Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
D S Dupuis, C Palmier, F C Colpaert, P J Pauwel. Autoradiography of serotonin 5-HT1A receptor-activated G proteins in guinea pig brain sections by agonist-stimulated [35S]GTPgammaS binding. Journal of neurochemistry. vol 70. issue 3. 1998-03-12. PMID:9489749. |
it appears that under the present experimental conditions, g protein activation through 5-ht1a but not 5-ht(1b/d) receptors can be measured in guinea pig brain sections. |
1998-03-12 |
2023-08-12 |
Not clear |
X Li, D G Rainnie, R W McCarley, R W Green. Presynaptic nicotinic receptors facilitate monoaminergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 5. 1998-03-04. PMID:9465015. |
blockade of this response revealed a hyperpolarization mediated by serotonin acting on 5-ht1a receptors. |
1998-03-04 |
2023-08-12 |
rat |
P Tagliaferro, A J Ramos, E M López, J Pecci Saavedra, A Brusc. Neural and astroglial effects of a chronic parachlorophenylalanine-induced serotonin synthesis inhibition. Molecular and chemical neuropathology. vol 32. issue 1-3. 1998-02-26. PMID:9437667. |
it was postulated that s-100 protein, a glial neurotrophic factor, could be modulated by 5ht probably through the glial 5ht1a receptors. |
1998-02-26 |
2023-08-12 |
rat |
E Gur, B Lerer, M E Newma. Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo microdialysis study. Journal of neural transmission (Vienna, Austria : 1996). vol 104. issue 8-9. 1998-02-26. PMID:9451712. |
the effect of systemic administration of the 5-ht1a and 5-ht1b antagonist, (+/-)-pindolol (10 mg/kg), to increase 5-ht levels in hippocampus, was also not affected by chronic ecs. |
1998-02-26 |
2023-08-12 |
rat |
O C Meijer, E R de Kloe. Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity. Critical reviews in neurobiology. vol 12. issue 1-2. 1998-02-24. PMID:9444479. |
under physiological fluctuations of corticosteroid concentrations, predominantly mr-mediated effects suppress the activity of the raphe-hippocampal system, notably serotonin (5-ht)1a receptor-related activity: 5-ht1a receptors are down-regulated, and the cellular response to 5-ht1a receptor activation is attenuated. |
1998-02-24 |
2023-08-12 |
human |
O C Meijer, E R de Kloe. Corticosterone and serotonergic neurotransmission in the hippocampus: functional implications of central corticosteroid receptor diversity. Critical reviews in neurobiology. vol 12. issue 1-2. 1998-02-24. PMID:9444479. |
stimulatory actions of corticosteroids involving gr occupation include increased responsiveness of hippocampal neurons to 5-ht1a receptor stimulation, attenuated autoinhibition of 5-ht, and a permissive effect on stress-induced increases in 5-ht release. |
1998-02-24 |
2023-08-12 |
human |
A Cagnotto, D Crespi, L Mancini, C Manzoni, M L Presti, M Gariboldi, A Vezzani, T Mennin. Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453582. |
lasting increase in serotonin 5-ht1a but not 5-ht4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. |
1998-02-24 |
2023-08-12 |
rat |
A Cagnotto, D Crespi, L Mancini, C Manzoni, M L Presti, M Gariboldi, A Vezzani, T Mennin. Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. Journal of neurochemistry. vol 70. issue 2. 1998-02-24. PMID:9453582. |
we examined the effect of kindling on serotonergic neurotransmission in the hippocampus by measuring serotonin (5-ht) release and uptake in hippocampal synaptosomes and 5-ht1a and 5-ht4 receptor subtypes during and at different times after electrical kindling of the dentate gyrus. |
1998-02-24 |
2023-08-12 |
rat |
Y G Ni, M M Panicker, R Miled. Efficient coupling of 5-HT1a receptors to the phospholipase C pathway in Xenopus oocytes. Brain research. Molecular brain research. vol 51. issue 1-2. 1998-02-17. PMID:9427513. |
compared to the original 5-ht1a receptor construct g-21, both new constructs increased greatly the expression of functional 5-ht1a receptors in xenopus oocytes, which developed large inward current responses to 5-ht. |
1998-02-17 |
2023-08-12 |
human |
G Asmundsson, D Caringi, D J Mokler, T Kobayashi, T Ishide, A All. Extracellular serotonin changes in VLM during muscle contraction: effects of 5-HT1A-receptor activation. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435630. |
microdialysis of a 5-ht1a agonist, 8-oh-dpat (10 mm), into the rvlm for 30 min (n = 6) blunted the map change and reduced 5-ht release during contraction. |
1998-02-09 |
2023-08-12 |
rat |
G Asmundsson, D Caringi, D J Mokler, T Kobayashi, T Ishide, A All. Extracellular serotonin changes in VLM during muscle contraction: effects of 5-HT1A-receptor activation. The American journal of physiology. vol 273. issue 6. 1998-02-09. PMID:9435630. |
administration of nan-190, a 5-ht1a antagonist, into the rvlm had no effect on 5-ht release and cardiovascular responses during muscle contraction and blocked the changes in 5-ht, map, and heart rate to static contraction after subsequent microdialysis of 8-oh-dpat. |
1998-02-09 |
2023-08-12 |
rat |
J Cortijo, M Martí-Cabrera, E Bernabeu, T Domènech, J Bou, A G Fernández, J Beleta, J M Palacios, E J Morcill. Characterization of 5-HT receptors on human pulmonary artery and vein: functional and binding studies. British journal of pharmacology. vol 122. issue 7. 1998-02-05. PMID:9421295. |
way100635 (1 nm to 1 microm), zacopride (1 nm to 1 microm), or sb204070 (1 nm) did not significantly alter the concentration-response curves for 5-ht, sumatriptan, ergotamine, scmgt or 2-me in human pulmonary artery or vein thus indicating that 5-ht1a, 5-ht3 and 5-ht4 receptors are presumably not involved in the contractile response to these agonists. |
1998-02-05 |
2023-08-12 |
human |
J Cortijo, M Martí-Cabrera, E Bernabeu, T Domènech, J Bou, A G Fernández, J Beleta, J M Palacios, E J Morcill. Characterization of 5-HT receptors on human pulmonary artery and vein: functional and binding studies. British journal of pharmacology. vol 122. issue 7. 1998-02-05. PMID:9421295. |
binding studies using selective radioligands for different 5-ht receptors could not detect the presence of 5-ht1a receptor binding in human pulmonary blood vessels whereas the 5-ht(1b/1d) radioligand [3h]-5ct significantly labelled a population of specific binding sites in both vessel types. |
1998-02-05 |
2023-08-12 |
human |
R Corradetti, A M Pugliese, E Le Poul, N Laaris, M Hamon, L Lanfume. Electrophysiological effects of WAY 100635, a new 5-HT1A receptor antagonist, on dorsal raphe nucleus serotoninergic neurones and CA1 pyramidal cells in vitro. Acta physiologica Hungarica. vol 84. issue 4. 1998-02-02. PMID:9328615. |
way 100635 selectively blocked 5-ht1a receptor-mediated responses of 5-ht, 8-oh-dpat, lesopitron and 5-ct. |
1998-02-02 |
2023-08-12 |
Not clear |
P B Bergqvist, C Wikell, S Hjorth, G Apelqvist, F Bengtsso. Effect of citalopram on brain serotonin release in experimental hepatic encephalopathy: implications for thymoleptic drug safety in liver insufficiency. Clinical neuropharmacology. vol 20. issue 6. 1998-01-30. PMID:9403225. |
subsequent systemic administration of cit (5 mg/kg subcutaneously) resulted in a more pronounced attenuation of the brain 5-ht release in pcs rats than in sham-operated controls, possibly indicating a higher susceptibility to indirect mid-brain 5-ht1a autoreceptor activation in experimental portal-systemic encephalopathy (pse). |
1998-01-30 |
2023-08-12 |
rat |
P Hertel, G G Nomikos, T H Svensso. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine. British journal of pharmacology. vol 122. issue 8. 1998-01-28. PMID:9422809. |
consequently, the reduction in 5-ht cell firing by risperidone appears to be related to increased availability of 5-ht in the somatodendritic region of the neurones leading to an enhanced 5-ht1a autoreceptor activation and, in turn, to inhibition of firing, and is probably only to a minor extent caused by its alpha 1-adrenoceptor antagonistic action. |
1998-01-28 |
2023-08-12 |
rat |
P Tao, J Me. [Effects of 5-HT on activity of arcuate neurons of rat hypothalamic slices]. Sheng li xue bao : [Acta physiologica Sinica]. vol 48. issue 2. 1998-01-27. PMID:9389167. |
the results suggest that the inhibitory effect of 5-ht on arcuate neurons may be mediated by 5-ht1 receptor, while some by 5-ht1a receptor. |
1998-01-27 |
2023-08-12 |
rat |
R Ciccocioppo, I Panocka, C Polidori, C T Dourish, M Mass. Blockade of pre- and post-synaptic 5-HT1A receptors does not modify the effect of fluoxetine or 5-hydroxytryptophan on ethanol and food intake in rats. Psychopharmacology. vol 134. issue 1. 1998-01-27. PMID:9399367. |
however, these agents can also increase 5-ht levels at somatodendritic 5-ht1a autoreceptors, with negative effects on serotonergic transmission. |
1998-01-27 |
2023-08-12 |
rat |
C Sànche. Interaction studies of 5-HT1A receptor antagonists and selective 5-HT reuptake inhibitors in isolated aggressive mice. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369340. |
interaction studies of 5-ht1a receptor antagonists and selective 5-ht reuptake inhibitors in isolated aggressive mice. |
1998-01-22 |
2023-08-12 |
mouse |
C Sànche. Interaction studies of 5-HT1A receptor antagonists and selective 5-HT reuptake inhibitors in isolated aggressive mice. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369340. |
recently published studies have suggested that behavioral and neurochemical changes induced by selective serotonin (5-hydroxytryptamine, 5-ht) reuptake inhibitors are potentiated by coadministration of a 5-ht1a receptor antagonist. |
1998-01-22 |
2023-08-12 |
mouse |