| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M J Owen. Molecular and cellular mechanisms of antidepressant drugs. Depression and anxiety. vol 4. issue 4. 1997-06-18. PMID:9166647. |
monoamine oxidase inhibitors and the 5-ht1a agonists increase serotonergic function by desensitizing the somatodendritic autoreceptor; the terminal 5-ht autoreceptor is not affected by these agents. |
1997-06-18 |
2023-08-12 |
Not clear |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
preferential potentiation of the effects of serotonin uptake inhibitors by 5-ht1a receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. |
1997-06-17 |
2023-08-12 |
Not clear |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
5-ht1a autoreceptor antagonists enhance the effects of antidepressants by preventing a negative feedback of serotonin (5-ht) at somatodendritic level. |
1997-06-17 |
2023-08-12 |
Not clear |
| L Romero, F Artiga. Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. Journal of neurochemistry. vol 68. issue 6. 1997-06-17. PMID:9166757. |
the maximal elevations of extracellular concentration of 5-ht (5-ht(ext)) induced by the 5-ht uptake inhibitor paroxetine in forebrain were potentiated by the 5-ht1a antagonist way-100635 (1 mg/kg s.c.) in a regionally dependent manner (striatum > frontal cortex > dorsal hippocampus). |
1997-06-17 |
2023-08-12 |
Not clear |
| M S Nash, J P Wood, N N Osborn. Protein kinase C activation by serotonin potentiates agonist-induced stimulation of cAMP production in cultured rat retinal pigment epithelial cells. Experimental eye research. vol 64. issue 2. 1997-06-17. PMID:9176059. |
serotonin stimulates inositol phosphate production and intracellular calcium mobilization in cultured rat retinal pigment epithelial (rpe) cells through interaction with 5-ht2a receptors, but decreases camp production in cultured human rpe cells via 5-ht1a receptors. |
1997-06-17 |
2023-08-12 |
human |
| M S Nash, J P Wood, N N Osborn. Protein kinase C activation by serotonin potentiates agonist-induced stimulation of cAMP production in cultured rat retinal pigment epithelial cells. Experimental eye research. vol 64. issue 2. 1997-06-17. PMID:9176059. |
the antagonists ketanserin, methysergide and spiperone attenuated the action of serotonin, while yohimbine and spiroxatrine were ineffectual, thus indicating that the potentiating effect was through the 5-ht1a receptor. |
1997-06-17 |
2023-08-12 |
human |
| G D Bartoszyk, R Hegenbart, H Ziegle. EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties. European journal of pharmacology. vol 322. issue 2-3. 1997-06-16. PMID:9098681. |
emd 68843, a serotonin reuptake inhibitor with selective presynaptic 5-ht1a receptor agonistic properties. |
1997-06-16 |
2023-08-12 |
rat |
| G D Bartoszyk, R Hegenbart, H Ziegle. EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties. European journal of pharmacology. vol 322. issue 2-3. 1997-06-16. PMID:9098681. |
the 5-ht1a receptor agonist 8-hydroxy-(di-n-propylamino)tetralin (8-oh-dpat; 0.55 mg/kg s.c.) and the 5-ht (5-hydroxytryptamine, serotonin) reuptake inhibitor/5-ht1a receptor ligand 5-[4-[4-(5-cyano-3-indolyl)-butyl]-1-piperazinyl]-benzofuran-2-carbox ami de (emd 68843; 55 mg/kg p.o.) |
1997-06-16 |
2023-08-12 |
rat |
| M Filip, E Przegalińsk. Effects of MP-3022 on the 8-OH-DPAT-induced discriminative stimulus in rats. Polish journal of pharmacology. vol 48. issue 4. 1997-06-16. PMID:9112679. |
substitution studies showed that the 8-oh-dpat cue was mimicked in a dose-dependent manner by buspirone and ipsapirone, the 5-ht1a receptor partial agonists, but not by 1-(3-chlorophenyl)piperazine (m-cpp), a nonselective 5-ht agonist. |
1997-06-16 |
2023-08-12 |
rat |
| D A Bayliss, Y W Li, E M Talle. Effects of serotonin on caudal raphe neurons: activation of an inwardly rectifying potassium conductance. Journal of neurophysiology. vol 77. issue 3. 1997-06-13. PMID:9084602. |
the 5-ht1a agonist 8-oh-dpat mimicked, and the 5-ht1a antagonists (+)way 10,0135 and nan 190 blocked, effects of 5-ht. |
1997-06-13 |
2023-08-12 |
rat |
| D A Bayliss, Y W Li, E M Talle. Effects of serotonin on caudal raphe neurons: inhibition of N- and P/Q-type calcium channels and the afterhyperpolarization. Journal of neurophysiology. vol 77. issue 3. 1997-06-13. PMID:9084603. |
current inhibition by 5-ht was mimicked by 8-oh-dpat, a specific 5-ht1a agonist, and blocked by the 5-ht1a antagonists nan 190 and (+) way 100135, but was unaffected by ketanserin, a 5-ht2a/c antagonist. |
1997-06-13 |
2023-08-12 |
rat |
| M J Millan, S Perrin-Monneyro. Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors. European journal of pharmacology. vol 321. issue 3. 1997-06-12. PMID:9085055. |
combined blockade of 5-ht1a and 5-ht1b autoreceptors markedly enhances the actions of serotonin reuptake inhibitors. |
1997-06-12 |
2023-08-12 |
rat |
| A Kulikov, S Aguerre, O Berton, A Ramos, P Mormede, F Chaoulof. Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152385. |
[3h]8-hydroxy-2-(di-n-pro-pylamino)tetralin binding at midbrain 5-ht1a autoreceptors and hippocampal 5-ht1a postsynaptic receptors, [3h]ketanserin binding at cortical and striatal 5-ht2a receptors and [3h]citalopram binding at midbrain and hippocampal 5-ht transporters did not vary between strains. |
1997-06-12 |
2023-08-12 |
rat |
| A Kulikov, S Aguerre, O Berton, A Ramos, P Mormede, F Chaoulof. Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152385. |
the inhibition of 5-ht synthesis by 5-ht1a autoreceptor stimulation was similar in both strains. |
1997-06-12 |
2023-08-12 |
rat |
| A Kulikov, S Aguerre, O Berton, A Ramos, P Mormede, F Chaoulof. Central serotonergic systems in the spontaneously hypertensive and Lewis rat strains that differ in the elevated plus-maze test of anxiety. The Journal of pharmacology and experimental therapeutics. vol 281. issue 2. 1997-06-12. PMID:9152385. |
this study shows that although the low-anxiety (shr) and high-anxiety (lew) strains vary in some aspects of 5-ht function, key components such as the 5-ht1a autoreceptors are not different. |
1997-06-12 |
2023-08-12 |
rat |
| E M Talley, N N Sadr, D A Baylis. Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151764. |
postnatal development of serotonergic innervation, 5-ht1a receptor expression, and 5-ht responses in rat motoneurons. |
1997-06-10 |
2023-08-12 |
rat |
| E M Talley, N N Sadr, D A Baylis. Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151764. |
previous work has shown that this effect of 5-ht was mediated by the 5-ht1a receptor and may be secondary to inhibition of n- and p/q-type calcium channels. |
1997-06-10 |
2023-08-12 |
rat |
| E M Talley, N N Sadr, D A Baylis. Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151764. |
therefore, we investigated the possibility that age-related changes in effects of 5-ht on the ahp resulted from altered expression of the 5-ht1a receptor. |
1997-06-10 |
2023-08-12 |
rat |
| E M Talley, N N Sadr, D A Baylis. Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151764. |
finally, immunohistochemistry for 5-ht revealed that these developmental changes in 5-ht1a receptor expression occurred coincident with a postnatal increase in serotonergic innervation of the hypoglossal nucleus (nxii). |
1997-06-10 |
2023-08-12 |
rat |
| E M Talley, N N Sadr, D A Baylis. Postnatal development of serotonergic innervation, 5-HT1A receptor expression, and 5-HT responses in rat motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 17. issue 11. 1997-06-10. PMID:9151764. |
together, these findings indicate that developmental changes occur in the serotonergic innervation of nxii and in the expression of 5-ht1a receptors in hms during the early postnatal period, resulting in markedly different effects of 5-ht on firing behavior in neonatal and juvenile hms. |
1997-06-10 |
2023-08-12 |
rat |