| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawn Bruijnzeel, Rajiv Tando. Spotlight on brexpiprazole and its potential in the treatment of schizophrenia and as adjunctive therapy for the treatment of major depression. Drug design, development and therapy. vol 10. 2017-05-08. PMID:27274197. |
brexpiprazole is a dopamine d-2 partial agonist with potent activity at the serotonin 5ht1a and 5ht2a and noradrenergic alpha-1b and alpha-2c receptors. |
2017-05-08 |
2023-08-13 |
Not clear |
| C Grasso, G Li Volsi, M Barres. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Archives italiennes de biologie. vol 154. issue 2-3. 2017-03-15. PMID:27918061. |
serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-ht1a and 5-ht2 receptors. |
2017-03-15 |
2023-08-13 |
rat |
| C Grasso, G Li Volsi, M Barres. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Archives italiennes de biologie. vol 154. issue 2-3. 2017-03-15. PMID:27918061. |
to ascertain the specificity of the effects induced by 5-ht, we utilized 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) and alpha-methyl-5-hydroxytryptamine (α-met-5-ht), agonists for 5-ht1a and 5-ht2 receptors, respectively. |
2017-03-15 |
2023-08-13 |
rat |
| C Grasso, G Li Volsi, M Barres. Serotonin modifies the spontaneous spiking activity of gracile nucleus neurons in rats: role of 5-HT1A and 5-HT2 receptors. Archives italiennes de biologie. vol 154. issue 2-3. 2017-03-15. PMID:27918061. |
these results indicate that 5-ht is able to modulate the background firing activity of gn neurons by 5-ht1a and 5-ht2 receptors. |
2017-03-15 |
2023-08-13 |
rat |
| V A Mikhailenko, I P Butkevic. The Role of 5-HT1A Receptors in Long-Term Adaptation of Newborn Rats to Hypoxia. Bulletin of experimental biology and medicine. vol 161. issue 4. 2017-03-08. PMID:27591870. |
the protective effect of buspirone can result from strengthening of the adaptive potencies of the serotoninergic system via activation of 5-ht1a receptors that up-regulate secretion of trophic factor s100β under conditions of serotonin deficiency typical of rats exposed to neonatal hypoxia. |
2017-03-08 |
2023-08-13 |
rat |
| Gerald C Claghorn, Ivana A T Fonseca, Zoe Thompson, Curtis Barber, Theodore Garlan. Serotonin-mediated central fatigue underlies increased endurance capacity in mice from lines selectively bred for high voluntary wheel running. Physiology & behavior. vol 161. 2017-03-06. PMID:27106566. |
serotonin (5-hydroxytryptamine; 5-ht) is implicated in central fatigue, and 5-ht1a pharmaceuticals are known to influence locomotor endurance in both rodents and humans. |
2017-03-06 |
2023-08-13 |
mouse |
| John L Beyer, Richard H Weisle. Adjunctive brexpiprazole for the treatment of major depressive disorder. Expert opinion on pharmacotherapy. vol 17. issue 17. 2017-02-27. PMID:27788337. |
it is thought to exert its antidepressant effect by a partial agonism of both the dopamine d2 and serotonin 5ht1a receptors. |
2017-02-27 |
2023-08-13 |
Not clear |
| Wan Fu, Heng Xie, Moshe Laudon, Shouhong Zhou, Shaowen Tian, Yong Yo. Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats. Psychopharmacology. vol 233. issue 12. 2017-02-14. PMID:27007604. |
previous studies have demonstrated that piromelatine (a melatonin and serotonin 5-ht1a and 5-ht1d agonist) exerts an antidepressant activity in rodent models of acute stress and improves cognitive impairments in a rat model of alzheimer's disease (ad). |
2017-02-14 |
2023-08-13 |
rat |
| Xiao-Wen Chen, Yuan-Yuan Sun, Lei Fu, Jian-Qi L. Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27487565. |
a series of novel benzisothiazolylpiperazine derivatives combining potent dopamine d2 and d3, and serotonin 5-ht1a and 5-ht2a receptor properties were synthesized and evaluated for their potential antipsychotic properties. |
2017-02-13 |
2023-08-13 |
rat |
| Aram Rasul, Husameldin El-Nour, Sol-Britt Lonne-Rahm, Oscar Fransson, Charlotta Johansson, Björn Johansson, Marwe Zubeidi, Emma Seeberg, Diana Radu Djurfeldt, Efrain C Azmitia, Klas Nordlin. Serotonergic Markers in Atopic Dermatitis. Acta dermato-venereologica. vol 96. issue 6. 2017-01-13. PMID:26831833. |
biopsies were taken from lesional and non-lesional ad skin, and investigated for expression of serotonin, its receptors 5-ht1a and 5-ht2, and serotonin transporter protein (sert), using immunohistochemistry. |
2017-01-13 |
2023-08-13 |
Not clear |
| Claire Bopp, Cyril Auger, Pierre Diemunsch, Valérie Schini-Kert. The effect of urapidil, an alpha-1 adrenoceptor antagonist and a 5-HT1A agonist, on the vascular tone of the porcine coronary and pulmonary arteries, the rat aorta and the human pulmonary artery. European journal of pharmacology. vol 779. 2017-01-06. PMID:26957055. |
concentration-relaxation curves either to urapidil, 5-ht, or the 5-ht1a receptor agonist 8-oh-dpat were constructed after pre-contraction of rings. |
2017-01-06 |
2023-08-13 |
human |
| Jorge J Pérez-Maceira, Cristina Otero-Rodiño, María J Mancebo, José L Soengas, Manuel Aldegund. Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 186. issue 3. 2017-01-05. PMID:26832922. |
in rainbow trout, the food intake inhibition induced by serotonin occurs through 5-ht2c and 5-ht1a receptors, though the mechanisms involved are still unknown. |
2017-01-05 |
2023-08-13 |
Not clear |
| Jorge J Pérez-Maceira, Cristina Otero-Rodiño, María J Mancebo, José L Soengas, Manuel Aldegund. Food intake inhibition in rainbow trout induced by activation of serotonin 5-HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. vol 186. issue 3. 2017-01-05. PMID:26832922. |
therefore, we assessed if a direct stimulation of 5-ht2c and 5-ht1a serotonin receptors (resulting in decreased food intake in rainbow trout), affects gene expression of neuropeptides involved in the control of food intake, such as pro-opiomelanocortin (pomc), cocaine- and amphetamine-regulated transcript (cart), corticotrophin releasing factor (crf), and agouti-related peptide (agrp). |
2017-01-05 |
2023-08-13 |
Not clear |
| Gennady N Smagin, Dekun Song, David P Budac, Jessica A Waller, Yan Li, Alan L Pehrson, Connie Sánche. Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 68. 2017-01-02. PMID:26945513. |
vortioxetine is a novel multimodal antidepressant that acts as a serotonin (5-ht)3, 5-ht7, and 5-ht1d receptor antagonist; 5-ht1b receptor partial agonist; 5-ht1a receptor agonist; and 5-ht transporter inhibitor in vitro. |
2017-01-02 |
2023-08-13 |
rat |
| Zeyad T Sahli, Pradeep Banerjee, Frank I Taraz. The Preclinical and Clinical Effects of Vilazodone for the Treatment of Major Depressive Disorder. Expert opinion on drug discovery. vol 11. issue 5. 2016-12-30. PMID:26971593. |
augmentation of the leading class of antidepressant treatment, selective serotonin reuptake inhibitors (ssris), with the 5-ht1a receptor agonist buspirone has been shown to be effective in treating patients that do not respond to initial ssri therapy. |
2016-12-30 |
2023-08-13 |
Not clear |
| Peter J Gagolewicz, Hans C Dringenber. Age-Dependent Switch of the Role of Serotonergic 5-HT1A Receptors in Gating Long-Term Potentiation in Rat Visual Cortex In Vivo. Neural plasticity. vol 2016. 2016-12-30. PMID:27247804. |
while 5-ht application (0.1-10 mm) itself did not alter ltp levels, the broad-acting 5-ht receptor antagonists methiothepin (1 mm) resulted in a clear facilitation of ltp in adult animals, an effect that was mimicked by the selective 5-ht1a receptor antagonist way 100635 (1 mm). |
2016-12-30 |
2023-08-13 |
rat |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
this study tests the hypothesis that activation of 5-ht1a autoreceptors, which would lessen 5-ht neuron firing, contributes to cocaine-seeking behaviors. |
2016-12-14 |
2023-08-13 |
mouse |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
using 5-ht neuron-specific reduction of 5-ht1a autoreceptor gene expression in mice, we demonstrate that 5-ht1a autoreceptors are necessary for cocaine conditioned place preference. |
2016-12-14 |
2023-08-13 |
mouse |
| In-Jee You, Sherie R Wright, Alvaro L Garcia-Garcia, Andrew R Tapper, Paul D Gardner, George F Koob, E David Leonardo, Laura M Bohn, Sunmee We. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 5. 2016-12-14. PMID:26324408. |
therefore, our findings suggest an important role for 5-ht1a autoreceptors, and thus drnnac 5-ht neuronal activity, in the etiology and vulnerability to cocaine reward and addiction. |
2016-12-14 |
2023-08-13 |
mouse |
| A L Garcia-Garcia, Q Meng, J Richardson-Jones, A Dranovsky, E D Leonard. Disruption of 5-HT1A function in adolescence but not early adulthood leads to sustained increases of anxiety. Neuroscience. vol 321. 2016-12-13. PMID:26049143. |
evidence from studies in mice demonstrate that the serotonergic system in general, and serotonin 1a (5-ht1a) receptors in particular, are critical during the early postnatal period for the normal development of circuits that subserve anxious behavior. |
2016-12-13 |
2023-08-13 |
mouse |