| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Gobbi, S Cavanus, A Miari, T Mennin. Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: an autoradiographic study. Neuropharmacology. vol 30. issue 4. 1991-08-20. PMID:1649418. |
the results confirmed that buspirone is a selective 5-ht1a ligand, since it inhibited the binding of [3h]5-ht with lower ic50 values (about 100 nm) in regions of the brain of the rat where this receptor subtype is predominant (such as hippocampal areas). |
1991-08-20 |
2023-08-11 |
rat |
| M Gobbi, S Cavanus, A Miari, T Mennin. Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: an autoradiographic study. Neuropharmacology. vol 30. issue 4. 1991-08-20. PMID:1649418. |
acute treatment reduced the binding of [3h]5-ht in all the regions of the brain studied, including those with low levels of 5-ht1a receptors, indicating the occupancy of 5-ht1 receptors by either buspirone or its metabolite. |
1991-08-20 |
2023-08-11 |
rat |
| M H Thiébot, L Dangoumau, G Richard, A J Puec. Safety signal withdrawal: a behavioural paradigm sensitive to both "anxiolytic" and "anxiogenic" drugs under identical experimental conditions. Psychopharmacology. vol 103. issue 3. 1991-08-01. PMID:1676183. |
various 5-ht-related drugs also lessened the behavioural blockade:pcpa (3 x 150 mg/kg) and the 5-ht1a receptor agonists, buspirone (0.25-2 mg/kg), gepirone (0.25-1 mg/kg) but not 8-oh-dpat. |
1991-08-01 |
2023-08-11 |
rat |
| J H Kehne, T C McCloskey, B M Baron, E M Chi, B L Harrison, J P Whitten, M G Palfreyma. NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations. European journal of pharmacology. vol 193. issue 3. 1991-07-31. PMID:1675993. |
the benzodiazepine agonist diazepam suppressed both siv and tip, whereas the 5-ht1a partial agonists, buspirone and mdl 73,005ef, suppressed siv without affecting tip. |
1991-07-31 |
2023-08-11 |
rat |
| G A Higgins, P J Elliot. Differential behavioural activation following intra-raphe infusion of 5-HT1A receptor agonists. European journal of pharmacology. vol 193. issue 3. 1991-07-31. PMID:1675996. |
the behavioural profiles of other 5-ht1a selective compounds, gepirone and bmy7378 were found to be similar to 8-ohdpat. |
1991-07-31 |
2023-08-11 |
rat |
| P Martin, M H Tissier, J Adrien, A J Puec. Antidepressant-like effects of buspirone mediated by the 5-HT1A post-synaptic receptors in the learned helplessness paradigm. Life sciences. vol 48. issue 26. 1991-07-18. PMID:1828519. |
antidepressant-like effects of buspirone mediated by the 5-ht1a post-synaptic receptors in the learned helplessness paradigm. |
1991-07-18 |
2023-08-11 |
Not clear |
| P Martin, M H Tissier, J Adrien, A J Puec. Antidepressant-like effects of buspirone mediated by the 5-HT1A post-synaptic receptors in the learned helplessness paradigm. Life sciences. vol 48. issue 26. 1991-07-18. PMID:1828519. |
the 5-ht1a receptor agonists buspirone and 8-oh-dpat have strong effects on serotoninergic systems. |
1991-07-18 |
2023-08-11 |
Not clear |
| C H Brennan, J M Littleto. Chronic exposure to anxiolytic drugs, working by different mechanisms causes up-regulation of dihydropyridine binding sites on cultured bovine adrenal chromaffin cells. Neuropharmacology. vol 30. issue 2. 1991-06-20. PMID:1674364. |
the inhibition produced by buspirone was unaffected by flumazenil, but was mimicked by the selective 5-ht1a receptor agonist, 8-oh dpat and prevented by the 5-ht receptor antagonist spiperone [10(-6) m]. |
1991-06-20 |
2023-08-11 |
cattle |
| A M Montgomery, I C Rose, L J Herber. 5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward. Journal of neural transmission. General section. vol 83. issue 1-2. 1991-05-28. PMID:1826841. |
5-ht1a agonists and dopamine: the effects of 8-oh-dpat and buspirone on brain-stimulation reward. |
1991-05-28 |
2023-08-11 |
rat |
| A M Montgomery, I C Rose, L J Herber. 5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward. Journal of neural transmission. General section. vol 83. issue 1-2. 1991-05-28. PMID:1826841. |
two specific 5-ht1a agonists, 8-oh-dpat (0-300 micrograms/kg), and buspirone (0-3.0 mg/kg), were tested on variable-interval, threshold-current self-stimulation of rat lateral hypothalamus. |
1991-05-28 |
2023-08-11 |
rat |
| D Treit, K C Berridg. A comparison of benzodiazepine, serotonin, and dopamine agents in the taste-reactivity paradigm. Pharmacology, biochemistry, and behavior. vol 37. issue 3. 1991-05-23. PMID:1982355. |
the putative 5-ht1a agonists, buspirone and gepirone, had a general inhibitory action on both positive and aversive palatability reactions. |
1991-05-23 |
2023-08-11 |
rat |
| K Bervoets, M J Millan, F C Colpaer. Agonist action at 5-HT1C receptors facilitates 5-HT1A receptor-mediated spontaneous tail-flicks in the rat. European journal of pharmacology. vol 191. issue 2. 1991-05-21. PMID:2150818. |
the 5-ht1a receptor partial agonists, buspirone and (+/-)-flesinoxan, evoked tail-flicks only in the presence of tfmpp, mcpp or doi. |
1991-05-21 |
2023-08-11 |
rat |
| I Lucki, S Wielan. 5-Hydroxytryptamine1A receptors and behavioral responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 3. issue 5-6. 1991-04-29. PMID:2078281. |
the special role of behavioral studies in attempting to understand the substrates for the psychotherapeutic actions of 5-hydroxytryptamine1a (5-ht1a)-selective agents, such as buspirone and other azapirones, is reviewed. |
1991-04-29 |
2023-08-11 |
Not clear |
| S Gleeson, J E Barret. 5-HT1A agonist effects on punished responding of squirrel monkeys. Pharmacology, biochemistry, and behavior. vol 37. issue 2. 1991-04-26. PMID:1981937. |
buspirone and other drugs that act as 5-ht1a agonists appear to be clinically effective anxiolytics in humans, yet their anticonflict effects, though robust in pigeons, are equivocal in rodents. |
1991-04-26 |
2023-08-11 |
monkey |
| M J Millan, F C Colpaer. 5-hydroxytryptamine (HT)1A receptors and the tail-flick response. III. Structurally diverse 5-HT1A partial agonists attenuate mu- but not kappa-opioid antinociception in mice and rats. The Journal of pharmacology and experimental therapeutics. vol 256. issue 3. 1991-04-24. PMID:1672381. |
in contrast to the partial agonists, the buspirone metabolite, 1-pyrimidinylpiperazine, which lacks 5-ht1a affinity, and the putative 5-ht1a antagonists, methiothepin, spiperone, bmy 7378 [(8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspirol [4]-decane-7,9-dione) 2hcl] and alprenolol, did not reduce the action of morphine. |
1991-04-24 |
2023-08-11 |
mouse |
| M J Millan, K Bervoets, F C Colpaer. 5-hydroxytryptamine (5-HT)1A receptors and the tail-flick response. I. 8-hydroxy-2-(di-n-propylamino) tetralin HBr-induced spontaneous tail-flicks in the rat as an in vivo model of 5-HT1A receptor-mediated activity. The Journal of pharmacology and experimental therapeutics. vol 256. issue 3. 1991-04-24. PMID:1826033. |
5-ht1a partial agonists, the pyrimidinylpiperazines, buspirone, gepirone and ipsapirone, the halogenated phenylpiperazine, ly 165,163 [1-(2-(4-aminophenyl) ethyl-4-(3-trifluoromethylphenyl)-piperazine], and the benzodioxane, mdl 72832 [8-(4-(1,4-benzodioxan-2-yl-methylamino)-butyl-8-azaspiro-(4 ,5)-decane- 7,9-dione] did not elicit stfs and antagonized the effect of 8-oh-dpat. |
1991-04-24 |
2023-08-11 |
rat |
| Y Claustre, J Benavides, B Scatto. Potential mechanisms involved in the negative coupling between serotonin 5-HT1A receptors and carbachol-stimulated phosphoinositide turnover in the rat hippocampus. Journal of neurochemistry. vol 56. issue 4. 1991-04-15. PMID:1848278. |
various 5-ht1a receptor agonists were found to inhibit carbachol (10 microm)-stimulated formation of total inositol phosphates in immature rat hippocampal slices with the following rank order of potency (ic50 values in nm): 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat) (11) greater than ipsapirone (20) greater than gepirone (120) greater than ru 24969 (140) greater than buspirone (560) greater than 1-(m-trifluoromethylphenyl)piperazine (1,500) greater than methysergide (5,644); selective 5-ht1b, 5-ht2, and 5-ht3 receptor agonists were inactive. |
1991-04-15 |
2023-08-11 |
rat |
| E F Coccaro, S Gabriel, L J Sieve. Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274641. |
buspirone challenge: preliminary evidence for a role for central 5-ht1a receptor function in impulsive aggressive behavior in humans. |
1991-02-26 |
2023-08-11 |
human |
| E F Coccaro, S Gabriel, L J Sieve. Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274641. |
the prolactin (prl) response to challenge with buspirone hydrochloride, a serotonin1a (5-ht1a) receptor agonist, was examined in 5 healthy male volunteers and in 10 healthy male and female patients with primary dsm-iii personality disorder. |
1991-02-26 |
2023-08-11 |
human |
| E F Coccaro, S Gabriel, L J Sieve. Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans. Psychopharmacology bulletin. vol 26. issue 3. 1991-02-26. PMID:2274641. |
these data suggest that the prl response to buspirone challenge reflects the responsivity of 5-ht1a receptors in the limbic-hypothalamus in humans and that reduced sensitivity of these receptors is associated with an important component of impulsive aggressive behaviors in personality disorder patients. |
1991-02-26 |
2023-08-11 |
human |