| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alfredo Menese. Neural activity, memory, and dementias: serotonergic markers. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:27926574. |
in addition, at least, 5-ht1a, 5-ht4, 5-ht6, and 5-ht7 receptors as well as serotonin transporter seem to be useful neural markers and therapeutic targets. |
2018-01-11 |
2023-08-13 |
Not clear |
| Chihiro Yokoyama, Aya Mawatari, Akihiro Kawasaki, Chiho Takeda, Kayo Onoe, Hisashi Doi, Adrian Newman-Tancredi, Luc Zimmer, Hirotaka Ono. Marmoset Serotonin 5-HT1A Receptor Mapping with a Biased Agonist PET Probe 18F-F13714: Comparison with an Antagonist Tracer 18F-MPPF in Awake and Anesthetized States. The international journal of neuropsychopharmacology. vol 19. issue 12. 2018-01-08. PMID:27608810. |
marmoset serotonin 5-ht1a receptor mapping with a biased agonist pet probe 18f-f13714: comparison with an antagonist tracer 18f-mppf in awake and anesthetized states. |
2018-01-08 |
2023-08-13 |
marmoset |
| Marc Fakhour. Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:25823514. |
the overarching goal of this review is to present recent findings from studies examining the serotonergic pathway in mdd, with a focus on sert and the serotonin 1a (5-ht1a), serotonin 1b (5-ht1b), and serotonin 2a (5-ht2a) receptors. |
2017-12-22 |
2023-08-13 |
mouse |
| Grzegorz Satała, Beata Duszyńska, Katarzyna Stachowicz, Anna Rafalo, Bartlomiej Pochwat, Christine Luckhart, Paul R Albert, Mireille Daigle, Kenji F Tanaka, René Hen, Tomasz Lenda, Gabriel Nowak, Andrzej J Bojarski, Bernadeta Szewczy. Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies. Molecular neurobiology. vol 53. issue 10. 2017-12-22. PMID:26660328. |
concentration-dependent dual mode of zn action at serotonin 5-ht1a receptors: in vitro and in vivo studies. |
2017-12-22 |
2023-08-13 |
Not clear |
| Faranak Vahid-Ansari, Mireille Daigle, M Chiara Manzini, Kenji F Tanaka, René Hen, Sean D Geddes, Jean-Claude Béïque, Jonathan James, Zul Merali, Paul R Alber. Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 49. 2017-12-15. PMID:29101244. |
freud-1/cc2d1a represses the gene transcription of serotonin-1a (5-ht1a) autoreceptors, which negatively regulate 5-ht tone. |
2017-12-15 |
2023-08-13 |
Not clear |
| Weam W Ibrahim, Marwa M Safar, Mahmoud M Khattab, Azza M Agh. 17β-Estradiol augments antidepressant efficacy of escitalopram in ovariectomized rats: Neuroprotective and serotonin reuptake transporter modulatory effects. Psychoneuroendocrinology. vol 74. 2017-12-08. PMID:27685339. |
17β-estradiol augmented the modulatory effects of escitalopram on the hippocampal levels of brain-derived neurotrophic factor and serotonin reuptake transporter as well as tumor necrosis factor-alpha without altering its effects on the gene expressions of serotonin receptor 1a, estrogen receptors alpha and beta, or acetylcholinestearase content. |
2017-12-08 |
2023-08-13 |
human |
| Mariana G Fronza, Lucimar M Pinto Brod, Angela Maria Casaril, Manoela Sacramento, Diego Alves, Lucielli Savegnag. Computational and biological evidences on the serotonergic involvement of SeTACN antidepressant-like effect in mice. PloS one. vol 12. issue 11. 2017-12-05. PMID:29091968. |
was prevented by the pretreatment with way100635 (a selective 5ht1a antagonist), ketanserin (a 5ht2a/c antagonist) and ondansetron (a selective 5ht3 antagonist), pcpa (an inhibitor of serotonin synthesis) but not with sch23390 (dopaminergic d1 antagonist) and sulpiride (d2 antagonist). |
2017-12-05 |
2023-08-13 |
mouse |
| Elena M Kondaurova, Tatiana V Ilchibaeva, Anton S Tsybko, Rimma V Kozhemyakina, Nina K Popova, Vladimir S Naumenk. 5-HT1A receptor gene silencers Freud-1 and Freud-2 are differently expressed in the brain of rats with genetically determined high level of fear-induced aggression or its absence. Behavioural brain research. vol 310. 2017-12-01. PMID:27150226. |
serotonin 5-ht1a receptor is known to play a crucial role in the mechanisms of genetically defined aggression. |
2017-12-01 |
2023-08-13 |
rat |
| José Ángel García-Pedraza, Mónica García, María Luisa Martín, Nélida Eleno, Asunción Morá. Chronic Sarpogrelate Treatment Reveals 5-HT7 Receptor in the Serotonergic Inhibition of the Rat Vagal Bradycardia. Journal of cardiovascular pharmacology. vol 69. issue 1. 2017-11-27. PMID:27676327. |
the iv administration of 5-ht (10-200 μg/kg) dose dependently decreased the vagally induced bradycardia, and agonists 5-ct (5-ht1/7), 8-oh-dpat (5-ht1a), or as-19 (5-ht7) (50 μg/kg each) mimicked the 5-ht-induced inhibitory effect. |
2017-11-27 |
2023-08-13 |
rat |
| Filip Tylš, Tomáš Páleníček, Lukáš Kadeřábek, Michaela Lipski, Anna Kubešová, Jiří Horáče. Sex differences and serotonergic mechanisms in the behavioural effects of psilocin. Behavioural pharmacology. vol 27. issue 4. 2017-11-20. PMID:26461483. |
the contribution of serotonin receptors in the behavioural action was tested in male rats with selective serotonin receptor antagonists: 5-ht1a receptor antagonist (way100635 1 mg/kg), 5-ht2a receptor antagonist (mdl100907 0.5 mg/kg), 5-ht2b receptor antagonist (sb215505 1 mg/kg) and 5-ht2c receptor antagonist (sb242084 1 mg/kg). |
2017-11-20 |
2023-08-13 |
rat |
| Andrea de Bartolomeis, Andrea Fagiolini, Giuseppe Main. [Vortioxetine in the treatment of major depression]. Rivista di psichiatria. vol 51. issue 6. 2017-11-20. PMID:27996982. |
vortioxetine is a multi-modal antidepressant that functions both as serotonin transporter (sert) inhibitor and as 5-ht3, 5-ht7 and 5-ht1d receptors antagonist, 5-ht1a receptor agonist and 5-ht1b receptor partial agonist. |
2017-11-20 |
2023-08-13 |
Not clear |
| Michael Strupp-Levitsky, Jeffrey M Miller, Harry Rubin-Falcone, Francesca Zanderigo, Matthew S Milak, Gregory Sullivan, R Todd Ogden, Maria A Oquendo, Christine DeLorenzo, Norman Simpson, Ramin V Parsey, J John Man. Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults. Psychiatry research. Neuroimaging. vol 255. 2017-11-16. PMID:27567324. |
the serotonin neurotransmitter system is modulated in part by the uptake of synaptically released serotonin (5-ht) by the serotonin transporter (5-htt), and by specific serotonin autoreceptors such as the somatodendritic 5-ht1a receptor, which can limit serotonin neuron depolarization. |
2017-11-16 |
2023-08-13 |
human |
| Michael Strupp-Levitsky, Jeffrey M Miller, Harry Rubin-Falcone, Francesca Zanderigo, Matthew S Milak, Gregory Sullivan, R Todd Ogden, Maria A Oquendo, Christine DeLorenzo, Norman Simpson, Ramin V Parsey, J John Man. Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults. Psychiatry research. Neuroimaging. vol 255. 2017-11-16. PMID:27567324. |
the lack of correlation between 5-ht1a and 5-htt binding observed in the current study may be due to the different temporal responsiveness of regulatory processes controlling the somatodendritic 5-ht1a receptor and 5-htt in response to changing availability of intrasynaptic serotonin. |
2017-11-16 |
2023-08-13 |
human |
| Christine Luckhart, Tristan J Philippe, Brice Le François, Faranak Vahid-Ansari, Sean D Geddes, Jean-Claude Béïque, Diane C Lagace, Mireille Daigle, Paul R Alber. Sex-dependent adaptive changes in serotonin-1A autoreceptor function and anxiety in Deaf1-deficient mice. Molecular brain. vol 9. issue 1. 2017-11-06. PMID:27488351. |
despite a sustained increase in 5-ht1a autoreceptor binding levels, the amplitude of the 5-ht1a autoreceptor-mediated current in 5-ht neurons was unaltered in deaf1-/- mice, suggesting compensatory changes in receptor function. |
2017-11-06 |
2023-08-13 |
mouse |
| Frederico G Graef. Translational approach to the pathophysiology of panic disorder: Focus on serotonin and endogenous opioids. Neuroscience and biobehavioral reviews. vol 76. issue Pt A. 2017-10-30. PMID:28073587. |
experimental results obtained in rat models of panic indicate that serotonin interacts synergistically with endogenous opioids in the dorsal periaqueductal gray through 5-ht1a and μ-opioid receptors to inhibit proximal defense and, supposedly, panic attacks. |
2017-10-30 |
2023-08-13 |
human |
| Carmelo Millón, Antonio Flores-Burgess, Manuel Narváez, Dasiel O Borroto-Escuela, Luis Santín, Belen Gago, José Angel Narváez, Kjell Fuxe, Zaida Díaz-Cabial. Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system. Brain structure & function. vol 221. issue 9. 2017-10-13. PMID:26792005. |
galanin (1-15) enhances the antidepressant effects of the 5-ht1a receptor agonist 8-oh-dpat: involvement of the raphe-hippocampal 5-ht neuron system. |
2017-10-13 |
2023-08-13 |
rat |
| Lance R McMaho. Enhanced discriminative stimulus effects of Δ(9)-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys. Drug and alcohol dependence. vol 165. 2017-10-09. PMID:27289270. |
cannabidiol, a therapeutic with potential serotonin (5-hydroxytryptamine; 5-ht) 5-ht1a receptor agonist activity, is the second most prevalent cannabinoid in cannabis after Δ(9)-thc. |
2017-10-09 |
2023-08-13 |
monkey |
| Renata Ferreira, Marcus Lira Brandão, Manoel Jorge Nobr. 5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats. Hormones and behavior. vol 84. 2017-10-03. PMID:27328163. |
connections from and to this region are known to be critical in regulating anxiety, in which serotonin (5-ht) plays a fundamental role, particularly through changes in 5-ht1a receptors functioning. |
2017-10-03 |
2023-08-13 |
human |
| Renata Ferreira, Marcus Lira Brandão, Manoel Jorge Nobr. 5-HT1A receptors of the prelimbic cortex mediate the hormonal impact on learned fear expression in high-anxious female rats. Hormones and behavior. vol 84. 2017-10-03. PMID:27328163. |
furthermore, we investigate the role of the 5-ht system of the prl, particularly the 5-ht1a receptors, as a possible modulator of estrous cycle influence on the expression of learned fear through intra-prl microinjections of 5-ht itself or the full 5-ht1a agonist 8-oh-dpat (8-hydroxy-2-(di-n-propylamine)tetralin). |
2017-10-03 |
2023-08-13 |
human |
| J Borg, S Cervenka, R Kuja-Halkola, G J Matheson, E G Jönsson, P Lichtenstein, S Henningsson, T Ichimiya, H Larsson, P Stenkrona, C Halldin, L Fard. Contribution of non-genetic factors to dopamine and serotonin receptor availability in the adult human brain. Molecular psychiatry. vol 21. issue 8. 2017-09-25. PMID:26821979. |
eleven monozygotic and 10 dizygotic healthy male twin pairs were examined with pet and [(11)c]raclopride binding to the d2- and d3-dopamine receptor and [(11)c]way100635 binding to the serotonin 5-ht1a receptor. |
2017-09-25 |
2023-08-13 |
human |