| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Farde, H Ito, C G Swahn, V W Pike, C Halldi. Quantitative analyses of carbonyl-carbon-11-WAY-100635 binding to central 5-hydroxytryptamine-1A receptors in man. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 39. issue 11. 1998-12-14. PMID:9829590. |
the serotonin 5-hydroxytryptamine-1a (5-ht1a) receptor subtype is of central interest in research on the pathophysiology and treatment of psychiatric disorders. |
1998-12-14 |
2023-08-12 |
human |
| K A Miczek, S Hussain, S Faccidom. Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists. Psychopharmacology. vol 139. issue 1-2. 1998-12-09. PMID:9768554. |
one of the critical mechanisms by which alcohol heightens aggression involves forebrain serotonin (5-ht) systems, possibly via actions on 5-ht1a receptors. |
1998-12-09 |
2023-08-12 |
mouse |
| K A Miczek, S Hussain, S Faccidom. Alcohol-heightened aggression in mice: attenuation by 5-HT1A receptor agonists. Psychopharmacology. vol 139. issue 1-2. 1998-12-09. PMID:9768554. |
if these effects are in fact due to action at somatodendritic 5-ht1a autoreceptors, then the anti-aggressive effects would be associated with decreased 5-ht neurotransmission. |
1998-12-09 |
2023-08-12 |
mouse |
| L L Hwang, N J Du. 5-Hydroxytryptamine responses in immature rat rostral ventrolateral medulla neurons in vitro. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744919. |
the present study shows that, in the immature rat rvlm neurons, 5-ht causes a slow hyperpolarization and depolarization probably by interacting with 5-ht1a and 5-ht2 receptors, which are g-proteins coupled. |
1998-12-03 |
2023-08-12 |
rat |
| D Schmitz, T Gloveli, R M Empson, U Heineman. Serotonin reduces polysynaptic inhibition via 5-HT1A receptors in the superficial entorhinal cortex. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744926. |
serotonin reduces polysynaptic inhibition via 5-ht1a receptors in the superficial entorhinal cortex. |
1998-12-03 |
2023-08-12 |
Not clear |
| D Schmitz, T Gloveli, R M Empson, U Heineman. Serotonin reduces polysynaptic inhibition via 5-HT1A receptors in the superficial entorhinal cortex. Journal of neurophysiology. vol 80. issue 3. 1998-12-03. PMID:9744926. |
we conclude that serotonin suppresses polysynaptic inhibition in projection neurons of layers ii and iii of the ec by depression of epsps on inhibitory interneurons via 5-ht1a receptors. |
1998-12-03 |
2023-08-12 |
Not clear |
| K G Harikumar, A Chattopadhya. Modulation of agonist and antagonist interactions in serotonin 1A receptors by alcohols. FEBS letters. vol 438. issue 1-2. 1998-12-02. PMID:9821966. |
the serotonin type ia (5-ht1a) receptors are members of a superfamily of seven transmembrane domain receptors that couple to gtp binding regulatory proteins (g-proteins). |
1998-12-02 |
2023-08-12 |
cattle |
| C Davidson, J A Stamfor. Contrasting effects of chronic paroxetine on 5-HT1A control of dorsal raphe cell firing and 5-HT release. Neuroreport. vol 9. issue 11. 1998-11-18. PMID:9721928. |
contrasting effects of chronic paroxetine on 5-ht1a control of dorsal raphe cell firing and 5-ht release. |
1998-11-18 |
2023-08-12 |
Not clear |
| C Davidson, J A Stamfor. Contrasting effects of chronic paroxetine on 5-HT1A control of dorsal raphe cell firing and 5-HT release. Neuroreport. vol 9. issue 11. 1998-11-18. PMID:9721928. |
we constructed cumulative concentration response curves to the selective 5-ht1a agonist (+)-8-oh-dpat on both extracellular recordings of 5-ht neurones and electrically stimulated 5-ht release in dorsal raphe brain slices. |
1998-11-18 |
2023-08-12 |
Not clear |
| C Davidson, J A Stamfor. Contrasting effects of chronic paroxetine on 5-HT1A control of dorsal raphe cell firing and 5-HT release. Neuroreport. vol 9. issue 11. 1998-11-18. PMID:9721928. |
chronic paroxetine did not, however, desensitize the 5-ht1a receptors controlling 5-ht release but increased the 8-oh-dpat emax from 54.9% to 79.2% inhibition of 5-ht release. |
1998-11-18 |
2023-08-12 |
Not clear |
| C Davidson, J A Stamfor. Contrasting effects of chronic paroxetine on 5-HT1A control of dorsal raphe cell firing and 5-HT release. Neuroreport. vol 9. issue 11. 1998-11-18. PMID:9721928. |
these data suggest that there are either two distinct populations of 5-ht1a receptors or separate second messenger systems, one controlling 5-ht release and another influencing firing. |
1998-11-18 |
2023-08-12 |
Not clear |
| M Leone, A Attanasio, D Croci, A Ferraris, D D'Amico, L Grazzi, A Nespolo, G Busson. 5-HT1A receptor hypersensitivity in migraine is suggested by the m-chlorophenylpiperazine test. Neuroreport. vol 9. issue 11. 1998-11-18. PMID:9721941. |
to further investigate the type of cerebral serotonin receptors that may be altered in migraine, the prolactin (prl) and cortisol responses to m-chlorophenylpiperazine (mcpp), a selective 5-ht1a,-5-ht(2a/c) receptor agonist, were monitored in 12 patients suffering from migraine without aura and in 14 matched healthy controls. |
1998-11-18 |
2023-08-12 |
human |
| P Hertel, N Lindblom, G G Nomikos, T H Svensso. Modulation of central serotonergic neurotransmission by risperidone: underlying mechanism(s) and significance of action. Progress in neuro-psychopharmacology & biological psychiatry. vol 22. issue 5. 1998-11-18. PMID:9723122. |
consequently, the risperidone-induced increase in 5-ht output in the fc may be related to its alpha 2 adrenoceptor antagonistic action, an effect probably executed at the nerve terminal level, whereas the reduction in 5-ht cell firing by risperidone appears to be associated with increased availability of 5-ht in the somatodendritic region of the neurones leading to an enhanced 5-ht1a autoreceptor activation and, in turn, to inhibition of cell firing. |
1998-11-18 |
2023-08-12 |
rat |
| C Karlsson, G Bodelsson, M Bodelsson, M Stjernquis. Endothelium-derived prostanoids reduce 5-hydroxytryptamine-induced contraction in the human uterine artery. Human reproduction (Oxford, England). vol 13. issue 7. 1998-11-17. PMID:9740455. |
removal of the endothelium did not change the response to 5-ht in the presence of the 5-ht(1b/d) receptor antagonist gr127935 and the 5-ht1a and 5-ht1b receptor antagonist -pindolol. |
1998-11-17 |
2023-08-12 |
human |
| R M Sibug, J C Compaan, O C Meijer, J Van der Gugten, B Olivier, E R De Kloe. Flesinoxan treatment reduces 5-HT1A receptor mRNA in the dentate gyrus independently of high plasma corticosterone levels. European journal of pharmacology. vol 353. issue 2-3. 1998-11-13. PMID:9726650. |
it is concluded that flesinoxan reduces 5-ht1a receptor expression in the dentate gyrus both through homologous downregulation and a corticosterone-mediated effect on the serotonergic (5-ht) system. |
1998-11-13 |
2023-08-12 |
rat |
| O C Meijer, R Kortekaas, M S Oitzl, E R de Kloe. Acute rise in corticosterone facilitates 5-HT(1A) receptor-mediated behavioural responses. European journal of pharmacology. vol 351. issue 1. 1998-11-12. PMID:9698199. |
corticosterone influences 5-ht1a receptor-mediated responses in the rat hippocampus in vitro: activation of the high affinity mineralocorticoid receptor suppresses 5-ht1a receptor-mediated hyperpolarization, while subsequent activation of lower affinity glucocorticoid receptors enhances the effect of 5-ht. |
1998-11-12 |
2023-08-12 |
rat |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
these results suggest that the modification of endogenous 5-ht release via the 5-ht1a autoreceptor is not involved in the 8-oh-dpat-induced increase of hippocampal ach release, and that the increase of ach release induced by locally applied 8-oh-dpat involves mainly hippocampal postsynaptic 5-ht1a receptor stimulation. |
1998-11-12 |
2023-08-12 |
rat |
| K Nakai, T Fujii, K Fujimoto, T Suzuki, K Kawashim. Effect of WAY-100135 on the hippocampal acetylcholine release potentiated by 8-OH-DPAT, a serotonin1A receptor agonist, in normal and p-chlorophenylalanine-treated rats as measured by in vivo microdialysis. Neuroscience research. vol 31. issue 1. 1998-11-12. PMID:9704975. |
in addition, a possibility that subtypes of 5-ht receptors other than the 5-ht1a receptor, probably 5-ht7 receptor in the septum as well as postsynaptic 5-ht1a receptor in the hippocampus, are involved in the increased hippocampal ach release induced by systemically administered 8-oh-dpat is discussed. |
1998-11-12 |
2023-08-12 |
rat |
| L L Cheng, S J Wang, P W Gea. Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors. The European journal of neuroscience. vol 10. issue 6. 1998-11-09. PMID:9753102. |
serotonin depresses excitatory synaptic transmission and depolarization-evoked ca2+ influx in rat basolateral amygdala via 5-ht1a receptors. |
1998-11-09 |
2023-08-12 |
rat |
| L L Cheng, S J Wang, P W Gea. Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors. The European journal of neuroscience. vol 10. issue 6. 1998-11-09. PMID:9753102. |
the effect of 5-ht was mimicked by the selective 5-ht1a agonist 8-hydroxy-dipropylaminotetralin (8-oh-dpat) and was blocked by the selective 5-ht1a antagonist 1-(2-methoxyphenyl)-4[4-(2-phthalimido)butyl]piperazine oxadiazol-3-yl]methyl]phenyl]-methanesulphonamide. |
1998-11-09 |
2023-08-12 |
rat |