All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
H Okazawa, F Yamane, P Blier, M Diksi. Effects of acute and chronic administration of the serotonin1A agonist buspirone on serotonin synthesis in the rat brain. Journal of neurochemistry. vol 72. issue 5. 1999-05-06. PMID:10217280. the unaltered 5-ht synthesis rates in the chronic treatment study likely reflect a normalization of this parameter due to a desensitization of 5-ht1a autoreceptors on the cell body of 5-ht neurons, which has been previously shown to occur following long-term treatment with 5-ht1a agonists. 1999-05-06 2023-08-12 rat
C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. inhibition of hippocampal 5-ht synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-ht1a and 5-ht1b/d autoreceptors. 1999-05-04 2023-08-12 rat
C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. pretreatment of rats with the selective 5-ht1a receptor antagonist way 100635 for a period of 7 days using subcutaneously implanted osmotic minipumps (1 mg/kg/day) was sufficient to block the inhibition of 5-ht synthesis following the 5-ht 1a receptor agonist 8-oh-dpat (0.3 mg/kg s.c.), but failed to inhibit the decrease of hippocampal 5-ht synthesis by fluoxetine (10 mg/kg i.p.) 1999-05-04 2023-08-12 rat
C L Barton, P H Hutso. Inhibition of hippocampal 5-HT synthesis by fluoxetine and paroxetine: evidence for the involvement of both 5-HT1A and 5-HT1B/D autoreceptors. Synapse (New York, N.Y.). vol 31. issue 1. 1999-05-04. PMID:10025679. these results indicate that both 5-ht1a and 5-ht1b/1d receptors, which function in the rat as inhibitory somatodendritic and nerve terminal autoreceptors, independently regulate hippocampal 5-ht synthesis and must be simultaneously blocked to prevent the inhibition of 5-ht synthesis by selective serotonin reuptake inhibitors which increase 5-ht availability at both nerve terminals in hippocampus and 5-ht cell bodies in the raphe nuclei. 1999-05-04 2023-08-12 rat
M Nishi, E C Azmiti. Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029236. we examined the response and regulation of 5-ht1a receptor on hippocampal cultured fetal neurons grown in the absence of serotonin and steroids using three experimental designs: 1) functional response using an antibody against phosphorylated cyclic adenosine monophosphate response element binding protein (pcreb); 2) transcriptional regulation using in situ hybridization; and 3) translational expression using antipeptide 5-ht1a receptor antibody. 1999-05-04 2023-08-12 rat
M Nishi, E C Azmiti. Agonist- and antagonist-induced plasticity of rat 5-HT1A receptor in hippocampal cell culture. Synapse (New York, N.Y.). vol 31. issue 3. 1999-05-04. PMID:10029236. our results indicate that the 5-ht1a receptor is sensitive to both agonists (downregulation) and antagonists (upregulation) in hippocampal fetal neurons grown in the absence of serotonin and steroids. 1999-05-04 2023-08-12 rat
A Ghavami, K L Stark, M Jareb, S Ramboz, L Ségu, R He. Differential addressing of 5-HT1A and 5-HT1B receptors in epithelial cells and neurons. Journal of cell science. vol 112 ( Pt 6). 1999-05-04. PMID:10036246. the 5-ht1a and 5-ht1b serotonin receptors are expressed in a variety of neurons in the central nervous system. 1999-05-04 2023-08-12 mouse
S Andronati, V Sava, S Makan, G Kolodee. Synthesis of 3-aryl-1-[(4-phenyl-1-piperazinyl)butyl]indazole derivatives and their affinity to 5-HT1A serotonin and dopamine D1 receptors. Die Pharmazie. vol 54. issue 2. 1999-04-29. PMID:10084155. synthesis of 3-aryl-1-[(4-phenyl-1-piperazinyl)butyl]indazole derivatives and their affinity to 5-ht1a serotonin and dopamine d1 receptors. 1999-04-29 2023-08-12 Not clear
S Andronati, V Sava, S Makan, G Kolodee. Synthesis of 3-aryl-1-[(4-phenyl-1-piperazinyl)butyl]indazole derivatives and their affinity to 5-HT1A serotonin and dopamine D1 receptors. Die Pharmazie. vol 54. issue 2. 1999-04-29. PMID:10084155. eight 3-arylindazole derivatives have been synthesized and their affinity to 5-ht1a serotonin and d1 dopamine receptors was investigated by radioligand analysis. 1999-04-29 2023-08-12 Not clear
S Andronati, V Sava, S Makan, G Kolodee. Synthesis of 3-aryl-1-[(4-phenyl-1-piperazinyl)butyl]indazole derivatives and their affinity to 5-HT1A serotonin and dopamine D1 receptors. Die Pharmazie. vol 54. issue 2. 1999-04-29. PMID:10084155. an inverse dependence on the structure of the studied compounds was observed for the serotonin 5-ht1a receptors. 1999-04-29 2023-08-12 Not clear
S Hammoumi, A Payen, J D Favre, J L Balmes, J Y Benard, M Husson, J P Ferrand, J P Martin, M Daous. Does the short variant of the serotonin transporter linked polymorphic region constitute a marker of alcohol dependence? Alcohol (Fayetteville, N.Y.). vol 17. issue 2. 1999-04-22. PMID:10064377. pharmacological and clinical studies have shown that the 5-ht transporter (5-htt) and the 5-ht1a receptor appear to be candidate loci for the aetiology of alcohol dependence. 1999-04-22 2023-08-12 Not clear
C Stenfors, T Magnusson, L G Larsson, H Yu, M Hållbus, O Magnusson, S B Ros. Synergism between 5-HT1B/1D and 5-HT1A receptor antagonists on turnover and release of 5-HT in guinea-pig brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 2. 1999-04-20. PMID:10048595. synergism between 5-ht1b/1d and 5-ht1a receptor antagonists on turnover and release of 5-ht in guinea-pig brain in vivo. 1999-04-20 2023-08-12 Not clear
C Stenfors, T Magnusson, L G Larsson, H Yu, M Hållbus, O Magnusson, S B Ros. Synergism between 5-HT1B/1D and 5-HT1A receptor antagonists on turnover and release of 5-HT in guinea-pig brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 2. 1999-04-20. PMID:10048595. the effects on 5-ht turnover (5-hiaa/5-ht ratio) and extracellular 5-ht and 5-hiaa levels (in vivo microdialysis in freely moving animals) were analysed in guinea-pig brains following the 5-ht1b receptor antagonist, gr 127935 [n-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl-1 ,2,4-oxadiazol-3-yl) [1,1-biphenyl]-4-carboxamide], or the 5-ht1a receptor antagonist, way-100635 (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride), administered alone or in combination. 1999-04-20 2023-08-12 Not clear
C Stenfors, T Magnusson, L G Larsson, H Yu, M Hållbus, O Magnusson, S B Ros. Synergism between 5-HT1B/1D and 5-HT1A receptor antagonists on turnover and release of 5-HT in guinea-pig brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 359. issue 2. 1999-04-20. PMID:10048595. the synergistic effect of the two receptor antagonists on the 5-ht turnover and the terminal release of 5-ht indicate somatodendritic 5-ht release and stimulation of inhibitory 5-ht1a receptors at this level. 1999-04-20 2023-08-12 Not clear
L Stern, J Zohar, R Cohen, Y Sasso. Treatment of severe, drug resistant obsessive compulsive disorder with the 5HT1D agonist sumatriptan. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 8. issue 4. 1999-04-13. PMID:9928925. in pharmacological challenge tests, mcpp, a 5-ht agonist, with an affinity for 5ht2c as well as 5ht1a and 5ht1d receptors, was associated with a transient exacerbation of obsessive compulsive symptoms. 1999-04-13 2023-08-12 Not clear
J B Blair, D Marona-Lewicka, A Kanthasamy, V L Lucaites, D L Nelson, D E Nichol. Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine. Journal of medicinal chemistry. vol 42. issue 6. 1999-04-13. PMID:10090793. both 3a and 3b induced a brief "serotonin syndrome" and salivation, an indication of 5-ht1a receptor activation. 1999-04-13 2023-08-12 human
J B Blair, D Marona-Lewicka, A Kanthasamy, V L Lucaites, D L Nelson, D E Nichol. Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine. Journal of medicinal chemistry. vol 42. issue 6. 1999-04-13. PMID:10090793. thus, thienopyrrole does appear to serve as a potent bioisostere for the indole nucleus in compounds that bind to the serotonin 5-ht1a receptor. 1999-04-13 2023-08-12 human
L Sprah, M Zivin, D Ske. Ergoline derivative LEK-8829-induced turning behavior in rats with unilateral striatal ibotenic acid lesions: interaction with bromocriptine. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027846. lek-8829 [9,10-didehydro-n-methyl-(2-propynyl)-6-methyl-8- aminomethylergoline bimaleinate] is an antagonist of dopamine d2 receptors and serotonin (5-ht)2 and 5-ht1a receptors in intact animals and a d1 receptor agonist in dopamine-depleted animals. 1999-04-01 2023-08-12 rat
S F de Boer, M Lesourd, E Mocaer, J M Koolhaa. Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027850. the present study characterized the effects of the novel, selective, and potent 5-hydroxytryptamine1a (serotonin) (5-ht1a) receptor agonist, alnespirone [s-20499, (s)-n-4-[5-methoxychroman-3-yl)propylamino)butyl- 8-azaspiro-(4,5)-diacetamide, hydrochloride] on offensive and defensive resident-intruder aggression in wild-type rats and compared its actions with those of the prototypical full 5-ht1a agonist 8-hydroxy-2- dipropylaminotetralin (8-oh-dpat), the partial 5-ht1a agonists ipsapirone and buspirone, and the mixed 5-ht1a/1b agonist eltoprazine. 1999-04-01 2023-08-12 rat
N G Simon, A Cologer-Clifford, S F Lu, S E McKenna, S H. Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression. Neuroscience and biobehavioral reviews. vol 23. issue 2. 1999-03-29. PMID:9884126. pharmacological studies have shown that serotonin, via its action at 5ht1a and/or 5ht1b receptor sites, modulates the display of intermale aggressive behavior and that its effects serve to decrease behavioral expression. 1999-03-29 2023-08-12 Not clear