All Relations between 5-ht receptor 1a and dorsal raphe

Reference Sentence Publish Date Extraction Date Species
L Lanfumey, M C Pardon, N Laaris, C Joubert, N Hanoun, M Hamon, C Cohen-Salmo. 5-HT1A autoreceptor desensitization by chronic ultramild stress in mice. Neuroreport vol 10 issue 16 2000 10599847 This treatment produced a significant decrease in the potency of the 5-HT1A agonist ipsapirone to inhibit the electrical activity of serotoninergic neurons in the dorsal raphe nucleus, without modifying 5-HT1A receptor binding in various brain areas. 2000-02-28 2022-01-08 mouse
C Davidson, J A Stamfor. Effect of chronic paroxetine treatment on 5-HT1B and 5-HT1D autoreceptors in rat dorsal raphe nucleus. Neurochemistry international vol 36 issue 2 2000 10676872 These data suggest that chronic paroxetine treatment may desensitise 5-HT1B autoreceptors in the dorsal raphe nucleus but that this effect is unmasked only when the dominant 5-HT1A autoreceptor control is antagonised. 2000-02-25 2022-01-08 rat
E Le Poul, C Boni, N Hanoun, A M Laporte, N Laaris, J Chauveau, M Hamon, L Lanfume. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology vol 39 issue 1 2000 10665824 Electrophysiological recordings in brain slices showed that chronic fluoxetine treatment reduced the potency of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin to inhibit neuronal activity in the dorsal raphe nucleus, but did not affect 5-HT1A-evoked responses of CA1 pyramidal cells in the hippocampus. 2000-02-18 2022-01-08 rat
G Juckel, U Hegerl, M Moln\\xc3\\xa1r, V Cs\\xc3\\xa9pe, G Karmo. Auditory evoked potentials reflect serotonergic neuronal activity--a study in behaving cats administered drugs acting on 5-HT1A autoreceptors in the dorsal raphe nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 21 issue 6 2000 10633476 Auditory evoked potentials reflect serotonergic neuronal activity--a study in behaving cats administered drugs acting on 5-HT1A autoreceptors in the dorsal raphe nucleus. 2000-01-28 2022-01-08 Not clear
G Juckel, U Hegerl, M Moln\\xc3\\xa1r, V Cs\\xc3\\xa9pe, G Karmo. Auditory evoked potentials reflect serotonergic neuronal activity--a study in behaving cats administered drugs acting on 5-HT1A autoreceptors in the dorsal raphe nucleus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 21 issue 6 2000 10633476 The present study examines the effects of microinjection of a 5-HT1A agonist (8-OH-DPAT) and a 5-HT1A antagonist (spiperone) into the dorsal raphe nucleus (DRN) on AEP recorded epidurally from the primary and secondary auditory cortex in behaving cats. 2000-01-28 2022-01-08 Not clear
A Evrard, A M Laporte, M Chastanet, R Hen, M Hamon, J Adrie. 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice. The European journal of neuroscience vol 11 issue 11 1999 10583471 Altogether, these data indicate that in the mouse, the firing of 5-HT neurons in the dorsal raphe nucleus is under both an inhibitory control through 5-HT1A receptors and an excitatory influence through 5-HT1B receptors. 1999-12-28 2022-01-08 mouse
A Evrard, A M Laporte, M Chastanet, R Hen, M Hamon, J Adrie. 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice. The European journal of neuroscience vol 11 issue 11 1999 10583471 5-HT1A and 5-HT1B receptors control the firing of serotoninergic neurons in the dorsal raphe nucleus of the mouse: studies in 5-HT1B knock-out mice. 1999-12-28 2022-01-08 mouse
J S Sprouse, L S Reynolds, J P Braselton, H Rollema, S H Zor. Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 21 issue 5 1999 10516958 The goal of the present study was to examine the 5-HT1A properties of ziprasidone in vivo using as a marker of central 5-HT1A activity the inhibition of firing of serotonin-containing neurons in the dorsal raphe nucleus. 1999-11-15 2022-01-08 rat
S Herges, D A Taylo. Modulation of cocaine-induced locomotor activity, rears and head bobs by application of WAY100635 into the dorsal and median raphe nuclei of the rat. Naunyn-Schmiedeberg's archives of pharmacology vol 360 issue 2 1999 10494881 It may be suggested from these results that stimulation of somatodendritic 5-HT1A autoreceptors located in the dorsal raphe nucleus mediates an inhibitory effect on cocaine-induced locomotor activity and head bobs, whereas somatodendritic 5-HT1A autoreceptors in the median raphe nucleus are not involved in the inhibitory role of 5-HT on the stimulant effect of cocaine on locomotor activity and head bobs. 1999-11-08 2022-01-08 rat
J M Casanovas, I Herv\\xc3\\xa1s, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport vol 10 issue 7 1999 10380960 This agent also reversed the decrease in 5-HT output elicited by the novel 5-HT1A receptor agonist BAY x 3702 (30 microM) in mPFC and dorsal raphe nucleus. 1999-09-16 2022-01-08 rat
E T Fonoff, C P Silva, G Ballester, C Timo-Iari. Electro-oscillographic correlation between dorsal raphe nucleus, neocortex and hippocampus during wakefulness before and after serotoninergic inactivation. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas vol 32 issue 4 1999 10347812 In the present study we analyzed frequency modulation (through instantaneous frequency variation) of theta waves occurring in three cortical areas, in hippocampal CA1 and in the dorsal raphe nucleus of Wistar rats during normal wakefulness and after injection of the 5-HT1a receptor agonist 8-OH-DPAT into the dorsal raphe. 1999-09-09 2022-01-08 rat
J L Yau, T Olsson, J Noble, J R Seck. Serotonin receptor subtype gene expression in the hippocampus of aged rats following chronic amitriptyline treatment. Brain research. Molecular brain research vol 70 issue 2 1999 10407176 Amitriptyline treatment decreased 5-HT1A receptor mRNA expression in the dorsal raphe nucleus of the aged rats (24% fall compared to saline treated controls, p<0.01) but not in the young rats. 1999-09-08 2022-01-08 rat
B O Ward, L S Wilkinson, T W Robbins, B J Everit. Forebrain serotonin depletion facilitates the acquisition and performance of a conditional visual discrimination task in rats. Behavioural brain research vol 100 issue 1-2 1999 10212053 This latter finding was also observed in a third experiment, in which the infusion of the 5-HT1A receptor partial agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OHDPAT), directly into the dorsal raphe nucleus improved the performance of unlesioned rats following an increase in the rate of stimulus presentations. 1999-07-28 2022-01-08 rat
E Le Poul, N Laaris, E Doucet, C M Fattaccini, E Moca\\xc3\\xabr, M Hamon, L Lanfume. Chronic alnespirone-induced desensitization of somatodendritic 5-HT1A autoreceptors in the rat dorsal raphe nucleus. European journal of pharmacology vol 365 issue 2-3 1999 9988099 Chronic alnespirone-induced desensitization of somatodendritic 5-HT1A autoreceptors in the rat dorsal raphe nucleus. 1999-04-29 2022-01-08 rat
E Le Poul, N Laaris, E Doucet, C M Fattaccini, E Moca\\xc3\\xabr, M Hamon, L Lanfume. Chronic alnespirone-induced desensitization of somatodendritic 5-HT1A autoreceptors in the rat dorsal raphe nucleus. European journal of pharmacology vol 365 issue 2-3 1999 9988099 In contrast, in vitro electrophysiological recordings performed 24 h after the last injection of alnespirone showed that the potency of the 5-HT1A receptor agonist, 8-OH-DPAT, to depress the firing of serotoninergic neurons in the dorsal raphe nucleus, was significantly reduced after a 21-day treatment with alnespirone. 1999-04-29 2022-01-08 rat
B Bjorvatn, R Ursi. Changes in sleep and wakefulness following 5-HT1A ligands given systemically and locally in different brain regions. Reviews in the neurosciences vol 9 issue 4 1999 9886141 Microdialysis perfusion of a selective 5-HT1A agonist into the dorsal Raphe nucleus causes an increase in REM sleep, whereas the other sleep/wake stages are unaltered. 1999-03-23 2022-01-08 Not clear
J Sprouse, J Braselton, L Reynold. 5-HT1A agonist activity of pindolol: reversal of the inhibitory effects on cell firing in the dorsal raphe nucleus but not in the hippocampus by WAY-100,635. Annals of the New York Academy of Sciences vol 861 issue 1999 9928287 5-HT1A agonist activity of pindolol: reversal of the inhibitory effects on cell firing in the dorsal raphe nucleus but not in the hippocampus by WAY-100,635. 1999-02-25 2022-01-08 Not clear
F Lejeune, M J Milla. Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. Synapse (New York, N.Y.) vol 30 issue 2 1998 9723787 This study examined the influence of the highly selective 5-HT1A receptor ligands, flesinoxan, S 15535, and WAY 100,635, upon the electrical activity of dopaminergic neurons in the ventral tegmental area (VTA), as compared to serotonergic neurons in the dorsal raphe nucleus (DRN) of anesthetized rats. 1998-11-16 2022-01-08 rat
R M Sibug, J C Compaan, O C Meijer, J Van der Gugten, B Olivier, E R De Kloe. Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels. European journal of pharmacology vol 353 issue 2-3 1998 9726650 Flesinoxan administration resulted in a significant, dose-dependent downregulation of 5-HT1A receptor mRNA in the dentate gyrus and dorsal raphe nucleus. 1998-11-13 2022-01-08 rat
H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology vol 352 issue 2-3 1998 9716368 Alterations in the activity of the central 5-HT system are important in understanding the pathophysiology of depression, and therefore, we examined whether this model was associated with changes in the expression of 5-HT1A receptor, 5-HT1B receptor, and 5-HT transporter mRNA in the dorsal raphe nucleus and the hippocampus. 1998-11-04 2022-01-08 rat
H H Hansen, J D Mikkelse. Long-term effects on serotonin transporter mRNA expression of chronic neonatal exposure to a serotonin reuptake inhibitor. European journal of pharmacology vol 352 issue 2-3 1998 9716368 The expression of 5-HT transporter, 5-HT1A receptor, and 5-HT1B receptor mRNA was examined in the dorsal raphe nucleus and in the CA1 of the hippocampus by means of quantitative in situ hybridisation histochemistry. 1998-11-04 2022-01-08 rat
L G Larsson, C Stenfors, S B Ros. Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. European journal of pharmacology vol 346 issue 2-3 1998 9652362 Since previous studies by others have indicated that the reserve of somatodendritic 5-HT1A receptors is greater in dorsal raphe nucleus innervating frontal cortex and striatum than in median raphe nucleus which mainly innervates hippocampus, the observed different regional potency of the two 5-HT1A receptor antagonists may be explained by this difference in the 5-HT1A receptor reserve. 1998-09-16 2022-01-08 rat
R Corradetti, N Laaris, N Hanoun, A M Laporte, E Le Poul, M Hamon, L Lanfume. Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. British journal of pharmacology vol 123 issue 3 1998 9504386 Studies were performed on 5-HT1A receptors located on 5-hydroxytryptaminergic neurones in the dorsal raphe nucleus (DRN) and on pyramidal cells in the CA1 and CA3 regions of the hippocampus in rat brain slices. 1998-04-13 2022-01-08 Not clear
J De Vry, R Schohe-Loop, H G Heine, J M Greuel, F Mauler, B Schmidt, H Sommermeyer, T Glase. Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist. The Journal of pharmacology and experimental therapeutics vol 284 issue 3 1998 9495870 In a rat brain slice preparation containing the dorsal raphe nucleus (DRN), a model of somatodendritic 5-HT1A receptor function, BAY x 3702 inhibited potently (1 nM) neuronal firing. 1998-04-09 2022-01-08 rat
H Razani, P B Hedlund, A C Hansson, K Fuxe, S O Ogre. 5-HT1A receptor activation: short-term effects on the mRNA expression of the 5-HT1A receptor and galanin in the raphe nuclei. Neuroreport vol 8 issue 16 1998 9427327 8-OH-DPAT increased the hybridization signal of the 5-HT1A receptor by 105% in the dorsal raphe nucleus (B7) 30 min after the injection. 1998-02-26 2022-01-08 Not clear
R Corradetti, A M Pugliese, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro. Acta physiologica Hungarica vol 84 issue 4 1998 9328615 Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro. 1998-02-02 2022-01-08 Not clear
R Corradetti, A M Pugliese, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro. Acta physiologica Hungarica vol 84 issue 4 1998 9328615 The novel 5-HT1A receptor antagonist WAY 100635 [(N-(2-(-4(2-metoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyc lohexane carboxamide)] has been tested on 5-HT1A receptor-mediated inhibition of firing and intracellularly recorded hyperpolarisation of serotoninergic cells of the dorsal raphe nucleus (DRN) and on hyperpolarisation of hippocampal CA1 pyramidal cells. 1998-02-02 2022-01-08 Not clear
B Bjorvatn, S Fagerland, T Eid, R Ursi. Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. Brain research vol 770 issue 1-2 1998 9372206 Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. 1998-01-21 2022-01-08 rat
B Bjorvatn, S Fagerland, T Eid, R Ursi. Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. Brain research vol 770 issue 1-2 1998 9372206 Sleep/waking stages and behavior were studied following the selective 5-HT1A agonist 8-OH-DPAT given subcutaneously (s.c.) (0.010-0.375 mg/kg) as well as perfused continuously (10 microM) for 6 h into the dorsal raphe nucleus (DRN) using microdialysis. 1998-01-21 2022-01-08 rat
E Le Poul, N Laaris, M Hamon, L Lanfume. Fluoxetine-induced desensitization of somatodendritic 5-HT1A autoreceptors is independent of glucocorticoid(s). Synapse (New York, N.Y.) vol 27 issue 4 1998 9372553 Previous in vitro studies showed that glucocorticoid receptor activation (notably by corticosterone) could induce a functional desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus [Laaris et al. 1998-01-14 2022-01-08 rat
L J Sim, R Xiao, S R Childer. In vitro autoradiographic localization of 5-HT1A receptor-activated G-proteins in the rat brain. Brain research bulletin vol 44 issue 1 1998 9288830 [35S]GTPgammaS autoradiography, performed in brain sections with the 5-HT1A agonist 8-OH-DPAT, revealed high levels of 5-HT1A-stimulated [35S]GTPgammaS binding in the hippocampus, lateral septum, prelimbic cortex, entorhinal cortex, and dorsal raphe nucleus. 1998-01-09 2022-01-08 Not clear
J M Casanovas, M L\\xc3\\xa9sourd, F Artiga. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. British journal of pharmacology vol 122 issue 4 1998 9375971 We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). 1998-01-02 2022-01-08 Not clear
M B Viana, F G Graeff, P A L\\xc3\\xb6schman. Kainate microinjection into the dorsal raphe nucleus induces 5-HT release in the amygdala and periaqueductal gray. Pharmacology, biochemistry, and behavior vol 58 issue 1 1997 9264086 Earlier results obtained in one of our laboratories showed that microinjection into the dorsal raphe nucleus (DRN) of the excitatory amino acid kainic acid, the benzodiazepine (BZD) inverse agonist FG 7142, and the 5-HT1A receptor agonist 8-OHDPAT changed the behavior of rats in the elevated T-maze, an animal model of anxiety. 1997-09-30 2022-01-08 rat
N Laaris, E Le Poul, M Hamon, L Lanfume. Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus--in vitro electrophysiological evidence. Fundamental & clinical pharmacology vol 11 issue 3 1997 9243251 Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus--in vitro electrophysiological evidence. 1997-09-04 2022-01-08 rat
N Laaris, E Le Poul, M Hamon, L Lanfume. Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus--in vitro electrophysiological evidence. Fundamental & clinical pharmacology vol 11 issue 3 1997 9243251 Somatodendritic 5-HT1A autoreceptors play a key role in the control of the electrical and metabolic activity of serotoninergic neurons in the dorsal raphe nucleus. 1997-09-04 2022-01-08 rat
N Laaris, E Le Poul, M Hamon, L Lanfume. Stress-induced alterations of somatodendritic 5-HT1A autoreceptor sensitivity in the rat dorsal raphe nucleus--in vitro electrophysiological evidence. Fundamental & clinical pharmacology vol 11 issue 3 1997 9243251 These data show that some forms of stress can reduce the 5-HT1A autoreceptor-dependent inhibitory control of the electrophysiological activity of serotoninergic neurons in the dorsal raphe nucleus. 1997-09-04 2022-01-08 rat
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology vol 329 issue 1 1997 9218690 The present study was undertaken to compare the properties of the [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) binding site in the dorsal raphe nucleus with the hippocampal 5-HT1A receptor. 1997-08-22 2022-01-08 Not clear
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology vol 329 issue 1 1997 9218690 [3H]8-OH-DPAT appears to bind to a single population of binding sites in both the hippocampus and the dorsal raphe nucleus, although the K(d) for the radioligand at the dorsal raphe site was five times that observed at the hippocampal 5-HT1A receptor. 1997-08-22 2022-01-08 Not clear
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology vol 329 issue 1 1997 9218690 Similarly, although 5-HT and selective 5-HT1A receptor ligands displayed high affinity for the [3H]8-OH-DPAT binding site in the dorsal raphe nucleus, the affinity at the dorsal raphe site was less than that observed at the hippocampal 5-HT1A receptor. 1997-08-22 2022-01-08 Not clear
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology vol 329 issue 1 1997 9218690 An inhibition of phosphoinositide hydrolysis in the dorsal raphe nucleus also was found with the putative 5-HT1A receptor selective ligands, flesinoxan and gepirone. 1997-08-22 2022-01-08 Not clear
R G Johnson, D Fiorella, J C Winter, R A Rabi. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe. European journal of pharmacology vol 329 issue 1 1997 9218690 These studies demonstrate that the 8-OH-DPAT binding site in the dorsal raphe nucleus displays a binding profile which is similar to the hippocampal 5-HT1A receptor, but unlike this 5-HT1A receptor the binding site in the dorsal raphe nucleus is negatively coupled to phosphoinositide turnover. 1997-08-22 2022-01-08 Not clear
A R Allen, A Singh, Z P Zhuang, M P Kung, H F Kung, I Luck. The 5-HT1A receptor antagonist p-MPPI blocks responses mediated by postsynaptic and presynaptic 5-HT1A receptors. Pharmacology, biochemistry, and behavior vol 57 issue 1-2 1997 9164586 Pretreatment with p-MPPI also blocked the ability of 8-OH-DPAT to reduce extracellular 5-HT in the striatum, a response mediated by presynaptic 5-HT1A receptors in the dorsal raphe nucleus, but did not alter striatal 5-HT when administered alone. 1997-07-30 2022-01-08 Not clear
L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry vol 68 issue 6 1997 9166757 Therefore, potentiation by 5-HT1A antagonists occurs preferentially in forebrain areas innervated by serotonergic neurons of the dorsal raphe nucleus. 1997-06-17 2022-01-08 Not clear
L Lanfumey, S Haj-Dahmane, A M Laporte, P Martin, M Hamon, H Gozla. Effects of chronic diazepam treatment on pre- and postsynaptic 5-HT1A receptors in the rat brain. European journal of pharmacology vol 323 issue 2-3 1997 9128832 In vitro binding and quantitative autoradiographic experiments with [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) showed that the characteristics of 5-HT1A receptor binding sites in the hippocampus and the dorsal raphe nucleus were not significantly altered by the administration of diazepam under the treatment protocols A, B and C. Furthermore, in vitro electrophysiological recordings of serotoninergic neurons in the dorsal raphe nucleus of brain stem slices revealed no modification in the sensitivity of somatodendritic 5-HT1A autoreceptors in rats treated with diazepam according to the protocols A and B. 1997-06-16 2022-01-08 rat
F Lejeune, A Newman-Tancredi, V Audinot, M J Milla. Interactions of (+)- and (-)-8- and 7-hydroxy-2-(di-n-propylamino)tetralin at human (h)D3, hD2 and h serotonin1A receptors and their modulation of the activity of serotoninergic and dopaminergic neurones in rats. The Journal of pharmacology and experimental therapeutics vol 280 issue 3 1997 9067310 In our study, we evaluated the influence of their (+)- and (-) isomers on the electrical activity of serotoninergic neurones of the dorsal raphe nucleus (DRN), which bear 5-HT1A autoreceptors, and of dopaminergic neurones of the ventral tegmental area (VTA), which possess inhibitory D3 and D2 receptors. 1997-04-11 2022-01-07 rat
L Romero, N Bel, J M Casanovas, F Artiga. Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. International clinical psychopharmacology vol 11 Suppl 4 issue 1997 8923121 This effect is maximal in forebrain areas innervated by the dorsal raphe nucleus and can be prevented by the administration of non-selective [(-)pindolol, (-)tertatolol] and selective (WAY-100635) 5-HT1A antagonists. 1997-03-19 2022-01-07 Not clear
L Romero, N Bel, F Artigas, C de Montigny, P Blie. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 15 issue 4 1997 8887989 In microdialysis studies, somatodendritic 5-HT1A receptors in the dorsal raphe nucleus (DRN) were activated by the local infusion of 50 microM citalopram, a selective 5-HT reuptake inhibitor (SSRI). 1997-03-06 2022-01-07 rat
S M Korte, O C Meijer, E R de Kloet, B Buwalda, J Keijser, F Sluyter, G van Oortmerssen, B Bohu. Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice. Brain research vol 736 issue 1-2 1997 8930340 No difference in ligand binding was found for the 5-HT1A autoreceptor on cell bodies in the dorsal raphe nucleus. 1997-02-26 2022-01-07 mouse
R G Johnson, C M Severin, R A Rabi. Serotonergic binding in the rat dorsal raphe nucleus: critical role of MAO inhibition. Journal of pharmacological and toxicological methods vol 36 issue 2 1997 8912226 The biochemical properties of the 5-HT1A receptor in dorsal raphe nucleus (DRN) were investigated using a micropunch procedure. 1997-02-13 2022-01-07 Not clear
S A Jones-Humble, M J Durcan, D Lyerly, R M Norton, F L Tang, A V Russell, M J Watson, P J Gengo, P F Morgan, C M Wang, B R Cooper, R F Co. Preclinical neurochemical and electrophysiological profile of 1192U90, a potential antipsychotic. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol 15 issue 3 1997 8873105 Intravenous injection or iontophoretic application of 1192U90 or the 5-HT1A agonist (+/-)8-OH-DPAT inhibited the firing rates of dorsal raphe nucleus (DRN) neurons in rats, and the effects of both compounds were blocked by iontophoretically applied S(-) propranolol, a 5-HT1A antagonist. 1997-01-15 2022-01-07 rat
L D Van de Ka. Forebrain pathways mediating stress-induced renin secretion. Clinical and experimental pharmacology & physiology vol 23 issue 2 1996 8819647 Activation of serotonin1A (5HT1A) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. 1996-12-10 2022-01-07 rat
S M Remy, R Schreiber, M Dalmus, J De Vr. Somatodendritic 5-HT1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT. Psychopharmacology vol 125 issue 1 1996 8724453 In the rat shock-induced ultrasonic vocalization test, the anxiolytic effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) obtained after systemic (IP) and intracerebral injection into the dorsal raphe nucleus (DRN) were selectively abolished by pretreatment with the 5-HT1A receptor antagonist WAY-100635 [N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclo-hexane-carboxamide trihydrochloride]. 1996-11-27 2022-01-07 Not clear
G Pi\\xc3\\xb1eyro, C de Montigny, M Weiss, P Blie. Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain. Synapse (New York, N.Y.) vol 22 issue 1 1996 8822478 These results, in keeping with previous anatomical studies, suggest the existence of electrotonic coupling of 5-HT neurons and indicate that 5-HT release in the rat dorsal raphe nucleus may be controlled independently of firing-regulating 5-HT1A autoreceptors. 1996-11-08 2022-01-07 Not clear
D D Mousseau, V L Rao, R F Butterwort. Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms. Journal of neurochemistry vol 67 issue 3 1996 8752118 Using quantitative receptor autoradiography, the binding of 8-hydroxy-2-(di-n-[3H]propylamino) tetralin, a ligand used to label the somatodendritic 5-HT1A autoreceptor of the dorsal raphe nucleus, was found to be unaffected in this region, suggesting that the structural integrity of the 5-HT cell bodies is maintained throughout the course of pyrithiamine treatment. 1996-10-02 2022-01-07 rat
R Corradetti, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide (WAY 100635) on dorsal raphe serotonergic neurons and CA1 hippocampal pyramidal cells in vitro. The Journal of pharmacology and experimental therapeutics vol 278 issue 2 1996 8768719 The aim of the present study was to examine the effects of N-(2-(4-2-methoxphenyl)-1-piperazinyl)ethyl)-N-(2-pyridnyl) cyclohexane carboxamide (WAY 100635) on 5-HT1A receptor-mediated responses in the dorsal raphe nucleus (DRN) and the CA1 hippocampal region. 1996-09-18 2022-01-07 Not clear
C A Fornal, C W Metzler, R A Gallegos, S C Veasey, A C McCreary, B L Jacob. WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. The Journal of pharmacology and experimental therapeutics vol 278 issue 2 1996 8768728 The present study examined the effects of systemic administration of two reportedly selective 5-HT1A receptor antagonists, (S)-WAY-100135 {N-tert-butyl-3-[4-(2-methoxyphenyl) piperazin-1-yl]-2-phenylpropanamide} and its more potent analog WAY-100635 {N-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide}, on the single-unit activity of serotonergic neurons in the dorsal raphe nucleus of freely moving cats. 1996-09-18 2022-01-07 Not clear
M K Mundey, A Fletcher, C A Marsde. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. British journal of pharmacology vol 117 issue 4 1996 8646424 but did not affect the maximum inhibition induced by 8-OHDPAT indicating competitive antagonism between 8-OHDPAT and WAY100635 at the 5-HT1A somato-dendritic autoreceptor in the dorsal raphe nucleus of the guinea-pig. 1996-07-24 2022-01-07 Not clear
N Aguirre, J L Galbete, B Lasheras, J Del R\\xc3\\xad. Methylenedioxymethamphetamine induces opposite changes in central pre- and postsynaptic 5-HT1A receptors in rats. European journal of pharmacology vol 281 issue 1 1996 8566108 [3H]8-Hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) was used to label 5-HT1A receptors in the brain stem region containing the dorsal raphe nucleus and in the frontal cortex. 1996-03-06 2022-01-07 rat
N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology vol 34 issue 9 1996 8532191 Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. 1996-01-26 2022-01-07 rat
N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology vol 34 issue 9 1996 8532191 In the rat brain, the dorsal raphe nucleus contains a large proportion of serotoninergic neurons, which are mostly regulated by somato-dendritic 5-HT1A autoreceptors. 1996-01-26 2022-01-07 rat
N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology vol 34 issue 9 1996 8532191 Control by corticosteroids of 5-HT1A receptor-mediated inhibitory control of the firing of serotoninergic neurons in the dorsal raphe nucleus was investigated using an in vitro electrophysiological approach. 1996-01-26 2022-01-07 rat
N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology vol 34 issue 9 1996 8532191 Complementary autoradiographic experiments showed that [3H]8-OH-DPAT specific binding to 5-HT1A sites in the dorsal raphe nucleus (and the hippocampus) was not significantly altered following adrenalectomy and exposure of brain stem slices to corticosterone. 1996-01-26 2022-01-07 rat
N Laaris, S Haj-Dahmane, M Hamon, L Lanfume. Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus. Neuropharmacology vol 34 issue 9 1996 8532191 These data suggest that GR are involved in the suppressive effects of high levels of corticosterone on the 5-HT1A receptor-dependent regulation of 5-HT neuronal activity in the rat dorsal raphe nucleus. 1996-01-26 2022-01-07 rat
I Nevo, X Langlois, A M Laporte, M Kleven, W Koek, L Lima, C Maudhuit, M P Martres, M Hamo. Chronic alcoholization alters the expression of 5-HT1A and 5-HT1B receptor subtypes in rat brain. European journal of pharmacology vol 281 issue 3 1996 8521905 Quantitative autoradiography indicated that the ethanol treatment provoked an increase (approximately +30%) in the labeling by [3H]8-hydroxy-2-(di-n-propylamino)tetralin ([3H]8-OH-DPAT) and [3H]N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexane carboxamide ([3H]WAY-100635) of 5-HT1A autoreceptors in the dorsal raphe nucleus, accompanied by a concomitant decrease in the labeling of postsynaptic 5-HT1A receptors in the hippocampus (approximately -20%), anterior (approximately -30%) and posterior (approximately -32%) cortices. 1996-01-25 2022-01-07 rat
E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 2 1995 7477436 Electrophysiological and autoradiographic approaches were used to assess possible changes in 5-hydroxytryptamine (serotonin) 5-HT1A receptors in the rat dorsal raphe nucleus after a subchronic treatment with fluoxetine or paroxetine, two specific serotonin reuptake inhibitors with antidepressant properties. 1995-12-27 2022-01-07 rat
E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 2 1995 7477436 Electrophysiological recordings performed 24 h after the last injection showed that the potency of the 5-HT1A receptor agonist, 8-OH-DPAT, to depress the firing of serotoninergic neurons in the dorsal raphe nucleus within brain stem slices was significantly reduced as early as after a 3-day treatment with either drug. 1995-12-27 2022-01-07 rat
E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 2 1995 7477436 At no time during the treatment, was the specific binding of [3H]8-OH-DPAT (agonist radioligand) or [3H]WAY-100 635 (antagonist radioligand) to 5-HT1A receptors modified in the dorsal raphe nucleus or in other brain areas, suggesting that neither the density nor the coupling of these receptors to G-proteins were probably altered in rats injected with fluoxetine or paroxetine for up to 21 days. 1995-12-27 2022-01-07 rat
E Le Poul, N Laaris, E Doucet, A M Laporte, M Hamon, L Lanfume. Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 2 1995 7477436 These results show that adaptive desensitization of somatodendritic 5-HT1A autoreceptors within the dorsal raphe nucleus can already be detected after a 3-day treatment with selective serotonin reuptake inhibitors. 1995-12-27 2022-01-07 rat
L Arborelius, G G Nomikos, P Grillner, P Hertel, B B H\\xc3\\xb6\\xc3\\xb6k, U Hacksell, T H Svensso. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 2 1995 7477438 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. 1995-12-27 2022-01-07 rat
L Arborelius, G G Nomikos, P Grillner, P Hertel, B B H\\xc3\\xb6\\xc3\\xb6k, U Hacksell, T H Svensso. 5-HT1A receptor antagonists increase the activity of serotonergic cells in the dorsal raphe nucleus in rats treated acutely or chronically with citalopram. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 2 1995 7477438 In this study we have examined the acute effects of systemic administration of the selective serotonin reuptake inhibitor (SSRI), citalopram, in combination with either of the two selective 5-HT1A receptor antagonists, [(S)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin [(S)-UH-301] or (+)-N-tertbutyl 3-(4-(2-methoxyphenyl)piperazin-1-yl)-2-phenyl-propionamide dihydrochloride [(+)-WAY100135], on the activity of single 5-HT neurons in the dorsal raphe nucleus (DRN) of anesthetized rats using extracellular recording techniques. 1995-12-27 2022-01-07 rat
N Bonhomme, M Cador, L Stinus, M Le Moal, U Spampinat. Short and long-term changes in dopamine and serotonin receptor binding sites in amphetamine-sensitized rats: a quantitative autoradiographic study. Brain research vol 675 issue 1-2 1995 7796132 A significant increase of [3H]SCH 23390 binding to D1 DA receptors was observed in the substantia nigra pars reticulata 1 day but not 15 days after the cessation of AMPH treatment, whereas [3H]8-OH-DPAT binding to 5-HT1A sites was found to be significantly enhanced in the dorsal raphe nucleus at both time points. 1995-08-03 2022-01-07 rat
A Gobert, F Lejeune, J M Rivet, V Audinot, A Newman-Tancredi, M J Milla. Modulation of the activity of central serotoninergic neurons by novel serotonin1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. The Journal of pharmacology and experimental therapeutics vol 273 issue 3 1995 7791073 The novel, high efficacy, 5-HT1A agonists, WY 48,723 (an arylpiperazine), (+)-flesinoxan (a benzodioxane) and S 14671 and S 14506 (methoxynaphtylpiperazines) mimicked the aminotetralin, 8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide (8-OH-DPAT), in inhibiting the firing of dorsal raphe nucleus (DRN) neurons. 1995-07-21 2022-01-07 rat
E Le Poul, L Lima, A M Laporte, C Even, E Doucet, C M Fattaccini, N Laaris, M Hamon, L Lanfume. [Central serotonin receptors and chronic treatment with selective serotonin reuptake inhibitors in the rat: comparative effects of fluoxetine and paroxetine]. L'Encephale vol 21 issue 2 1995 7781583 Nevertheless, in vitro electrophysiological recordings of serotonergic neurons in the dorsal raphe nucleus allowed the demonstration of a clearcut functional desensitization of somatodendritic 5-HT1A autoreceptors. 1995-07-20 2022-01-07 rat
C Davidson, J A Stamfor. The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT1B/D receptor antagonists. Neuroscience letters vol 188 issue 1 1995 7783975 The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT1B/D receptor antagonists. 1995-07-20 2022-01-07 Not clear
R Craven, D Grahame-Smith, N Newberr. WAY-100635 and GR127935: effects on 5-hydroxytryptamine-containing neurones. European journal of pharmacology vol 271 issue 1 1995 7698189 N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2- pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) is a potent and selective 5-HT1A receptor antagonist in a slice preparation of the guinea pig dorsal raphe nucleus: the inhibitory actions on 5-HT neuronal firing of 5-hydroxytryptamine (5-HT, serotonin), 5-carboxamidotryptamine (5-CT) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), but not those of baclofen, were abolished by 30 nM WAY-100635. 1995-05-04 2022-01-07 Not clear
L Romero, P Celada, F Artiga. Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/G(o) proteins in dorsal raphe nucleus. European journal of pharmacology vol 265 issue 1-2 1995 7883021 We have examined the effects of 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT, 0.1 mg/kg s.c.) on in vivo striatal 5-HT release in conscious rats with somatodendritic 5-HT1A receptors inactivated by the application of pertussis toxin in the dorsal raphe nucleus. 1995-04-10 2022-01-07 rat
R Schreiber, K Opitz, T Glaser, J De Vr. Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats: involvement of presynaptic 5-HT1A receptors. Psychopharmacology vol 112 issue 1 1995 7870997 Local application of 8-OH-DPAT (10 micrograms, 0.5 microliters) into the dorsal raphe nucleus (DRN, a brain area rich in somatodendritic 5-HT1A autoreceptors), reduced the EtOH preference significantly as compared to the saline injection in the same animal (-12%, 8:00-12:00 P.M.). 1995-03-29 2022-01-07 rat
S M Tejani-Butt, D M Labo. Time course of the effects of adrenalectomy and corticosterone replacement on 5-HT1A receptors and 5-HT uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis. Psychopharmacology vol 113 issue 3-4 1995 7862863 Time course of the effects of adrenalectomy and corticosterone replacement on 5-HT1A receptors and 5-HT uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis. 1995-03-20 2022-01-07 Not clear
T Jolas, R Schreiber, A M Laporte, M Chastanet, J De Vry, T Glaser, J Adrien, M Hamo. Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? The Journal of pharmacology and experimental therapeutics vol 272 issue 2 1995 7853210 Previous studies have shown that injection of 5-hydroxytryptamine (serotonin) receptor agonists in the dorsal raphe nucleus (DRN) to stimulate somatodendritic 5-HT1A autoreceptors or in the hippocampus to stimulate postsynaptic 5-HT1A receptors, induces anxiolytic-like effects in the rat. 1995-03-15 2022-01-07 rat
H H Berendsen, F G Bourgondien, C L Broekkam. Role of dorsal and median raphe nuclei in lower lip retraction in rats. European journal of pharmacology vol 263 issue 3 1995 7843270 The results suggest that lower lip retraction is mediated by 5-HT1A receptors in the median rather than in the dorsal raphe nucleus. 1995-03-03 2022-01-07 rat
H Gozlan, A M Laporte, S Thibault, L E Schechter, F Bola\\xc3\\xb1os, M Hamo. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology vol 33 issue 3-4 1994 7984280 Analyses of the time-course recovery of respective binding sites after EEDQ administration showed that the turnover rate of 5-HT1A sites did not significantly differ in the dorsal raphe nucleus and in various forebrain areas (hippocampus, septum, cerebral cortex; half-life: approximately 4 days), but was lower than that of cortical 5-HT2A sites (half-life: 2.9 days). 1994-12-30 2022-01-07 rat
J G Hensler, R C Ferry, D M Labow, G B Kovachich, A Fraze. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse (New York, N.Y.) vol 17 issue 1 1994 8042142 Within the dorsal raphe nucleus the binding of 3H-CN-IMI was compared in adjacent coronal sections of rat brain to the binding of 3H-DPAT to 5-HT1A receptors, which have a known somatodendritic localization. 1994-08-23 2022-01-07 rat
S Haj-Dahmane, T Jolas, A M Laporte, H Gozlan, A J Farr\\xc3\\xa9, M Hamon, L Lanfume. Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. European journal of pharmacology vol 255 issue 1-3 1994 8026543 As previously shown for agonists acting at the somato-dendritic 5-HT1A autoreceptors in the dorsal raphe nucleus, lesopitron inhibited the firing of serotoninergic neurons both in vitro (in brainstem slices, IC50 = 120 nM) and in vivo (in chloral hydrate-anaesthetized rats, ID50 = 35 micrograms/kg i.v. 1994-08-08 2022-01-07 monkey
M K Mundey, A Fletcher, C A Marsde. Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. Neuropharmacology vol 33 issue 1 1994 8183439 Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus. 1994-06-16 2022-01-07 Not clear
T Jolas, S Haj-Dahmane, E J Kidd, X Langlois, L Lanfumey, C M Fattaccini, V Vantalon, A M Laporte, J Adrien, H Gozla. Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. The Journal of pharmacology and experimental therapeutics vol 268 issue 3 1994 8138956 In contrast, in vitro and in vivo electrophysiological recordings of serotoninergic neurons in the dorsal raphe nucleus revealed a clearcut functional desensitization of somatodendritic 5-HT1A autoreceptors. 1994-04-25 2022-01-07 rat
T Jolas, S Haj-Dahmane, E J Kidd, X Langlois, L Lanfumey, C M Fattaccini, V Vantalon, A M Laporte, J Adrien, H Gozla. Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. The Journal of pharmacology and experimental therapeutics vol 268 issue 3 1994 8138956 These data support the idea that postsynaptic (in the hippocampus) and somatodendritic (in the dorsal raphe nucleus) 5-HT1A receptors are differently regulated in the rat brain, because only the latter receptors desensitized after a long-term blockade of serotonin reuptake by cericlamine. 1994-04-25 2022-01-07 rat
M J Millan, H Canton, A Gobert, F Lejeune, J M Rivet, K Bervoets, M Brocco, P Widdowson, T Mennini, V Audino. Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. The Journal of pharmacology and experimental therapeutics vol 268 issue 1 1994 8301575 At 5-HT1A autoreceptors, S 14489, S 15535 and S 15931 acted as agonists in inhibiting striatal 5-hydroxytryptophan accumulation (0.16-2.5 mg/kg, s.c.) and in abolishing the electrical activity of the dorsal raphe nucleus (0.005-0.100 mg/kg, i.v.). 1994-03-10 2022-01-07 Not clear
L Lanfumey, S Haj-Dahmane, M Hamo. Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. European journal of pharmacology vol 249 issue 1 1994 8282017 The higher potency of the latter compound was also noted at the level of presynaptic 5-HT1A receptors where both (+)-WAY 100 135 and SDZ 216-525 prevented the negative influence of 5-HT1A receptor agonists (8-OH-DPAT, flesinoxan or lesopitron) on the nerve impulse flow within dorsal raphe nucleus 5-HT neurones in brain stem slices. 1994-02-14 2022-01-07 Not clear
C M Contreras, M L Marv\\xc3\\xa1n, A Mu\\xc3\\xb1oz-M\\xc3\\xa9nde. Clomipramine increases the responsiveness of raphe-cortical neurons in the rat. Neuropsychobiology vol 27 issue 4 1993 8232839 The cerebral cortex of the rat possesses 5-HT1A receptor subtype; however, whether the activation of this receptor by dorsal raphe nucleus stimulation produces a similar action on neuronal cortical firing as antidepressants acting on serotonin (5-HT) function is unknown. 1993-12-03 2022-01-07 rat
J Mos, B Olivier, M Poth, R Van Oorschot, H Van Ake. The effects of dorsal raphe administration of eltoprazine, TFMPP and 8-OH-DPAT on resident intruder aggression in the rat. European journal of pharmacology vol 238 issue 2-3 1993 8405111 To evaluate the role of somatodendritic 5-HT1A receptors in the mediation of aggressive behaviour, eltoprazine, TFMPP (1-(3-trifluoromethylphenyl)piperazine hydrochloride) and 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) were administered locally into the dorsal raphe nucleus of rats. 1993-11-09 2022-01-07 rat
T Jolas, S Haj-Dahmane, L Lanfumey, C M Fattaccini, E J Kidd, J Adrien, H Gozlan, B Guardiola-Lemaitre, M Hamo. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 347 issue 5 1993 7686633 ), (-)tertatolol prevented the inhibitory effects of the 5-HT1A receptor agonists 8-OH-DPAT, ipsapirone and lesopitron on the firing rate of serotoninergic neurones within the dorsal raphe nucleus. 1993-08-05 2022-01-07 rat
T Jolas, S Haj-Dahmane, L Lanfumey, C M Fattaccini, E J Kidd, J Adrien, H Gozlan, B Guardiola-Lemaitre, M Hamo. (-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain. Naunyn-Schmiedeberg's archives of pharmacology vol 347 issue 5 1993 7686633 These data indicate that (-)tertatolol is a potent competitive antagonist at both pre (in the dorsal raphe nucleus)-and post (in the hippocampus)-synaptic 5-HT1A receptors in the rat brain. 1993-08-05 2022-01-07 rat
M Ginefri-Gayet, J Gaye. Hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABAB receptors. European journal of pharmacology vol 235 issue 2-3 1993 8389714 Hypothermia induced by infusion of methionine sulfoximine into the dorsal raphe nucleus of the rat: involvement of 5-HT1A and GABAB receptors. 1993-07-13 2022-01-07 rat
D Treit, A Robinson, S Rotzinger, C Pesol. Anxiolytic effects of serotonergic interventions in the shock-probe burying test and the elevated plus-maze test. Behavioural brain research vol 54 issue 1 1993 8504010 In the present experiments, serotonergic function was disrupted in rats, either by chemical depletion using the synthesis inhibitor p-CPA, by inhibitory autoreceptor activation using the selective 5-HT1A receptor ligand 8-OH-DPAT, or by electrolytic lesions of the serotonin-containing, dorsal raphe nucleus. 1993-07-08 2022-01-07 rat
F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research vol 606 issue 2 1993 8490720 5-HT1A binding, measured after 6 months, was unchanged in all regions examined including the dorsal raphe nucleus. 1993-06-14 2022-01-07 rat
C M Contreras, M L Marv\\xc3\\xa1n, A Mu\\xc3\\xb1oz-M\\xc3\\xa9ndez, A Ram\\xc3\\xadrez-Morale. Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions. Boletin de estudios medicos y biologicos vol 40 issue 1-4 1993 1296670 From an electrophysiological point of view, it is concluded that the excitatory actions on firing rate elicited by dorsal raphe nucleus stimulation or clomipramine treatment are mediated by 5-HT2 receptor subtype activation which is likely to be acting as a 5-HT1A modulator in such places where both receptor subtypes coexist. 1993-04-28 2022-01-07 Not clear
M J Millan, J M Rivet, H Canton, F Lejeune, A Gobert, P Widdowson, K Bervoets, M Brocco, J L Peglio. S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist at presynaptic and postsynaptic sites respectively. European journal of pharmacology vol 230 issue 1 1993 8381359 At presynaptic 5-HT1A receptors, S 15535 acted as an agonist in inhibiting striatal accumulation of 5-hydroxytryptophan (0.04-0.63 mg/kg s.c.) and in spiperone reversibly reducing electrical activity of the dorsal raphe nucleus (0.004-0.031 mg/kg i.v.). 1993-03-09 2022-01-07 Not clear
K Yoshimoto, W J McBrid. Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical research vol 17 issue 5 1992 1356241 The effects of microinfusing L-glutamate, serotonin (5-HT), (+-)-8-hydroxy-2-(di-N-propylamino) tetralin (8-OH DPAT; a 5-HT1A agonist), and muscimol (a GABAA agonist) into the dorsal raphe nucleus on the extracellular levels of 5-HT, dopamine (DA) and their metabolites in the nucleus accumbens were studied in unanesthetized, freely moving, adult male Wistar rats, using the technique of microdialysis coupled with small-bore HPLC. 1992-10-22 2022-01-07 rat
K Yoshimoto, W J McBrid. Regulation of nucleus accumbens dopamine release by the dorsal raphe nucleus in the rat. Neurochemical research vol 17 issue 5 1992 1356241 The data indicate that (a) the 5-HT neurons projecting to the nucleus accumbens from the dorsal raphe nucleus can be activated by excitatory amino acid receptors and inhibited by stimulation of 5-HT1A autoreceptors, and (b) the dorsal raphe nucleus 5-HT neuronal system may regulate the ventral tegmental area DA projection to the nucleus accumbens. 1992-10-22 2022-01-07 rat
M C Miquel, E Doucet, M Riad, J Adrien, D Verg\\xc3\\xa9, M Hamo. Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain research. Molecular brain research vol 14 issue 4 1992 1326699 Twenty one days after the treatment, the 5-HT1A receptor protein was no longer detected within the dorsal raphe nucleus but was still present in the hippocampus and entorhinal cortex. 1992-10-19 2022-01-07 rat
M C Miquel, E Doucet, M Riad, J Adrien, D Verg\\xc3\\xa9, M Hamo. Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain research. Molecular brain research vol 14 issue 4 1992 1326699 Quantitative in situ hybridization showed an 85% decrease in the levels of 5-HT1A receptor mRNA within the dorsal raphe nucleus, but no significant change in the hippocampus, interpeduncular nucleus and entorhinal cortex of 5,7-dihydroxytryptamine-treated rats. 1992-10-19 2022-01-07 rat
M C Miquel, E Doucet, M Riad, J Adrien, D Verg\\xc3\\xa9, M Hamo. Effect of the selective lesion of serotoninergic neurons on the regional distribution of 5-HT1A receptor mRNA in the rat brain. Brain research. Molecular brain research vol 14 issue 4 1992 1326699 These data demonstrate that 5-HT1A receptors are synthesized by serotoninergic neurons in the dorsal raphe nucleus, and by neurons located postsynaptically with regard to serotoninergic projections in other areas. 1992-10-19 2022-01-07 rat
K C Corley, V B Singh, T H Phan, M C Boadle-Bibe. Effect of gepirone on increases in tryptophan hydroxylase in response to sound stress. European journal of pharmacology vol 213 issue 3 1992 1377631 Gepirone may block the sound stress-induced biochemical increases by its inhibition of serotonergic neuronal firing in the dorsal raphe nucleus that is mediated by its agonist action at the somatodendritic (5-HT1A) autoreceptors. 1992-08-06 2022-01-07 rat
J M Greuel, T Glase. The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. European journal of pharmacology vol 211 issue 2 1992 1535319 The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. 1992-07-28 2022-01-09 Not clear
J M Greuel, T Glase. The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. European journal of pharmacology vol 211 issue 2 1992 1535319 The present electrophysiological study examined the actions of the putative 5-HT1A receptor antagonists NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine) and BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4,5]- decane-7,9-dione dihydrochloride) in the rat dorsal raphe nucleus in vitro. 1992-07-28 2022-01-09 Not clear
F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry vol 58 issue 4 1992 1548468 The potencies of 5'-guanylylimidodiphosphate to inhibit the specific binding of 125I-Bolton-Hunter-8-methoxy-2-(N-propyl-N-propylamino)tetralin (125I-BH-8-MeO-N-PAT) to 5-HT1A sites and of N-ethylmaleimide to block these sites irreversibly were identical in the dorsal raphe nucleus and the hippocampal areas in rat brain sections. 1992-04-17 2022-01-09 Not clear
F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry vol 58 issue 4 1992 1548468 However, in most cases, the observed variations were of greater amplitude between the CA1 area and the dentate gyrus, where 5-HT1A sites are located postsynaptically, than between any one of these areas and the dorsal raphe nucleus where they act as (presynaptic) somatodendritic autoreceptors. 1992-04-17 2022-01-09 Not clear
H Tanaka, H Shimizu, Y Kumasaka, A Hirose, T Tatsuno, M Nakamur. Autoradiographic localization and pharmacological characterization of [3H]tandospirone binding sites in the rat brain. Brain research vol 546 issue 2 1991 1648988 In addition, there was no significant difference in the dissociation constant of [3H]tandospirone binding between the dentate gyrus, CA1 area, dorsal raphe nucleus, lateral septum and entorhinal cortex (about 10 nM) suggesting that [3H]tandospirone binds to 5-HT1A receptors with same affinities in these brain structures. 1991-08-22 2022-01-07 Not clear
G A Higgins, P J Elliot. Differential behavioural activation following intra-raphe infusion of 5-HT1A receptor agonists. European journal of pharmacology vol 193 issue 3 1991 1675996 Microinfusion of the selective 5-HT1A receptor agonist, 8-hydroxy-(di-N-propylamino)tetralin (8-OHDPAT), into the dorsal raphe nucleus (DRN) produced a marked behavioural hypoactivity and flat body posture. 1991-07-31 2022-01-07 Not clear
L E Schechter, F J Bola\\xc3\\xb1os, H Gozlan, L Lanfumey, S Haj-Dahmane, A M Laporte, C M Fattaccini, M Hamo. Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. The Journal of pharmacology and experimental therapeutics vol 255 issue 3 1991 1702155 for 14 days did not alter the characteristics of 5-HT1A sites in the hippocampus, septum and dorsal raphe nucleus. 1991-02-07 2022-01-07 rat
T Sharp, S Hjort. Application of brain microdialysis to study the pharmacology of the 5-HT1A autoreceptor. Journal of neuroscience methods vol 34 issue 1-3 1991 2259248 We have observed that a range of 5-HT1A agonists, including 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), inhibit 5-HT release in hippocampus, most probably by acting on somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus. 1991-01-31 2022-01-07 Not clear
H E Connor, G A Higgin. Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. European journal of pharmacology vol 182 issue 1 1990 2144824 Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. 1990-10-19 2022-01-07 rat
H E Connor, G A Higgin. Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. European journal of pharmacology vol 182 issue 1 1990 2144824 The aim of this study was to investigate the cardiovascular effects of the 5-HT1A receptor agonists, 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), flesinoxan and 5-carboxamidotryptamine (5-CT) following injection into the dorsal raphe nucleus of conscious rats. 1990-10-19 2022-01-07 rat
H E Connor, G A Higgin. Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats. European journal of pharmacology vol 182 issue 1 1990 2144824 The results suggest that 8-OH-DPAT activates 5-HT1A receptors in the dorsal raphe nucleus to cause hypotension and bradycardia. 1990-10-19 2022-01-07 rat
A Hirose, M Sasa, A Akaike, S Takaor. Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997. Neuropharmacology vol 29 issue 2 1990 1970426 In the short-latency neurons, the stimulation-induced spikes of the medial septal nucleus were inhibited by conditioning stimuli applied to the dorsal raphe nucleus and iontophoretic application of 5-HT and the 5-HT1A agonists, SM-3997 (3 a alpha,4 beta,7 beta,7a alpha-hexahydro-2-(4-(4-(2-pyrimidinyl)-1- piperazinyl)-butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione dihydrogen citrate) and 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin). 1990-05-30 2022-01-07 rat
T Sharp, S R Bramwell, D Clark, D G Grahame-Smit. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. Journal of neurochemistry vol 53 issue 1 1989 2470860 Injection of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (0.5 and 2.5 micrograms) into the dorsal raphe nucleus caused a dose-related fall in hippocampal output of 5-HT compared to saline-injected controls. 1989-07-13 2022-01-07 rat
J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology vol 149 issue 1-2 1988 2969339 Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. 1988-08-31 2022-01-07 Not clear
J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology vol 149 issue 1-2 1988 2969339 The neuroleptic spiperone, which binds to 5-HT1A, 5-HT2 and dopamine (DA) receptors, was studied for its effects on serotonin (5-HT) and DA neurons in dorsal raphe nucleus and substantia nigra pars compacta, respectively. 1988-08-31 2022-01-07 Not clear
J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology vol 149 issue 1-2 1988 2969339 spiperone, but not LY53837 (a 5-HT2 antagonist), antagonized the inhibition induced by 5-HT1A agonists 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) and buspirone in the dorsal raphe nucleus. 1988-08-31 2022-01-07 Not clear
J T Lum, M F Pierce. Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. European journal of pharmacology vol 149 issue 1-2 1988 2969339 It is concluded that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. 1988-08-31 2022-01-07 Not clear
D Verg\\xc3\\xa9, G Daval, M Marcinkiewicz, A Patey, S el Mestikawy, H Gozlan, M Hamo. Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 6 issue 12 1987 2947981 The selective degeneration of serotoninergic neurons produced by an intracerebral injection of 5,7-dihydroxytryptamine was associated only with a significant loss of 5-HT1A binding to the dorsal raphe nucleus (-60%) and of 5-HT1B binding to the substantia nigra (-37%). 1987-02-10 2022-01-07 rat
A Basse-Tomusk, G V Rebe. Ipsapirone depresses neuronal activity in the dorsal raphe nucleus and the hippocampal formation. European journal of pharmacology vol 130 issue 1-2 1987 3780856 Ipsapirone, a putative, novel anxiolytic with a high affinity for 5-HT1A binding sites, suppressed neuronal activity in both the dorsal raphe nucleus and hippocampal formation of urethane-anesthetized rats. 1987-01-06 2022-01-07 rat
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