| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N G Simon, A Cologer-Clifford, S F Lu, S E McKenna, S H. Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression. Neuroscience and biobehavioral reviews. vol 23. issue 2. 1999-03-29. PMID:9884126. |
pharmacological studies have shown that serotonin, via its action at 5ht1a and/or 5ht1b receptor sites, modulates the display of intermale aggressive behavior and that its effects serve to decrease behavioral expression. |
1999-03-29 |
2023-08-12 |
Not clear |
| N G Simon, A Cologer-Clifford, S F Lu, S E McKenna, S H. Testosterone and its metabolites modulate 5HT1A and 5HT1B agonist effects on intermale aggression. Neuroscience and biobehavioral reviews. vol 23. issue 2. 1999-03-29. PMID:9884126. |
as an initial step toward characterizing the interaction between the systems, studies were conducted that assessed hormonal modulation of serotonin function at 5ht1a and 5ht1b receptor sites. |
1999-03-29 |
2023-08-12 |
Not clear |
| A Adell, F Artiga. A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863668. |
the present study has examined several characteristics of the release of 5-ht in the median raphe nucleus in terms of its dependence of nerve impulse, provenance of a vesicular storage fraction as well as the regulatory role played by 5-ht1a receptors. |
1999-03-25 |
2023-08-12 |
rat |
| A Adell, F Artiga. A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863668. |
the perfusion of 1-100 microm of 8-oh-dpat or the novel 5-ht1a agonist bay x 3702 decreased the efflux of 5-ht, whereas the perfusion of the 5-ht1a antagonist way-100635 failed to alter 5-ht release. |
1999-03-25 |
2023-08-12 |
rat |
| A Adell, F Artiga. A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat. British journal of pharmacology. vol 125. issue 6. 1999-03-25. PMID:9863668. |
also, the basal release of 5-ht in the median raphe nucleus does not appear to be under the tonic control of somatodendritic 5-ht1a receptors by endogenous 5-ht. |
1999-03-25 |
2023-08-12 |
rat |
| L Palego, A Giromella, D Marazziti, F Borsini, A G Naccarato, G Giannaccini, A Lucacchini, G B Cassano, M R Mazzon. Effects of postmortem delay on serotonin and (+)8-OH-DPAT-mediated inhibition of adenylyl cyclase activity in rat and human brain tissues. Brain research. vol 816. issue 1. 1999-03-25. PMID:9878719. |
5-ht and the 5-ht1a receptor agonist, (+)8-hydroxy-2(di-n-propylamino)tetraline (8-oh-dpat), were able to inhibit forskolin-stimulated adenylyl cyclase activity in a dose-dependent manner for 48 h after death in rat and human brain. |
1999-03-25 |
2023-08-12 |
human |
| B Bjorvatn, R Ursi. Changes in sleep and wakefulness following 5-HT1A ligands given systemically and locally in different brain regions. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886141. |
microinjection of serotonin into the region of the cholinergic basalis neurons produces an increase in slow wave activity, presumably by stimulating 5-ht1a receptors. |
1999-03-23 |
2023-08-12 |
Not clear |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
emerging evidence also indicates that 5-ht1a and 5-ht4 receptor agonists, as well as, 5-ht1a antagonists, 5-ht2 antagonists, 5-ht3 antagonists and 5-ht uptake inhibitors may have therapeutic utility in the treatment of alzheimer's disease and amnesia. |
1999-03-23 |
2023-08-12 |
Not clear |
| N A Darmani, W Zha. Production of serotonin syndrome by 8-OH DPAT in Cryptotis parva. Physiology & behavior. vol 65. issue 2. 1999-03-22. PMID:9855483. |
the purpose of the present study was to determine whether activation of 5-ht1a receptors by its selective agonist, 8-oh dpat, can induce the serotonin syndrome (ss) in this species. |
1999-03-22 |
2023-08-12 |
rat |
| G J Della Rocca, Y V Mukhin, M N Garnovskaya, Y Daaka, G J Clark, L M Luttrell, R J Lefkowitz, J R Raymon. Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. The Journal of biological chemistry. vol 274. issue 8. 1999-03-18. PMID:9988712. |
serotonin 5-ht1a receptor-mediated erk activation requires calcium/calmodulin-dependent receptor endocytosis. |
1999-03-18 |
2023-08-12 |
human |
| G J Della Rocca, Y V Mukhin, M N Garnovskaya, Y Daaka, G J Clark, L M Luttrell, R J Lefkowitz, J R Raymon. Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. The Journal of biological chemistry. vol 274. issue 8. 1999-03-18. PMID:9988712. |
the gi-coupled serotonin (5-hydroxytryptamine (5-ht)) 5-ht1a receptor, heterologously expressed in chinese hamster ovary or human embryonic kidney 293 cells, mediated rapid activation of erk1/2 via a mechanism dependent upon both ras activation and clathrin-mediated endocytosis. |
1999-03-18 |
2023-08-12 |
human |
| F G Moeller, T Allen, D R Cherek, D M Dougherty, S Lane, A C Swan. Ipsapirone neuroendocrine challenge: relationship to aggression as measured in the human laboratory. Psychiatry research. vol 81. issue 1. 1999-03-16. PMID:9829648. |
thirty-one human subjects were administered a neuroendocrine challenge with the 5-ht1a agonist ipsapirone after completing six sessions of a laboratory measure of aggression, the point subtraction aggression paradigm (psap), in order to determine if a laboratory measure of aggression was related to serotonin function. |
1999-03-16 |
2023-08-12 |
human |
| L Verdot, B Garreau, C Barthelemy, J Martineau, M Ferrer-Di-Martino, J P Muh, J Hoebek. Immunoreactivity of sera to a peptide derived from the serotonin 5-HT1A receptor in a group of children with developmental disorders: possible role in non-autistic epilepsy. International journal of molecular medicine. vol 1. issue 1. 1999-03-16. PMID:9852218. |
immunoreactivity of sera to a peptide derived from the serotonin 5-ht1a receptor in a group of children with developmental disorders: possible role in non-autistic epilepsy. |
1999-03-16 |
2023-08-12 |
Not clear |
| C Grånäs, G Nordvall, D Larhamma. Mutagenesis of the human 5-HT1B receptor: differences from the closely related 5-HT1A receptor and the role of residue F331 in signal transduction. Journal of receptor and signal transduction research. vol 18. issue 4-6. 1999-03-12. PMID:9879059. |
no reduction in the affinity of 5-ht was seen for the s212a mutant, although an equivalent mutation in the 5-ht1a receptor resulted in a 100-fold reduction of 5-ht binding. |
1999-03-12 |
2023-08-12 |
human |
| M Perez, C Jorand-Lebrun, P J Pauwels, I Pallard, S Halaz. Dimers of 5HT1 ligands preferentially bind to 5HT1B/1D receptor subtypes. Bioorganic & medicinal chemistry letters. vol 8. issue 11. 1999-03-11. PMID:9871775. |
new dimers of known 5ht1 ligands (5ht, 1-np or 8-oh-dpat) have been prepared and evaluated at human cloned 5ht1b, 5ht1d and 5ht1a receptors. |
1999-03-11 |
2023-08-12 |
human |
| I Misane, C Johansson, S O Ogre. Analysis of the 5-HT1A receptor involvement in passive avoidance in the rat. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806333. |
both ndo 008 and the two enantiomers of 8-oh-dpat induced the serotonin syndrome at the dose range that produced inhibition of the pa response, thus, indicating activation of postsynaptic 5-ht1a receptors. |
1999-03-04 |
2023-08-12 |
rat |
| I Misane, C Johansson, S O Ogre. Analysis of the 5-HT1A receptor involvement in passive avoidance in the rat. British journal of pharmacology. vol 125. issue 3. 1999-03-04. PMID:9806333. |
a 3 day pretreatment procedure (200+100+100 mg kg(-1)) with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pcpa) did not alter pa retention and did not prevent the inhibitory action of the 5-ht1a agonists, indicating that their effects on pa do not depend on endogenous 5-ht. |
1999-03-04 |
2023-08-12 |
rat |
| M Kakoki, Y Hirata, H Hayakawa, H Nishimatsu, Y Suzuki, D Nagata, E Suzuki, K Kikuchi, T Nagano, M Omat. Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney. Hypertension (Dallas, Tex. : 1979). vol 33. issue 1 Pt 2. 1999-02-26. PMID:9931149. |
metergoline (10(-6) mol/l), a 5-hydroxytryptamine (5-ht)1/2 antagonist, or nan-190 (10(-6) mol/l), a 5-ht1a antagonist, almost completely abolished the vasorelaxation and no release caused by bopindolol, celiprolol, and nebivolol. |
1999-02-26 |
2023-08-12 |
rat |
| K Krebs-Thomson, M A Geye. Evidence for a functional interaction between 5-HT1A and 5-HT2 receptors in rats. Psychopharmacology. vol 140. issue 1. 1999-02-25. PMID:9862404. |
evidence of a functional interaction between serotonin 5-ht1a and 5-ht2 receptor subtypes has been compromised by incomplete experimental designs and conflicting data. |
1999-02-25 |
2023-08-12 |
rat |
| Q Q Sun, N Dal. G-proteins are involved in 5-HT receptor-mediated modulation of N- and P/Q- but not T-type Ca2+ channels. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 3. 1999-02-25. PMID:9920652. |
5-ht produces voltage-independent inhibition of the n-, p/q-, and t-type ca2+ currents in sensory neurons of xenopus larvae by acting on 5-ht1a and 5-ht1d receptors. |
1999-02-25 |
2023-08-12 |
rat |