| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sietse F de Boer, Adrian Newman-Tancred. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT₁A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology. vol 233. issue 6. 2016-10-12. PMID:26694810. |
hence, an adequate interpretation of the role of 5-ht activity in regulating aggression depends on elucidating the predominant site of action, i.e., raphe presynaptic autoreceptors versus forebrain postsynaptic heteroreceptors, of these 5-ht1a receptor agonists. |
2016-10-12 |
2023-08-13 |
rat |
| Yi-Na Sun, Tao Wang, Yong Wang, Ling-Na Han, Li-Bo Li, Yu-Ming Zhang, Jian Li. Activation of 5-HT₁A receptors in the medial subdivision of the central nucleus of the amygdala produces anxiolytic effects in a rat model of Parkinson's disease. Neuropharmacology. vol 95. 2016-03-08. PMID:25797491. |
here we assessed the importance of cem 5-ht1a receptors for anxiety in rats with unilateral 6-hydroxydopamine (6-ohda) lesion of the medial forebrain bundle (mfb). |
2016-03-08 |
2023-08-13 |
rat |
| Yuwen Chung-Davidson, Huiyong Wang, Anne M Scott, Weiming L. Pheromone 3kPZS evokes context-dependent serotonin sexual dimorphism in the brain of the sea lamprey (Petromyzon marinus). Integrative zoology. vol 10. issue 1. 2015-09-28. PMID:24920007. |
we examined the neurotransmitter serotonin (5-hydroxytryptamine, 5-ht) and the expression of 5-ht1a receptors in the forebrain and brainstem of sea lamprey exposed to the vehicle (0.91 ppm methanol) or 10(-10) m 3kpzs for 2 h using high performance liquid chromatography-electrospray ionization tandem mass spectrometry, immunohistochemistry and real-time quantitative polymerase chain reaction. |
2015-09-28 |
2023-08-13 |
Not clear |
| Yan Ping Hui, Tao Wang, Ling Na Han, Li Bo Li, Yi Na Sun, Jian Liu, Hong Fei Qiao, Qiao Jun Zhan. Anxiolytic effects of prelimbic 5-HT(1A) receptor activation in the hemiparkinsonian rat. Behavioural brain research. vol 277. 2015-09-08. PMID:24906197. |
this study sought to assess whether unilateral lesions of the medial forebrain bundle (mfb) using 6-hydroxydopamine in rats are able to induce anxiety-like behaviors, the role of serotonin-1a (5-ht1a) receptors of the prelimbic (prl) sub-region of ventral medial prefrontal cortex in the regulation of these behaviors, the density of 5-ht neurons in the dorsal raphe nucleus (drn) and co-localization of 5-ht1a receptor and neuronal glutamate transporter eaac1-immunoreactive (eaac1-ir) cells in the prl. |
2015-09-08 |
2023-08-13 |
rat |
| Y P Hui, Q J Zhang, L Zhang, L Chen, Y Guo, H F Qiao, Y Wang, J Li. Activation of prelimbic 5-HT1A receptors produces antidepressant-like effects in a unilateral rat model of Parkinson's disease. Neuroscience. vol 268. 2014-12-12. PMID:24680938. |
in this study, we examined whether complete unilateral lesions of the medial forebrain bundle (mfb) using 6-hydroxydopamine in rats are able to induce depressive-like behaviors, the role of prl 5-ht1a receptors in the regulation of these behaviors, and co-localization of 5-ht1a receptor and neuronal glutamate transporter eaac1-immunoreactive (eaac1-ir) neurons in the prl. |
2014-12-12 |
2023-08-12 |
rat |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
in the forebrain, 5ht1a and 2a receptors were increased, whereas 5ht2c receptors were decreased in the hippocampus. |
2011-10-31 |
2023-08-12 |
mouse |
| Lydia Günther, Markus Donix, Monika Jähkel, Jochen Oehle. A diverse development of 5-HT1A receptor binding is relevant to behavioral differences observed in adult mice of two genetically closely related inbred strains. Pharmacology, biochemistry, and behavior. vol 97. issue 2. 2011-02-03. PMID:20801151. |
abh mice display a higher forebrain 5-ht1a receptor binding compared to abg mice. |
2011-02-03 |
2023-08-12 |
mouse |
| Lydia Günther, Markus Donix, Monika Jähkel, Jochen Oehle. A diverse development of 5-HT1A receptor binding is relevant to behavioral differences observed in adult mice of two genetically closely related inbred strains. Pharmacology, biochemistry, and behavior. vol 97. issue 2. 2011-02-03. PMID:20801151. |
so the strain-specific forebrain 5-ht1a receptor binding pattern develops during the first 3 postnatal weeks and genetically driven mechanisms seem to be crucial. |
2011-02-03 |
2023-08-12 |
mouse |
| Tiago A Ferreira, Luisa Lo Iacono, Cornelius T Gros. Serotonin receptor 1A modulates actin dynamics and restricts dendritic growth in hippocampal neurons. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20561047. |
mice lacking serotonin receptor 1a (htr1a) display increased anxiety behavior that depends on the expression of the receptor in the forebrain during the third to fifth postnatal weeks. |
2011-01-13 |
2023-08-12 |
mouse |
| Frederico G Graeff, Hélio Zangross. The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders. Central nervous system agents in medicinal chemistry. vol 10. issue 3. 2011-01-07. PMID:20528764. |
the attenuation of generalized anxiety, also caused by the same drug treatment, would be due to the desensitization of 5-ht2c receptors and, less certainly, to increased stimulation of 5-ht1a receptors in forebrain structures. |
2011-01-07 |
2023-08-12 |
human |
| Tzuri Lifschytz, Tanya Goltser-Dubner, Galit Landshut, Bernard Lere. Effect of triiodothyronine on 5-HT1A and 5-HT1B receptor expression in rat forebrain and on latency to feed in the novelty suppressed feeding test. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 4. 2010-07-30. PMID:20206658. |
effect of triiodothyronine on 5-ht1a and 5-ht1b receptor expression in rat forebrain and on latency to feed in the novelty suppressed feeding test. |
2010-07-30 |
2023-08-12 |
rat |
| Maarten van den Buuse, Lena Wischhof, Ruo Xi Lee, Sally Martin, Tim Kar. Neuregulin 1 hypomorphic mutant mice: enhanced baseline locomotor activity but normal psychotropic drug-induced hyperlocomotion and prepulse inhibition regulation. The international journal of neuropsychopharmacology. vol 12. issue 10. 2010-06-29. PMID:19400983. |
the density of dopamine d2 receptors in the forebrain and of 5-ht1a receptors in the hippocampus and raphe nuclei was not different between nrg1+/- mice and controls. |
2010-06-29 |
2023-08-12 |
mouse |
| Yukihiro Ohno, Saki Shimizu, Junta Imak. Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. Journal of pharmacological sciences. vol 109. issue 4. 2009-06-22. PMID:19352073. |
effects of tandospirone, a 5-ht1a agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain fos expression in mice. |
2009-06-22 |
2023-08-12 |
mouse |
| Esther Berrocoso, Juan A Mic. Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice. The international journal of neuropsychopharmacology. vol 12. issue 1. 2009-03-13. PMID:18405417. |
the results imply that blockade of the 5-ht1a receptors in the forebrain will counteract the favourable (antidepressant-like) effect at raphe nuclei level, and consequently, the overall effect evidenced is an antagonism. |
2009-03-13 |
2023-08-12 |
mouse |
| Esther Berrocoso, Juan A Mic. Role of serotonin 5-HT1A receptors in the antidepressant-like effect and the antinociceptive effect of venlafaxine in mice. The international journal of neuropsychopharmacology. vol 12. issue 1. 2009-03-13. PMID:18405417. |
this suggests a predominant role of 5-ht1a receptors located in the forebrain area for the antidepressant-like effect. |
2009-03-13 |
2023-08-12 |
mouse |
| A Bonnin, W Peng, W Hewlett, P Levit. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Neuroscience. vol 141. issue 2. 2006-10-04. PMID:16824687. |
we undertook a detailed analysis of expression mapping of the gi/o-coupled 5-ht1 (5-ht1a, 1b, 1d and 1f) receptor subtypes in the fetal and early postnatal mouse forebrain. |
2006-10-04 |
2023-08-12 |
mouse |
| Kim G C Hellemans, José N Nobrega, Mary C Olmstea. Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding. Behavioural brain research. vol 159. issue 2. 2005-07-19. PMID:15817184. |
early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-ht1a receptor binding. |
2005-07-19 |
2023-08-12 |
rat |
| Kim G C Hellemans, José N Nobrega, Mary C Olmstea. Early environmental experience alters baseline and ethanol-induced cognitive impulsivity: relationship to forebrain 5-HT1A receptor binding. Behavioural brain research. vol 159. issue 2. 2005-07-19. PMID:15817184. |
forebrain 5-ht1a binding was assessed post-mortem using in vitro receptor autoradiography with the agonist [3h]8-oh-dpat (3h-8-hydroxy-2-[di-n-propylamino]tetralin). |
2005-07-19 |
2023-08-12 |
rat |
| S E Gartside, M M Leitch, A H Youn. Altered glucocorticoid rhythm attenuates the ability of a chronic SSRI to elevate forebrain 5-HT: implications for the treatment of depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12784107. |
the data indicate that, despite desensitization of 5-ht1a autoreceptors, concurrent flattened glucocorticoid rhythm compromises the ability of ssris to elevate forebrain 5-ht. |
2003-10-06 |
2023-08-12 |
rat |
| Joachim Klisch, K M Bode-Greuel, E Horvath, C Klisch, Th El. Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil. Neuroscience letters. vol 342. issue 1-2. 2003-07-31. PMID:12727309. |
modulation of the serotonin (5ht) system via 5ht1a or 5ht2a receptors exerts a neuroprotective effect on delayed neuronal death after transient forebrain ischemia. |
2003-07-31 |
2023-08-12 |
Not clear |