| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Gaggi, R Dall' Olio, M Santangelo, P Roncad. Actions of nimodipine on the serotonergic systems of rat brain. General pharmacology. vol 29. issue 3. 1997-11-10. PMID:9378249. |
nimodipine antagonized the effects on 5-ht metabolism induced by 8-hydroxy-2-(di-n-propyl-amino)-tetralin through stimulation of 5-ht1a autoreceptors. |
1997-11-10 |
2023-08-12 |
rat |
| R Gaggi, R Dall' Olio, M Santangelo, P Roncad. Actions of nimodipine on the serotonergic systems of rat brain. General pharmacology. vol 29. issue 3. 1997-11-10. PMID:9378249. |
it was concluded that the effects of nimodipine on brain 5-ht metabolism appeared to be linked to activation of serotonergic neurotransmission likely due to inhibition of the back-regulation mechanism mediated by presynaptic 5-ht1a receptors. |
1997-11-10 |
2023-08-12 |
rat |
| N S Kula, R J Baldessarini, J W Kebabian, V Bakthavachalam, L X. RBI-257: a highly potent dopamine D4 receptor-selective ligand. European journal of pharmacology. vol 331. issue 2-3. 1997-10-27. PMID:9274997. |
rbi-257 had much lower affinity at d1 and d5 dopamine receptors in transfected cells, as well as dopamine d1-like receptors, alpha1, alpha2 or beta(1,2) adrenoceptors, sigma(1,2) receptors and 5-ht1a or 5-ht2a receptors, and transporters for dopamine, norepinephrine or serotonin in rat forebrain tissue. |
1997-10-27 |
2023-08-12 |
rat |
| J Dong, C de Montigny, P Blie. Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 3. 1997-10-27. PMID:9303566. |
after 14 days of treatment, there was a complete recovery of their firing activity and a desensitization of their somatodendritic 5-ht1a autoreceptors, as assessed using microiontophoretic applications of 5-ht and 8-hydroxy-2(di-n-propylamino)tetraline (8-oh-dpat) onto 5-ht neurons. |
1997-10-27 |
2023-08-12 |
rat |
| J Dong, C de Montigny, P Blie. Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 3. 1997-10-27. PMID:9303566. |
in conclusion, long-term administration of ipsapirone most likely increases 5-ht neurotransmission by enhancing the tonic activation of postsynaptic 5-ht1a receptors. |
1997-10-27 |
2023-08-12 |
rat |
| M F O'Neill, T Parameswara. RU24969-induced behavioural syndrome requires activation of both 5HT1A and 5HT1B receptors. Psychopharmacology. vol 132. issue 3. 1997-10-23. PMID:9292625. |
the effects of ru24969 were attenuated by both the 5ht1a antagonist way100635 (0.03 1.25 mg/kg s.c.) and the 5ht(1b/d) antagonist gr127935 (1.0-5.0 mg/kg s.c.). |
1997-10-23 |
2023-08-12 |
rat |
| P Sargent, D J Williamson, G Pearson, J Odontiadis, P J Cowe. Effect of paroxetine and nefazodone on 5-HT1A receptor sensitivity. Psychopharmacology. vol 132. issue 3. 1997-10-23. PMID:9292630. |
animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (ssris) may involve neuroadaptive changes in pre- and post-synaptic serotonin1a (5-ht1a) receptors. |
1997-10-23 |
2023-08-12 |
human |
| N Collinson, G R Dawso. On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635. Psychopharmacology. vol 132. issue 1. 1997-10-20. PMID:9272757. |
on the elevated plus-maze the anxiolytic-like effects of the 5-ht(1a) agonist, 8-oh-dpat, but not the anxiogenic-like effects of the 5-ht(1a) partial agonist, buspirone, are blocked by the 5-ht1a antagonist, way 100635. |
1997-10-20 |
2023-08-12 |
Not clear |
| Q Li, N A Muma, G Battaglia, L D Van de Ka. A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316875. |
the aim of the present study was to determine whether the previously observed desensitization of hypothalamic 5-hydroxytryptamine1a (5-ht1a) receptors, during daily injections of fluoxetine, is mediated by sustained blockade of 5-ht reuptake. |
1997-10-17 |
2023-08-12 |
Not clear |
| Q Li, N A Muma, G Battaglia, L D Van de Ka. A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors. The Journal of pharmacology and experimental therapeutics. vol 282. issue 3. 1997-10-17. PMID:9316875. |
in conclusion, these results suggest that blockade of 5-ht uptake sites produces a delayed and gradual desensitization of 5-ht1a receptors in the hypothalamus. |
1997-10-17 |
2023-08-12 |
Not clear |
| G Griebel, R J Rodgers, G Perrault, D J Sange. Risk assessment behaviour: evaluation of utility in the study of 5-HT-related drugs in the rat elevated plus-maze test. Pharmacology, biochemistry, and behavior. vol 57. issue 4. 1997-10-16. PMID:9259011. |
the drugs used were 5-ht1a receptor partial (buspirone and ipsapirone) and full (8-oh-dpat and flesinoxan) agonists, mixed 5-ht2a/2c receptor antagonists (ritanserin, ketanserin, mianserin, and pirenperone), selective 5-ht3 receptor antagonists (ics 205-930, mdl 72222, ondansetron, and (rs)-zacopride), and selective (fluoxetine, fluvoxamine, and zimelidine) and nonselective (imipramine) 5-ht reuptake inhibitors. |
1997-10-16 |
2023-08-12 |
rat |
| R J Blanchard, G Griebel, B Guardiola-Lemaître, M M Brush, J Lee, D C Blanchar. An ethopharmacological analysis of selective activation of 5-HT1A receptors: the mouse 5-HT1A syndrome. Pharmacology, biochemistry, and behavior. vol 57. issue 4. 1997-10-16. PMID:9259022. |
these findings provide evidence consonant with the view that selective activation of 5-ht1a receptors in mice produces distinct behavioral changes in part associated with the 5-ht syndrome. |
1997-10-16 |
2023-08-12 |
mouse |
| H Lilienthal, A Weinand-Härer, H Winterhoff, G Winnek. Effects of maternal exposure to 3,3',4,4'-tetrachlorobiphenyl or propylthiouracil in rats trained to discriminate apomorphine from saline. Toxicology and applied pharmacology. vol 146. issue 1. 1997-10-15. PMID:9299608. |
differences between controls and groups exposed to pcb 77 or ptu were detected in a blocking test using the mixed serotonin 5-ht1a agonist and partial d2 antagonist buspirone. |
1997-10-15 |
2023-08-12 |
rat |
| b' K Chaouche-Teyara, P Lacolley, P Challande, B Fournier, S Laurent, M Safar, H Dabir\\xc3\\xa. Effects of clonidine and flesinoxan on blood pressure variability in conscious spontaneously hypertensive rats. Journal of cardiovascular pharmacology. vol 30. issue 2. 1997-10-01. PMID:9269953.' |
these results show that centrally mediated inhibition of sympathetic tone by stimulation of either alpha2-adrenoceptors or 5-ht1a (serotonin) receptors can reduce bpv. |
1997-10-01 |
2023-08-12 |
rat |
| C Davidson, M Ho, G W Price, B J Jones, J A Stamfor. (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors. British journal of pharmacology. vol 121. issue 4. 1997-09-25. PMID:9208142. |
we have studied the effects of the purportedly selective 5-ht1a receptor antagonist (+)-way 100135 on electrically stimulated 5-hydroxytryptamine (5-ht) efflux in the ventrolateral geniculate nucleus (vlgn), and its affinity at human 5-ht1b and 5-ht1d receptors stably expressed in chinese hamster ovary (cho) cells. |
1997-09-25 |
2023-08-12 |
human |
| C Davidson, M Ho, G W Price, B J Jones, J A Stamfor. (+)-WAY 100135, a partial agonist, at native and recombinant 5-HT1B/1D receptors. British journal of pharmacology. vol 121. issue 4. 1997-09-25. PMID:9208142. |
in conclusion, (+)-way 100135 was found to be not a selective 5-ht1a autoreceptor antagonist but may act as a partial agonist at the 5-ht1b/1d receptor, displaying agonist or antagonist properties depending on the stimulation protocol used and the resultant 5-ht 'tone' at the receptor. |
1997-09-25 |
2023-08-12 |
human |
| G Hilaire, C Bou, R Montea. Serotonergic modulation of central respiratory activity in the neonatal mouse: an in vitro study. European journal of pharmacology. vol 329. issue 2-3. 1997-09-25. PMID:9226402. |
the effects of adding serotonin (5-hydroxytryptamine, 5-ht) and related agents to the superfusate suggested that the respiratory rhythm generator undergoes an excitatory modulation via medullary 5-ht1a receptors. |
1997-09-25 |
2023-08-12 |
mouse |
| J M Jansen, K F Koehler, M H Hedberg, A M Johansson, U Hacksell, G Nordvall, J P Snyde. Molecular design using the minireceptor concept. Journal of chemical information and computer sciences. vol 37. issue 4. 1997-09-22. PMID:9254913. |
the active site extracted from a homology-based model of the serotonin 5-ht1a receptor was optimized around a set of three ligands using the same approach. |
1997-09-22 |
2023-08-12 |
Not clear |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
effect of a selective 5-ht reuptake inhibitor in combination with 5-ht1a and 5-ht1b receptor antagonists on extracellular 5-ht in rat frontal cortex in vivo. |
1997-09-15 |
2023-08-12 |
rat |
| T Sharp, V Umbers, S E Gartsid. Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo. British journal of pharmacology. vol 121. issue 5. 1997-09-15. PMID:9222551. |
selective 5-hydroxytryptamine (5-ht; serotonin) reuptake inhibitors (ssris) cause a greater increase in extracellular 5-ht in the forebrain when the somatodendritic 5-ht1a autoreceptor is blocked. |
1997-09-15 |
2023-08-12 |
rat |