All Relations between 5-ht receptor 1a and serotonin

Publication Sentence Publish Date Extraction Date Species
B Olivier, J Schipper, J A van der Heyden, A van Hest, J Mos, M T Tul. Preclinical evidence for the role of serotonin receptor-subtypes in depression. Acta neuropsychiatrica. vol 4. issue 2. 2016-03-10. PMID:26956533. by testing different 5-ht ligands in two animal models of depression (forced swimming and drl72-s test) and comparison with data from literature, evidence is provided for potential antidepressant qualities of 5-ht1a receptor-agonists and 5-ht1c receptor-antagonists. 2016-03-10 2023-08-13 Not clear
N K Popova, A V Kulikov, E M Kondaurova, A S Tsybko, E A Kulikova, I B Krasnov, B S Shenkman, E Yu Bazhenova, N A Sinyakova, V S Naumenk. Risk neurogenes for long-term spaceflight: dopamine and serotonin brain system. Molecular neurobiology. vol 51. issue 3. 2016-03-08. PMID:25084757. however, spaceflight failed to alter the expression of tryptophan hydroxylase-2, 5-ht transporter, 5-ht1a, and 5-ht3 receptor genes, though it reduced 5-ht2a receptor gene expression in the hypothalamus. 2016-03-08 2023-08-13 mouse
Boris Mlinar, Alberto Montalbano, Gilda Baccini, Francesca Tatini, Rolando Berlinguer Palmini, Renato Corradett. Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. The Journal of general physiology. vol 145. issue 3. 2016-03-04. PMID:25712017. the firing activity of serotonergic neurons in raphe nuclei is regulated by negative feedback exerted by extracellular serotonin (5-ht)o acting through somatodendritic 5-ht1a autoreceptors. 2016-03-04 2023-08-13 Not clear
Boris Mlinar, Alberto Montalbano, Gilda Baccini, Francesca Tatini, Rolando Berlinguer Palmini, Renato Corradett. Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. The Journal of general physiology. vol 145. issue 3. 2016-03-04. PMID:25712017. the steady-state [5-ht]o, sensed by 5-ht1a autoreceptors, is determined by the balance between the rates of 5-ht release and reuptake. 2016-03-04 2023-08-13 Not clear
Boris Mlinar, Alberto Montalbano, Gilda Baccini, Francesca Tatini, Rolando Berlinguer Palmini, Renato Corradett. Nonexocytotic serotonin release tonically suppresses serotonergic neuron activity. The Journal of general physiology. vol 145. issue 3. 2016-03-04. PMID:25712017. by using 5-ht1a autoreceptor-activated g protein-gated inwardly rectifying potassium channels of patched serotonergic neurons as 5-hto sensors, we show substantial nonexocytotic 5-ht release under conditions of abolished firing activity, ca(2+) influx, vesicular monoamine transporter 2-mediated vesicular accumulation of 5-ht, and sert-mediated 5-ht transport. 2016-03-04 2023-08-13 Not clear
Takashi Kawano, Tetsuya Takahashi, Satomi Kaminaga, Takao Kadono, Daiki Yamanaka, Hideki Iwata, Satoru Eguchi, Masataka Yokoyam. A comparison of midazolam and dexmedetomidine for the recovery of serotonin syndrome in rats. Journal of anesthesia. vol 29. issue 4. 2016-03-03. PMID:25596946. 8-oh-dpat-treated rats showed serotonin syndrome-like behaviors (low body posture, forepaw treading), hyperlocomotion, and decreased body temperature, which were completely inhibited by pretreatment with way 100635, a selective 5-ht1a antagonist (n = 8). 2016-03-03 2023-08-13 rat
José-Ángel García-Pedraza, Mónica García, María-Luisa Martín, Asunción Morá. Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats. Clinical and experimental pharmacology & physiology. vol 42. issue 6. 2016-02-29. PMID:25854421. administration (0.00000125 to 0.1 μg/kg) of 5-ct or l-694,247 (5-ht1d agonist) mimicked 5-ht vasodilator effect, while other agonists (1-pbg, α-methyl-5-ht, as-19 (5-ht₇), 8-oh-dpat (5-ht1a) or cgs-12066b (5-ht1b)) did not alter baseline haemodynamic variables. 2016-02-29 2023-08-13 rat
Anna Czopek, Marcin Kołaczkowski, Adam Bucki, Hanna Byrtus, Maciej Pawłowski, Grzegorz Kazek, Andrzej J Bojarski, Agata Piaskowska, Justyna Kalinowska-Tłuścik, Anna Partyka, Anna Wesołowsk. Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent. Bioorganic & medicinal chemistry. vol 23. issue 13. 2016-02-26. PMID:25936259. a series of novel spirohydantoin derivatives with arylpiperazinylbutyl moiety were synthesized and evaluated for serotonin 5-ht1a, 5-ht2a, 5-ht7 and dopamine d2 receptors. 2016-02-26 2023-08-13 mouse
Anita H Clayton, Carl Gommoll, Dalei Chen, Rene Nunez, Maju Mathew. Sexual dysfunction during treatment of major depressive disorder with vilazodone, citalopram, or placebo: results from a phase IV clinical trial. International clinical psychopharmacology. vol 30. issue 4. 2016-02-26. PMID:26039688. vilazodone, a selective serotonin reuptake inhibitor and 5-ht1a receptor partial agonist antidepressant approved for the treatment of mdd in adults, was evaluated to determine its effects on sexual function. 2016-02-26 2023-08-13 Not clear
Ramesh Boinpally, Nayra Gad, Samir Gupta, Antonia Periclo. Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects. Clinical therapeutics. vol 36. issue 11. 2016-02-19. PMID:25236915. vilazodone is a serotonin reuptake inhibitor and 5-ht1a partial agonist approved for the treatment of major depressive disorder in adults. 2016-02-19 2023-08-13 human
Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. 2016-02-16 2023-08-13 mouse
Elisabetta Tronci, Camino Fidalgo, Manolo Cart. Foetal Cell Transplantation for Parkinson's Disease: Focus on Graft-Induced Dyskinesia. Parkinson's disease. vol 2015. 2016-02-16. PMID:26881178. in agreement, clinical investigations have shown that grafted tissue may contain a large number of serotonin neurons, in the order of half of the da cells; moreover, the serotonin 5-ht1a receptor agonist buspirone has been found to produce significant dampening of gid in grafted patients. 2016-02-16 2023-08-13 Not clear
Richard R Neubi. RGS-Insensitive G Proteins as In Vivo Probes of RGS Function. Progress in molecular biology and translational science. vol 133. 2016-02-15. PMID:26123300. guanine nucleotide-binding proteins of the inhibitory (gi/o) class play critical physiological roles and the receptors that activate them are important therapeutic targets (e.g., mu opioid, serotonin 5ht1a, etc.). 2016-02-15 2023-08-13 mouse
Gabriel Nowa. Zinc, future mono/adjunctive therapy for depression: Mechanisms of antidepressant action. Pharmacological reports : PR. vol 67. issue 3. 2016-02-12. PMID:25933983. the mechanisms involving nmda and ampa glutamate, 5-ht1a serotonin and the gpr39 zinc-sensing receptor and intracellular pathways will be discussed. 2016-02-12 2023-08-13 Not clear
Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. vortioxetine is a novel multimodal antidepressant that is a 5-ht1b receptor partial agonist, a 5-ht1a receptor agonist, an inhibitor of the serotonin (5-ht) transporter, and a 5-ht1d, 5-ht3, and 5-ht7 receptor antagonist in vitro. 2016-02-02 2023-08-13 rat
Mostafa El Mansari, Maurice Lecours, Pierre Blie. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. vol 232. issue 13. 2016-02-02. PMID:25665528. in vivo studies have shown that vortioxetine enhances levels of 5-ht and desensitizes 5-ht1a autoreceptors. 2016-02-02 2023-08-13 rat
James G Pfau. Treatment for hypoactive sexual desire. Cell. vol 163. issue 3. 2016-02-01. PMID:26496594. flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-ht1a autoreceptors and block postsynaptic action of serotonin at 5-ht2a receptors. 2016-02-01 2023-08-13 Not clear
Antonios Stamatakis, Theodora Kalpachidou, Androniki Raftogianni, Efstratia Zografou, Athanasia Tzanou, Stavroula Pondiki, Fotini Stylianopoulo. Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain. Psychoneuroendocrinology. vol 52. 2016-01-29. PMID:25486578. rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (erα, erβ), oxytocin and serotonin (5-ht1a) in their brain. 2016-01-29 2023-08-13 rat
Joshua Kaufman, Gregory M Sullivan, Jie Yang, R Todd Ogden, Jeffrey M Miller, Maria A Oquendo, J John Mann, Ramin V Parsey, Christine DeLorenz. Quantification of the Serotonin 1A Receptor Using PET: Identification of a Potential Biomarker of Major Depression in Males. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 7. 2016-01-25. PMID:25578798. multiple lines of research have implicated the serotonin 1a (5-ht1a) receptor in major depressive disorder (mdd). 2016-01-25 2023-08-13 human
Paweł Żmudzki, Grażyna Chłoń-Rzepa, Andrzej J Bojarski, Małgorzata Zygmunt, Grzegorz Kazek, Barbara Mordyl, Maciej Pawłowsk. Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione. Archiv der Pharmazie. vol 348. issue 4. 2016-01-21. PMID:25773578. in our previous paper, we have reported that some 8-alkoxy-1,3-dimethyl-1h-purine-2,6(3h,7h)-dione derivatives possessed high affinity and displayed agonistic activity for the serotonin 5-ht1a receptor. 2016-01-21 2023-08-13 Not clear