| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James Oluwagbamigbe Fajemiroye, Pablinny Moreira Galdino, Joelma Abadia Marciano De Paula, Fagundes Fabio Rocha, Moses A Akanmu, Frederico Argollo Vanderlinde, Jordan K Zjawiony, Elson Alves Cost. Anxiolytic and antidepressant like effects of natural food flavour (E)-methyl isoeugenol. Food & function. vol 5. issue 8. 2015-03-30. PMID:24920211. |
the involvement of monoamine system was studied by mice pretreatment with way100635 (antagonist of 5-ht1a), α-methyl-p-tyrosine (ampt; depletor of catecholamine) or p-chlorophenylalanine (pcpa; depletor of serotonin storage). |
2015-03-30 |
2023-08-13 |
mouse |
| Francesca Zanderigo, R Todd Ogden, Ramin V Parse. Noninvasive blood-free full quantification of positron emission tomography radioligand binding. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 1. 2015-03-17. PMID:25370860. |
as a study case, we show here the methodology in comparison to analysis with full arterial-line blood sampling in a cohort of 23 available scans with [(11)c]cumi-101, a partial agonist of the serotonin 5-ht1a receptors. |
2015-03-17 |
2023-08-13 |
human |
| Tea Terzić, Matej Kastelic, Vita Dolžan, Blanka Kores Plesniča. Influence of 5-HT1A and 5-HTTLPR genetic variants on the schizophrenia symptoms and occurrence of treatment-resistant schizophrenia. Neuropsychiatric disease and treatment. vol 11. 2015-03-11. PMID:25759587. |
this study aimed to explore the influence of two genetic polymorphisms of the 5-hydroxytryptamine 1a receptor (5-ht1a) and solute carrier family 6, member 4 (slc6a4) genes on the clinical symptoms and treatment resistance in slovenian patients with schizophrenia. |
2015-03-11 |
2023-08-13 |
human |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
the ascending midbrain 5-ht neurons known to contain 5-ht1a autoreceptors may be dysregulated in depression due to a reduced trophic support. |
2015-03-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
with in situ proximity ligation assay (pla) and supported by co-location of the fgfr1 and 5-ht1a immunoreactivities in midbrain raphe 5-ht cells, evidence for the existence of fgfr1-5-ht1a heteroreceptor complexes were obtained in the dorsal and median raphe nuclei of the sprague-dawley rat. |
2015-03-10 |
2023-08-13 |
rat |
| Dasiel O Borroto-Escuela, Manuel Narvaez, Mileidys Pérez-Alea, Alexander O Tarakanov, Antonio Jiménez-Beristain, Giuseppa Mudó, Luigi F Agnati, Francisco Ciruela, Natale Belluardo, Kjell Fux. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25485703. |
taken together, the 5-ht1a autoreceptors by being recruited into a fgfr1-5-ht1a heteroreceptor complex in the midbrain raphe 5-ht nerve cells may develop a novel function, namely a trophic role in many midbrain 5-ht neuron systems originating from the dorsal and medianus raphe nuclei. |
2015-03-10 |
2023-08-13 |
rat |
| Nasser Samir El-Okdi, Daniel Lumbrezer, Djuro Karanovic, Abhimanyu Ghose, Ragheb Assal. Serotonin syndrome after the use of tramadol and ziprasidone in a patient with a deep brain stimulator for Parkinson disease. American journal of therapeutics. vol 21. issue 4. 2015-03-02. PMID:24158007. |
ziprasidone is an atypical antipsychotic that can also cause dangerous interactions to cause ss because it is not only a potent 5-ht1a agonist but also has been reported to inhibit serotonin reuptake with an affinity similar to tricyclic antidepressants, in addition to inhibiting reuptake of norepinephrine. |
2015-03-02 |
2023-08-12 |
Not clear |
| J W Lunden, L G Kirb. Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. Neuroscience. vol 254. 2015-02-23. PMID:24055683. |
gene expression for brain-derived neurotrophic factor (bdnf), tyrosine kinase receptor b (trkb), corticotrophin releasing-factor (crf)-r1, crf-r2, alpha 1 subunit of the gabaa receptor (gabaa-α1), μ-opioid receptor (mor), 5-ht1a receptor, tryptophan hydroxylase2 (tph2) and the 5-ht transporter was then measured using quantitative real-time polymerase chain reaction at multiple time-points across the model of morphine exposure, withdrawal and post withdrawal stress. |
2015-02-23 |
2023-08-12 |
rat |
| Vladimir S Naumenko, Elena M Kondaurova, Daria V Bazovkina, Anton S Tsybko, Tatyana V Il'chibaeva, Nina K Popov. On the role of 5-HT(1A) receptor gene in behavioral effect of brain-derived neurotrophic factor. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24706292. |
reduced 5-ht1a and 5-ht(2a) receptor mrna levels in the frontal cortex and tph-2 mrna level in the midbrain of akr mice. |
2015-02-21 |
2023-08-13 |
mouse |
| Paulina S Rojas, David Neira, Mauricio Muñoz, Sergio Lavandero, Jenny L Fiedle. Serotonin (5-HT) regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24752854. |
serotonin (5-ht) regulates neurite outgrowth through 5-ht1a and 5-ht7 receptors in cultured hippocampal neurons. |
2015-02-21 |
2023-08-13 |
rat |
| Paulina S Rojas, David Neira, Mauricio Muñoz, Sergio Lavandero, Jenny L Fiedle. Serotonin (5-HT) regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons. Journal of neuroscience research. vol 92. issue 8. 2015-02-21. PMID:24752854. |
thus, we hypothesized that 5-ht promotes neurite outgrowth through 5-ht1a r and 5-ht7 r. the involvement of 5-ht1a r and 5-ht7 r in the morphology of rat hippocampal neurons was evaluated by treating primary cultures at 2 days in vitro with 5-ht and specific antagonists for 5-ht1a r and 5-ht7 r (way-100635 and sb269970, respectively). |
2015-02-21 |
2023-08-13 |
rat |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25225185. |
using electrophysiologic techniques, the present study assessed the in vivo action of brexpiprazole on serotonin (5-ht) receptor subtypes 5-ht1a, 5-ht1b, and 5-ht2a; dopamine (da) d2 autoreceptors, and α1- and α2-adrenergic receptors. |
2015-02-17 |
2023-08-13 |
Not clear |
| Chris A Oosterhof, Mostafa El Mansari, Pierre Blie. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of pharmacology and experimental therapeutics. vol 351. issue 3. 2015-02-17. PMID:25225185. |
in the drn, brexpiprazole completely inhibited the firing of 5-ht neurons via 5-ht1a agonism and was more potent than aripiprazole (ed50 = 230 and 700 μg/kg, respectively). |
2015-02-17 |
2023-08-13 |
Not clear |
| Francesca Borrelli, Ester Pagano, Barbara Romano, Stefania Panzera, Francesco Maiello, Diana Coppola, Luciano De Petrocellis, Lorena Buono, Pierangelo Orlando, Angelo A Izz. Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. Carcinogenesis. vol 35. issue 12. 2015-02-14. PMID:25269802. |
specifically, cbg potently blocks transient receptor potential (trp) m8 (trpm8), activates trpa1, trpv1 and trpv2 channels, blocks 5-hydroxytryptamine receptor 1a (5-ht1a) receptors and inhibits the reuptake of endocannabinoids. |
2015-02-14 |
2023-08-13 |
mouse |
| Jacek Sapa, Małgorzata Zygmunt, Katarzyna Kulig, Barbara Malawska, Magdalena Dudek, Barbara Filipek, Marek Bednarski, Aleksandra Kusak, Gabriel Nowa. Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives. Pharmacological reports : PR. vol 66. issue 4. 2015-02-12. PMID:24948076. |
the aim of this study was to examine the anticonvulsant activity of some novel pyrrolidin-2-one derivatives with considerable affinity to serotonin 5-ht1a and α1-adrenergic receptors. |
2015-02-12 |
2023-08-13 |
Not clear |
| Yuji Odagaki, Masakazu Kinoshita, Ryoichi Toyoshim. Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes. Journal of pharmacological sciences. vol 125. issue 2. 2015-02-09. PMID:24849282. |
the increases induced by cch and 5-ht were essentially additive, though not completely, indicating that the machrs and 5-ht1a receptors were coupled independently to distinct pools of gi/o proteins. |
2015-02-09 |
2023-08-13 |
rat |
| Vladimir S Naumenko, Nina K Popova, Enza Lacivita, Marcello Leopoldo, Evgeni G Ponimaski. Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. CNS neuroscience & therapeutics. vol 20. issue 7. 2015-02-06. PMID:24935787. |
interplay between serotonin 5-ht1a and 5-ht7 receptors in depressive disorders. |
2015-02-06 |
2023-08-13 |
Not clear |
| Vladimir S Naumenko, Nina K Popova, Enza Lacivita, Marcello Leopoldo, Evgeni G Ponimaski. Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. CNS neuroscience & therapeutics. vol 20. issue 7. 2015-02-06. PMID:24935787. |
this review focuses on possible cross talk between two serotonin receptors, 5-ht1a and the 5-ht7 . |
2015-02-06 |
2023-08-13 |
Not clear |
| Analia Bortolozzi, Pau Celada, Francesc Artiga. Novel therapeutic strategies in major depression: focus on RNAi and ketamine. Current pharmaceutical design. vol 20. issue 23. 2015-01-30. PMID:24180396. |
in particular, rnai strategies have been used to evoke antidepressant-like effects in laboratory animals by knocking-down the expression of genes involved in antidepressant effects, such as the serotonin transporter (sert) or the 5-ht1a autoreceptor. |
2015-01-30 |
2023-08-12 |
Not clear |
| Ansel T Hillmer, Dustin W Wooten, Alisha K Bajwa, Andrew T Higgins, Patrick J Lao, Tobey J Betthauser, Todd E Barnhart, Howard A Rowley, Charles K Stone, Sterling C Johnson, Jogeshwar Mukherjee, Bradley T Christia. First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 55. issue 12. 2015-01-30. PMID:25453045. |
the serotonin-1a (5-ht1a; 5-ht is 5-hydroxytryptamine) receptor is implicated in an array of neurologic and psychiatric disorders. |
2015-01-30 |
2023-08-13 |
monkey |