| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the depressant effects of microiontophoretically-applied tandospirone and 5-ht, on the firing activity of ca3 pyramidal neurones in the hippocampus were blocked by the intravenous injection of the 5-ht1a receptor antagonist, bmy-7378. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the depressant effect of microiontophoretically-applied 5-ht onto these same neurones was markedly reduced during concurrent background application of tandospirone, suggesting that the latter acted as a partial agonist at postsynaptic 5-ht1a receptors. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
the sustained administration of tandospirone for 14 days (10 mg/kg/day, s.c.) altered neither the effectiveness of microiontophoretically-applied 5-ht and tandospirone nor that of endogenous 5-ht, released by the electrical simulation of the afferent 5-ht pathway, in suppressing the firing activity of pyramidal neurones in the hippocampus, suggesting that postsynaptic 5-ht1a receptors had not desensitized. |
1991-11-04 |
2023-08-11 |
rat |
| R Godbout, Y Chaput, P Blier, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681446. |
this, combined with the sustained activation of normosensitive postsynaptic 5-ht1a receptors by tandospirone, during such a treatment, should result in an enhanced tonic activation of postsynaptic 5-ht1a receptors. |
1991-11-04 |
2023-08-11 |
rat |
| P Blier, O Curet, Y Chaput, C de Montign. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--II. Effects of acute administration of 1-PP and long-term administration of tandospirone on noradrenergic neurotransmission. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681447. |
1-(2-pyrimidinyl)-piperazine (1-pp) is a common metabolite of the antidepressant/anxiolytic 5-ht1a agonists, tandospirone (sm-3997), gepirone, buspirone and ipsapirone. |
1991-11-04 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
involvement of 5-ht1a receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. |
1991-11-04 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
the antidepressant-like activity of gepirone, a drug with a high and selective affinity for 5-hydroxytryptamine1a (5-ht1a) receptors, was studied in the forced swimming test in rats. |
1991-11-04 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
the anti-immobility effect of gepirone (10 mg/kg) was dose-dependently antagonized by the 5-ht1a receptor and alpha 1-adrenoceptor antagonist, nan-190 (0.25 and 0.5 mg/kg), the beta-adrenoceptor blocker with the affinity for 5-ht1a and 5-ht1b receptors, pindolol (2 and 4 mg/kg), the 5-ht1a, 5-ht2 and dopamine receptor blocker spiperone (0.01 and 0.03 mg/kg) and by the dopamine receptor antagonist, haloperidol (0.125 and 0.25 mg/kg). |
1991-11-04 |
2023-08-11 |
rat |
| E Chojnacka-Wójcik, E Tatarczyńska, K Gołembiowska, E Przegalińsk. Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats. Neuropharmacology. vol 30. issue 7. 1991-11-04. PMID:1681449. |
the results obtained suggest that the anti-immobility effect of gepirone is mediated by activation of 5-ht1a receptors, most probably located postsynaptically and that dopamine may be involved in this action. |
1991-11-04 |
2023-08-11 |
rat |
| A Płaźnik, R Stefański, W Pałejko, W Kostowsk. Serotonergic mechanisms in the nucleus accumbens affected by chronic desipramine treatment. Pharmacology, biochemistry, and behavior. vol 39. issue 1. 1991-11-01. PMID:1833782. |
local microinjections of 5-ht, quipazine as well as 5-ht1a receptor agonist buspirone, 8-oh-dpat and ndo-008, inhibited rat locomotor activity in the open-field test. |
1991-11-01 |
2023-08-11 |
rat |
| T Yamamoto, S Shibata, K Teshima, Y Inoue, M Ushio, K Tominaga, M Ohno, S Watanabe, S Uek. [Behavioral pharmacological and electroencephalographic effects of the 5-HT1A partial agonist ipsapirone]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 98. issue 1. 1991-10-16. PMID:1679740. |
the behavioral and eeg effects of the 5-ht1a partial agonist ipsapirone were investigated to determine its pharmacological characteristics as an anxiolytic drug in rats, mice and rabbits, as compared with those of buspirone and diazepam. |
1991-10-16 |
2023-08-11 |
mouse |
| D P Taylor, S L Moo. Buspirone and related compounds as alternative anxiolytics. Neuropeptides. vol 19 Suppl. 1991-09-30. PMID:1679210. |
the azapirones appear to act as serotonin 5-ht1a partial agonists as they all share high affinity for 5-ht1a binding sites in vitro as well as in anatomical studies. |
1991-09-30 |
2023-08-11 |
Not clear |
| P Marti. 1-(2-pyrimidinyl)-piperazine may alter the effects of the 5-HT1A agonist in the learned helplessness paradigm in rats. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1678895. |
the 5-ht1a agonists buspirone, gepirone and ipsapirone have been shown to possess antidepressive-like properties in several animal models of depression as well as in clinical studies. |
1991-09-26 |
2023-08-11 |
rat |
| P Marti. 1-(2-pyrimidinyl)-piperazine may alter the effects of the 5-HT1A agonist in the learned helplessness paradigm in rats. Psychopharmacology. vol 104. issue 2. 1991-09-26. PMID:1678895. |
thus, 1-pp has been evaluated alone (0.06-4 mg/kg/day) or in combination with a selective 5-ht1a agonist 8-oh-dpat (0.25 mg/kg/day) which is not metabolized to 1-pp and buspirone (0.5 mg/kg/day). |
1991-09-26 |
2023-08-11 |
rat |
| D J Sanger, G Perrault, E Morel, D Joly, B Zivkovi. Animal models of anxiety and the development of novel anxiolytic drugs. Progress in neuro-psychopharmacology & biological psychiatry. vol 15. issue 2. 1991-09-13. PMID:1678541. |
compounds, which, like buspirone, are active at 5ht1a receptors may be anxiolytic as may be antagonists at 5ht2 and 5ht3 receptors. |
1991-09-13 |
2023-08-11 |
Not clear |
| Y Kataoka, K Shibata, A Miyazaki, Y Inoue, K Tominaga, S Koizumi, S Ueki, M Niw. Involvement of the dorsal hippocampus in mediation of the antianxiety action of tandospirone, a 5-hydroxytryptamine1A agonistic anxiolytic. Neuropharmacology. vol 30. issue 5. 1991-09-11. PMID:1865994. |
the present findings provide evidence that suggests that tandospirone has an antianxiety action, presumably by stimulating 5-ht1a receptors in the dorsal hippocampus. |
1991-09-11 |
2023-08-11 |
rat |
| H Tanaka, H Shimizu, Y Kumasaka, A Hirose, T Tatsuno, M Nakamur. Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain. Brain research. vol 546. issue 2. 1991-08-22. PMID:1648988. |
in addition, there was no significant difference in the dissociation constant of [3h]tandospirone binding between the dentate gyrus, ca1 area, dorsal raphe nucleus, lateral septum and entorhinal cortex (about 10 nm) suggesting that [3h]tandospirone binds to 5-ht1a receptors with same affinities in these brain structures. |
1991-08-22 |
2023-08-11 |
rat |
| H Tanaka, H Shimizu, Y Kumasaka, A Hirose, T Tatsuno, M Nakamur. Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain. Brain research. vol 546. issue 2. 1991-08-22. PMID:1648988. |
5-ht1a receptors in the hippocampus may participate in the anxiolytic effects of tandospirone. |
1991-08-22 |
2023-08-11 |
rat |
| J Pascual, J Bercian. An open trial of buspirone in migraine prophylaxis. Preliminary report. Clinical neuropharmacology. vol 14. issue 3. 1991-08-22. PMID:2070365. |
because of evidence that supports an important role for the 5-ht1a receptor subtype in migraine, buspirone--the novel 5-ht1a receptor agonist with anxiolytic properties--was given to 33 patients suffering from severe migraine exacerbations. |
1991-08-22 |
2023-08-11 |
Not clear |
| J Pascual, J Bercian. An open trial of buspirone in migraine prophylaxis. Preliminary report. Clinical neuropharmacology. vol 14. issue 3. 1991-08-22. PMID:2070365. |
our results, at first, seem to support the role of a 5-ht1a hypersensitivity in migraine pathogenesis, and warrant further trials to confirm whether buspirone represents an alternative in preventive treatment of migraine exacerbations. |
1991-08-22 |
2023-08-11 |
Not clear |