| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Millan, M Brocco, S Veiga, L Cistarelli, C Melon, A Gober. WAY 100,635 enhances both the 'antidepressant' actions of duloxetine and its influence on dialysate levels of serotonin in frontal cortex. European journal of pharmacology. vol 341. issue 2-3. 1998-05-21. PMID:9543235. |
thus, blockade of 5-ht1a (auto)receptors selectively facilitates the influence of duloxetine on serotonin levels in the frontal cortex in rats and, in the forced swimming model, enhances its 'antidepressant' properties in parallel. |
1998-05-21 |
2023-08-12 |
rat |
| C C Wilson, K M Faber, J H Harin. Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519268. |
serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-ht1a receptors: evidence for a glial mechanism. |
1998-05-14 |
2023-08-12 |
rat |
| C C Wilson, K M Faber, J H Harin. Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519268. |
the present study sought to verify effects of 5-ht on synaptic density at the ultrastructural level, to determine whether the 5-ht1a receptor is important for the maintenance of synaptic connections and to obtain evidence implicating s100 beta in the apparent neurotrophic actions of 5-ht. |
1998-05-14 |
2023-08-12 |
rat |
| C C Wilson, K M Faber, J H Harin. Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519268. |
these observations suggest that 5-ht functions to maintain synaptic connections in the dentate molecular layer via a 5-ht1a mechanism. |
1998-05-14 |
2023-08-12 |
rat |
| C C Wilson, K M Faber, J H Harin. Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism. Brain research. vol 782. issue 1-2. 1998-05-14. PMID:9519268. |
the results of this study suggest that the maintenance of synaptic connections in the dentate molecular layer is influenced by s100 beta levels that are controlled by 5-ht stimulation of astrocytic 5-ht1a receptors. |
1998-05-14 |
2023-08-12 |
rat |
| K Kageyama, F Tozawa, N Horiba, H Watanobe, T Sud. Serotonin stimulates corticotropin-releasing factor gene expression in the hypothalamic paraventricular nucleus of conscious rats. Neuroscience letters. vol 243. issue 1-3. 1998-05-14. PMID:9535102. |
these results suggest that 5-ht stimulates crf release, which has interactions with 5-ht1a and 5-ht3 receptors on crf neurons in the pvn, and activates crf synthesis in conscious rats. |
1998-05-14 |
2023-08-12 |
rat |
| D L Boger, J E Patterson, Q Ji. Structural requirements for 5-HT2A and 5-HT1A serotonin receptor potentiation by the biologically active lipid oleamide. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 8. 1998-05-13. PMID:9539697. |
herein, the potentiation of the 5-ht1a receptor response is disclosed, and a study of the structural features of oleamide required for potentiation of the 5-ht2a and 5-ht1a response to serotonin (5-ht) is described. |
1998-05-13 |
2023-08-12 |
Not clear |
| G J Kant, R M Wylie, K Chu, S Ghos. Effects of the serotonin agonists 8-OH-DPAT, buspirone, and DOI on water maze performance. Pharmacology, biochemistry, and behavior. vol 59. issue 3. 1998-05-05. PMID:9512079. |
we have previously reported that the serotonin 5-ht1a agonist 8-oh-dpat and the 5-ht2c agonist tfmpp impair performance on a water maze. |
1998-05-05 |
2023-08-12 |
rat |
| G J Kant, R M Wylie, K Chu, S Ghos. Effects of the serotonin agonists 8-OH-DPAT, buspirone, and DOI on water maze performance. Pharmacology, biochemistry, and behavior. vol 59. issue 3. 1998-05-05. PMID:9512079. |
these experiments demonstrate that serotonin agonists, especially the 5-ht1a subtype, can impair learning. |
1998-05-05 |
2023-08-12 |
rat |
| V Matto, L Allikmets, T Skrebuhhov. Apomorphine-induced aggressiveness and [3H]citalopram binding after antidepressant treatment in rats. Pharmacology, biochemistry, and behavior. vol 59. issue 3. 1998-05-05. PMID:9512081. |
our study indicates that the 5-ht reuptake blockade has no major influence on the apomorphine-induced aggressive behavior, but the 5-ht1a receptor subtype may be involved in the mediation of the aggressive behavior in this paradigm. |
1998-05-05 |
2023-08-12 |
rat |
| D Salgado-Commissariat, K A Alkadh. Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517442. |
serotonin inhibits epileptiform discharge by activation of 5-ht1a receptors in ca1 pyramidal neurons. |
1998-05-05 |
2023-08-12 |
rat |
| D Salgado-Commissariat, K A Alkadh. Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517442. |
in the bicuculline model, both serotonin (20 microm) and its 5-ht1a agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat, 10 microm) completely blocked the epileptiform discharge and caused membrane hyperpolarization and reduction in input resistance. |
1998-05-05 |
2023-08-12 |
rat |
| D Salgado-Commissariat, K A Alkadh. Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517442. |
this study provides evidence suggesting that in rat ca1 pyramidal neurons, serotonin can inhibit epileptiform activity in a variety of accepted epilepsy cellular models and that inhibition of epileptiform bursts by serotonin may be mediated by activation of the 5-ht1a receptor subtype. |
1998-05-05 |
2023-08-12 |
rat |
| P Somboonthum, T Matsuda, S Asano, M Sakaue, A Bab. MKC-242, a novel 5-HT1A receptor agonist, facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517445. |
we have previously reported that 5-¿3-[((2s)-1,4-benzodioxan-2-ylmethyl)amino]propoxy¿-1,3-be nzodioxole (mkc-242), a potent and selective serotonin (5-ht)1a receptor agonist, exerts anxiolytic- and antidepressant-like effects in animal models and that the antidepressant-like effect may be mediated by postsynaptic 5-ht1a receptors. |
1998-05-05 |
2023-08-12 |
rat |
| C Moret, M Brile. 5-HT autoreceptors in the regulation of 5-HT release from guinea pig raphe nucleus and hypothalamus. Neuropharmacology. vol 36. issue 11-12. 1998-05-05. PMID:9517443. |
in the raphe, way100635, a 5-ht1a receptor antagonist, at 1 microm, did not prevent naratriptan (10 microm) from reducing the extracellular levels of 5-ht. |
1998-05-05 |
2023-08-12 |
Not clear |
| A M Coelho, J Fioramonti, L Buen. Mast cell degranulation induces delayed rectal allodynia in rats: role of histamine and 5-HT. Digestive diseases and sciences. vol 43. issue 4. 1998-05-05. PMID:9558027. |
this effect was suppressed by doxantrazole (mast cell stabilizing agent) and way 100635 (5-ht1a receptor antagonist), and reproduced by 5-htp (5-ht precursor) and 8-oh-dpat (5-ht1a receptor agonist). |
1998-05-05 |
2023-08-12 |
rat |
| A M Coelho, J Fioramonti, L Buen. Mast cell degranulation induces delayed rectal allodynia in rats: role of histamine and 5-HT. Digestive diseases and sciences. vol 43. issue 4. 1998-05-05. PMID:9558027. |
consequently, mast cell degranulation initiates a delayed somatic and visceral allodynia, with the participation of serotonin, through 5-ht1a receptor activation, on the visceral response. |
1998-05-05 |
2023-08-12 |
rat |
| G Chidlow, N N Osborn. Antagonism of muscarinic receptors in the rabbit iris-ciliary body by 8-OH-DPAT and other 5-HT1A receptor agonists. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 10. 1998-04-29. PMID:9503254. |
physiological studies have shown that serotonin and 5-ht1a agonists can influence muscarinic function in the rabbit iris-ciliary body (icb). |
1998-04-29 |
2023-08-12 |
rabbit |
| L Lima, A M Laporte, C Gaymard, M Spedding, E Mocaër, M Hamo. Atypical in vitro and in vivo binding of [3H]S-14506 to brain 5-HT1A receptors. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 10. 1998-04-29. PMID:9503258. |
the tritiated derivative of the potent 5-ht1a receptor agonist s-14506 ¿1[2-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphtyl)pipera zine¿ was tested for its capacity to selectively label the serotonin 5-ht1a receptors both in vitro in the rat and the mouse brain, and in vivo in the mouse. |
1998-04-29 |
2023-08-12 |
mouse |
| D L Li, R M Simmons, S Iyenga. 5HT1A receptor antagonists enhance the functional activity of fluoxetine in a mouse model of feeding. Brain research. vol 781. issue 1-2. 1998-04-29. PMID:9507085. |
5ht1a autoreceptors regulate synaptic levels of serotonin. |
1998-04-29 |
2023-08-12 |
mouse |