| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Blier, C de Montign. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. Journal of cardiovascular pharmacology. vol 15 Suppl 7. 1991-02-11. PMID:1702486. |
gepirone and 8-oh-dpat, two 5-ht1a agonists, when administered intravenously or applied by microiontophoresis, dose-dependently decreased the firing rate of these 5-ht neurons. |
1991-02-11 |
2023-08-11 |
rat |
| P Blier, C de Montign. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. Journal of cardiovascular pharmacology. vol 15 Suppl 7. 1991-02-11. PMID:1702486. |
gepirone acted as a full agonist at the somatodendritic 5-ht autoreceptor, which is of the 5-ht1a subtype. |
1991-02-11 |
2023-08-11 |
rat |
| P Blier, C de Montign. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. Journal of cardiovascular pharmacology. vol 15 Suppl 7. 1991-02-11. PMID:1702486. |
at these postsynaptic 5-ht1a receptors, however, gepirone acted as a partial agonist. |
1991-02-11 |
2023-08-11 |
rat |
| P Blier, C de Montign. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. Journal of cardiovascular pharmacology. vol 15 Suppl 7. 1991-02-11. PMID:1702486. |
the 14-day treatment with gepirone did not induce a desensitization of 5-ht1a receptors on postsynaptic pyramidal neurons. |
1991-02-11 |
2023-08-11 |
rat |
| P J Elliott, D M Walsh, S P Close, G A Higgins, A G Haye. Behavioural effects of serotonin agonists and antagonists in the rat and marmoset. Neuropharmacology. vol 29. issue 10. 1991-01-24. PMID:2123971. |
drugs acting as agonists at the 5-ht1a receptor (8-ohdpat, gepirone, bmy-7378, nan-190, papp (ly165163) and flesinoxan) and 5-ht2/1c receptors (doi) were found to reverse neuroleptic-induced catalepsy in the rat whereas 5-ht2/1c antagonists (mianserin, ritanserin and ici-170,809) and the 5-ht1 antagonist ((+/-)pindolol) increased catalepsy. |
1991-01-24 |
2023-08-11 |
rat |
| G Curzo. Serotonin and appetite. Annals of the New York Academy of Sciences. vol 600. 1991-01-14. PMID:2252331. |
thus, 5-ht1a agonists (8-ohdpat, buspirone, gepirone, etc.) |
1991-01-14 |
2023-08-11 |
human |
| J L Rausch, R Ruegg, F G Moelle. Gepirone as a 5-HT1A agonist in the treatment of major depression. Psychopharmacology bulletin. vol 26. issue 2. 1990-12-14. PMID:1978370. |
gepirone as a 5-ht1a agonist in the treatment of major depression. |
1990-12-14 |
2023-08-11 |
human |
| J L Rausch, R Ruegg, F G Moelle. Gepirone as a 5-HT1A agonist in the treatment of major depression. Psychopharmacology bulletin. vol 26. issue 2. 1990-12-14. PMID:1978370. |
twenty-four patients with major depression were treated in a single-blind design with 25 mg to 75 mg gepirone, a pyrimidinyl piperidinedione analog of buspirone with serotonin1a (5-ht1a) receptor affinity properties. |
1990-12-14 |
2023-08-11 |
human |
| C F Flaherty, P S Grigson, M K Demetrikopoulos, M S Weaver, K L Krauss, G A Rowa. Effect of serotonergic drugs on negative contrast in consummatory behavior. Pharmacology, biochemistry, and behavior. vol 36. issue 4. 1990-11-14. PMID:2145592. |
the effect of acute and chronic administration of the 5-ht1a agonist buspirone on successive negative contrast was investigated in experiments 1-6. |
1990-11-14 |
2023-08-11 |
rat |
| C F Flaherty, P S Grigson, M K Demetrikopoulos, M S Weaver, K L Krauss, G A Rowa. Effect of serotonergic drugs on negative contrast in consummatory behavior. Pharmacology, biochemistry, and behavior. vol 36. issue 4. 1990-11-14. PMID:2145592. |
in experiment 7 the 5-ht1a agonist gepirone (2.5, 5.0 and 10.0 mg/kg) was also found to be ineffective in reducing contrast but, at the higher doses, decreased overall sucrose intake. |
1990-11-14 |
2023-08-11 |
rat |
| L W Rogers, J Giordan. Effects of systemically administered monoamine reuptake blocking agents on patterns of buspirone-induced analgesia in rats. Life sciences. vol 47. issue 11. 1990-11-13. PMID:2145489. |
we have recently shown the serotonin 5-ht1a receptor agonist buspirone to produce analgesia in several pain tests in rats. |
1990-11-13 |
2023-08-11 |
rat |
| L W Rogers, J Giordan. Effects of systemically administered monoamine reuptake blocking agents on patterns of buspirone-induced analgesia in rats. Life sciences. vol 47. issue 11. 1990-11-13. PMID:2145489. |
as a 5-ht1a agonist, buspirone may change serotonergic (5-ht) tone to alter the balance of central monoaminergic (ma) systems that function in analgesia. |
1990-11-13 |
2023-08-11 |
rat |
| K Rickel. Buspirone in clinical practice. The Journal of clinical psychiatry. vol 51 Suppl. 1990-11-06. PMID:2211569. |
buspirone, an azapirone derivative and a 5-ht1a partial agonist, is the first nonbenzodiazepine anxiolytic introduced into medicine for the treatment of generalized anxiety disorder. |
1990-11-06 |
2023-08-11 |
Not clear |
| S Wieland, I Luck. Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test. Psychopharmacology. vol 101. issue 4. 1990-09-27. PMID:1975107. |
the 5-ht1a agonists 8-oh-dpat (0.125-1.0 mg/kg, sc) and tandospirone (sm-3997) (5-20 mg/kg, sc) both produced dose-related decreases in immobility time following subchronic treatment in rats. |
1990-09-27 |
2023-08-11 |
rat |
| S Wieland, I Luck. Antidepressant-like activity of 5-HT1A agonists measured with the forced swim test. Psychopharmacology. vol 101. issue 4. 1990-09-27. PMID:1975107. |
in addition, the 5-ht1a agonists, buspirone (20 mg/kg), gepirone (20 mg/kg) and ipsapirone (10 and 20 mg/kg) demonstrated antidepressant-like effects. |
1990-09-27 |
2023-08-11 |
rat |
| A Hamik, D Oksenberg, C Fischette, S J Peroutk. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biological psychiatry. vol 28. issue 2. 1990-09-12. PMID:1974152. |
tandospirone is most potent at the 5-ht1a receptor, displaying a ki value of 27 +/- 5 nm. |
1990-09-12 |
2023-08-11 |
rat |
| A Hamik, D Oksenberg, C Fischette, S J Peroutk. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biological psychiatry. vol 28. issue 2. 1990-09-12. PMID:1974152. |
based on adenylate cyclase studies which measure 5-ht1a receptor-mediated effects, tandospirone displays approximately 60% of the agonist effect of 8-oh-dpat, a selective 5-ht1a agonist. |
1990-09-12 |
2023-08-11 |
rat |
| A Hamik, D Oksenberg, C Fischette, S J Peroutk. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biological psychiatry. vol 28. issue 2. 1990-09-12. PMID:1974152. |
thus, the primary pharmacological effect of tandospirone appears to be partial agonism at the 5-ht1a receptor, an activity similar to other pyrimidinyl-piperazines which are being developed as novel anxiolytic agents. |
1990-09-12 |
2023-08-11 |
rat |
| P Blier, C de Montign. Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973935. |
the sustained administration of the serotonin (5-hydroxytryptamine1a, 5-ht1a) agonist gepirone (15 mg/kg/day subcutaneously) in the rat produced an initial decrease of the firing activity of dorsal raphe 5-ht neurons, which was followed by a progressive recovery to normal after 14 days of treatment. |
1990-09-05 |
2023-08-11 |
rat |
| P Blier, C de Montign. Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies. Journal of clinical psychopharmacology. vol 10. issue 3 Suppl. 1990-09-05. PMID:1973935. |
at this point, the somatodendritic 5-ht1a autoreceptor had desensitized, as indicated by the reduced effectiveness of intravenous lysergic acid diethylamide (lsd) and of microiontophoretic applications of 5-ht, lsd, 8-hydroxy-2-(n,n-propylamino) tetralin (8-oh-dpat), and gepirone, but not of gamma-aminobutyric acid in depressing the firing activity of 5-ht neurons. |
1990-09-05 |
2023-08-11 |
rat |