| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Zhuang, C Gross, L Santarelli, V Compan, A C Trillat, R He. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432489. |
specifically, we have created mice that lack or express reduced levels of two serotonin receptors: 5-ht1a and 5-ht1b receptors. |
1999-09-17 |
2023-08-12 |
mouse |
| X Zhuang, C Gross, L Santarelli, V Compan, A C Trillat, R He. Altered emotional states in knockout mice lacking 5-HT1A or 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2 Suppl. 1999-09-17. PMID:10432489. |
as a result, the 5-ht1a and 5-ht1b receptors control the tone of the serotonergic system and mediate some of the postsynaptic effects of serotonin. |
1999-09-17 |
2023-08-12 |
mouse |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
postsynaptic 5-ht1a receptors control 5-ht release in the rat medial prefrontal cortex. |
1999-09-16 |
2023-08-12 |
rat |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
5-htt1a receptor agonists reduce the neuronal release of 5-hydroxytryptamine (5-ht) by activation of raphe 5-ht1a autoreceptors. |
1999-09-16 |
2023-08-12 |
rat |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
using in vivo microdialysis in unanesthetized rats, we show that the local application of the selective 5-ht1a receptor agonist 8-oh-dpat decreased the 5-ht output to approximately 50% of controls in medial prefrontal cortex (mpfc) but not in dorsal hippocampus. |
1999-09-16 |
2023-08-12 |
rat |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
the decrease in 5-ht output was counteracted by the concurrent application of the selective 5-ht1a receptor antagonist way-100635. |
1999-09-16 |
2023-08-12 |
rat |
| J M Casanovas, I Hervás, F Artiga. Postsynaptic 5-HT1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. vol 10. issue 7. 1999-09-16. PMID:10380960. |
this agent also reversed the decrease in 5-ht output elicited by the novel 5-ht1a receptor agonist bay x 3702 (30 microm) in mpfc and dorsal raphe nucleus. |
1999-09-16 |
2023-08-12 |
rat |
| A Gobert, M J Milla. Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2. 1999-09-14. PMID:10432475. |
modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-ht) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-ht reuptake inhibitors: comparative roles of beta-adrenergic, 5-ht1a, and 5-ht1b receptors. |
1999-09-14 |
2023-08-12 |
rat |
| A Gobert, M J Milla. Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2. 1999-09-14. PMID:10432475. |
(-)-pindolol, which possesses significant affinity for 5-ht1a, 5-ht1b, and beta 1/2-adrenergic receptors (ar)s, dose-dependently increased extracellular levels of dopamine (da) and noradrenaline (nad) versus 5-ht, in dialysates of the frontal cortex (fcx), but not accumbens and striatum, of freely-moving rats. |
1999-09-14 |
2023-08-12 |
rat |
| A Gobert, M J Milla. Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 21. issue 2. 1999-09-14. PMID:10432475. |
in conclusion, (-)-pindolol modulates, both alone and together with 5-ht reuptake inhibitors, dopaminergic, adrenergic, and serotonergic transmission in the fcx via a complex pattern of actions at beta 1/2-ars, 5-ht1a, and 5-ht1b receptors. |
1999-09-14 |
2023-08-12 |
rat |
| V L Arvanov, X Liang, P Magro, R Roberts, R Y Wan. A pre- and postsynaptic modulatory action of 5-HT and the 5-HT2A, 2C receptor agonist DOB on NMDA-evoked responses in the rat medial prefrontal cortex. The European journal of neuroscience. vol 11. issue 8. 1999-09-10. PMID:10457188. |
bath application of either dob or 5-ht [in the presence of antagonists to 5-ht1a, 5-ht3 and gamma-aminobutytric acid (gaba) receptors] produced a concentration-dependent biphasic modulation of the nmda responses. |
1999-09-10 |
2023-08-12 |
rat |
| E J Homan, E Kroodsma, S Copinga, L Unelius, N Mohell, H V Wikström, C J Gro. Structural analogues of 5-OMe-BPAT: synthesis and interactions with dopamine D2, D3, and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 6. 1999-09-09. PMID:10428381. |
structural analogues of 5-ome-bpat: synthesis and interactions with dopamine d2, d3, and serotonin 5-ht1a receptors. |
1999-09-09 |
2023-08-12 |
Not clear |
| E J Homan, E Kroodsma, S Copinga, L Unelius, N Mohell, H V Wikström, C J Gro. Structural analogues of 5-OMe-BPAT: synthesis and interactions with dopamine D2, D3, and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 6. 1999-09-09. PMID:10428381. |
several structural analogues of 5-methoxy-2-[n-(2-benzamidoethyl)-n-n-propylamino]tetralin (5-ome-bpat, 1), a representative of a series of 2-aminotetralin-derived benzamides with potential atypical antipsychotic properties, were synthesized and evaluated for their ability to bind to dopamine d2a, d3, and serotonin 5-ht1a receptors in vitro. |
1999-09-09 |
2023-08-12 |
Not clear |
| E J Homan, E Kroodsma, S Copinga, L Unelius, N Mohell, H V Wikström, C J Gro. Structural analogues of 5-OMe-BPAT: synthesis and interactions with dopamine D2, D3, and serotonin 5-HT1A receptors. Bioorganic & medicinal chemistry. vol 7. issue 6. 1999-09-09. PMID:10428381. |
the effects of the amide modifications on the serotonin 5-ht1a receptor affinity were less pronounced, suggesting that the benzamidoethyl side-chain of 1 as a whole enhances the affinity for this receptor subtype probably through hydrophobic interactions with an accessory binding site. |
1999-09-09 |
2023-08-12 |
Not clear |
| H H Berendsen, C L Broekkam. Antagonism of the 5-HT1A receptor stimulus in a conditioned taste aversion procedure. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 9. issue 4. 1999-09-03. PMID:10422896. |
the conditioned taste aversion procedure in mice was used to test for blockade of the drug stimulus of the 5-ht1a receptor agonists (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin hbr (8-oh-dpat), 1-(4-trifluoromethyl-2-pyridinyl)-4- [4-[2-oxo-1-pyrrolidinyl]butyl]piperazine (e)-2-butenedioate (org 13011) and the 5-ht reuptake inhibitor fluoxetine. |
1999-09-03 |
2023-08-12 |
mouse |
| D S Dupuis, S Tardif, T Wurch, F C Colpaert, P J Pauwel. Modulation of 5-HT1A receptor signalling by point-mutation of cysteine351 in the rat Galpha(o) protein. Neuropharmacology. vol 38. issue 7. 1999-09-03. PMID:10428422. |
for comparison, maximal responses of 8-oh-dpat and buspirone were enhanced versus 5-ht upon co-expression of the 5-ht1a receptor with the respective galpha(o) proteins, probably due to an altered receptor: galpha(o) protein density ratio. |
1999-09-03 |
2023-08-12 |
rat |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
the antidepressant efficacy of selective serotonin reuptake inhibitors (ssris) might be enhanced by co-administration of 5-ht1a receptor antagonists. |
1999-09-01 |
2023-08-12 |
Not clear |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
thus, we have recently shown that the selective 5-ht1a receptor antagonist, way 100635, blocks the inhibitory effect of an ssri on 5-ht cell firing, and enhances its ability to elevate extracellular 5-ht in the forebrain. |
1999-09-01 |
2023-08-12 |
Not clear |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
our data suggest that (-)-tertatolol enhances the effect of paroxetine on forebrain 5-ht via blockade of 5-ht1a autoreceptors which mediate paroxetine-induced inhibition of 5-ht cell firing. |
1999-09-01 |
2023-08-12 |
Not clear |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
in comparison, the mechanisms by which (-)-penbutolol enhances the effect of paroxetine on extracellular 5-ht is unclear, since (-)-penbutolol itself appears to have agonist properties at the 5-ht1a autoreceptor. |
1999-09-01 |
2023-08-12 |
Not clear |