All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Leslie Citrom. Cariprazine for the Treatment of Schizophrenia: A Review of this Dopamine D3-Preferring D3/D2 Receptor Partial Agonist. Clinical schizophrenia & related psychoses. vol 10. issue 2. 2016-09-01. PMID:27440212. cariprazine is also a partial agonist at the serotonin 5-ht1a receptor and acts as an antagonist at 5-ht2b and 5-ht2a receptors. 2016-09-01 2023-08-13 Not clear
Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. following depletion of 5-ht with para-chlorophenylalanine methyl-ester hydrochloride (pcpa), vilazodone still suppressed neuronal firing of dorsal raphe nucleus (drn) 5-ht neurons to a similar extent than controls, indicating that this inhibition is via 5-ht1a receptors activation. 2016-08-30 2023-08-13 human
Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. following 2-day intraperitoneal administration of vilazodone (5 mg/kg/day), there was a significant decrease in 5-ht neuronal firing which recovered to baseline levels by day 14 of administration, likely due to 5-ht1a autoreceptor desensitization. 2016-08-30 2023-08-13 human
Mostafa El Mansari, Agnes Crnic, Chris Oosterhof, Pierre Blie. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. vol 99. 2016-08-30. PMID:26362359. after repeated vilazodone regimen, while there was no change in sensitivity of 5-ht1a receptors, the enhancement in 5-ht transmission yielded an increase in the tonic activation of these receptors located in the hippocampus. 2016-08-30 2023-08-13 human
James O Fajemiroye, Prabhakar R Polepally, Narayan D Chaurasiya, Babu L Tekwani, Jordan K Zjawiony, Elson A Cost. Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor. Scientific reports. vol 5. 2016-08-29. PMID:26199018. pharmacological tools like α-methyl-p-tyrosine (ampt, catecholamine depletor), p-chlorophenylalanine (serotonin depletor), prazosin (praz, selective α1-receptor antagonist), way-100635 (selective serotonin 5-ht1a receptor antagonist) as well as monoamine oxidase (mao) and functional binding assays were conducted to investigate possible neural mechanisms. 2016-08-29 2023-08-13 mouse
Brice Le François, Jeremy Soo, Anne M Millar, Mireille Daigle, Anne-Marie Le Guisquet, Samuel Leman, Frédéric Minier, Catherine Belzung, Paul R Alber. Chronic mild stress and antidepressant treatment alter 5-HT1A receptor expression by modifying DNA methylation of a conserved Sp4 site. Neurobiology of disease. vol 82. 2016-08-24. PMID:26188176. the serotonin 1a receptor (5-ht1a), a critical regulator of the brain serotonergic tone, is implicated in major depressive disorder (mdd) where it is often found to be dys-regulated. 2016-08-24 2023-08-13 mouse
Antón Barreiro-Iglesias, Karolina S Mysiak, Angela L Scott, Michell M Reimer, Yujie Yang, Catherina G Becker, Thomas Becke. Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. Cell reports. vol 13. issue 5. 2016-08-24. PMID:26565906. pharmacological manipulations and receptor knockdown indicate that serotonin acts at least in part via 5-ht1a receptors. 2016-08-24 2023-08-13 zebrafish
Serena Deiana, Akihito Watanabe, Yuki Yamasaki, Naoki Amada, Tetsuro Kikuchi, Colin Stott, Gernot Riede. MK-801-induced deficits in social recognition in rats: reversal by aripiprazole, but not olanzapine, risperidone, or cannabidiol. Behavioural pharmacology. vol 26. issue 8 Spec No. 2016-08-22. PMID:26287433. collectively, the combined activity of aripiprazole on dopamine d2 and serotonin 5ht1a receptors appears to provide a significant advantage over risperidone and olanzapine with respect to the rescue of cognitive deficits reminiscent of schizophrenia. 2016-08-22 2023-08-13 human
D Heal. The Fluoxetine and Suicide Controversy : A Review of the Evidence. CNS drugs. vol 1. issue 3. 2016-08-17. PMID:27520521. the serotonin (5-hydroxytryptarnine; 5-ht) system may be involved in these reactions.the best management of such reactions will involve counselling patients beforehand about the possibility of these reactions, stopping treatment with the agents if such a reaction is suspected, or adding an agent with 5-ht1a antagonistic properties (e.g. 2016-08-17 2023-08-13 Not clear
Henk Temmingh, Dan J Stei. Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS drugs. vol 29. issue 10. 2016-08-15. PMID:26482261. recent findings implicate the serotonin transporter (sert) genes, brain-derived neurotropic factor (bdnf) genes, and the serotonin 1a (5ht1a) receptor, but are preliminary and in need of replication. 2016-08-15 2023-08-13 Not clear
Ana F Almeida-Santos, Renata C M Ferreira, Igor D Duarte, Daniele C Aguiar, Thiago R L Romero, Fabricio A Moreir. The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors. European journal of pharmacology. vol 765. 2016-08-12. PMID:26325094. the antipsychotic aripiprazole induces antinociceptive effects: possible role of peripheral dopamine d2 and serotonin 5-ht1a receptors. 2016-08-12 2023-08-13 mouse
Ana F Almeida-Santos, Renata C M Ferreira, Igor D Duarte, Daniele C Aguiar, Thiago R L Romero, Fabricio A Moreir. The antipsychotic aripiprazole induces antinociceptive effects: Possible role of peripheral dopamine D2 and serotonin 5-HT1A receptors. European journal of pharmacology. vol 765. 2016-08-12. PMID:26325094. aripiprazole is an antipsychotic that acts by multiple mechanisms, including partial agonism at dopamine d2 and serotonin 5-ht1a receptors. 2016-08-12 2023-08-13 mouse
Belén Goitia, María Celeste Rivero-Echeto, Noelia V Weisstaub, Jay A Gingrich, Edgar Garcia-Rill, Verónica Bisagno, Francisco J Urban. Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26484945. in 5-ht2a -/- mice, nan-190, a specific 5-ht1a antagonist, prevented the 100 μm 5-ht inhibition while blocking h-currents that prolonged inhibition during post-puff periods. 2016-08-05 2023-08-13 mouse
Víctor Rovira, Emilio Geijo-Barriento. Intra- and Interhemispheric Propagation of Electrophysiological Synchronous Activity and Its Modulation by Serotonin in the Cingulate Cortex of Juvenile Mice. PloS one. vol 11. issue 3. 2016-08-02. PMID:26930051. these actions of serotonin were mimicked by the activation of either 5-ht1b or 5-ht2a receptors, but not by the activation of the 5-ht1a subtype. 2016-08-02 2023-08-13 mouse
Subhash Ajmani, Sudhir A Kulkarn. Application of GQSAR for Scaffold Hopping and Lead Optimization in Multitarget Inhibitors. Molecular informatics. vol 31. issue 6-7. 2016-08-02. PMID:27477466. the present study demonstrates application of a novel group based qsar (gqsar) method to assist in lead optimization of multikinase (pdgfr-beta, fgfr-1 and src) and scaffold hopping of multiserotonin target (serotonin receptor 1a and serotonin transporter) inhibitors. 2016-08-02 2023-08-13 Not clear
Lirong Wang, Chao Ma, Peter Wipf, Xiang-Qun Xi. Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1A Ligand Functionality. Molecular informatics. vol 31. issue 1. 2016-08-02. PMID:27478180. in this study, we investigated the molecular properties of agonists and antagonists of human 5-hydroxytryptamine receptor subtype 1a (5-ht1a ). 2016-08-02 2023-08-13 human
Emma D Deek. Flibanserin: First Global Approval. Drugs. vol 75. issue 15. 2016-07-29. PMID:26412054. the drug has a high affinity for serotonin 5-ht1a and 5-ht2a receptors (5-ht1a agonist/5-ht2a antagonist) and is believed to treat hsdd by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. 2016-07-29 2023-08-13 Not clear
Diane C Chugani, Harry T Chugani, Max Wiznitzer, Sumit Parikh, Patricia A Evans, Robin L Hansen, Ruth Nass, James J Janisse, Pamela Dixon-Thomas, Michael Behen, Robert Rothermel, Jacqueline S Parker, Ajay Kumar, Otto Muzik, David J Edwards, Deborah Hirt. Efficacy of Low-Dose Buspirone for Restricted and Repetitive Behavior in Young Children with Autism Spectrum Disorder: A Randomized Trial. The Journal of pediatrics. vol 170. 2016-07-26. PMID:26746121. to determine safety and efficacy of the 5ht1a serotonin partial agonist buspirone on core autism and associated features in children with autism spectrum disorder (asd). 2016-07-26 2023-08-13 Not clear
François Montastruc, Aurore Palmaro, Haleh Bagheri, Laurent Schmitt, Jean-Louis Montastruc, Maryse Lapeyre-Mestr. Role of serotonin 5-HT2C and histamine H1 receptors in antipsychotic-induced diabetes: A pharmacoepidemiological-pharmacodynamic study in VigiBase. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 10. 2016-07-12. PMID:26256010. we investigated potential relationships between antipsychotics׳ receptor occupancy (serotonin 5-ht1a, 5-ht2a, 5-ht2c, histamine h1, muscarinic m3, adrenergic α1, α2 or dopaminergic d2 d3 occupancies) and reports of diabetes using vigibase(®), the world health organization (who) global individual case safety report (icsr) database. 2016-07-12 2023-08-13 Not clear
Claire Chevreuil, Elisabeth Polard, Eric Lemonnier, Paul Guillemot, Danièle Bentué-Ferre. [Not Available]. Therapie. vol 66. issue 2. 2016-07-12. PMID:27393647. its mechanism of action is different as aripiprazole is a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist. 2016-07-12 2023-08-13 Not clear