All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
Savelii R Kuvarzin, Ilya Sukhanov, Kirill Onokhin, Konstantin Zakharov, Raul R Gainetdino. Unlocking the Therapeutic Potential of Ulotaront as a Trace Amine-Associated Receptor 1 Agonist for Neuropsychiatric Disorders. Biomedicines. vol 11. issue 7. 2023-07-29. PMID:37509616. ulotaront is an agonist of trace amine-associated receptor 1 and serotonin 5-ht1a receptors, but can modulate dopamine neurotransmission indirectly. 2023-07-29 2023-08-14 Not clear
HaiXiang Ma, LeYuan Gu, YuLing Wang, Qing Xu, Yuanli Zhang, WeiHui Shao, Qian Yu, XiTing Lian, Lu Liu, JiaXuan Gu, Na Ji, XiaoLing Liu, Kazuki Nagayasu, HongHai Zhan. The States of Different 5-HT Receptors Located in the Dorsal Raphe Nucleus Are Crucial for Regulating the Awakening During General Anesthesia. Molecular neurobiology. 2023-07-29. PMID:37516665. in addition, we first discovered that the different 5-ht receptors located in the dr, known as 5-ht autoreceptors, are essential for the regulation of general anesthetic awakening, with 5-ht1a and 5-ht2a/c receptors playing a regulatory role. 2023-07-29 2023-08-14 mouse
Tarun Gupta, Varinder Singh, Mohamed Hefnawy, Mohammed M Alanazi, Bader Alsuwayt, Atul Kabra, Amit Kumar, Chirag Pasricha, Ravinder Sing. Ameliorating the Role of Aripiprazole in Memory Deficits Induced by Intracerebroventricular Streptozotocin-Induced Dementia of Alzheimer's Type. ACS omega. vol 8. issue 28. 2023-07-24. PMID:37483219. dopamine d2 and 5-hydroxytryptamine receptor 1a (5-ht1a) receptors' activation has been reported to play a crucial role in managing neurological outcomes in the brain and other health disorders. 2023-07-24 2023-08-14 mouse
Xue Wang, Hongyue Yang, Xiaoling Zhang, Qi Fa. The effect of nursing intervention on self-care self-efficacy and genes related to anxiety in patients with bone marrow transplantation. Cellular and molecular biology (Noisy-le-Grand, France). vol 69. issue 3. 2023-06-11. PMID:37300683. the expression level of two genes affecting anxiety (i.e., 5-hydroxytryptamine receptor 1a (5-ht1a) and corticotropin releasing hormone receptor 1 (crhr1)) was also investigated. 2023-06-11 2023-08-14 Not clear
Soichiro Kitamura, Yasuyuki Kimura, Keisuke Takahata, Sho Moriguchi, Manabu Kubota, Hitoshi Shimada, Hironobu Endo, Yuhei Takado, Kazunori Kawamura, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuch. Serotonergic neurotransmission in limbic regions may reflect therapeutic response of depressive patients: A PET study with 11C-WAY-100635 and 18F-MPPF. The international journal of neuropsychopharmacology. 2023-06-06. PMID:37279545. while binding of both ligands reflects 5-ht1a receptor density, 18f-mppf biding may also be affected by extracellular 5-ht concentrations. 2023-06-06 2023-08-14 Not clear
Meng Zhang, Li-Yuan Liu, Yong Xu, Wen-Zhi Wang, Nian-Zhuang Qiu, Fang-Fang Zhang, Feng Zhang, Xiao-Dan Wang, Wei Chen, Xiao-Yan Xu, Yong-Feng Gao, Mei-Hua Chen, Yu-Qin Li, Han-Ting Zhang, Hao Wan. Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease. Metabolic brain disease. 2023-05-31. PMID:37256468. moreover, the expression of the alpha 1a adrenergic receptor (adra1a), serotonin 1 a receptor (5ht1a), and γ-aminobutyric acid a receptor subunit alpha-2 (gabra2) was significantly downregulated in the hippocampus of 3×tg-ad mice, while histamine h3 receptor (h3r) expression was significantly upregulated. 2023-05-31 2023-08-14 mouse
Yong-Jik Lee, Hyun-Min Kim, Yoo-Na Jang, Yoon-Mi Han, Hong Seog Seo, Tae Woo Jung, Ji Hoon Jeong, Hyun Jung Lee, Kyung Oh Jun. Buspirone Induces Weight Loss and Normalization of Blood Pressure via the Stimulation of PPAR PPAR research. vol 2023. 2023-05-11. PMID:37168052. buspirone induces weight loss and normalization of blood pressure via the stimulation of ppar buspirone, as a partial agonist for a 5-hydroxytryptamine (serotonin) receptor 1a (5-ht1a), has been prescribed as an anxiolytic drug for patients. 2023-05-11 2023-08-14 Not clear
Sandeep Singh, Alexander Botvinnik, Orr Shahar, Gilly Wolf, Corel Yakobi, Michal Saban, Adham Salama, Amit Lotan, Bernard Lerer, Tzuri Lifschyt. Effect of psilocybin on marble burying in ICR mice: role of 5-HT1A receptors and implications for the treatment of obsessive-compulsive disorder. Translational psychiatry. vol 13. issue 1. 2023-05-10. PMID:37164956. on this background, we set out to explore (1) the role of serotonin 2a (5-ht2a) and serotonin 1a (5-ht1a) receptors in the effect of psilocybin on marble burying; (2) the effect of staggered versus bolus psilocybin administration and persistence of the effect; (3) the effect of the 5-ht1a partial agonist, buspirone, on marble-burying and the head twitch response (htr) induced by psilocybin, a rodent correlate of psychedelic effects. 2023-05-10 2023-08-14 mouse
Eric D Achtyes, Seth C Hopkins, Nina Dedic, Heather Dworak, Courtney Zeni, Kenneth Kobla. Ulotaront: review of preliminary evidence for the efficacy and safety of a TAAR1 agonist in schizophrenia. European archives of psychiatry and clinical neuroscience. 2023-05-10. PMID:37165101. the mechanism of action (moa) of ulotaront is thought to be mediated by agonism at taar1 and serotonin 5-ht1a receptors. 2023-05-10 2023-08-14 Not clear
Patrizia Ambrogini, Davide Lattanzi, Marica Pagliarini, Michael Di Palma, Stefano Sartini, Riccardo Cuppini, Kjell Fuxe, Dasiel Oscar Borroto-Escuel. 5HT1AR-FGFR1 Heteroreceptor Complexes Differently Modulate GIRK Currents in the Dorsal Hippocampus and the Dorsal Raphe Serotonin Nucleus of Control Rats and of a Genetic Rat Model of Depression. International journal of molecular sciences. vol 24. issue 8. 2023-04-28. PMID:37108630. serotonin 5ht1a receptor (r) activation at the soma-dendritic level of serotonergic raphe neurons and glutamatergic hippocampal pyramidal neurons leads to a decrease in neuronal firing by activation of g protein-coupled inwardly-rectifying potassium (girk) channels. 2023-04-28 2023-08-14 rat
Akihiro Hasumi, Hideyuki Maed. Cannabidiol improves haloperidol-induced motor dysfunction in zebrafish: a comparative study with a dopamine activating drug. Journal of cannabis research. vol 5. issue 1. 2023-03-04. PMID:36871008. recent behavioral studies in rats have reported that cbd mediates serotonin (5-ht1a) receptor action to improve motor dysfunction induced by dopamine (d2) receptor blockade. 2023-03-04 2023-08-14 rat
Nuh Mehmet Bozkurt, Gokhan Una. Vortioxetine Improved Negative and Cognitive Symptoms of Schizophrenia in Subchronic MK-801 Induced Schizophrenia Model in Rats. Behavioural brain research. 2023-03-01. PMID:36858318. vortioxetine is a new multimodal antidepressant with 5-ht1a agonism, 5-ht1b partial agonism, 5-ht3, 5-ht7, and 5-ht1d antagonism, and serotonin reuptake inhibition. 2023-03-01 2023-08-14 rat
David B Finlay, Warwick Mackie, Hunter D J Webb, Lucy R Thomsen, Mhairi Nimick, Rhonda J Rosengren, Julie A Marusich, Michelle Glass, Jenny L Wile. The piperazine analogue para-fluorophenylpiperazine alters timing of the physiological effects of the synthetic cannabinoid receptor agonist AMB-FUBINACA, without changing its discriminative stimulus, signalling effects, or metabolism. Pharmacology, biochemistry, and behavior. 2023-02-22. PMID:36805861. a characteristic of amb-fubinaca use in new zealand has included the observation that forensic samples (from autopsies) and drugs seized by police have often been found to contain para-fluorophenylpiperazine (pfpp), a relatively little-characterised piperazine analogue that has been suggested to act through 5ht1a serotonin receptors. 2023-02-22 2023-08-14 mouse
Ragini, Sakshi, Ashok Saini, Indra Man. Endocytosis and signaling of 5-HT1A receptor. Progress in molecular biology and translational science. vol 196. 2023-02-22. PMID:36813354. 5-ht binds to its receptor 5-ht1a to initiate gtp exchange at the gi/o protein, which activates the receptor g protein complex. 2023-02-22 2023-08-14 Not clear
Pattath Narayanan Suresh Kumar, Rohith Suresh, Vikas Meno. An Open-Label Rater-Blinded Randomized Trial of Vilazodone versus Escitalopram in Major Depression. Indian journal of psychological medicine. vol 45. issue 1. 2023-02-13. PMID:36778613. vilazodone, a novel selective serotonin reuptake inhibitor and 5-ht1a partial agonist, was approved in 2011 for treatment for major depression. 2023-02-13 2023-08-14 Not clear
b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' expression patterns of serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a during human fetal lung development. 2023-02-11 2023-08-14 human
b' Jelena Nikoli\\xc4\\x87, Katarina Vukojevi\\xc4\\x87, Violeta \\xc5\\xa0olji\\xc4\\x87, Josip Mi\\xc5\\xa1kovi\\xc4\\x87, Martina Orlovi\\xc4\\x87 Vlaho, Mirna Saraga-Babi\\xc4\\x87, Natalija Filipovi\\xc4\\x8. Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development. International journal of molecular sciences. vol 24. issue 3. 2023-02-11. PMID:36769290.' we analyzed the expression of the serotonin receptors 5-ht1a, 5-ht2a, and 5-ht3a at four different stages of fetal lung development from 12 to 40 weeks of gestation, divided into four groups: the pseudoglandular stage (12-16th week of development; 2023-02-11 2023-08-14 human
Ching-Yi Lin, Kevin Li, Rajaa Thalluri, Yu-Shang Le. Upregulated 5-HT1A receptor regulation of lower urinary tract function in rats following complete spinal cord injury. Journal of neurotrauma. 2023-02-10. PMID:36762948. here, we investigate the expression levels of the serotonin 1a (5-ht1a) receptor in segments both rostral and caudal to the injured site, as well as the effects of blocking 5-ht1a receptor on micturition using pharmacological interventions in spinally-intact rats or t8 complete sci rats. 2023-02-10 2023-08-14 rat
Jiajia Dai, Hyangin Kim, Zerong You, Michael F McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Ma. Role of 5-HT1A-mediated upregulation of brain indoleamine 2,3 dioxygenase 1 in the reduced antidepressant and antihyperalgesic effects of fluoxetine during maintenance treatment. Frontiers in pharmacology. vol 13. 2023-01-02. PMID:36588734. fluoxetine exposure induced upregulation of the 5-hydroxytryptamine 1a (5-ht1a) auto-receptor and indoleamine 2,3 dioxygenase 1 (ido1, a rate-limiting enzyme of tryptophan metabolism) in the brainstem dorsal raphe nucleus (drn), which shifted the tryptophan metabolism away from the 5-ht biosynthesis. 2023-01-02 2023-08-14 Not clear
João P F Kurita, Anderson H F F Leão, Vinicius S Bioni, Raphael Wuo-Silva, Alvaro C Lima, Murilo A Paiva-Santos, Gabriela F Marinho, Débora M G Cunha, Marcela Becegato, Leonardo B Lopes-Silva, Alessandra M Ribeiro, Regina H Silv. Memory and anxiety-like behavior of rats in the plus-maze discriminative avoidance task: Role of serotonergic transmission in the basolateral amygdala. Behavioral neuroscience. 2022-12-22. PMID:36548050. the results showed that an increase in serotonin (5-ht) availability or the blockade of 5ht1a and 5ht2a bla receptors impaired aversive memory formation. 2022-12-22 2023-08-14 rat