All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
M N Subhash, B N Srinivas, K Y Vinod, S Jagadees. Inactivation of 5-HT1A and [3H]5-HT binding sites by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in rat brain. Neurochemical research. vol 23. issue 10. 1999-01-07. PMID:9804289. inactivation of 5-ht1a and [3h]5-ht binding sites by n-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (eedq) was studied in regions of rat brain. 1999-01-07 2023-08-12 rat
M N Subhash, B N Srinivas, K Y Vinod, S Jagadees. Inactivation of 5-HT1A and [3H]5-HT binding sites by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in rat brain. Neurochemical research. vol 23. issue 10. 1999-01-07. PMID:9804289. the affinity of [3h]5-ht to 5-ht1 sites was decreased significantly in both cortex and hippocampus after exposure to eedq, without affecting the kd of 5-ht1a sites. 1999-01-07 2023-08-12 rat
B Vacher, B Bonnaud, P Funes, N Jubault, W Koek, M B Assié, C Cos. Design and synthesis of a series of 6-substituted-2-pyridinylmethylamine derivatives as novel, high-affinity, selective agonists at 5-HT1A receptors. Journal of medicinal chemistry. vol 41. issue 25. 1999-01-07. PMID:9836623. a search for novel, selective agonists with high intrinsic activity at the 5-ht1a subtype of serotonin (5-ht) receptors was undertaken. 1999-01-07 2023-08-12 Not clear
K A Metwally, M Dukat, C T Egan, C Smith, A DuPre, C B Gauthier, K Herrick-Davis, M Teitler, R A Glenno. Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding. Journal of medicinal chemistry. vol 41. issue 25. 1999-01-07. PMID:9836624. spiperone (1) is a widely used pharmacological tool that acts as a potent dopamine d2, serotonin 5-ht1a, and serotonin 5-ht2a antagonist. 1999-01-07 2023-08-12 rat
J K Staley, R T Malison, R B Inni. Imaging of the serotonergic system: interactions of neuroanatomical and functional abnormalities of depression. Biological psychiatry. vol 44. issue 7. 1999-01-06. PMID:9787877. with the rapid development of novel pet and spect radiotracers, future studies of the serotonergic system that evaluate presynaptic (5-ht transporter) and postsynaptic (5-ht1a and 5-ht2a receptors) markers and the interaction of synaptic levels of 5-ht with these sites will make profound contributions to the understanding of the role of the serotonergic synapse in the pathophysiology of depression. 1999-01-06 2023-08-12 human
I Hervás, F Artiga. Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors. European journal of pharmacology. vol 358. issue 1. 1998-12-31. PMID:9809863. when citalopram was present in the perfusion fluid, fluoxetine (10 mg/kg) reduced 5-ht output, an effect reversed by the administration of the selective 5-ht1a receptor antagonist ¿n-[2-(4-(2-methoxyphenyl)-1-piperazinyl) ethyl]-n-(2-pyridyl) cyclohexane carboxamide.3hcl¿ (way 100635). 1998-12-31 2023-08-12 rat
K G Harikumar, A Chattopadhya. Metal ion and guanine nucleotide modulations of agonist interaction in G-protein-coupled serotonin1A receptors from bovine hippocampus. Cellular and molecular neurobiology. vol 18. issue 5. 1998-12-30. PMID:9777253. the serotonin type 1a (5-ht1a) receptors are members of a superfamily of seven transmembrane domain receptors that couple to gtp-binding regulatory proteins (g-proteins). 1998-12-30 2023-08-12 cattle
S Ramboz, R Oosting, D A Amara, H F Kung, P Blier, M Mendelsohn, J J Mann, D Brunner, R He. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 24. 1998-12-28. PMID:9826725. although 5-ht1a receptors are involved in controlling the activity of serotonergic neurons, 5-ht1a knockout mice had normal levels of 5-ht and 5-hydroxyindoleacetic acid, possibly because of an up-regulation of 5-ht1b autoreceptors. 1998-12-28 2023-08-12 mouse
N Haddjeri, B Seletti, F Gilbert, C de Montigny, P Blie. Effect of ergotamine on serotonin-mediated responses in the rodent and human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 5. 1998-12-23. PMID:9778659. in the rat dorsal hippocampus and dorsal raphe nucleus, the microiontophoretic application of ergotamine and 5-ht suppressed the firing activity of ca3 pyramidal neurons and 5-ht neurons, an effect antagonized by selective 5-ht1a receptor antagonists. 1998-12-23 2023-08-12 human
N Haddjeri, B Seletti, F Gilbert, C de Montigny, P Blie. Effect of ergotamine on serotonin-mediated responses in the rodent and human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 5. 1998-12-23. PMID:9778659. co-application of ergotamine prevented the inhibitory action of 5-ht on the firing activity of ca3 pyramidal neurons but not of 5-ht neurons, indicating that ergotamine acted as a partial 5-ht1a receptor agonist in the dorsal hippocampus and as a full agonist at 5-ht1a autoreceptors. 1998-12-23 2023-08-12 human
N Haddjeri, B Seletti, F Gilbert, C de Montigny, P Blie. Effect of ergotamine on serotonin-mediated responses in the rodent and human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 19. issue 5. 1998-12-23. PMID:9778659. in conclusion, the present results suggest that ergotamine acted in the rat brain as a 5-ht1a receptor agonist and as an agonist of terminal 5-ht autoreceptor of a yet undefined subtype. 1998-12-23 2023-08-12 human
G Vitale, L A Pini, A Ottani, M Sandrin. Effect of acetylsalicylic acid on formalin test and on serotonin system in the rat brain. General pharmacology. vol 31. issue 5. 1998-12-23. PMID:9809474. increased serotonin (5-ht) content in rat brain but did not modify the number or the affinity of 5-ht1a receptors in the pons and the cerebral cortex, whereas the number of cortical 5-ht2 receptors decreased significantly. 1998-12-23 2023-08-12 rat
I Hervás, N Bel, A G Fernández, J M Palacios, F Artiga. In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei. Naunyn-Schmiedeberg's archives of pharmacology. vol 358. issue 3. 1998-12-22. PMID:9774218. thus, the present data suggest that the comparable effects of ssris in drn- and mrn-innervated forebrain regions are not explained by a preferential attenuation of 5-ht release by terminal 5-ht1b autoreceptors in hippocampus, an area with a low inhibitory influence of somatodendritic 5-ht1a receptors. 1998-12-22 2023-08-12 rat
M Beato, A Nistr. Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class. Proceedings. Biological sciences. vol 265. issue 1410. 1998-12-22. PMID:9842733. selective blockers of the 5-ht1a or 5-ht1b/d receptor classes, either alone or in combination, largely (but not completely) attenuated this inhibitory action of 5-ht. 1998-12-22 2023-08-12 rat
N Haddjeri, P Blier, C de Montign. Long-term antidepressant treatments result in a tonic activation of forebrain 5-HT1A receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 23. 1998-12-18. PMID:9822768. however, after long-term treatment with the tricyclic antidepressant imipramine, the selective 5-ht reuptake inhibitor paroxetine, the reversible monoamine oxidase-a inhibitor befloxatone, the alpha2-adrenergic antagonist mirtazapine, or the 5-ht1a receptor agonist gepirone or multiple electroconvulsive shock (ecs) administration, way 100635 markedly increased (60-200%) the firing activity of ca3 pyramidal neurons. 1998-12-18 2023-08-12 rat
M Darmon, X Langlois, L Suffisseau, C M Fattaccini, M Hamo. Differential membrane targeting and pharmacological characterization of chimeras of rat serotonin 5-HT1A and 5-HT1B receptors expressed in epithelial LLC-PK1 cells. Journal of neurochemistry. vol 71. issue 6. 1998-12-18. PMID:9832127. differential membrane targeting and pharmacological characterization of chimeras of rat serotonin 5-ht1a and 5-ht1b receptors expressed in epithelial llc-pk1 cells. 1998-12-18 2023-08-12 rat
M Darmon, X Langlois, L Suffisseau, C M Fattaccini, M Hamo. Differential membrane targeting and pharmacological characterization of chimeras of rat serotonin 5-HT1A and 5-HT1B receptors expressed in epithelial LLC-PK1 cells. Journal of neurochemistry. vol 71. issue 6. 1998-12-18. PMID:9832127. the serotonin 5-ht1a and 5-ht1b receptors are two structurally related but pharmacologically distinguishable 5-ht receptor types. 1998-12-18 2023-08-12 rat
R Perrone, F Berardi, N A Colabufo, M Leopoldo, V Tortorell. N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide: a potent and selective dopamine D4 ligand. Journal of medicinal chemistry. vol 41. issue 24. 1998-12-17. PMID:9822559. among these, n-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide (17) emerged since it exhibited very high affinity for dopamine d4 receptor (ic50 = 0.057 nm) with selectivity of >10 000 for the d4 versus the d2 receptor; compound 17 was also selective versus serotonin 5-ht1a and adrenergic alpha1 receptors. 1998-12-17 2023-08-12 human
J R Moiseiwitsch, J R Raymond, H Tamir, J M Laude. Regulation by serotonin of tooth-germ morphogenesis and gene expression in mouse mandibular explant cultures. Archives of oral biology. vol 43. issue 10. 1998-12-16. PMID:9796780. rather, these results raise the possibility that 5-ht may exert effects directly on tooth-germ morphogenesis mediated by intracellular uptake of 5-ht and/or activation of 5-ht1a and 5-ht3 receptors. 1998-12-16 2023-08-12 mouse
L Farde, H Ito, C G Swahn, V W Pike, C Halldi. Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 39. issue 11. 1998-12-14. PMID:9829590. the serotonin 5-hydroxytryptamine-1a (5-ht1a) receptor subtype is of central interest in research on the pathophysiology and treatment of psychiatric disorders. 1998-12-14 2023-08-12 human