maximal number of cortical 5-ht2 receptor binding sites may be the result of gepirone's agonist action at postsynaptic 5-ht1a receptors. 1991-12-26 2023-08-11 rat
M L Brandão, J A Lopez-Garcia, F G Graeff, M H Robert. Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurones of the rat midbrain tectum. Brain research. vol 556. issue 2. 1991-12-17. PMID:1682008. the 5-ht1a receptor agonists, 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat), buspirone and gepirone caused consistent reduction in the firing rate of cells depressed by 5-ht while they did not change the firing activity of cells excited by 5-ht. 1991-12-17 2023-08-11 rat
G D Tollefson, S P Lancaster, J Montague-Clous. The association of buspirone and its metabolite 1-pyrimidinylpiperazine in the remission of comorbid anxiety with depressive features and alcohol dependency. Psychopharmacology bulletin. vol 27. issue 2. 1991-11-21. PMID:1924664. we investigated 51 dually diagnosed patients (generalized anxiety disorder with depressive features plus alcohol abuse/dependency) under a randomized, double-blind, placebo-controlled trial employing the 5-ht1a compound buspirone. 1991-11-21 2023-08-11 Not clear
R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. the acute and long-term effects of the antidepressant/anxiolytic selective 5-ht1a receptor ligand, tandospirone (sm-3997) on 5-ht neurotransmission were assessed using single-cell extracellular recording in chloral hydrate-anaesthetized rats. 1991-11-04 2023-08-11 rat
R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. the depressant effects of microiontophoretically-applied tandospirone and 5-ht, on the firing activity of ca3 pyramidal neurones in the hippocampus were blocked by the intravenous injection of the 5-ht1a receptor antagonist, bmy-7378. 1991-11-04 2023-08-11 rat