| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masayoshi Mori, Yusuke Murata, Asami Matsuo, Tomoyo Takemoto, Kazunori Min. Chronic Treatment with the 5-HT1A Receptor Partial Agonist Tandospirone Increases Hippocampal Neurogenesis. Neurology and therapy. vol 3. issue 1. 2015-05-22. PMID:26000223. |
chronic treatment with the 5-ht1a receptor partial agonist tandospirone increases hippocampal neurogenesis. |
2015-05-22 |
2023-08-13 |
human |
| Fatemeh Sheikhmoonesi, Mehran Zarghami, Seyyedeh Fatemeh Bahari Saravi, Alireza Khalilian, Shahram Al. A triple-blinded, randomized, placebo-controlled trial to examine the efficacy of buspirone added to typical antipsychotic drugs in patients with chronic schizophrenia. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. vol 20. issue 2. 2015-05-18. PMID:25983765. |
the purpose of this study was to test the hypothesis that the addition of buspirone, a partial agonist of 5ht1a receptor, to ongoing treatment with typical antipsychotics would improve the positive and negative symptoms in patients with chronic schizophrenia. |
2015-05-18 |
2023-08-13 |
Not clear |
| Sung Won Kim, Joanna S Fowler, Phil Skolnick, Lisa Muench, Yeona Kang, Colleen Shea, Jean Logan, Dohyun Kim, Pauline Carter, Payton King, David Alexoff, Nora D Volko. Therapeutic doses of buspirone block D3 receptors in the living primate brain. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24679922. |
buspirone, originally characterized as a 5-ht1a partial agonist and used as an anxiolytic, also binds to d3r and d4r with high affinity, with lower affinity to d2r, and interferes with cocaine reward. |
2015-04-14 |
2023-08-12 |
Not clear |
| M K Fomina, D F Avgustinovich, T G Tolstikov. [Effects of buspirone complex with glycyrrhizic acid on behavior of mice with anxious-depressive state]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. vol 100. issue 7. 2015-03-03. PMID:25669106. |
we report here studies of the effects of subchronic administration of 5-ht1a receptor agonist buspirone and its novel complex with glycyrrhizic acid (ga) to c57bl/6j mice at the different stages of the anxious-depressive state formation, induced by conditions of social stress. |
2015-03-03 |
2023-08-13 |
mouse |
| Adam J Prus, Todd M Hillhouse, Amber L LaCross. Acute, but not repeated, administration of the neurotensin NTS1 receptor agonist PD149163 decreases conditioned footshock-induced ultrasonic vocalizations in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 49. 2014-12-31. PMID:24275076. |
pd149163 and the 5-ht1a receptor partial agonist buspirone produced a statistically significant reduction of 22khz usv counts. |
2014-12-31 |
2023-08-12 |
rat |
| Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocell. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. vol 81. 2014-12-15. PMID:24548822. |
second, the effects produced by intravenous administration of 5-ht1a ligands (partial agonist buspirone 10mgkg(-1), antagonist way100135 0.5-5mgkg(-1)), 5-ht2a antagonist sarpogrelate (10mgkg(-1)), 5-ht3 antagonist alosetron (0.1mgkg(-1)), 5-ht4 antagonist gr125487 (5mgkg(-1)) and 5-ht re-uptake inhibitor fluoxetine (10mgkg(-1)) on i/r-induced inflammatory response were investigated in i/r mice and compared to those obtained in sham-operated animals (s). |
2014-12-15 |
2023-08-12 |
mouse |
| Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocell. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. vol 81. 2014-12-15. PMID:24548822. |
the ability of α7 nicotinic receptor (α7nachr) antagonist methyllycaconitine (5mgkg(-1)) to counteract the beneficial action provided by buspirone on i/r-induced neutrophil infiltration suggests that the anti-inflammatory effect produced by 5-ht1a receptor antagonism could be partly ascribed to the indirect activation of α7nach receptors. |
2014-12-15 |
2023-08-12 |
mouse |
| Garikoitz Azkona, Ainhoa Sagarduy, Asier Aristieta, Nerea Vazquez, Verónica Zubillaga, José Angel Ruíz-Ortega, Esther Pérez-Navarro, Luisa Ugedo, Rosario Sánchez-Pernaut. Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats. Neuropharmacology. vol 79. 2014-12-03. PMID:24333147. |
we then investigated the molecular substrates implicated in the anti-dyskinetic effect of buspirone, a 5ht1a partial agonist. |
2014-12-03 |
2023-08-12 |
rat |
| Garikoitz Azkona, Ainhoa Sagarduy, Asier Aristieta, Nerea Vazquez, Verónica Zubillaga, José Angel Ruíz-Ortega, Esther Pérez-Navarro, Luisa Ugedo, Rosario Sánchez-Pernaut. Buspirone anti-dyskinetic effect is correlated with temporal normalization of dysregulated striatal DRD1 signalling in L-DOPA-treated rats. Neuropharmacology. vol 79. 2014-12-03. PMID:24333147. |
pharmacological experiments combining buspirone with 5ht1a and drd3 antagonists confirmed that normalization of both pdarpp32 and perk2 is required, but not sufficient, for blocking dyskinesias. |
2014-12-03 |
2023-08-12 |
rat |
| Huma Ikram, Muhammad Azhar, Muhammad Jameel, Khalida Ban. Conformational analysis and geometry optimization of buspirone-A 5-HT1A receptor agonist. Pakistan journal of pharmaceutical sciences. vol 27. issue 5 Spec no. 2014-11-07. PMID:25176246. |
buspirone, a partial 5-ht1a receptor agonist, is a clinically prescribed anxiolytic. |
2014-11-07 |
2023-08-13 |
Not clear |
| R H McAllister-Williams, H A Alhaj, A Massey, J Pankiv, U Reckerman. Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone. Psychological medicine. vol 44. issue 4. 2014-10-22. PMID:23809646. |
somatodendritic 5-hydroxytryptamine1a (5-ht1a) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone. |
2014-10-22 |
2023-08-12 |
Not clear |
| Sumitaka Inoue, Hiroki Shikanai, Machiko Matsumoto, Sachiko Hiraide, Yasuhiro Saito, Yoshiki Yanagawa, Mitsuhiro Yoshioka, Kei-ichi Shimamura, Hiroko Togash. Metaplastic regulation of the median raphe nucleus via serotonin 5-HT1A receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats. Journal of pharmacological sciences. vol 124. issue 3. 2014-09-30. PMID:24599137. |
pretreatment with the 5-ht1a receptor agonists tandospirone (10 mg/kg, i.p.) |
2014-09-30 |
2023-08-12 |
rat |
| Kenji Maeda, Linda Lerdrup, Haruhiko Sugino, Hitomi Akazawa, Naoki Amada, Robert D McQuade, Tine Bryan Stensbøl, Christoffer Bundgaard, Jørn Arnt, Tetsuro Kikuch. Brexpiprazole II: antipsychotic-like and procognitive effects of a novel serotonin-dopamine activity modulator. The Journal of pharmacology and experimental therapeutics. vol 350. issue 3. 2014-09-29. PMID:24947464. |
in the nor test, the 5-ht1a agonist buspirone and the 5-ht2a antagonist m100907 [(r)-(2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)piperidin-4-yl]methanol] partially but significantly reversed pcp-induced impairment. |
2014-09-29 |
2023-08-13 |
rat |
| Takashi Uehara, Tadasu Matsuoka, Tomiki Sumiyosh. Tandospirone, a 5-HT1A partial agonist, ameliorates aberrant lactate production in the prefrontal cortex of rats exposed to blockade of N-methy-D-aspartate receptors; Toward the therapeutics of cognitive impairment of schizophrenia. Frontiers in behavioral neuroscience. vol 8. 2014-09-18. PMID:25232308. |
tandospirone, a 5-ht1a partial agonist, ameliorates aberrant lactate production in the prefrontal cortex of rats exposed to blockade of n-methy-d-aspartate receptors; toward the therapeutics of cognitive impairment of schizophrenia. |
2014-09-18 |
2023-08-13 |
rat |
| Eunju Shin, Carlo Lisci, Elisabetta Tronci, Camino Fidalgo, Roberto Stancampiano, Anders Björklund, Manolo Cart. The anti-dyskinetic effect of dopamine receptor blockade is enhanced in parkinsonian rats following dopamine neuron transplantation. Neurobiology of disease. vol 62. 2014-09-03. PMID:24135006. |
beginning at 20weeks after transplantation rats were subjected to pharmacological treatments with either l-dopa (6mg/kg) or amphetamine (1.5mg/kg) alone, or in combination with the d1 receptor antagonist sch23390, the d2 receptor antagonist eticlopride, and the 5-ht1a agonist/d2 receptor antagonist buspirone. |
2014-09-03 |
2023-08-12 |
rat |
| Eunju Shin, Carlo Lisci, Elisabetta Tronci, Camino Fidalgo, Roberto Stancampiano, Anders Björklund, Manolo Cart. The anti-dyskinetic effect of dopamine receptor blockade is enhanced in parkinsonian rats following dopamine neuron transplantation. Neurobiology of disease. vol 62. 2014-09-03. PMID:24135006. |
in agreement with our previous results, the effect of buspirone was independent from 5-ht1a receptor activation, as it was not counteracted by the selective 5-ht1a antagonist way100635, but likely due to d2 receptor blockade. |
2014-09-03 |
2023-08-12 |
rat |
| Maximiliano Rapanelli, Luciana Romina Frick, Micaela Bernardez-Vidal, Bonifacio Silvano Zanutt. Different MK-801 administration schedules induce mild to severe learning impairments in an operant conditioning task: role of buspirone and risperidone in ameliorating these cognitive deficits. Behavioural brain research. vol 257. 2014-06-25. PMID:24095879. |
next, we orally administered risperidone (serotonin receptor 2a and dopamine receptor 2 antagonist, 1mg/kg) or buspirone (serotonin receptor 1a partial agonist, 10mg/kg) to animals treated with the mk-801 schedule described above. |
2014-06-25 |
2023-08-12 |
rat |
| Louis F Fabre, Cees J Timme. Effects of food on the bioavailability of gepirone from extended-release tablets in humans: results of two open-label crossover studies. Current therapeutic research, clinical and experimental. vol 64. issue 8. 2014-06-19. PMID:24944406. |
the new antidepressant gepirone acts preferentially on 5-hydroxytryptamine type 1a (5-ht1a) receptors and functions as a 5-ht1a agonist. |
2014-06-19 |
2023-08-13 |
Not clear |
| David S Baldwi. Serotonin noradrenaline reuptake inhibitors: A new generation of treatment for anxiety disorders. International journal of psychiatry in clinical practice. vol 10 Suppl 2. 2014-06-14. PMID:24921677. |
the probable role of disturbed serotonergic neurotransmission in anxiety is widely accepted and is the theoretical basis for the use of serotonergic agents such as the 5-ht1a receptor partial agonist, buspirone, and the selective serotonin reuptake inhibitors (ssri), such as sertraline and paroxetine, which have largely replaced the earlier antidepressants. |
2014-06-14 |
2023-08-13 |
Not clear |
| Kristin A Connors, Theodore W Valenti, Kelly Lawless, James Sackerman, Emmanuel S Onaivi, Bryan W Brooks, Georgianna G Goul. Similar anxiolytic effects of agonists targeting serotonin 5-HT1A or cannabinoid CB receptors on zebrafish behavior in novel environments. Aquatic toxicology (Amsterdam, Netherlands). vol 151. 2014-05-22. PMID:24411165. |
in mammals both 5-ht1a and cb agonists, such as buspirone and win55,212-2, reduce anxious behaviors. |
2014-05-22 |
2023-08-12 |
zebrafish |