| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Fei Zhang, Lei Wu, Dong-Jun Wan, Ruo-Zhuo Liu, Zhao Dong, Min Chen, Sheng-Yuan Y. Evaluation of the efficacy and safety of vilazodone for treating major depressive disorder. Neuropsychiatric disease and treatment. vol 11. 2015-09-08. PMID:26345981. |
vilazodone is a novel serotonin (5-ht)-reuptake inhibitor and 5-ht1a partial agonist that was recently developed for the treatment of major depressive disorder (mdd). |
2015-09-08 |
2023-08-13 |
Not clear |
| Asres Berhan, Alex Barke. Vortioxetine in the treatment of adult patients with major depressive disorder: a meta-analysis of randomized double-blind controlled trials. BMC psychiatry. vol 14. 2015-09-02. PMID:25260373. |
it is a selective serotonin (5-ht) 3a and 5-ht7 receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and inhibitor of serotonin transporters. |
2015-09-02 |
2023-08-13 |
Not clear |
| Connie Sanchez, Karen E Asin, Francesc Artiga. Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data. Pharmacology & therapeutics. vol 145. 2015-08-31. PMID:25016186. |
vortioxetine, a novel antidepressant for the treatment of major depressive disorder (mdd), is a 5-ht3, 5-ht7 and 5-ht1d receptor antagonist, 5-ht1b receptor partial agonist, 5-ht1a receptor agonist and serotonin (5-ht) transporter (sert) inhibitor. |
2015-08-31 |
2023-08-13 |
Not clear |
| Yifat Glikmann-Johnston, Michael M Saling, Jian Chen, Graeme O'Keefe, Sylvia Gong, Henri Tochon-Danguy, Rachel Mulligan, David C Reuten. Hippocampal 5-HT1A receptor binding is related to object-location memory in humans. Brain structure & function. vol 220. issue 1. 2015-08-28. PMID:24807817. |
animal studies suggest that serotonin, mediated by the 5-ht1a receptor, plays a key role in spatial learning and memory. |
2015-08-28 |
2023-08-13 |
human |
| Deepali Gupta, Mahesh Radhakrishnan, Yeshwant Kurh. Anxiolytic-like effects of alverine citrate in experimental mouse models of anxiety. European journal of pharmacology. vol 742. 2015-08-25. PMID:25199966. |
a serotonergic (5ht) system plays an important role in pathogenesis of anxiety and predominantly involves 5ht1a receptor action in mediating anxiety-like behavior; the antagonism of 5ht1a receptor has demonstrated to produce anxiolytic-like effects. |
2015-08-25 |
2023-08-13 |
mouse |
| Donald R Gehlert, Janice Sha. 5-Hydroxytryptamine 1A (5HT1A) receptors mediate increases in plasma glucose independent of corticosterone. European journal of pharmacology. vol 745. 2015-08-24. PMID:25446927. |
5-hydroxytryptamine 1a (5ht1a) receptors mediate increases in plasma glucose independent of corticosterone. |
2015-08-24 |
2023-08-13 |
mouse |
| María Eugenia Cornide-Petronio, Ramón Anadón, Antón Barreiro-Iglesias, María Celina Rodici. Tryptophan hydroxylase and serotonin receptor 1A expression in the retina of the sea lamprey. Experimental eye research. vol 135. 2015-08-24. PMID:25925848. |
the serotonin 1a receptor (5-ht1a) is a major determinant of the activity of both serotonergic cells and their targets due to its pre- and post-synaptic location. |
2015-08-24 |
2023-08-13 |
Not clear |
| María Eugenia Cornide-Petronio, Ramón Anadón, Antón Barreiro-Iglesias, María Celina Rodici. Tryptophan hydroxylase and serotonin receptor 1A expression in the retina of the sea lamprey. Experimental eye research. vol 135. 2015-08-24. PMID:25925848. |
the expression of tph and 5-ht1a in neuroblasts also indicates that serotonin might be playing developmental roles in the larval lamprey retina. |
2015-08-24 |
2023-08-13 |
Not clear |
| Alfredo Menese. Serotonin, neural markers, and memory. Frontiers in pharmacology. vol 6. 2015-08-10. PMID:26257650. |
5-ht1a, 5-ht4, 5-ht5, 5-ht6, and 5-ht7 receptors as well as sert (serotonin transporter) seem to be useful neural markers and/or therapeutic targets. |
2015-08-10 |
2023-08-13 |
Not clear |
| Julia Cassani, Ana María Dorantes-Barrón, Lilian Mayagoitia Novales, Guadalupe Alva Real, Rosa Estrada-Reye. Anti-depressant-like effect of kaempferitrin isolated from Justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: evidence for the involvement of the serotonergic system. Molecules (Basel, Switzerland). vol 19. issue 12. 2015-08-07. PMID:25532842. |
pretreatment with p-chlorophenylalanine methyl ester (pcpa), a serotonin synthesis inhibitor, n-{2-(4-(2-methoxyphenyl)-1-piperazinyl}-n-(2-pyridinyl)cyclohexecarboxamide (way-100635), a selective 5-ht1a receptor antagonist, and 8oh-dpat, a selective 5-ht1a agonist, but not pindolol (10 mg/kg) blocked the anti- immobility effect induced by km. |
2015-08-07 |
2023-08-13 |
mouse |
| Pingyuan Gong, Jinting Liu, She Li, Xiaolin Zho. Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation. Psychoneuroendocrinology. vol 50. 2015-07-31. PMID:25247748. |
inspired by the finding that the receptor 5-ht1a modulates the level of serotonin in the brain, this study investigated to what extent a polymorphism (c-1019g, rs6295) of 5-ht1a gene modulates individuals' alexithymic characteristics and attachment orientation in 504 chinese han people. |
2015-07-31 |
2023-08-13 |
Not clear |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
enhanced 5-ht1a receptor-dependent feedback control over dorsal raphe serotonin neurons in the sert knockout mouse. |
2015-07-24 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
5-ht1a receptors are widely expressed in the brain and play a critical role in feedback inhibition of serotonin (5-ht) neurons through multiple mechanisms. |
2015-07-24 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
here, we examined several aspects of 5-ht1a receptor function in the 5-ht transporter knockout mouse (sert-ko), a model of vulnerability to stress and mood disorders. |
2015-07-24 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
since 5-ht1a receptors in the mpfc provide a key feedback regulation of the dorsal raphe nucleus (drn), we used a disinhibition strategy to examined endogenous feedback control of 5-ht neurons. |
2015-07-24 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
blocking 5-ht1a receptors disinhibited several fold more 5-ht neurons in the drn of sert-ko than in wt mice, revealing the presence of enhanced feedback inhibition of 5-ht neurons in the sert-ko. |
2015-07-24 |
2023-08-13 |
mouse |
| Mariano Soiza-Reilly, Nathalie M Goodfellow, Evelyn K Lambe, Kathryn G Common. Enhanced 5-HT1A receptor-dependent feedback control over dorsal raphe serotonin neurons in the SERT knockout mouse. Neuropharmacology. vol 89. 2015-07-24. PMID:25261781. |
taken together our results indicate that increased stress sensitivity in the sert-ko is associated with the enhanced capacity of 5-ht1a receptors to inhibit neurons in the mpfc as well as to exert feedback inhibition of drn 5-ht neurons. |
2015-07-24 |
2023-08-13 |
mouse |
| Zeng Li, Jiye Huang, Haifeng Sun, Shengbin Zhou, Lin Guo, Yu Zhou, Xuechu Zhen, Hong Li. Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles. Bioorganic & medicinal chemistry. vol 22. issue 21. 2015-07-22. PMID:25308766. |
design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-spd derivatives possessing dopamine d1, d2 and serotonin 5-ht1a multiple action profiles. |
2015-07-22 |
2023-08-13 |
Not clear |
| Zeng Li, Jiye Huang, Haifeng Sun, Shengbin Zhou, Lin Guo, Yu Zhou, Xuechu Zhen, Hong Li. Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles. Bioorganic & medicinal chemistry. vol 22. issue 21. 2015-07-22. PMID:25308766. |
a novel scaffold derived from l-spd with a substituted thiophene group in the d ring were designed, synthesized, and evaluated for their binding affinities at dopamine (d1, d2 and d3) and serotonin (5-ht1a and 5-ht2a) receptors. |
2015-07-22 |
2023-08-13 |
Not clear |
| Ambalika Sarkar, Parul Chachra, Vidita A Vaidy. Postnatal fluoxetine-evoked anxiety is prevented by concomitant 5-HT2A/C receptor blockade and mimicked by postnatal 5-HT2A/C receptor stimulation. Biological psychiatry. vol 76. issue 11. 2015-07-20. PMID:24315410. |
we examined the role of serotonin 2a (5-ht2a), serotonin 2c (5-ht2c) and serotonin 1a (5-ht1a) receptors, implicated in the development of anxiety, in the behavioral consequences of postnatal fluoxetine (pnflx). |
2015-07-20 |
2023-08-12 |
Not clear |