| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Claire Chevreuil, Elisabeth Polard, Eric Lemonnier, Paul Guillemot, Danièle Bentué-Ferre. [Not Available]. Therapie. vol 66. issue 2. 2016-07-12. PMID:27393647. |
its mechanism of action is different as aripiprazole is a partial dopamine d2 and serotonin 5-ht1a receptor agonist and 5-ht2a receptor antagonist. |
2016-07-12 |
2023-08-13 |
Not clear |
| Carl Gommoll, Giovanna Forero, Maju Mathews, Rene Nunez, Xiongwen Tang, Suresh Durgam, Angelo Sambunari. Vilazodone in patients with generalized anxiety disorder: a double-blind, randomized, placebo-controlled, flexible-dose study. International clinical psychopharmacology. vol 30. issue 6. 2016-07-06. PMID:26291335. |
vilazodone is a selective serotonin reuptake inhibitor and a 5-ht1a receptor partial agonist that is approved for treatment of major depressive disorder in adults in the usa and mexico. |
2016-07-06 |
2023-08-13 |
human |
| A Spiacci, T de Oliveira Sergio, G S F da Silva, M L Glass, L C Schenberg, N Garcia-Cairasco, H Zangross. Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia. Neuroscience. vol 307. 2016-07-06. PMID:26319117. |
intra-dpag injection of 5-ht (20 nmol), (±)-8-hydroxy-2-(di-n-propylamino) tetralin hydrobromide (8-oh-dpat) (8 nmol), a 5-ht1a receptor agonist, or (±)-2,5-dimethoxy-4-iodo amphetamine hydrochloride (doi) (16 nmol), a preferential 5-ht2a agonist, reduced the number of upward jumps directed to the border of the experimental chamber during hypoxia, interpreted as escape attempts, without affecting the rats' locomotion. |
2016-07-06 |
2023-08-13 |
rat |
| Piero Porcelli, Raffaele Cozzolongo, Filomena Cariola, Vito Giannuzzi, Elsa Lanzilotta, Mattia Gentile, Gabriella Sonnante, Gioacchino Leandr. Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C. Psychopathology. vol 48. issue 6. 2016-07-06. PMID:26609890. |
since the 5-ht network is involved in interferon (ifn)-induced depression, this paper aimed to investigate the role of alexithymia and the functional gene variants of the 5-ht1a receptor (htr1a) and the 5-ht transporter (5-httlpr) in induction of depression during antiviral treatment. |
2016-07-06 |
2023-08-13 |
Not clear |
| Russell A Morton, C Fernando Valenzuel. Third Trimester Equivalent Alcohol Exposure Reduces Modulation of Glutamatergic Synaptic Transmission by 5-HT1A Receptors in the Rat Hippocampal CA3 Region. Frontiers in neuroscience. vol 10. 2016-07-04. PMID:27375424. |
in slices from naïve animals, application of a 5-ht1a receptor antagonist blocked the effect of 5-ht on the fepsps recorded in presence of picrotoxin, suggesting that third trimester ethanol exposure acts by inhibiting the function of these receptors. |
2016-07-04 |
2023-08-13 |
human |
| Ling Huang, Wenjun Zhang, Xiaohua Zhang, Lei Yin, Bangyin Chen, Jinchun Son. Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics. Bioorganic & medicinal chemistry letters. vol 25. issue 22. 2016-06-28. PMID:26483200. |
the present study describes the optimization of a series of novel benzoxazole-piperidine (piperazine) derivatives combining high dopamine d2 and serotonin 5-ht1a, 5-ht2a receptor affinities. |
2016-06-28 |
2023-08-13 |
human |
| Ana M Gamo, Juan A González-Vera, Ainoa Rueda-Zubiaurre, Dulce Alonso, Henar Vázquez-Villa, Lidia Martín-Couce, Óscar Palomares, Juan A López, Mar Martín-Fontecha, Bellinda Benhamú, María L López-Rodríguez, Silvia Ortega-Gutiérre. Chemoproteomic Approach to Explore the Target Profile of GPCR ligands: Application to 5-HT1A and 5-HT6 Receptors. Chemistry (Weinheim an der Bergstrasse, Germany). vol 22. issue 4. 2016-06-28. PMID:26560738. |
as proof of concept, this methodology has been applied to selected ligands of the therapeutically relevant serotonin 5-ht1a and 5-ht6 receptors, and we have identified and validated some of their off-targets. |
2016-06-28 |
2023-08-13 |
Not clear |
| Martin Reznitsky, Per Plenge, Anders Hay-Schmid. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study. Neuroscience letters. vol 612. 2016-06-28. PMID:26683905. |
autoradiography showed that serotonin receptors 5-ht1b and 5-ht2c and the serotonin transporter were present in stn, whereas the 5-ht1a and 5-ht2a not were present. |
2016-06-28 |
2023-08-13 |
rat |
| Jussi Hirvonen, Lauri Tuominen, Kjell Någren, Jarmo Hietal. Neuroticism and serotonin 5-HT1A receptors in healthy subjects. Psychiatry research. vol 234. issue 1. 2016-06-27. PMID:26337006. |
neuroticism and serotonin 5-ht1a receptors in healthy subjects. |
2016-06-27 |
2023-08-13 |
human |
| Jussi Hirvonen, Lauri Tuominen, Kjell Någren, Jarmo Hietal. Neuroticism and serotonin 5-HT1A receptors in healthy subjects. Psychiatry research. vol 234. issue 1. 2016-06-27. PMID:26337006. |
serotonin 5-ht1a receptors are altered in mood and anxiety disorders, but whether 5-ht1a receptors are associated with neuroticism in healthy subjects is unclear. |
2016-06-27 |
2023-08-13 |
human |
| Jussi Hirvonen, Lauri Tuominen, Kjell Någren, Jarmo Hietal. Neuroticism and serotonin 5-HT1A receptors in healthy subjects. Psychiatry research. vol 234. issue 1. 2016-06-27. PMID:26337006. |
we measured brain serotonin 5-ht1a receptor in 34 healthy subjects in vivo using positron emission tomography (pet) and [carbonyl-(11)c]way-100635. |
2016-06-27 |
2023-08-13 |
human |
| Jussi Hirvonen, Lauri Tuominen, Kjell Någren, Jarmo Hietal. Neuroticism and serotonin 5-HT1A receptors in healthy subjects. Psychiatry research. vol 234. issue 1. 2016-06-27. PMID:26337006. |
we found a strong negative association between serotonin 5-ht1a receptor bpp and neuroticism. |
2016-06-27 |
2023-08-13 |
human |
| Jussi Hirvonen, Lauri Tuominen, Kjell Någren, Jarmo Hietal. Neuroticism and serotonin 5-HT1A receptors in healthy subjects. Psychiatry research. vol 234. issue 1. 2016-06-27. PMID:26337006. |
previous observations have reported lower serotonin 5-ht1a receptor density in major depression. |
2016-06-27 |
2023-08-13 |
human |
| A Sagarduy, J Llorente, C Miguelez, T Morera-Herreras, J A Ruiz-Ortega, L Uged. Buspirone requires the intact nigrostriatal pathway to reduce the activity of the subthalamic nucleus via 5-HT1A receptors. Experimental neurology. vol 277. 2016-06-27. PMID:26687972. |
cell-attached recordings in parasagittal slices from naïve rats showed that whilst serotonin excited the majority of stn neurons, buspirone showed an inhibitory main effect but only in 27% of the studied cells which was prevented by the 5-ht1a receptor selective antagonist way-100635. |
2016-06-27 |
2023-08-13 |
rat |
| Sarah L Grei. Brexpiprazole: First Global Approval. Drugs. vol 75. issue 14. 2016-06-24. PMID:26310190. |
brexpiprazole is a novel serotonin-dopamine activity modulator that acts as a partial agonist of serotonin 1a (5-ht1a) and dopamine d2 receptors, as well as a potent antagonist of 5-ht2a receptors and noradrenergic α1b and α2c receptors. |
2016-06-24 |
2023-08-13 |
Not clear |
| Steven C Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan L Pehrson, Connie Sanche. Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of psychopharmacology (Oxford, England). vol 29. issue 10. 2016-06-23. PMID:26174134. |
vortioxetine, a multimodal antidepressant acting through serotonin (5-ht) transporter (sert) inhibition, 5-ht3, 5-ht7 and 5-ht1d receptor antagonism, 5-ht1b receptor partial agonism, and 5-ht1a receptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. |
2016-06-23 |
2023-08-13 |
human |
| Agnieszka Gunia-Krzyzak, Karolina Pytka, Karolina Słoczyńska, Anna M Waszkielewicz, Grzegorz Satała, Andrzej J Bojarski, Jacek Sapa, Barbara Filipek, Marek Cegła, Elzbieta Pekala, Henryk Maron. PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180427. |
to identify possible mechanism of action, we evaluated serotonin receptors (5-ht1a, 5-ht6 and 5-ht7) binding affinities of the compounds but none of them proved to bind to any of tested receptors. |
2016-06-20 |
2023-08-13 |
mouse |
| Jeanine Alterio, Justine Masson, Jorge Diaz, Konstantina Chachlaki, Haysam Salman, Julie Areias, Sana Al Awabdh, Michel Boris Emerit, Michèle Darmo. Yif1B Is Involved in the Anterograde Traffic Pathway and the Golgi Architecture. Traffic (Copenhagen, Denmark). vol 16. issue 9. 2016-06-17. PMID:26077767. |
yif1b is an intracellular membrane-bound protein belonging to the yip family, shown previously to control serotonin 5-ht1a receptor targeting to dendrites. |
2016-06-17 |
2023-08-13 |
mouse |
| Alberto Montalbano, Renato Corradetti, Boris Mlina. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PloS one. vol 10. issue 10. 2016-06-06. PMID:26460748. |
pharmacological characterization of 5-ht1a autoreceptor-coupled girk channels in rat dorsal raphe 5-ht neurons. |
2016-06-06 |
2023-08-13 |
rat |
| Alberto Montalbano, Renato Corradetti, Boris Mlina. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. PloS one. vol 10. issue 10. 2016-06-06. PMID:26460748. |
g protein-activated inwardly rectifying potassium (girk) channels in 5-ht neurons are assumed to be principal effectors of 5-hydroxytryptamine 1a (5-ht1a) autoreceptors, but their pharmacology, subunit composition and the role in regulation of 5-ht neuron activity have not been fully elucidated. |
2016-06-06 |
2023-08-13 |
rat |