| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Sànche. Interaction studies of 5-HT1A receptor antagonists and selective 5-HT reuptake inhibitors in isolated aggressive mice. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369340. |
recently published studies have suggested that behavioral and neurochemical changes induced by selective serotonin (5-hydroxytryptamine, 5-ht) reuptake inhibitors are potentiated by coadministration of a 5-ht1a receptor antagonist. |
1998-01-22 |
2023-08-12 |
mouse |
| C Sànche. Interaction studies of 5-HT1A receptor antagonists and selective 5-HT reuptake inhibitors in isolated aggressive mice. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369340. |
in the present study the effects of concomitant administration of a selective 5-ht reuptake inhibitor with a 5-ht1a receptor antagonist (n-[2-[4-(2-methoxyphenyl)-1-piperazinyl] ethyl]-n-(2-pyridinyl) cyclo-hexanecarboxamide (way 100635) or a beta-adrenoceptor and 5-ht1a/1b receptor antagonist (pindolol or (-)-penbutolol) were studied in isolated aggressive mice. |
1998-01-22 |
2023-08-12 |
mouse |
| M B Assié, C Cosi, W Koe. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369342. |
here, 5-ht1a receptor activation was examined in vitro, by measuring forskolin-stimulated camp accumulation in hela cells expressing human 5-ht1a receptors, and in vivo, by using microdialysis to measure the extracellular concentration of hippocampal 5-hydroxytryptamine (5-ht) in rats. |
1998-01-22 |
2023-08-12 |
human |
| M B Assié, C Cosi, W Koe. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369342. |
nemonapride markedly decreased both forskolin-stimulated camp accumulation and the extracellular concentration of 5-ht; both effects were antagonized by the 5-ht1a receptor antagonist, n-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-n-(2-pyridinyl) cyclohexanecarboxamide (way100635). |
1998-01-22 |
2023-08-12 |
human |
| M B Assié, C Cosi, W Koe. 5-HT1A receptor agonist properties of the antipsychotic, nemonapride: comparison with bromerguride and clozapine. European journal of pharmacology. vol 334. issue 2-3. 1998-01-22. PMID:9369342. |
bromerguride decreased neither forskolin-stimulated camp accumulation nor extracellular 5-ht; instead, it antagonized the decrease of camp accumulation produced by 5-ht and the decrease of extracellular 5-ht produced by the 5-ht1a agonist (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat). |
1998-01-22 |
2023-08-12 |
human |
| C R Grünschlag, H L Haas, D R Steven. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372196. |
5-ht inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-ht1a receptors. |
1998-01-21 |
2023-08-12 |
rat |
| C R Grünschlag, H L Haas, D R Steven. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372196. |
5-carboxamidotryptamine, a 5-ht1 agonist, and the selective 5-ht1a agonist 8-hydroxy-dipropylaminotetralin mimicked the action of serotonin. |
1998-01-21 |
2023-08-12 |
rat |
| C R Grünschlag, H L Haas, D R Steven. 5-HT inhibits lateral entorhinal cortical neurons of the rat in vitro by activation of potassium channel-coupled 5-HT1A receptors. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372196. |
these results indicate that the observed conductance increase associated with 5-ht application accounts for most if not all of the observed depressant effects of 5-ht1a agonists on excitatory amino acid-mediated neurotransmission. |
1998-01-21 |
2023-08-12 |
rat |
| B Bjorvatn, S Fagerland, T Eid, R Ursi. Sleep/waking effects of a selective 5-HT1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. Brain research. vol 770. issue 1-2. 1998-01-21. PMID:9372206. |
this is consistent with the hypothesis that reduced 5-ht neurotransmission following 5-ht1a autoreceptor stimulation will disinhibit cholinergic rem-promoting mesopontine neurons and thereby lead to a rem sleep increase. |
1998-01-21 |
2023-08-12 |
rat |
| E Le Poul, N Laaris, M Hamon, L Lanfume. Fluoxetine-induced desensitization of somatodendritic 5-HT1A autoreceptors is independent of glucocorticoid(s). Synapse (New York, N.Y.). vol 27. issue 4. 1998-01-14. PMID:9372553. |
these data suggest that glucocorticoid receptors (and their possible activation by corticosterone) are not involved in the functional desensitization of somatodendritic 5-ht1a autoreceptors, which occurs during long-term treatment with a serotonin reuptake inhibitor such as fluoxetine. |
1998-01-14 |
2023-08-12 |
rat |
| R A Browning, A V Wood, M A Merrill, J W Dailey, P C Job. Enhancement of the anticonvulsant effect of fluoxetine following blockade of 5-HT1A receptors. European journal of pharmacology. vol 336. issue 1. 1998-01-14. PMID:9384247. |
in view of recent studies showing that 5-ht1a receptor antagonists (somatodendritic autoreceptor antagonists) enhance the increase in extracellular 5-hydroxytryptamine (5-ht, serotonin) produced by serotonin reuptake inhibitors, it was of interest to determine if these antagonists also enhance the anticonvulsant effect of fluoxetine in genetically epilepsy-prone rats (geprs). |
1998-01-14 |
2023-08-12 |
rat |
| R A Browning, A V Wood, M A Merrill, J W Dailey, P C Job. Enhancement of the anticonvulsant effect of fluoxetine following blockade of 5-HT1A receptors. European journal of pharmacology. vol 336. issue 1. 1998-01-14. PMID:9384247. |
these findings provide further evidence that the increase in extracellular serotonin observed after administering fluoxetine in combination with a 5-ht1a receptor antagonist is physiologically important and that the anticonvulsant effect of fluoxetine in the gepr is mediated through an increase in extracellular 5-ht. |
1998-01-14 |
2023-08-12 |
rat |
| M Shimpo, U Ikeda, Y Maeda, K Kurosaki, K Okada, T Saito, K Shimad. Serotonin inhibits nitric oxide synthesis in rat vascular smooth muscle cells stimulated with interleukin-1. European journal of pharmacology. vol 338. issue 1. 1998-01-14. PMID:9408009. |
addition of the 5-ht2 receptor antagonist ketanserin, but not the 5-ht1a receptor antagonist spiroxatrine, inhibited the effect of 5-ht. |
1998-01-14 |
2023-08-12 |
rat |
| L J Sim, R Xiao, S R Childer. In vitro autoradiographic localization of 5-HT1A receptor-activated G-proteins in the rat brain. Brain research bulletin. vol 44. issue 1. 1998-01-09. PMID:9288830. |
serotonin 5-ht1a receptors belong to the superfamily of g-protein-coupled receptors. |
1998-01-09 |
2023-08-12 |
rat |
| I S Shiah, L N Yatham, R W Lam, A P Zi. Effects of divalproex sodium on 5-HT1A receptor function in healthy human males: hypothermic, hormonal, and behavioral responses to ipsapirone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 17. issue 6. 1998-01-09. PMID:9397426. |
our findings suggest that dvp may enhance 5-ht neurotransmission in humans via a subsensitization of 5-ht1a autoreceptors but does not appear to affect postsynaptic 5-ht1a receptors. |
1998-01-09 |
2023-08-12 |
human |
| F J Bosker, A Klompmakers, H G Westenber. Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. European journal of pharmacology. vol 333. issue 2-3. 1998-01-05. PMID:9314028. |
postsynaptic 5-ht1a receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. |
1998-01-05 |
2023-08-12 |
Not clear |
| F J Bosker, A Klompmakers, H G Westenber. Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. European journal of pharmacology. vol 333. issue 2-3. 1998-01-05. PMID:9314028. |
using brain microdialysis, it was demonstrated that the release of 5-hydroxytryptamine (5-ht) in the central nucleus of the amygdala is under inhibitory control of somatodendritic and postsynaptic 5-ht1a receptors. |
1998-01-05 |
2023-08-12 |
Not clear |
| F J Bosker, A Klompmakers, H G Westenber. Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. European journal of pharmacology. vol 333. issue 2-3. 1998-01-05. PMID:9314028. |
systemic administration of flesinoxan, a selective 5-ht1a receptor agonist, significantly reduced the extracellular levels of 5-ht in the central nucleus of the amygdala. |
1998-01-05 |
2023-08-12 |
Not clear |
| F J Bosker, A Klompmakers, H G Westenber. Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. European journal of pharmacology. vol 333. issue 2-3. 1998-01-05. PMID:9314028. |
local administration of these compounds by reversed microdialysis into the raphe nuclei revealed that extracellular 5-ht levels in the central nucleus of the amygdala can be regulated through 5-ht1a receptors in the caudal linear raphe nucleus, but not in the dorsal and median raphe nuclei. |
1998-01-05 |
2023-08-12 |
Not clear |
| J M Casanovas, M Lésourd, F Artiga. The effect of the selective 5-HT1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. British journal of pharmacology. vol 122. issue 4. 1998-01-02. PMID:9375971. |
the effect of the selective 5-ht1a agonists alnespirone (s-20499) and 8-oh-dpat on extracellular 5-hydroxytryptamine in different regions of rat brain. |
1998-01-02 |
2023-08-12 |
rat |