All Relations between 5-ht receptor 1a and prosencephalon

Reference Sentence Publish Date Extraction Date Species
E Le Poul, C Boni, N Hanoun, A M Laporte, N Laaris, J Chauveau, M Hamon, L Lanfume. Differential adaptation of brain 5-HT1A and 5-HT1B receptors and 5-HT transporter in rats treated chronically with fluoxetine. Neuropharmacology vol 39 issue 1 2000 10665824 However, a significant decrease (-38%) in 5-HT1A mRNA levels in the anterior raphe area (but not forebrain regions) and increases in 5-HT1B mRNA levels in the striatum (+127%) and the cerebral cortex (+34%) were noted in fluoxetine-treated rats. 2000-02-18 2022-01-08 rat
S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology vol 127 issue 1 1999 10369467 Thus, we have recently shown that the selective 5-HT1A receptor antagonist, WAY 100635, blocks the inhibitory effect of an SSRI on 5-HT cell firing, and enhances its ability to elevate extracellular 5-HT in the forebrain. 1999-09-01 2022-01-08 Not clear
S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology vol 127 issue 1 1999 10369467 Our data suggest that (-)-tertatolol enhances the effect of paroxetine on forebrain 5-HT via blockade of 5-HT1A autoreceptors which mediate paroxetine-induced inhibition of 5-HT cell firing. 1999-09-01 2022-01-08 Not clear
S Williams, M Serafin, M M\\xc3\\xbchlethaler, L Bernhei. The serotonin inhibition of high-voltage-activated calcium currents is relieved by action potential-like depolarizations in dissociated cholinergic nucleus basalis neurons of the guinea-pig. The European journal of neuroscience vol 10 issue 10 1999 9786223 In dissociated cholinergic basal forebrain neurons using whole-cell recordings, it is shown that a selective serotonin 5-HT1A agonist (8-OH-DPAT) predominantly blocks N-type HVA calcium current, although a minor reduction of P-type current was also observed. 1999-06-07 2022-01-08 Not clear
J M Casanovas, M T Vilar\\xc3\\xb3, G Mengod, F Artiga. Differential regulation of somatodendritic serotonin 5-HT1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(Di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. Journal of neurochemistry vol 72 issue 1 1999 9886078 Single treatment with the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and alnespirone (S-20499) reduces the extracellular 5-HT concentration (5-HText) in the rat midbrain and forebrain. 1999-01-21 2022-01-08 rat
N Haddjeri, P Blier, C de Montign. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 18 issue 23 1998 9822768 Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. 1998-12-18 2022-01-08 rat
N Haddjeri, P Blier, C de Montign. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience vol 18 issue 23 1998 9822768 These data indicate that such antidepressant treatments, acting on entirely different primary targets, might alleviate depression by enhancing the tonic activation of forebrain postsynaptic 5-HT1A receptors. 1998-12-18 2022-01-08 rat
I Misane, H Razani, F H Wang, A Jansson, K Fuxe, S O Ogre. Intraventricular galanin modulates a 5-HT1A receptor-mediated behavioural response in the rat. The European journal of neuroscience vol 10 issue 4 1998 9749777 These results suggest that galanin can modulate postsynaptic 5-HT1A receptor transmission in vivo in discrete cell populations in forebrain regions such as the dorsal and ventral hippocampus and parts of the amygdala. 1998-10-22 2022-01-08 Not clear
H J Bengtsson, A Kullberg, M J Millan, S Hjort. The role of 5-HT1A autoreceptors and alpha1-adrenoceptors in the modulation of 5-HT release--III. Clozapine and the novel putative antipsychotic S 16924. Neuropharmacology vol 37 issue 3 1998 9681933 With regard to the interplay between alpha1-adrenoceptor and 5-HT1A (auto)receptor mechanisms in the control of 5-HT release in the rat forebrain, the present data suggest that an excitation mediated by the former is outweighed by the simultaneous activation of the latter-inhibitory-receptors. 1998-10-02 2022-01-08 Not clear
A Szab\\xc3\\xb3, B L Butz, R H Alpe. Further characterization of forebrain serotonin receptors mediating tachycardia in conscious rats. Brain research bulletin vol 45 issue 6 1998 9566502 It has been shown recently that activation of forebrain serotonin1A (5-HT1A) receptors, likely within the preoptic area, elicits a slight increase in blood pressure and a substantial tachycardia. 1998-06-08 2022-01-08 rat
J M Casanovas, M L\\xc3\\xa9sourd, F Artiga. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. British journal of pharmacology vol 122 issue 4 1998 9375971 We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). 1998-01-02 2022-01-08 Not clear
N S Kula, R J Baldessarini, J W Kebabian, V Bakthavachalam, L X. RBI-257: a highly potent dopamine D4 receptor-selective ligand. European journal of pharmacology vol 331 issue 2-3 1997 9274997 RBI-257 had much lower affinity at D1 and D5 dopamine receptors in transfected cells, as well as dopamine D1-like receptors, alpha1, alpha2 or beta(1,2) adrenoceptors, sigma(1,2) receptors and 5-HT1A or 5-HT2A receptors, and transporters for dopamine, norepinephrine or serotonin in rat forebrain tissue. 1997-10-27 2022-01-08 Not clear
C Nyakas, B J Oosterink, J Keijser, K Felszeghy, G I de Jong, J Korf, P G Luite. Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of chemical neuroanatomy vol 13 issue 1 1997 9271195 Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. 1997-09-29 2022-01-08 rat
C Nyakas, B J Oosterink, J Keijser, K Felszeghy, G I de Jong, J Korf, P G Luite. Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of chemical neuroanatomy vol 13 issue 1 1997 9271195 The effect of aging on 5-HT1A receptor binding in several forebrain areas associated with the basal forebrain cholinergic system was investigated in rats of 3-, 24- and 30-months-old by receptor autoradiography and biochemical binding assay using [3H]8-OH-DPAT as a ligand. 1997-09-29 2022-01-08 rat
C Nyakas, B J Oosterink, J Keijser, K Felszeghy, G I de Jong, J Korf, P G Luite. Selective decline of 5-HT1A receptor binding sites in rat cortex, hippocampus and cholinergic basal forebrain nuclei during aging. Journal of chemical neuroanatomy vol 13 issue 1 1997 9271195 The results clearly show that with increasing age the decrement of 5-HT1A receptor binding in the rat forebrain is remarkably region-selective and particularly affects the cholinergic cell groups that innervate cortex and hippocampus. 1997-09-29 2022-01-08 rat
T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology vol 121 issue 5 1997 9222551 Selective 5-hydroxytryptamine (5-HT; serotonin) reuptake inhibitors (SSRIs) cause a greater increase in extracellular 5-HT in the forebrain when the somatodendritic 5-HT1A autoreceptor is blocked. 1997-09-15 2022-01-08 rat
S Hjorth, D Westlin, H J Bengtsso. WAY100635-induced augmentation of the 5-HT-elevating action of citalopram: relative importance of the dose of the 5-HT1A (auto)receptor blocker versus that of the 5-HT reuptake inhibitor. Neuropharmacology vol 36 issue 4-5 1997 9225270 The data confirm previous findings that 5-HT1A autoreceptor blockade enhances the citalopram-induced increase of extracellular 5-HT in the forebrain. 1997-09-15 2022-01-08 Not clear
L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry vol 68 issue 6 1997 9166757 The maximal elevations of extracellular concentration of 5-HT (5-HT(ext)) induced by the 5-HT uptake inhibitor paroxetine in forebrain were potentiated by the 5-HT1A antagonist WAY-100635 (1 mg/kg s.c.) in a regionally dependent manner (striatum > frontal cortex > dorsal hippocampus). 1997-06-17 2022-01-08 Not clear
L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry vol 68 issue 6 1997 9166757 Therefore, potentiation by 5-HT1A antagonists occurs preferentially in forebrain areas innervated by serotonergic neurons of the dorsal raphe nucleus. 1997-06-17 2022-01-08 Not clear
A Szab\\xc3\\xb3, M Bowman, C J Braun, R H Alpe. Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats. European journal of pharmacology vol 315 issue 2 1997 8960883 Experiments were designed to test the hypothesis that activation of forebrain 5-HT1A receptors elicits cardiovascular responses. 1997-04-03 2022-01-07 rat
A Szab\\xc3\\xb3, M Bowman, C J Braun, R H Alpe. Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats. European journal of pharmacology vol 315 issue 2 1997 8960883 These results suggest that activation of 5-HT1A receptors in the preoptic area or an adjacent region of the forebrain produces: (1) an increase in heart rate consistent with sympathoadrenal activation; and (2) an increase in blood pressure which might be the result of sympathoexcitation or secondary to behavioral arousal. 1997-04-03 2022-01-07 rat
L Romero, I Herv\\xc3\\xa1s, F Artiga. The 5-HT1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neuroscience letters vol 219 issue 2 1997 8971795 The increases in extracellular serotonin (5-hydroxytryptamine; 5-HT) produced by some antidepressent drugs in forebrain are attenuated by the activation of somatodendritic 5-HT1A autoreceptors by the excess 5-HT induced by these agents in the midbrain raphe. 1997-03-20 2022-01-07 rat
L Romero, N Bel, J M Casanovas, F Artiga. Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. International clinical psychopharmacology vol 11 Suppl 4 issue 1997 8923121 This effect is maximal in forebrain areas innervated by the dorsal raphe nucleus and can be prevented by the administration of non-selective [(-)pindolol, (-)tertatolol] and selective (WAY-100635) 5-HT1A antagonists. 1997-03-19 2022-01-07 Not clear
S B Auerbach, S Hjort. Effect of chronic administration of the selective serotonin (5-HT) uptake inhibitor citalopram on extracellular 5-HT and apparent autoreceptor sensitivity in rat forebrain in vivo. Naunyn-Schmiedeberg's archives of pharmacology vol 352 issue 6 1997 9053730 Under these conditions, with uptake already blocked locally in the forebrain, systemic citalopram produces a decrease in extracellular 5-HT, an effect that can be inhibited by pretreatment with antagonists of 5-HT1A receptors. 1997-03-07 2022-01-07 rat
S M Korte, O C Meijer, E R de Kloet, B Buwalda, J Keijser, F Sluyter, G van Oortmerssen, B Bohu. Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice. Brain research vol 736 issue 1-2 1997 8930340 Enhanced 5-HT1A receptor expression in forebrain regions of aggressive house mice. 1997-02-26 2022-01-07 mouse
F Artigas, L Romero, C de Montigny, P Blie. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends in neurosciences vol 19 issue 9 1997 8873352 Overriding this feedback by using antagonists of 5-HT1A autoreceptors permits SSRIs to produce a marked increase of extracellular 5-HT in the forebrain. 1997-01-15 2022-01-07 Not clear
L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology vol 34 issue 10 1996 8570030 The present observations indicate that clonazepam produces a reduction of serotonin turnover rate in the hippocampus of the rat concomitant with a down-regulation of 5-HT1A binding sites, probably by an effect at the forebrain projections. 1996-03-04 2022-01-07 rat
S Numan, K H Lundgren, D E Wright, J P Herman, K B Seroog. Increased expression of 5HT2 receptor mRNA in rat striatum following 6-OHDA lesions of the adult nigrostriatal pathway. Brain research. Molecular brain research vol 29 issue 2 1995 7609629 In situ hybridization for 5HT1A, 5HT1C, and 5HT2 receptor subtype mRNAs was performed in rat striatum following unilateral injection of 6-OHDA into the medial forebrain bundle or directly into the ventral midbrain. 1995-08-15 2022-01-07 Not clear
S D Mendelson, B S McEwe. Quantitative autoradiographic analyses of the time course and reversibility of corticosterone-induced decreases in binding at 5-HT1A receptors in rat forebrain. Neuroendocrinology vol 56 issue 6 1995 1369598 Quantitative autoradiographic analyses of the time course and reversibility of corticosterone-induced decreases in binding at 5-HT1A receptors in rat forebrain. 1995-07-20 2022-01-07 rat
T Jolas, R Schreiber, A M Laporte, M Chastanet, J De Vry, T Glaser, J Adrien, M Hamo. Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? The Journal of pharmacology and experimental therapeutics vol 272 issue 2 1995 7853210 These data indicated that postsynaptic 5-HT1A receptors were not responsible for the inhibitory effects of 8-OH-DPAT and ipsapirone injected in forebrain areas on the electrical activity of serotonergic neurons and the USV response in rats. 1995-03-15 2022-01-07 rat
T Jolas, R Schreiber, A M Laporte, M Chastanet, J De Vry, T Glaser, J Adrien, M Hamo. Are postsynaptic 5-HT1A receptors involved in the anxiolytic effects of 5-HT1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? The Journal of pharmacology and experimental therapeutics vol 272 issue 2 1995 7853210 As shown by the autoradiographic labeling by [3H]8-OH-DPAT at distance from its injection site in the dorsal hippocampus, the diffusion of 5-HT1A receptor agonists (from injected areas in the forebrain to the DRN where they directly inhibit the electrical activity of serotonergic neurons) more likely accounted for their anxiolytic-like effects. 1995-03-15 2022-01-07 rat
A M Rasmusson, L E Goldstein, A Y Deutch, B S Bunney, R H Rot. 5-HT1a agonist +/-8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine. Synapse (New York, N.Y.) vol 18 issue 3 1995 7855734 In this study, we investigated the effects of +/-8-hydroxy-2(di-n-propylamino)tetralin [+/-8-OH-DPAT], a serotonergic 5-HT1a agonist, on basal and stress-induced changes in dopamine utilization and release in selected forebrain dopamine terminal fields in the rat. 1995-03-14 2022-01-07 Not clear
H Gozlan, A M Laporte, S Thibault, L E Schechter, F Bola\\xc3\\xb1os, M Hamo. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology vol 33 issue 3-4 1994 7984280 Analyses of the time-course recovery of respective binding sites after EEDQ administration showed that the turnover rate of 5-HT1A sites did not significantly differ in the dorsal raphe nucleus and in various forebrain areas (hippocampus, septum, cerebral cortex; half-life: approximately 4 days), but was lower than that of cortical 5-HT2A sites (half-life: 2.9 days). 1994-12-30 2022-01-07 rat
K Kasamo, K Tada, N Ueda, T Kojima, M Kogure, K Ishikaw. Effects of several 5-HT1A agonists on hippocampal rhythmical slow activity in unanesthetized rats. Neuropharmacology vol 33 issue 7 1994 7969811 These results indicate that 5-HT1A agonists reduce both power and median frequency values of wr-RSA through activation of post-synaptic 5-HT1A receptors in the forebrain in unanesthetized rats, in vivo. 1994-12-28 2022-01-07 rat
M C Miquel, H K Kia, C Boni, E Doucet, G Daval, L Matthiessen, M Hamon, D Verg\\xc3\\xa. Postnatal development and localization of 5-HT1A receptor mRNA in rat forebrain and cerebellum. Brain research. Developmental brain research vol 80 issue 1-2 1994 7955340 Postnatal development and localization of 5-HT1A receptor mRNA in rat forebrain and cerebellum. 1994-12-20 2022-01-07 Not clear
J H Prehn, M Welsch, C Backhauss, J Nuglisch, F Ausmeier, C Karkoutly, J Krieglstei. Effects of serotonergic drugs in experimental brain ischemia: evidence for a protective role of serotonin in cerebral ischemia. Brain research vol 630 issue 1-2 1994 8118677 In order to examine the effects of 5-HT1A receptor activation in a different context, 10 min of forebrain ischemia was induced in male Wistar rats by a bilateral occlusion of the common carotid arteries combined with systemic hypotension. 1994-04-05 2022-01-07 rat
P J Fletcher, D V Coscin. Injecting 5-HT into the PVN does not prevent feeding induced by injecting 8-OH-DPAT into the raphe. Pharmacology, biochemistry, and behavior vol 46 issue 2 1994 8265706 The selective 5-hydroxytryptamine1A (5-HT1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) activates raphe somatodendritic autoreceptors, leading to an inhibition of 5-HT neuronal activity and reduced synthesis and release of 5-HT in forebrain terminal areas. 1994-01-27 2022-01-07 rat
S Ahlenius, V Hillegaart, P Salmi, A Wijkstr\\xc3\\xb6. Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. Pharmacology & toxicology vol 72 issue 6 1993 8361951 Effects of 5-HT1A receptor agonists on patterns of rat motor activity in relation to effects on forebrain monoamine synthesis. 1993-09-30 2022-01-07 rat
J A Lawrence, H J Olverman, K Shirakawa, J S Kelly, S P Butche. Binding of 5-HT1A receptor and 5-HT transporter ligands in rat cortex and hippocampus following cholinergic and serotonergic lesions. Brain research vol 612 issue 1-2 1993 7687192 Lesions of either basal forebrain neurones or serotonergic neurones did not affect [3H]8-OH-DPAT binding, suggesting that 5-HT1A binding sites are not localised on cholinergic or serotonergic nerve terminals. 1993-08-13 2022-01-07 Not clear
F Radja, L Descarries, K M Dewar, T A Reade. Serotonin 5-HT1 and 5-HT2 receptors in adult rat brain after neonatal destruction of nigrostriatal dopamine neurons: a quantitative autoradiographic study. Brain research vol 606 issue 2 1993 8490720 5-HT1A, 5-HT1B, 5HT1nonAB and 5-HT2 sites were labeled with [3H]8-OH-DPAT, [125I]cyanopindolol, [3H]5-HT and [125I]DOI, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. 1993-06-14 2022-01-07 rat
H Shimizu, T Tatsuno, H Tanaka, A Hirose, Y Araki, M Nakamur. Serotonergic mechanisms in anxiolytic effect of tandospirone in the Vogel conflict test. Japanese journal of pharmacology vol 59 issue 1 1992 1354771 To clarify which 5-HT1A receptors, autoreceptors located in the raphe nuclei or post-synaptic receptors in the forebrain areas receiving a 5-HT input, mediate the anticonflict action of tandospirone (a 5-HT1A receptor-related anxiolytics), the behavioral effects of tandospirone were studied in 5,7-dihydroxytryptamine (5,7-DHT) treated rats. 1992-09-22 2022-01-07 rat
F Radja, G Daval, M Hamon, D Verg\\xc3\\xa. Pharmacological and physicochemical properties of pre-versus postsynaptic 5-hydroxytryptamine1A receptor binding sites in the rat brain: a quantitative autoradiographic study. Journal of neurochemistry vol 58 issue 4 1992 1548468 Numerous data suggested that the pharmacological and biochemical properties of 5-hydroxytryptamine1A (5-HT1A) receptors exhibit some regional differences in the CNS, notably within the raphe nuclei compared with various forebrain areas (such as the hippocampus). 1992-04-17 2022-01-09 Not clear
G A Higgins, P J Elliot. Differential behavioural activation following intra-raphe infusion of 5-HT1A receptor agonists. European journal of pharmacology vol 193 issue 3 1991 1675996 The contrasting behavioural profiles of the 5-HT1A agents observed after DRN or MRN microinfusions are probably related to the differential innervation of forebrain structures by each raphe nucleus. 1991-07-31 2022-01-07 Not clear
J G Cannon, S T Moe, J P Lon. Enantiomers of 11-hydroxy-10-methylaporphine having opposing pharmacological effects at 5-HT1A receptors. Chirality vol 3 issue 1 1991 2039679 Both bind strongly to 5-HT1A receptors from rat forebrain membrane tissue. 1991-07-08 2022-01-07 Not clear
P Blier, C de Montign. Electrophysiological investigation of the adaptive response of the 5-HT system to the administration of 5-HT1A receptor agonists. Journal of cardiovascular pharmacology vol 15 Suppl 7 issue 1991 1702486 It is concluded that the sustained administration of a 5-HT1A agonist results in an enhanced tonic activation of postsynaptic 5-HT1A receptors in the forebrain. 1991-02-11 2022-01-07 Not clear
S Ahlenius, V Hillegaart, A Wijkstr\\xc3\\xb6. Increased dopamine turnover in the ventral striatum by 8-OH-DPAT administration in the rat. The Journal of pharmacy and pharmacology vol 42 issue 4 1990 1974300 Both the 5-HT1A agonist flesinoxan (0.06-17.8 mumos kg-1 s.c. -50 min) and the mixed 5-HT1 and 5-HT2 agonist 5-MeODMT (1.6-26.0 mumols kg-1 s.c.-50 min) produced a decrease in forebrain 5-HTP accumulation (striatum and neocortex), following decarboxylase inhibition by means of NSD-1015 in reserpine treated rats, indicating stimulation of central 5-HT receptors by these two compounds. 1990-09-12 2022-01-07 rat
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