| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E Gartside, E M Clifford, P J Cowen, T Shar. Effects of (-)-tertatolol, (-)-penbutolol and (+/-)-pindolol in combination with paroxetine on presynaptic 5-HT function: an in vivo microdialysis and electrophysiological study. British journal of pharmacology. vol 127. issue 1. 1999-09-01. PMID:10369467. |
indeed, the agonist action of (+/-)-pindolol at 5-ht1a autoreceptors probably explains its inability to enhance the effect of paroxetine on 5-ht in the frontal cortex. |
1999-09-01 |
2023-08-12 |
Not clear |
| F Jenck, J R Martin, J L Morea. The 5-HT1A receptor agonist flesinoxan increases aversion in a model of panic-like anxiety in rats. Journal of psychopharmacology (Oxford, England). vol 13. issue 2. 1999-08-27. PMID:10475723. |
data suggest that selective activation of 5-ht1a receptors (pre- and/or post-synaptic in brain and/or periphery) following systemic administration of 5-ht1a receptor full agonists exacerbates aversion in animals or patients with panic anxiety; activation of these receptor subtypes may probably mediate the panicogenic action reported under certain circumstances with non-selective 5-ht mimetics. |
1999-08-27 |
2023-08-12 |
rat |
| M Durand, O Berton, S Aguerre, L Edno, I Combourieu, P Mormède, F Chaoulof. Effects of repeated fluoxetine on anxiety-related behaviours, central serotonergic systems, and the corticotropic axis axis in SHR and WKY rats. Neuropharmacology. vol 38. issue 6. 1999-08-25. PMID:10465693. |
in both strains, the 10 mg/kg dose of fluoxetine decreased hypothalamus 5-ht and 5-hiaa levels, and reduced midbrain and/or hippocampus [3h]citalopram binding at 5-ht transporters, but did not affect [3h]8-hydroxy-2-(di-n-propylamino)tetralin binding at hippocampal 5-ht1a receptors. |
1999-08-25 |
2023-08-12 |
rat |
| J F Cryan, C McGrath, B E Leonard, T R Norma. Onset of the effects of the 5-HT1A antagonist, WAY-100635, alone, and in combination with paroxetine, on olfactory bulbectomy and 8-OH-DPAT-induced changes in the rat. Pharmacology, biochemistry, and behavior. vol 63. issue 2. 1999-08-20. PMID:10371664. |
in this study we investigate the effects of combining a full antagonist at the 5-ht1a receptor, way 100635 (0.2 mg/kg, sc) with the selective serotonin reuptake inhibitor (ssri) paroxetine (5 mg/kg. |
1999-08-20 |
2023-08-12 |
rat |
| C T Chiu, H L Tsao, L W Fan, C C Wang, C S Chien, C M Yan. 5-Hydroxytryptamine-induced phosphoinositide hydrolysis and Ca2+ mobilisation in canine cultured aorta smooth muscle cells. Cellular signalling. vol 11. issue 5. 1999-08-12. PMID:10376810. |
in contrast, the concentration-effect curves of 5-ht-induced ip and [ca2+]i responses were not shifted until the concentrations of nan-190 and metoctopramide (5-ht1a and 5-ht3 receptor antagonists, respectively) were increased to as high as 1 microm with pk(b) values of 5.7-6.3 and 6.1-6.6, respectively, indicating that the 5-ht receptor-mediated responses had low affinity for these antagonists. |
1999-08-12 |
2023-08-12 |
Not clear |
| D G Rainni. Serotonergic modulation of neurotransmission in the rat basolateral amygdala. Journal of neurophysiology. vol 82. issue 1. 1999-08-10. PMID:10400936. |
the effect of 5-ht was mimicked by the 5-ht2 receptor agonist, alpha-methyl-5-hydroxytryptamine (alpha-methyl-5-ht), but not by the 5-ht1a receptor agonist, (+/-) 8-hydroxydipropylaminotetralin hydrobromide (8-oh-dpat), or the 5-ht1b agonist, cgs 12066a. |
1999-08-10 |
2023-08-12 |
rat |
| C Boast, A C Bartolomeo, H Morris, J A Moye. 5HT antagonists attenuate MK801-impaired radial arm maze performance in rats. Neurobiology of learning and memory. vol 71. issue 3. 1999-08-05. PMID:10196105. |
these results suggest that interactions between 5-ht and glutamate may mediate the beneficial effects of reducing cognitive impairment and that 5-ht antagonists, especially selective 5-ht1a antagonists, may be useful in treating ad. |
1999-08-05 |
2023-08-12 |
rat |
| M Hajós, E Hajós-Korcsok, T Shar. Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. British journal of pharmacology. vol 126. issue 8. 1999-07-29. PMID:10372816. |
role of the medial prefrontal cortex in 5-ht1a receptor-induced inhibition of 5-ht neuronal activity in the rat. |
1999-07-29 |
2023-08-12 |
rat |
| M Hajós, E Hajós-Korcsok, T Shar. Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. British journal of pharmacology. vol 126. issue 8. 1999-07-29. PMID:10372816. |
both transection of the frontal cortex as well as ablation of the medial region of the prefrontal cortex (mpfc) significantly attenuated the inhibition of 5-ht neurones induced by systemic administration of the 5-ht1a receptor agonist, 8-oh-dpat (0.5-16 microg kg(-1), i.v.). |
1999-07-29 |
2023-08-12 |
rat |
| M Hajós, E Hajós-Korcsok, T Shar. Role of the medial prefrontal cortex in 5-HT1A receptor-induced inhibition of 5-HT neuronal activity in the rat. British journal of pharmacology. vol 126. issue 8. 1999-07-29. PMID:10372816. |
these data add further support to the view that the inhibitory effect of 5-ht1a receptor agonists on the firing activity of drn 5-ht neurones involves, in part, activation of a 5-ht1a receptor-mediated postsynaptic feedback loop centred on the mpfc. |
1999-07-29 |
2023-08-12 |
rat |
| G W John, P J Pauwels, M Perez, S Halazy, B Le Grand, Y Verscheure, J P Valentin, C Palmier, T Wurch, P Chopin, M Marien, M S Kleven, W Koek, M B Assie, E Carilla-Durand, J P Tarayre, F C Colpaer. F 11356, a novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. The Journal of pharmacology and experimental therapeutics. vol 290. issue 1. 1999-07-26. PMID:10381763. |
f 11356 has subnanomolar affinity for cloned human and nonhuman 5-ht1b and 5-ht1d receptors, and its affinity for 5-ht1a and other 5-ht receptors, including the 5-ht1f subtype, is 50-fold lower and micromolar, respectively. |
1999-07-26 |
2023-08-12 |
human |
| E Gur, E Dremencov, B Lerer, M E Newma. Venlafaxine: acute and chronic effects on 5-hydroxytryptamine levels in rat brain in vivo. European journal of pharmacology. vol 372. issue 1. 1999-07-21. PMID:10374710. |
the effect of 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat, 0.2 mg/kg s.c.) to reduce 5-ht levels was unaffected by chronic venlafaxine at this dose, indicating that there was no change in sensitivity of presynaptic 5-ht1a autoreceptors. |
1999-07-21 |
2023-08-12 |
rat |
| M F O'Neill, G J Sange. GR46611 potentiates 5-HT1A receptor-mediated locomotor activity in the guinea pig. European journal of pharmacology. vol 370. issue 2. 1999-07-16. PMID:10323255. |
the current study set out to examine the effects of 5-ht(1b/d) receptor stimulation on locomotor activity in the guinea pig and to examine the interaction between 5-ht1a and 5-ht(1b/d) receptor stimulation on locomotor activity in that species. |
1999-07-16 |
2023-08-12 |
rat |
| M F O'Neill, G J Sange. GR46611 potentiates 5-HT1A receptor-mediated locomotor activity in the guinea pig. European journal of pharmacology. vol 370. issue 2. 1999-07-16. PMID:10323255. |
the 5-ht(1b/d) receptor agonist gr46611 had no effect on locomotor activity in guinea pigs at doses up to 40 mg kg(-1) s.c. 8-oh-dpat-induced behavioural activation was reversed by the selective 5-ht1a receptor antagonist way100635 (n-[-2-[4-(-methoxyphenyl)-1-piperazinyl]ethyl]-n-(pyrinidyl) cyclo hexanocarboxamide trihydro-chloride), with a minimum effective dose of 0.006 mg kg(-1), but not by the 5-ht(1b/d) receptor antagonist gr127935 (2'-methyl-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxyli c acid [4-methoxy-3-(4-methyl-piperazin-1-yl)phenyl]-amide) (0.25-1.0 mg kg(-1)). |
1999-07-16 |
2023-08-12 |
rat |
| M F O'Neill, G J Sange. GR46611 potentiates 5-HT1A receptor-mediated locomotor activity in the guinea pig. European journal of pharmacology. vol 370. issue 2. 1999-07-16. PMID:10323255. |
these findings suggest that activation of 5-ht(1b/d) receptors alone may not stimulate locomotor activity but it does potentiate the locomotion induced by 5-ht1a receptor stimulation in guinea pigs. |
1999-07-16 |
2023-08-12 |
rat |
| K M Faber, J H Harin. Synaptogenesis in the postnatal rat fascia dentata is influenced by 5-HT1a receptor activation. Brain research. Developmental brain research. vol 114. issue 2. 1999-07-12. PMID:10320763. |
neonatal serotonin (5-ht) depletion or 5-ht1a receptor blockade results in a significant and permanent reduction in the number of dentate granule cell dendritic spines. |
1999-07-12 |
2023-08-12 |
rat |
| K M Faber, J H Harin. Synaptogenesis in the postnatal rat fascia dentata is influenced by 5-HT1a receptor activation. Brain research. Developmental brain research. vol 114. issue 2. 1999-07-12. PMID:10320763. |
these results indicate that the loss of dendritic spines observed following 5-ht depletion or 5-ht1a antagonist treatment is accompanied by a decrease in synaptic profile density. |
1999-07-12 |
2023-08-12 |
rat |
| J Mendez, T M Kadia, R K Somayazula, K I El-Badawi, D S Cowe. Differential coupling of serotonin 5-HT1A and 5-HT1B receptors to activation of ERK2 and inhibition of adenylyl cyclase in transfected CHO cells. Journal of neurochemistry. vol 73. issue 1. 1999-07-08. PMID:10386967. |
differential coupling of serotonin 5-ht1a and 5-ht1b receptors to activation of erk2 and inhibition of adenylyl cyclase in transfected cho cells. |
1999-07-08 |
2023-08-12 |
Not clear |
| N K Jain, S K Kulkarn. Antinociceptive effect of sumatriptan in mice. Indian journal of experimental biology. vol 36. issue 10. 1999-07-07. PMID:10356959. |
the antinociceptive effect of sumatriptan was compared with an another 5-ht agonist (5-ht1a) buspirone which also produced antinociception. |
1999-07-07 |
2023-08-12 |
mouse |
| J Sandell, C Halldin, H Hall, S O Thorberg, T Werner, D Sohn, G Sedvall, L Fard. Radiosynthesis and autoradiographic evaluation of [11C]NAD-299, a radioligand for visualization of the 5-HT1A receptor. Nuclear medicine and biology. vol 26. issue 2. 1999-07-01. PMID:10100214. |
[11c]nad-299 binding was inhibited by addition of the 5-ht1a receptor ligands way-100635, pindolol, (+/-)-8-oh-dpat, 5-ht, and buspirone, leaving a low background of nonspecific binding. |
1999-07-01 |
2023-08-12 |
human |