| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D C Blanchard, R J Rodgers, C A Hendrie, K Hor. 'Taming' of wild rats (Rattus rattus) by 5HT1A agonists buspirone and gepirone. Pharmacology, biochemistry, and behavior. vol 31. issue 2. 1989-06-06. PMID:3244704. |
a battery of tests designed to elicit reactions to a variety of nonpainful threat stimuli was used to study the effects of the 5ht1a agonists buspirone (5-20 mg/kg), and gepirone (5-20 mg/kg) on the defensive repertoire of wild rattus rattus. |
1989-06-06 |
2023-08-11 |
human |
| J F Nash, H Y Meltze. Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. The Journal of pharmacology and experimental therapeutics. vol 249. issue 1. 1989-06-01. PMID:2565390. |
previous studies have demonstrated that the 5-hydroxytryptamine1a (5-ht1a) agonist buspirone stimulated rat prolactin (prl) secretion. |
1989-06-01 |
2023-08-11 |
rat |
| J F Nash, H Y Meltze. Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. The Journal of pharmacology and experimental therapeutics. vol 249. issue 1. 1989-06-01. PMID:2565390. |
administration of the 5-ht1a agonists gepirone (gep) or ipsapirone (ips) s.c. in doses from 1 to 10 mg/kg had no effect on prl secretion in male rats. |
1989-06-01 |
2023-08-11 |
rat |
| T Sharp, S R Bramwell, D G Grahame-Smit. 5-HT1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. British journal of pharmacology. vol 96. issue 2. 1989-05-05. PMID:2466516. |
similarly, the putative 5-ht1a agonists gepirone (5 mg kg-1, s.c.), ipsapirone (5 mg kg-1, s.c.) and buspirone (5 mg kg-1, s.c.) markedly reduced levels of 5-ht in hippocampal perfusates whereas their common metabolite 1-(2-pyrimidinyl) piperazine (5 mg kg-1, s.c.), which does not bind to central 5-ht1a recognition sites, had no effect. |
1989-05-05 |
2023-08-11 |
rat |
| F Gilbert, C T Dourish, C Brazell, S McClue, S M Stah. Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology. vol 13. issue 6. 1989-05-05. PMID:2907164. |
rats were injected with either the high affinity 5-ht1a agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) (0.016-1.0 mg/kg, s.c.) or the novel anxiolytics buspirone, gepirone or ipsapirone (2.0-16.0 mg/kg, s.c.), and either had their food intake measured 2 hr post injection or were sacrificed 30-40 min post injection for measurement of plasma acth. |
1989-05-05 |
2023-08-11 |
rat |
| W Marszalec, E G Anderso. Three putative 5-HT1A agonists act as 5-HT antagonists in frog sensory neurons. European journal of pharmacology. vol 154. issue 3. 1989-04-28. PMID:2976672. |
the putative 5-ht1a agonists 8-hydroxy-dipropylaminotetralin (dpat), buspirone and p-aminophenylethyl-m-trifluoromethylphenyl piperazine (papp) were tested for their ability to narrow the action potentials of bullfrog sensory neurons, a serotonergic response observed to be blocked by the 5-ht1a antagonists spiperone and spiroxitrine. |
1989-04-28 |
2023-08-11 |
Not clear |
| R S Mansbach, M A Geye. Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands. European journal of pharmacology. vol 156. issue 3. 1989-03-09. PMID:2975225. |
the non-benzodiazepine anxiolytics buspirone (1.25-5.0 mg/kg), gepirone (3.0-10.0 mg/kg) and the related 5-ht1a ligand ipsapirone (1.0-10.0 mg/kg) blocked potentiated startle, though effects of the non-selective serotonin antagonist methysergide (0.3-10.0 mg/kg) fell short of significance. |
1989-03-09 |
2023-08-11 |
rat |
| R S Mansbach, M A Geye. Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands. European journal of pharmacology. vol 156. issue 3. 1989-03-09. PMID:2975225. |
these data support a role for the 5-ht1a binding site in the anti-anxiety effects of buspirone and related compounds over a range of behavioral procedures. |
1989-03-09 |
2023-08-11 |
rat |
| C Waeber, P Schoeffter, J M Palacios, D Hoye. Molecular pharmacology of 5-HT1D recognition sites: radioligand binding studies in human, pig and calf brain membranes. Naunyn-Schmiedeberg's archives of pharmacology. vol 337. issue 6. 1989-03-02. PMID:2975354. |
in contrast, these sites showed low affinity for drugs with high affinity and/or selectivity for 5-ht1a (8-oh-dpat, buspirone), 5-ht1b (21-009, ru 24969), 5-ht1c (mesulergine, mianserin) and 5-ht2 sites (ketanserin, cinanserin). |
1989-03-02 |
2023-08-11 |
human |
| J E Barrett, C Fleck-Kandath, R S Mansbac. Effects of buspirone differ from those of gepirone and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on unpunished responding of pigeons. Pharmacology, biochemistry, and behavior. vol 30. issue 3. 1989-02-23. PMID:2905470. |
under several behavioral procedures, such as punished responding and drug discrimination, the effects of the atypical anxiolytic buspirone are similar to those of its analogue gepirone, and to those of the 5-ht1a receptor agonist 8-oh-dpat. |
1989-02-23 |
2023-08-11 |
Not clear |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
modification of 5-ht neuron properties by sustained administration of the 5-ht1a agonist gepirone: electrophysiological studies in the rat brain. |
1989-02-23 |
2023-08-11 |
rat |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
the sustained administration of the 5-ht1a agonist gepirone (15 mg/kg/day, s.c.) in the rat produced an initial decrease of the firing activity of dorsal raphe 5-ht neurons which was followed by a progressive recovery to normal after 14 days of treatment. |
1989-02-23 |
2023-08-11 |
rat |
| P Blier, C de Montign. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). vol 1. issue 5. 1989-02-23. PMID:2905533. |
it is concluded that the progressive restoration of the firing activity of 5-ht neurons, due to a desensitization of the somatodendritic 5-ht autoreceptor, combined with the direct activation of normosensitive postsynaptic 5-ht1a receptor by gepirone, should result in an augmented tonic activation of postsynaptic 5-ht1a receptors. |
1989-02-23 |
2023-08-11 |
rat |
| S J Cooper, M J Fryer, J C Neil. Specific effect of putative 5-HT1A agonists, 8-OH-DPAT and gepirone, to increase hypertonic saline consumption in the rat: evidence against a general hyperdipsic action. Physiology & behavior. vol 43. issue 4. 1989-01-11. PMID:2973613. |
specific effect of putative 5-ht1a agonists, 8-oh-dpat and gepirone, to increase hypertonic saline consumption in the rat: evidence against a general hyperdipsic action. |
1989-01-11 |
2023-08-11 |
rat |
| F G Szele, D L Murphy, N A Garric. Effects of fenfluramine, m-chlorophenylpiperazine, and other serotonin-related agonists and antagonists on penile erections in nonhuman primates. Life sciences. vol 43. issue 16. 1988-11-16. PMID:3172981. |
in contrast, serotonin (5-ht) agonists with 5-ht1a site specificity (8-oh-dpat, buspirone) as well as trazodone, ritanserin, and metergoline were no different from saline in producing penile erections. |
1988-11-16 |
2023-08-11 |
monkey |
| C R Gardne. Potential use of drugs modulating 5HT activity in the treatment of anxiety. General pharmacology. vol 19. issue 3. 1988-10-20. PMID:2901381. |
buspirone is clinically active in the treatment of anxiety and it, and other anxiolytic candidates, gepirone and isapirone, may act as agonists (or perhaps partial agonists) on 5ht1a receptors. |
1988-10-20 |
2023-08-11 |
Not clear |
| C T Dourish, M L Clark, S D Iverse. 8-OH-DPAT elicits feeding and not chewing: evidence from liquid diet studies and a diet choice test. Psychopharmacology. vol 95. issue 2. 1988-10-04. PMID:2970649. |
therefore, the effects of 8-oh-dpat and another 5-ht1a agonist gepirone on the consumption of a liquid chow diet, by free feeding male rats, were examined. |
1988-10-04 |
2023-08-11 |
rat |
| J I Koenig, H Y Meltzer, G A Gudelsk. 5-Hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone. Pharmacology, biochemistry, and behavior. vol 29. issue 4. 1988-09-29. PMID:2901112. |
it is concluded that buspirone, gepirone and ipsapirone produce hypothermia and increase plasma concentrations of corticosterone by activating 5-ht1a receptor mechanisms. |
1988-09-29 |
2023-08-11 |
rat |
| M Hamon, C M Fattaccini, J Adrien, M C Gallissot, P Martin, H Gozla. Alterations of central serotonin and dopamine turnover in rats treated with ipsapirone and other 5-hydroxytryptamine1A agonists with potential anxiolytic properties. The Journal of pharmacology and experimental therapeutics. vol 246. issue 2. 1988-09-19. PMID:2457083. |
administration of other 5-ht1a agonists like buspirone and gepirone, but not 8-oh-dpat. |
1988-09-19 |
2023-08-11 |
rat |
| J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology. vol 149. issue 1-2. 1988-08-31. PMID:2969339. |
spiperone, but not ly53837 (a 5-ht2 antagonist), antagonized the inhibition induced by 5-ht1a agonists 8-hydroxy-dipropylaminotetralin (8-oh-dpat) and buspirone in the dorsal raphe nucleus. |
1988-08-31 |
2023-08-11 |
Not clear |